| Compound ID |
Compound Name |
Compound Formula |
|
CP0061893
|
1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)amino)methyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-ethylurea
Show/Hide
|
C37H33F2N5O3S
|
12
|
| 1 |
IC50 = 0.31 nM
|
|
|
| 2 |
IC50 = 0.9 nM
|
|
|
| 3 |
IC50 = 1 nM
|
|
|
| 4 |
IC50 = 1.1 nM
|
|
|
| 5 |
IC50 = 2.1 nM
|
|
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| 6 |
IC50 = 9 nM
|
|
|
| 7 |
IC50 = 23 nM
|
|
|
| 8 |
IC50 = 26 nM
|
|
|
| 9 |
IC50 = 28 nM
|
|
|
| 10 |
IC50 = 40 nM
|
|
|
| 11 |
IC50 = 50 nM
|
|
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| 12 |
IC50 = 60 nM
|
|
|
|
CP0039875
|
1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)amino)methyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea
Show/Hide
|
C36H31F2N5O4S
|
12
|
| 1 |
IC50 = 0.5 nM
|
|
|
| 2 |
IC50 = 0.7 nM
|
|
|
| 3 |
IC50 = 0.8 nM
|
|
|
| 4 |
IC50 = 1.2 nM
|
|
|
| 5 |
IC50 = 1.9 nM
|
|
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| 6 |
IC50 = 6 nM
|
|
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| 7 |
IC50 = 10 nM
|
|
|
| 8 |
IC50 = 12 nM
|
|
|
| 9 |
IC50 = 24 nM
|
|
|
| 10 |
IC50 = 110 nM
|
|
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| 11 |
IC50 = 120 nM
|
|
|
| 12 |
IC50 = 190 nM
|
|
|
|
CP0061895
|
N-[4-[5-[[benzyl(methyl)amino]methyl]-1-[(2,6-difluorophenyl)methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]benzamide
Show/Hide
|
C41H32F2N4O3S
|
13
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 13 nM
|
|
|
| 3 |
IC50 = 15 nM
|
|
|
| 4 |
IC50 = 20 nM
|
|
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| 5 |
IC50 = 22 nM
|
|
|
| 6 |
IC50 = 26 nM
|
|
|
| 7 |
IC50 = 31 nM
|
|
|
| 8 |
IC50 = 100 nM
|
|
|
| 9 |
IC50 = 220 nM
|
|
|
| 10 |
IC50 = 380 nM
|
|
|
| 11 |
IC50 = 400 nM
|
|
|
| 12 |
IC50 = 800 nM
|
|
|
| 13 |
IC50 = 1500 nM
|
|
|
|
CP0061899
|
1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)amino)methyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-benzylurea
Show/Hide
|
C42H35F2N5O3S
|
13
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 30 nM
|
|
|
| 3 |
IC50 = 70 nM
|
|
|
| 4 |
IC50 = 190 nM
|
|
|
| 5 |
IC50 = 390 nM
|
|
|
| 6 |
IC50 = 500 nM
|
|
|
| 7 |
IC50 = 600 nM
|
|
|
| 8 |
IC50 = 900 nM
|
|
|
| 9 |
IC50 = 1100 nM
|
|
|
| 10 |
IC50 = 1200 nM
|
|
|
| 11 |
IC50 = 1400 nM
|
|
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| 12 |
IC50 = 4000 nM
|
|
|
| 13 |
IC50 = 6000 nM
|
|
|
|
CP0061901
|
N-[4-[5-[[benzyl(methyl)amino]methyl]-1-[(2,6-difluorophenyl)methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]acetamide
Show/Hide
|
C36H30F2N4O3S
|
14
|
| 1 |
IC50 = 29 nM
|
|
|
| 2 |
IC50 = 31 nM
|
|
|
| 3 |
IC50 = 52 nM
|
|
|
| 4 |
IC50 = 160 nM
|
|
|
| 5 |
IC50 = 210 nM
|
|
|
| 6 |
IC50 = 230 nM
|
|
|
| 7 |
IC50 = 240 nM
|
|
|
| 8 |
IC50 = 1100 nM
|
|
|
| 9 |
IC50 = 1600 nM
|
|
|
| 10 |
IC50 = 1700 nM
|
|
|
| 11 |
IC50 = 2000 nM
|
|
|
| 12 |
IC50 = 2300 nM
|
|
|
| 13 |
IC50 = 2400 nM
|
|
|
| 14 |
IC50 = 4400 nM
|
|
|
|
CP0061892
|
1-(2,6-Difluoro-benzyl)-5-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-6-(4-nitro-phenyl)-3-phenyl-1H-thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C34H27F2N5O4S
|
14
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
IC50 = 52 nM
|
|
|
| 3 |
IC50 = 58 nM
|
|
|
| 4 |
IC50 = 110 nM
|
|
|
| 5 |
IC50 = 200 nM
|
|
|
| 6 |
IC50 = 240 nM
|
|
|
| 7 |
IC50 = 400 nM
|
|
|
| 8 |
IC50 = 450 nM
|
|
|
| 9 |
IC50 = 900 nM
|
|
|
| 10 |
IC50 = 2000 nM
|
|
|
| 11 |
IC50 = 2650 nM
|
|
|
| 12 |
IC50 = 3600 nM
|
|
|
| 13 |
IC50 = 4500 nM
|
|
|
| 14 |
IC50 > 10000 nM
|
|
|
|
CP0061891
|
1-(2,6-difluorobenzyl)-6-(4-aminophenyl)-5-((benzyl(methyl)amino)methyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C34H28F2N4O2S
|
11
|
| 1 |
IC50 = 210 nM
|
|
|
| 2 |
IC50 = 370 nM
|
|
|
| 3 |
IC50 = 390 nM
|
|
|
| 4 |
IC50 = 500 nM
|
|
|
| 5 |
IC50 = 530 nM
|
|
|
| 6 |
IC50 = 710 nM
|
|
|
| 7 |
IC50 = 950 nM
|
|
|
| 8 |
IC50 = 1500 nM
|
|
|
| 9 |
IC50 = 1600 nM
|
|
|
| 10 |
IC50 = 4000 nM
|
|
|
| 11 |
IC50 > 10000 nM
|
|
|
|
CP0061898
|
1-(2,6-difluorobenzyl)-5-((benzyl(methyl)amino)methyl)-6-(4-(4,5-dihydro-1H-imidazol-2-ylamino)phenyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C37H32F2N6O2S
|
13
|
| 1 |
IC50 = 240 nM
|
|
|
| 2 |
IC50 = 350 nM
|
|
|
| 3 |
IC50 = 480 nM
|
|
|
| 4 |
IC50 = 800 nM
|
|
|
| 5 |
IC50 = 1020 nM
|
|
|
| 6 |
IC50 = 1400 nM
|
|
|
| 7 |
IC50 = 1800 nM
|
|
|
| 8 |
IC50 = 2100 nM
|
|
|
| 9 |
IC50 = 3300 nM
|
|
|
| 10 |
IC50 = 4400 nM
|
|
|
| 11 |
IC50 = 5000 nM
|
|
|
| 12 |
IC50 = 5200 nM
|
|
|
| 13 |
IC50 > 10000 nM
|
|
|
|
CP0220826
|
1-(2,6-difluorobenzyl)-5-((benzyl(methyl)amino)methyl)-6-(4-nitrophenyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C34H26F2N4O4S
|
7
|
| 1 |
IC50 = 600 nM
|
|
|
| 2 |
IC50 = 1100 nM
|
|
|
| 3 |
IC50 = 1400 nM
|
|
|
| 4 |
IC50 = 1600 nM
|
|
|
| 5 |
IC50 = 1900 nM
|
|
|
| 6 |
IC50 = 3000 nM
|
|
|
| 7 |
IC50 > 10000 nM
|
|
|
|
CP0061904
|
1-(2,6-Difluoro-benzyl)-5-[(methyl-phenethyl-amino)-methyl]-6-(4-nitro-phenyl)-3-phenyl-1H-thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C35H28F2N4O4S
|
8
|
| 1 |
IC50 = 1100 nM
|
|
|
| 2 |
IC50 = 1300 nM
|
|
|
| 3 |
IC50 = 1600 nM
|
|
|
| 4 |
IC50 = 1900 nM
|
|
|
| 5 |
IC50 = 3300 nM
|
|
|
| 6 |
IC50 = 5000 nM
|
|
|
| 7 |
IC50 = 7100 nM
|
|
|
| 8 |
IC50 > 10000 nM
|
|
|
|
CP0405522
|
6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C33H37F2N5O2
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0551247
|
1-(2,6-difluorobenzyl)-6-(4-chloro-2-methylbenzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C32H34ClF2N5O2
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0306971
|
1-(2,6-difluorobenzyl)-6-(4-(methylthio)benzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C32H35F2N5O2S
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0373684
|
(R)-1-(2,6-difluorobenzyl)-6-(4-chlorobenzyl)-3-((1-(2-(pyridin-2-yl)ethyl)pyrrolidin-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C33H34ClF2N5O2
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0521178
|
1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-6-((3-methylbenzo[b]thiophen-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C35H35F4N5O2S
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0373685
|
1-(2,6-difluorobenzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-6-((3-methylbenzo[b]thiophen-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C34H35F2N5O2S
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0433346
|
1-(2,6-difluorobenzyl)-6-(4-(ethylthio)benzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C33H37F2N5O2S
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0497522
|
1-(2,6-difluorobenzyl)-6-(4-chlorobenzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C31H32ClF2N5O2
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0439473
|
1-(2,6-difluorobenzyl)-6-(4-ethylbenzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C33H37F2N5O2
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0458481
|
(R)-1-(2,6-difluorobenzyl)-6-(4-chlorobenzyl)-3-((1-(pyridin-2-ylmethyl)pyrrolidin-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C32H32ClF2N5O2
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0509317
|
6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-((1-(pyridin-2-ylmethyl)piperidin-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C35H39F2N5O2
|
1
|
| 1 |
Ki = 25 nM
|
|
|
|
CP0433345
|
(R)-1-(2,6-difluorobenzyl)-6-(4-chlorobenzyl)-3-((1-(2-(pyridin-2-yl)ethyl)piperidin-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C34H36ClF2N5O2
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0485339
|
1-(2,6-difluorobenzyl)-6-(4-(trifluoromethyl)benzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C32H32F5N5O2
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0505402
|
1-(2,6-difluoro-benzyl)-6-(4-methyl-benzyl)-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione
Show/Hide
|
C32H35F2N5O2
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0490932
|
(R)-1-(2,6-difluorobenzyl)-6-(4-chlorobenzyl)-3-(2-(methylamino)-2-phenylethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C30H29ClF2N4O2
|
1
|
| 1 |
Ki = 45 nM
|
|
|
|
CP0505283
|
(R)-1-(2,6-difluorobenzyl)-6-(4-chlorobenzyl)-3-(2-(dimethylamino)-2-phenylethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C31H31ClF2N4O2
|
1
|
| 1 |
Ki = 70 nM
|
|
|
|
CP0540222
|
1-(2-fluorobenzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-6-((3-methylbenzo[b]thiophen-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C34H36FN5O2S
|
1
|
| 1 |
Ki = 80 nM
|
|
|
|
CP0551248
|
1-(2,6-difluoro-benzyl)-6-(2-methyl-benzyl)-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione
Show/Hide
|
C32H35F2N5O2
|
1
|
| 1 |
Ki = 85 nM
|
|
|
|
CP0551250
|
1-(2,6-difluorobenzyl)-6-(4-methoxybenzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C32H35F2N5O3
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0540219
|
6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-((1-benzylpiperidin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C36H40F2N4O2
|
1
|
| 1 |
Ki = 160 nM
|
|
|
|
CP0400120
|
6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-(2-(methyl(pyridin-2-ylmethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C32H35F2N5O2
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0540224
|
1-(2,6-difluorobenzyl)-6-(3,4-dichlorobenzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C31H31Cl2F2N5O2
|
1
|
| 1 |
Ki = 255 nM
|
|
|
|
CP0444726
|
1-(2,6-difluorobenzyl)-6-(4-tert-butylbenzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C35H41F2N5O2
|
1
|
| 1 |
Ki = 300 nM
|
|
|
|
CP0505596
|
1-benzyl-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-6-((3-methylbenzo[b]thiophen-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C34H37N5O2S
|
1
|
| 1 |
Ki = 305 nM
|
|
|
|
CP0373576
|
1-(cyclohexylmethyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-6-((3-methylbenzo[b]thiophen-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C34H43N5O2S
|
1
|
| 1 |
Ki = 380 nM
|
|
|
|
CP0537894
|
6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-((1-(pyridin-2-ylmethyl)piperidin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C35H39F2N5O2
|
1
|
| 1 |
Ki = 490 nM
|
|
|
|
CP0524361
|
6-(2-(1H-indol-3-yl)ethyl)-1-(2,6-difluorobenzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C34H36F2N6O2
|
1
|
| 1 |
Ki = 515 nM
|
|
|
|
CP0497520
|
6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-((1-cyclopentylpiperidin-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C34H42F2N4O2
|
1
|
| 1 |
Ki = 520 nM
|
|
|
|
CP0533077
|
1-(2,6-difluoro-benzyl)-7-[4-imidazol-1-yl-benzyl]-3-(3-methoxy-phenyl)-5,6,7,8-tetrahydro-1H-pyrido[3,4-d]pyrimidine-2,4-dione
Show/Hide
|
C31H27F2N5O3
|
1
|
| 1 |
Ki = 540 nM
|
|
|
|
CP0433343
|
6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-((1-(2-(pyridin-2-yl)ethyl)piperidin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C36H41F2N5O2
|
1
|
| 1 |
Ki = 600 nM
|
|
|
|
CP0522238
|
1-(2,6-difluorobenzyl)-6-(4-(methylsulfonyl)benzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C32H35F2N5O4S
|
1
|
| 1 |
Ki = 805 nM
|
|
|
|
CP0373577
|
1-(2,6-difluorobenzyl)-6-(3-chlorobenzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C31H32ClF2N5O2
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1
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| 1 |
Ki = 850 nM
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CP0497519
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6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-((1-benzylpiperidin-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C36H40F2N4O2
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1
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| 1 |
Ki = 945 nM
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CP0505597
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1-(2,6-difluoro-benzyl)-3-(3-methoxy-phenyl)-5,6,7,8-tetrahydro-1H-pyrido[3,4-d]pyrimidine-2,4-dione
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C21H19F2N3O3
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1
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| 1 |
Ki = 970 nM
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CP0405525
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1-(2,6-difluoro-benzyl)-7-(2-methoxy-benzyl)-3-(3-methoxy-phenyl)-5,6,7,8-tetrahydro-1H-pyrido[3,4-d]pyrimidine-2,4-dione
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C29H27F2N3O4
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1
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| 1 |
Ki = 980 nM
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CP0537895
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6-benzyl-1-(2,6-difluoro-benzyl)-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione
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C31H33F2N5O2
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1
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| 1 |
Ki = 990 nM
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CP0485338
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7-benzyl-1-(2,6-difluoro-benzyl)-3-(3-methoxy-phenyl)-5,6,7,8-tetrahydro-1H-pyrido[3,4-d]pyrimidine-2,4-dione
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C28H25F2N3O3
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1
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| 1 |
Ki = 1290 nM
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CP0439472
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(R)-1-(2,6-difluorobenzyl)-6-(4-chlorobenzyl)-3-((1-cyclopentylpyrrolidin-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C31H35ClF2N4O2
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1
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| 1 |
Ki = 1370 nM
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CP0496543
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1-(2,6-difluorobenzyl)-6-(4-chlorobenzyl)-3-(((R)-1-(((S)-1-(pyridin-2-ylmethyl)pyrrolidin-2-yl)methyl)piperidin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C38H43ClF2N6O2
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1
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| 1 |
Ki = 1370 nM
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CP0540221
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1-(2,6-difluorobenzyl)-6-(4-ethylbenzyl)-3-(2-(dimethylamino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C27H32F2N4O2
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1
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| 1 |
Ki = 1400 nM
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CP0540225
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1-(2,6-difluoro-benzyl)-7-[pyridin-4-yl-methyl]-3-(3-methoxy-phenyl)-5,6,7,8-tetrahydro-1H-pyrido[3,4-d]pyrimidine-2,4-dione
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C27H24F2N4O3
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1
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| 1 |
Ki = 1580 nM
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CP0510819
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6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-((1-methylpiperidin-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C30H36F2N4O2
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1
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| 1 |
Ki = 1710 nM
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CP0501788
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6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-(2-(isobutyl(methyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C30H38F2N4O2
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1
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| 1 |
Ki = 1800 nM
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CP0509319
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1-(2,6-difluoro-benzyl)-7-[2-(1H-indol-3-yl)-ethyl]-3-(3-methoxy-phenyl)-5,6,7,8-tetrahydro-1H-pyrido[3,4-d]pyrimidine-2,4-dione
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C31H28F2N4O3
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1
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| 1 |
Ki = 2200 nM
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CP0540220
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(S)-1-(2,6-difluorobenzyl)-6-(4-chlorobenzyl)-3-((1-(2-(pyridin-2-yl)ethyl)piperidin-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C34H36ClF2N5O2
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1
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| 1 |
Ki = 2410 nM
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CP0444724
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6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-(piperidin-3-ylmethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C29H34F2N4O2
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1
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| 1 |
Ki = 2450 nM
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CP0474463
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6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-((1-cyclopentylpiperidin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C34H42F2N4O2
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1
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| 1 |
Ki = 2580 nM
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CP0509318
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6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-((1-isobutylpiperidin-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C33H42F2N4O2
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1
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| 1 |
Ki = 2590 nM
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CP0400121
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1-methyl-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-6-((3-methylbenzo[b]thiophen-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C28H33N5O2S
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1
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| 1 |
Ki > 10000 nM
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CP0433344
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6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-((1-methylpiperidin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C30H36F2N4O2
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1
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| 1 |
Ki > 10000 nM
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CP0444777
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6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-((1-isobutylpiperidin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C33H42F2N4O2
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1
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| 1 |
Ki > 10000 nM
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CP0444780
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1-(2,6-difluoro-benzyl)-7-[4-methylbenzyl]-3-(3-methoxy-phenyl)-5,6,7,8-tetrahydro-1H-pyrido[3,4-d]pyrimidine-2,4-dione
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C29H27F2N3O3
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1
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| 1 |
Ki > 10000 nM
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CP0456701
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6-(3-methyl-benzo[b]thiophen-2-ylmethyl)-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione
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C27H31N5O2S
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1
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| 1 |
Ki > 10000 nM
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CP0474461
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(R)-1-(2,6-difluorobenzyl)-6-(4-chlorobenzyl)-3-(pyrrolidin-2-ylmethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C26H27ClF2N4O2
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1
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| 1 |
Ki > 10000 nM
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CP0474465
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1-(2,6-difluorobenzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-6-(pyridin-4-ylmethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C30H32F2N6O2
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1
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| 1 |
Ki > 10000 nM
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CP0521177
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6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-(piperidin-2-ylmethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
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C29H34F2N4O2
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1
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| 1 |
Ki > 10000 nM
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CP0524362
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1-(2,6-difluoro-benzyl)-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione
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C24H27F2N5O2
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1
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| 1 |
Ki > 10000 nM
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CP0533076
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1-(2,6-difluorobenzyl)-6-(4-(1H-imidazol-1-yl)benzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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C34H35F2N7O2
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1
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| 1 |
Ki > 10000 nM
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CP0540223
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1-(2,6-difluorobenzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-6-((1-methyl-1H-benzo[d]imidazol-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
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C33H35F2N7O2
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1
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| 1 |
Ki > 10000 nM
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