Brief Information of the Compound and Protein
Compound Name
6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-((1-(pyridin-2-ylmethyl)piperidin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
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PubChem ID
CID: 44436010
Canonical SMILES
Cc1ccc(CN2CCc3c(C2)c(=O)n(CC2CCCN(Cc4ccccn4)C2)c(=O)n3Cc2c(F)cccc2F)c(C)c1
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Compound Formula C35H39F2N5O2
Compound Structure
Protein Name
Gonadotropin-releasing hormone receptor
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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GnRH receptor
Uniprot ID
P30968
Gene Name
GNRHR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000053 COS-7 Chlorocebus aethiops (Green monkey)  1
1
Ki = 490 nM
   TI
   LI
   LO
   TS