Protein Information

General Information of the Protein

Protein ID	PT01836
Protein Name	Gonadotropin-releasing hormone receptor
Gene Name	GNRHR
Secondarily Gene Name	GRHR
Sequence	MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Peptide receptor (family A GPCR) > Short peptide receptor (family A GPCR) > GnRH receptor
Function	Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling. Show/Hide
Uniprot ID	Primary ID: P30968 Secondarily ID: O75793 Q14D13 Q92644 Show/Hide
Ensembl ID	ENSG00000109163
HGNC ID	HGNC:4421
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0495920 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-7-[(2,6-difluorophenyl)methyl]-2-[4-(methylcarbamoylamino)phenyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C34H32F2N4O4S	1
1	IC50 = 0.06 nM Bioactivity Info	TI LI LO TS
CP0039875 Compound Info	1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)amino)methyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea Show/Hide	C36H31F2N5O4S	7
1	IC50 = 0.06 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
3	IC50 = 0.6 nM Bioactivity Info	TI LI LO TS
4	IC50 = 1.6 nM Bioactivity Info	TI LI LO TS
5	IC50 = 1.9 nM Bioactivity Info	TI LI LO TS
6	IC50 = 10 nM Bioactivity Info	TI LI LO TS
7	IC50 = 270 nM Bioactivity Info	TI LI LO TS
CP0359982 Compound Info	3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobenzyl)-4,7-dihydro-5-isobutyryl-2-[4-(3-methyluriedo)phenyl]-4-oxothieno[2,3-b]pyridine Show/Hide	C35H34F2N4O3S	3
1	IC50 = 0.07 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
3	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0464346 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-7-[(2-fluorophenyl)methyl]-2-[4-(methylcarbamoylamino)phenyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C34H33FN4O4S	1
1	IC50 = 0.07 nM Bioactivity Info	TI LI LO TS
CP0061893 Compound Info	1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)amino)methyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-ethylurea Show/Hide	C37H33F2N5O3S	4
1	IC50 = 0.07 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
3	IC50 = 0.3 nM Bioactivity Info	TI LI LO TS
4	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0199103 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[[2-methoxyethyl(methyl)amino]methyl]-3-(6-methoxypyridin-3-yl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C32H32F2N6O6S	4
1	IC50 = 0.07 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
3	IC50 = 0.49 nM Bioactivity Info	TI LI LO TS
4	IC50 = 0.8 nM Bioactivity Info	TI LI LO TS
CP0231917 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[[methyl(2-pyridin-2-ylethyl)amino]methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C36H32F2N6O4S	1
1	IC50 = 0.07 nM Bioactivity Info	TI LI LO TS
CP0050490 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[[2-methoxyethyl(methyl)amino]methyl]-3-(4-methoxyphenyl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C33H33F2N5O6S	4
1	IC50 = 0.07 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.17 nM Bioactivity Info	TI LI LO TS
3	IC50 = 0.29 nM Bioactivity Info	TI LI LO TS
4	IC50 = 0.43 nM Bioactivity Info	TI LI LO TS
CP0048798 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[[methyl(pyridin-2-ylmethyl)amino]methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C35H30F2N6O4S	2
1	IC50 = 0.08 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.09 nM Bioactivity Info	TI LI LO TS
CP0050481 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[[2-methoxyethyl(methyl)amino]methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C32H31F2N5O5S	4
1	IC50 = 0.08 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
3	IC50 = 0.5 nM Bioactivity Info	TI LI LO TS
4	IC50 = 1.4 nM Bioactivity Info	TI LI LO TS
CP0295225 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[[2-methoxyethyl(methyl)amino]methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C31H31F2N7O6S	4
1	IC50 = 0.08 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.24 nM Bioactivity Info	TI LI LO TS
3	IC50 = 0.26 nM Bioactivity Info	TI LI LO TS
4	IC50 = 0.94 nM Bioactivity Info	TI LI LO TS
CP0338284 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C29H27F2N7O5S	4
1	IC50 = 0.08 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.33 nM Bioactivity Info	TI LI LO TS
3	IC50 = 0.82 nM Bioactivity Info	TI LI LO TS
4	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0351993 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[[methyl-[2-(2-oxopyrrolidin-1-yl)ethyl]amino]methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C35H34F2N6O5S	2
1	IC50 = 0.09 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.21 nM Bioactivity Info	TI LI LO TS
CP0497061 Compound Info	7-Chloro-2-oxo-4-[2-(4-oxo-azetidin-2-yl)-ethoxy]-3-((S)-3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid [1,2,5]thiadiazol-3-ylamide Show/Hide	C26H24ClN5O4S	2
1	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1.3 nM Bioactivity Info	TI LI LO TS
CP0309511 Compound Info	3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobenzyl)-4,7-dihydro-2-[4-(1-hydroxy-1-cyclopropanecarboxamido)-phenyl]-5-isobutyryl-4-oxothieno[2,3-b]pyridine Show/Hide	C37H37F2N3O4S	3
1	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.9 nM Bioactivity Info	TI LI LO TS
3	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0464280 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-7-[(2,6-difluorophenyl)methyl]-4-oxo-2-[4-(propanoylamino)phenyl]thieno[2,3-b]pyridine-5-carboxylate Show/Hide	C35H33F2N3O4S	1
1	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
CP0464345 Compound Info	N-[4-[5-benzoyl-3-[[benzyl(methyl)amino]methyl]-7-[(2,6-difluorophenyl)methyl]-4-oxothieno[2,3-b]pyridin-2-yl]phenyl]-2-methylpropanamide Show/Hide	C40H35F2N3O3S	1
1	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
CP0509912 Compound Info	1-[4-[5-[[benzyl(methyl)amino]methyl]-1-[(2,6-difluorophenyl)methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methylurea Show/Hide	C36H31F2N5O3S	1
1	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
CP0048796 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[[[6-(hydroxymethyl)pyridin-2-yl]methyl-methylamino]methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C36H32F2N6O5S	2
1	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.24 nM Bioactivity Info	TI LI LO TS
CP0231905 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[[2-methoxyethyl(methyl)amino]methyl]-3-(5-methylpyridin-2-yl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C32H32F2N6O5S	4
1	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.18 nM Bioactivity Info	TI LI LO TS
3	IC50 = 0.3 nM Bioactivity Info	TI LI LO TS
4	IC50 = 1.3 nM Bioactivity Info	TI LI LO TS
CP0050489 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[(dimethylamino)methyl]-3-(6-methoxypyridin-3-yl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C30H28F2N6O5S	4
1	IC50 = 0.12 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.26 nM Bioactivity Info	TI LI LO TS
3	IC50 = 0.55 nM Bioactivity Info	TI LI LO TS
4	IC50 = 0.95 nM Bioactivity Info	TI LI LO TS
CP0039874 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-7-(2,6-difluoro-benzyl)-2-(4-isobutyrylamino-phenyl)-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid isopropyl ester; hydrochloride Show/Hide	C37H37F2N3O4S	4
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.6 nM Bioactivity Info	TI LI LO TS
3	IC50 = 2 nM Bioactivity Info	TI LI LO TS
4	Ki = 0.2 nM Bioactivity Info	TI LI LO TS
CP0521653 Compound Info	3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobenzyl)-4,7-dihydro-2-(4-(2-hydroxy-2-methylpropionylamido)phenyl)-5-isobutyryl-4-oxothieno[2,3-b]pyridine Show/Hide	C37H37F2N3O4S	1
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0536569 Compound Info	N-[4-[3-[[benzyl(methyl)amino]methyl]-7-[(2,6-difluorophenyl)methyl]-5-(2-methylpropanoyl)-4-oxothieno[2,3-b]pyridin-2-yl]phenyl]-2-methylpropanamide Show/Hide	C37H37F2N3O3S	1
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0538121 Compound Info	3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobenzyl)-4,7-dihydro-2-[4-(2-hydroxyacetamido)phenyl]-5-isobutyryl-4-oxothieno[2,3-b]pyridine Show/Hide	C35H33F2N3O4S	1
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0897586 Compound Info	ethyl 3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobenzyl)-4,7-dihydro-2-(4-isobutyrylamidophenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate hydrochloride Show/Hide	C36H36ClF2N3O4S	1
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0405458 Compound Info	1-{4-[5-[(Benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidin-6-yl]-phenyl}-3-isopropyl-urea; HCL.H2O Show/Hide	C38H35F2N5O3S	1
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0495465 Compound Info	N-[4-[5-[[benzyl(methyl)amino]methyl]-1-[(2,6-difluorophenyl)methyl]-3-(3-methoxyphenyl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]propanamide Show/Hide	C38H34F2N4O4S	1
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0508582 Compound Info	1-{4-[5-[(Benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidin-6-yl]-phenyl}-3-ethoxy-urea; HCL.2.H2O Show/Hide	C37H33F2N5O4S	1
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0778924 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-7-(2,6-difluoro-benzyl)-2-(4-isobutyrylamino-phenyl)-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid isopropyl ester hydrochloride Show/Hide	C37H38ClF2N3O4S	3
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.6 nM Bioactivity Info	TI LI LO TS
3	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0050491 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-3-(5-fluoropyridin-2-yl)-5-[[2-methoxyethyl(methyl)amino]methyl]-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C31H29F3N6O5S	2
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0050492 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[[2-methoxyethyl(methyl)amino]methyl]-2,4-dioxo-3-pyridin-2-ylthieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C31H30F2N6O5S	4
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.3 nM Bioactivity Info	TI LI LO TS
3	IC50 = 0.83 nM Bioactivity Info	TI LI LO TS
4	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0143092 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[[methyl-[2-[methyl(methylsulfonyl)amino]ethyl]amino]methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C33H34F2N6O6S2	2
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.27 nM Bioactivity Info	TI LI LO TS
CP0338285 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[[methyl(pyridin-3-ylmethyl)amino]methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C35H30F2N6O4S	1
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0342912 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-3-(2-methoxyethyl)-5-[[2-methoxyethyl(methyl)amino]methyl]-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C29H33F2N5O6S	2
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.29 nM Bioactivity Info	TI LI LO TS
CP0344569 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-3-(2-ethoxyethyl)-5-[[2-methoxyethyl(methyl)amino]methyl]-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C30H35F2N5O6S	2
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.37 nM Bioactivity Info	TI LI LO TS
CP0448182 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-8-(2,6-difluoro-benzyl)-2-[4-(3-ethyl-ureido)-phenyl]-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid propyl ester Show/Hide	C35H36F2N6O4	1
1	IC50 = 0.3 nM Bioactivity Info	TI LI LO TS
CP0095035 Compound Info	7-Chloro-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide Show/Hide	C30H32ClN5O3	2
1	IC50 = 0.3 nM Bioactivity Info	TI LI LO TS
2	IC50 = 2.2 nM Bioactivity Info	TI LI LO TS
CP0445881 Compound Info	7-Chloro-2-oxo-4-[2-(5-oxo-pyrrolidin-2-yl)-ethoxy]-3-((R)-3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid [1,2,5]thiadiazol-3-ylamide Show/Hide	C27H26ClN5O4S	2
1	IC50 = 0.3 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.7 nM Bioactivity Info	TI LI LO TS
CP0091820 Compound Info	ELIGARD Show/Hide	C59H84N16O12	1
1	IC50 = 0.3 nM Bioactivity Info	TI LI LO TS
CP0272654 Compound Info	N-[4-[5-[[benzyl(methyl)amino]methyl]-1-[(2,6-difluorophenyl)methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]propanamide Show/Hide	C37H32F2N4O3S	4
1	IC50 = 0.3 nM Bioactivity Info	TI LI LO TS
2	IC50 = 4 nM Bioactivity Info	TI LI LO TS
3	IC50 = 9 nM Bioactivity Info	TI LI LO TS
4	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0481013 Compound Info	N-[4-[5-[[benzyl(methyl)amino]methyl]-1-[(2,6-difluorophenyl)methyl]-3-(3-methoxyphenyl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-2-methylpropanamide Show/Hide	C39H36F2N4O4S	1
1	IC50 = 0.3 nM Bioactivity Info	TI LI LO TS
CP0050493 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-3-(2-hydroxy-2-methylpropyl)-5-[[2-methoxyethyl(methyl)amino]methyl]-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C30H35F2N5O6S	1
1	IC50 = 0.3 nM Bioactivity Info	TI LI LO TS
CP0292069 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[[methyl-[2-(triazol-1-yl)ethyl]amino]methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C33H30F2N8O4S	1
1	IC50 = 0.3 nM Bioactivity Info	TI LI LO TS
CP0351991 Compound Info	1-[4-[1-[(2,6-difluorophenyl)methyl]-3-(2-hydroxyethyl)-5-[[2-methoxyethyl(methyl)amino]methyl]-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Show/Hide	C28H31F2N5O6S	1
1	IC50 = 0.3 nM Bioactivity Info	TI LI LO TS
CP0445780 Compound Info	4-(2-Azetidin-2-yl-ethoxy)-7-chloro-2-oxo-3-((S)-3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid [1,2,5]thiadiazol-3-ylamide Show/Hide	C26H26ClN5O3S	2
1	IC50 = 0.32 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.8 nM Bioactivity Info	TI LI LO TS
CP0457343 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-8-(2,6-difluoro-benzyl)-2-[4-(3-methoxy-ureido)-phenyl]-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid propyl ester Show/Hide	C34H34F2N6O5	1
1	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0449419 Compound Info	ethyl 7-benzyl-3-[[benzyl(methyl)amino]methyl]-4-oxo-2-[4-(propanoylamino)phenyl]thieno[2,3-b]pyridine-5-carboxylate Show/Hide	C35H35N3O4S	1
1	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0495919 Compound Info	3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobenzyl)-4,7-dihydro-5-(1-hydroxy-2-methylpropyl)-2-(4-isobutyrylamidophenyl)-4-oxothieno[2,3-b]pyridine Show/Hide	C37H39F2N3O3S	1
1	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0511042 Compound Info	3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobenzyl)-4,7-dihydro-2-(4-isobutyrylamidophenyl)-4-oxo-5-propionyl-thieno[2,3-b]pyridine Show/Hide	C36H35F2N3O3S	1
1	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0193577 Compound Info	N-[4-[5-[[benzyl(methyl)amino]methyl]-1-[(2,6-difluorophenyl)methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-2-methylpropanamide Show/Hide	C38H34F2N4O3S	1
1	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0504133 Compound Info	1-{4-[5-[(Benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidin-6-yl]-phenyl}-3-hydroxy-urea; HCL.H2O Show/Hide	C35H29F2N5O4S	1
1	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0037858 Compound Info	(S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(pyrimidin-4-yl)-3-(3,4,5-trimethylphenyl)-1,2-dihydroquinoline-6-carboxamide Show/Hide	C28H28ClN5O3	2
1	IC50 = 0.44 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.9 nM Bioactivity Info	TI LI LO TS
CP0405359 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-8-(2,6-difluoro-benzyl)-2-[4-(3-ethyl-ureido)-phenyl]-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester Show/Hide	C34H34F2N6O4	3
1	IC50 = 0.5 nM Bioactivity Info	TI LI LO TS
2	IC50 = 70.79 nM Bioactivity Info	TI LI LO TS
3	Ki = 4.786 nM Bioactivity Info	TI LI LO TS
CP0433534 Compound Info	7-Chloro-2-oxo-4-(2-piperidin-2-yl-ethoxy)-3-((S)-3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid [1,2,5]thiadiazol-3-ylamide Show/Hide	C28H30ClN5O3S	2
1	IC50 = 0.55 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1.6 nM Bioactivity Info	TI LI LO TS
CP0391243 Compound Info	7-Chloro-2-oxo-4-[2-(tetrahydro-furan-2-yl)-ethoxy]-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide Show/Hide	C29H29ClN4O4	2
1	IC50 = 0.6 nM Bioactivity Info	TI LI LO TS
2	IC50 = 3.3 nM Bioactivity Info	TI LI LO TS
CP0403266 Compound Info	4-[2-(1-Aza-bicyclo[2.2.2]oct-2-yl)-ethoxy]-7-chloro-2-oxo-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid [1,2,5]thiadiazol-3-ylamide Show/Hide	C30H32ClN5O3S	2
1	IC50 = 0.6 nM Bioactivity Info	TI LI LO TS
2	IC50 = 5.8 nM Bioactivity Info	TI LI LO TS
CP0500775 Compound Info	7-Chloro-4-(2-[1,3]dioxolan-2-yl-ethoxy)-2-oxo-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid [1,2,5]thiadiazol-3-ylamide Show/Hide	C26H25ClN4O5S	2
1	IC50 = 0.6 nM Bioactivity Info	TI LI LO TS
2	IC50 = 67 nM Bioactivity Info	TI LI LO TS
CP0461249 Compound Info	ethyl 7-benzyl-3-[[benzyl(methyl)amino]methyl]-2-[4-(2-methylpropanoylamino)phenyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C36H37N3O4S	1
1	IC50 = 0.6 nM Bioactivity Info	TI LI LO TS
CP0497860 Compound Info	1-{4-[5-[(Benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidin-6-yl]-phenyl}-3-isopropoxy-urea; HCL.0.5 H2O Show/Hide	C38H35F2N5O4S	1
1	IC50 = 0.6 nM Bioactivity Info	TI LI LO TS
CP0397324 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-8-(2,6-difluoro-benzyl)-2-[4-(3-methoxy-ureido)-phenyl]-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester Show/Hide	C33H32F2N6O5	1
1	IC50 = 0.7 nM Bioactivity Info	TI LI LO TS
CP0439544 Compound Info	7-Chloro-4-(2-morpholin-3-yl-ethoxy)-2-oxo-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid [1,2,5]thiadiazol-3-ylamide Show/Hide	C27H28ClN5O4S	2
1	IC50 = 0.7 nM Bioactivity Info	TI LI LO TS
2	IC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0854506 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-6-([1,2,5]thiadiazol-3-ylcarbamoyl)-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C29H29ClF3N5O5S	2
1	IC50 = 0.8 nM Bioactivity Info	TI LI LO TS
2	IC50 = 5.9 nM Bioactivity Info	TI LI LO TS
CP0455638 Compound Info	7-Chloro-2-oxo-4-(2-pyrrolidin-2-yl-ethoxy)-3-((S)-3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide Show/Hide	C29H30ClN5O3	2
1	IC50 = 0.8 nM Bioactivity Info	TI LI LO TS
2	IC50 = 2.2 nM Bioactivity Info	TI LI LO TS
CP0874937 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-6-(pyrimidin-4-ylcarbamoyl)-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C31H31ClF3N5O5	2
1	IC50 = 0.9 nM Bioactivity Info	TI LI LO TS
2	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0509637 Compound Info	7-Chloro-4-(2-oxetan-2-yl-ethoxy)-2-oxo-3-((R)-3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid [1,2,5]thiadiazol-3-ylamide Show/Hide	C26H25ClN4O4S	2
1	IC50 = 0.9 nM Bioactivity Info	TI LI LO TS
2	IC50 = 49 nM Bioactivity Info	TI LI LO TS
CP0213550 Compound Info	5-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-1H-pyridin-2-one Show/Hide	C37H46N4O2	1
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0496785 Compound Info	ethyl 2-(4-benzamidophenyl)-7-benzyl-3-[[benzyl(methyl)amino]methyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C39H35N3O4S	1
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0061895 Compound Info	N-[4-[5-[[benzyl(methyl)amino]methyl]-1-[(2,6-difluorophenyl)methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]benzamide Show/Hide	C41H32F2N4O3S	1
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0510377 Compound Info	6-(4-Amino-phenyl)-5-[(benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-3-(3-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione; HCL.H2O Show/Hide	C35H30F2N4O3S	1
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0853701 Compound Info	Trifluoro-acetate2-{2-[7-chloro-6-(6-chloro-pyrimidin-4-ylcarbamoyl)-3-(3,5-dimethyl-phenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C31H30Cl2F3N5O5	2
1	IC50 = 1.4 nM Bioactivity Info	TI LI LO TS
2	IC50 = 14.5 nM Bioactivity Info	TI LI LO TS
CP0227902 Compound Info	5-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-1-methyl-1H-pyridin-2-one Show/Hide	C38H48N4O2	1
1	IC50 = 1.4 nM Bioactivity Info	TI LI LO TS
CP0432859 Compound Info	7-Chloro-4-[2-(1-methyl-5-oxo-pyrrolidin-2-yl)-ethoxy]-2-oxo-3-((R)-3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid [1,2,5]thiadiazol-3-ylamide Show/Hide	C28H28ClN5O4S	2
1	IC50 = 1.4 nM Bioactivity Info	TI LI LO TS
2	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0880181 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-6-(2-methyl-pyrimidin-4-ylcarbamoyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C32H33ClF3N5O5	2
1	IC50 = 1.8 nM Bioactivity Info	TI LI LO TS
2	IC50 = 33.3 nM Bioactivity Info	TI LI LO TS
CP0299019 Compound Info	1-(1R,4S)-2-Aza-bicyclo[2.2.1]hept-2-yl-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(2-pyridin-4-yl-ethylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C36H44N4O	1
1	IC50 = 1.9 nM Bioactivity Info	TI LI LO TS
CP0889555 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-6-([1,2,5]thiadiazol-3-ylcarbamoyl)-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C29H29ClF3N5O5S	2
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 6.4 nM Bioactivity Info	TI LI LO TS
CP0392522 Compound Info	7-Chloro-4-[2-((R)-1-methyl-6-trifluoromethyl-piperidin-2-yl)-ethoxy]-2-oxo-3-((S)-3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide Show/Hide	C32H33ClF3N5O3	2
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0497965 Compound Info	7-Chloro-2-oxo-4-[2-((R)-6-trifluoromethyl-piperidin-2-yl)-ethoxy]-3-((S)-3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide Show/Hide	C31H31ClF3N5O3	2
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0486698 Compound Info	ethyl 2-(4-acetamidophenyl)-7-benzyl-3-[[benzyl(methyl)amino]methyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C34H33N3O4S	1
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0551303 Compound Info	ethyl 7-benzyl-3-[[benzyl(methyl)amino]methyl]-2-[4-[methyl(methylcarbamoyl)amino]phenyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C35H36N4O4S	1
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0869693 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-6-(5-methyl-isoxazol-3-ylcarbamoyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C31H32ClF3N4O6	2
1	IC50 = 2.3 nM Bioactivity Info	TI LI LO TS
2	IC50 = 77.5 nM Bioactivity Info	TI LI LO TS
CP0135587 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(2-pyridin-3-yl-ethylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C37H46N4O	1
1	IC50 = 2.6 nM Bioactivity Info	TI LI LO TS
CP0880585 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-6-(6-methyl-pyrimidin-4-ylcarbamoyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C32H33ClF3N5O5	2
1	IC50 = 2.8 nM Bioactivity Info	TI LI LO TS
2	IC50 = 44 nM Bioactivity Info	TI LI LO TS
CP0216361 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C39H50N4O	1
1	IC50 = 2.8 nM Bioactivity Info	TI LI LO TS
CP0866906 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-6-(3-methyl-isothiazol-5-ylcarbamoyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C31H32ClF3N4O5S	2
1	IC50 = 2.9 nM Bioactivity Info	TI LI LO TS
2	IC50 = 21.5 nM Bioactivity Info	TI LI LO TS
CP0397655 Compound Info	2-(4-Acryloylamino-phenyl)-3-[(benzyl-methyl-amino)-methyl]-8-(2,6-difluoro-benzyl)-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester Show/Hide	C34H31F2N5O4	1
1	IC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0458966 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-8-(2,6-difluoro-benzyl)-2-{4-[(furan-3-carbonyl)-amino]-phenyl}-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester Show/Hide	C36H31F2N5O5	1
1	IC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0847468 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-6-(pyrimidin-4-ylcarbamoyl)-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C31H31ClF3N5O5	2
1	IC50 = 3.2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 8.3 nM Bioactivity Info	TI LI LO TS
CP0847471 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-6-(pyridin-2-ylcarbamoyl)-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C32H32ClF3N4O5	2
1	IC50 = 3.6 nM Bioactivity Info	TI LI LO TS
2	IC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0850053 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-6-(pyridin-4-ylcarbamoyl)-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C32H32ClF3N4O5	2
1	IC50 = 3.8 nM Bioactivity Info	TI LI LO TS
2	IC50 = 10.6 nM Bioactivity Info	TI LI LO TS
CP0522236 Compound Info	5-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-1-methoxymethyl-1H-pyridin-2-one Show/Hide	C39H50N4O3	1
1	IC50 = 3.9 nM Bioactivity Info	TI LI LO TS
CP0327922 Compound Info	1-(1R,4S)-2-Aza-bicyclo[2.2.1]hept-2-yl-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C38H48N4O	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0371321 Compound Info	5-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-1,3-dimethyl-1H-pyridin-2-one Show/Hide	C39H50N4O2	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0409867 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-2-[4-(cyclopropanecarbonyl-amino)-phenyl]-8-(2,6-difluoro-benzyl)-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester Show/Hide	C35H33F2N5O4	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0063211 Compound Info	1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C38H48N4O	1
1	IC50 = 5.7 nM Bioactivity Info	TI LI LO TS
CP0361002 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-1-methyl-2-[2-(2-methyl-1-oxy-pyridin-4-yl)-ethylamino]-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C38H48N4O2	1
1	IC50 = 5.9 nM Bioactivity Info	TI LI LO TS
CP0112281 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-7-(2,6-difluoro-benzyl)-2-(4-methoxy-phenyl)-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester Show/Hide	C33H30F2N2O4S	1
1	IC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0364803 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-1-(1,3,3-trimethyl-6-aza-bicyclo[3.2.1]oct-6-yl)-propan-1-one Show/Hide	C42H56N4O	1
1	IC50 = 6.4 nM Bioactivity Info	TI LI LO TS
CP0122740 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-1-methyl-2-[2-(1-oxy-pyridin-4-yl)-ethylamino]-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C37H46N4O2	1
1	IC50 = 6.4 nM Bioactivity Info	TI LI LO TS
CP0336314 Compound Info	1-(6-Aza-bicyclo[3.2.1]oct-6-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C39H50N4O	1
1	IC50 = 6.8 nM Bioactivity Info	TI LI LO TS
CP0896758 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-6-(pyrazin-2-ylcarbamoyl)-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C31H31ClF3N5O5	2
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
2	IC50 = 16 nM Bioactivity Info	TI LI LO TS
CP0196863 Compound Info	1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(2-pyridin-4-yl-ethylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C36H44N4O	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0535305 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-8-(2,6-difluoro-benzyl)-5-oxo-2-{4-[(thiophene-3-carbonyl)-amino]-phenyl}-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester Show/Hide	C36H31F2N5O4S	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0213240 Compound Info	(S)-1-(2-aza-bicyclo[2.2.2]octan-2-yl)-2-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-1H-indol-5-yl)-2-methylpropan-1-one Show/Hide	C37H46N4O	1
1	IC50 = 7.2 nM Bioactivity Info	TI LI LO TS
CP0464146 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-2-[2-(2-hydroxymethyl-pyridin-4-yl)-ethylamino]-1-methyl-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C38H48N4O2	1
1	IC50 = 7.5 nM Bioactivity Info	TI LI LO TS
CP0464278 Compound Info	3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobenzyl)-4,7-dihydro-N-isopropyl-4-oxo-2-(4-propionylamidophenyl)-thieno[2,3-b]pyridine-5-carboxamide Show/Hide	C36H36F2N4O3S	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0272840 Compound Info	5-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-1-methyl-piperidin-2-one Show/Hide	C38H52N4O2	1
1	IC50 = 8.2 nM Bioactivity Info	TI LI LO TS
CP0256294 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-N,N-diisobutyl-isobutyramide Show/Hide	C39H54N4O	1
1	IC50 = 8.3 nM Bioactivity Info	TI LI LO TS
CP0076599 Compound Info	1-(1S,4R)-2-Aza-bicyclo[2.2.1]hept-2-yl-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C38H48N4O	1
1	IC50 = 8.7 nM Bioactivity Info	TI LI LO TS
CP0208585 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-1-methyl-2-[2-(2-methyl-pyridin-4-yl)-ethylamino]-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C38H48N4O	1
1	IC50 = 8.7 nM Bioactivity Info	TI LI LO TS
CP0334675 Compound Info	1-(8-Aza-bicyclo[3.2.1]oct-8-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C39H50N4O	1
1	IC50 = 8.8 nM Bioactivity Info	TI LI LO TS
CP0845332 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-6-(2-methoxy-pyrimidin-4-ylcarbamoyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C32H33ClF3N5O6	2
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
2	IC50 = 133 nM Bioactivity Info	TI LI LO TS
CP0524417 Compound Info	2-[4-(2-aminoacetamido)phenyl]-3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobenzyl)-4,7-dihydro-5-isobutyryl-4-oxothieno[2,3-b]pyridine Show/Hide	C35H34F2N4O3S	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0510586 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-8-(2,6-difluoro-benzyl)-5-oxo-2-(4-propionylamino-phenyl)-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester Show/Hide	C34H33F2N5O4	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0257614 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-[3-{(S)-2-[2-(2,6-dimethyl-1-oxy-pyridin-4-yl)-ethylamino]-1-methyl-ethyl}-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-2-methyl-propan-1-one Show/Hide	C39H50N4O2	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0110348 Compound Info	(S)-1-((S)-2-((S)-2-(2-((S)-2-((S)-2-((S)-2-((S)-3-(1H-imidazol-5-yl)-2-((S)-2-oxopyrrolidine-5-carboxamido)propanamido)-3-(1H-indol-2-yl)propanamido)-3-hydroxypropanamido)-3-(4-hydroxyphenyl)propanamido)acetamido)-4-methylpentanamido)-5-(diaminomethylene Show/Hide	C53H72N16O12	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0921767 Compound Info	Trifluoro-acetate2-{2-[7-chloro-6-(4-dimethylamino-phenylcarbamoyl)-3-(3,5-dimethyl-phenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C35H38ClF3N4O5	2
1	IC50 = 10.9 nM Bioactivity Info	TI LI LO TS
2	IC50 = 360 nM Bioactivity Info	TI LI LO TS
CP0219557 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-2-[2-(6-methoxy-pyridin-3-yl)-ethylamino]-1-methyl-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C38H48N4O2	1
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0221205 Compound Info	4-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-pyridine-2-carbonitrile Show/Hide	C38H45N5O	1
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0043368 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid diethylamide Show/Hide	C32H40N4O	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0463978 Compound Info	2-[3-{(S)-2-[2-(2-Acetyl-pyridin-4-yl)-ethylamino]-1-methyl-ethyl}-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-1-(2-aza-bicyclo[2.2.2]oct-2-yl)-2-methyl-propan-1-one Show/Hide	C39H48N4O2	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0196182 Compound Info	1-(3-Aza-bicyclo[3.2.2]non-3-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C40H52N4O	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0219252 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-N,N-diisobutyl-isobutyramide Show/Hide	C40H56N4O	1
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0291132 Compound Info	1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C37H46N4O	1
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0847905 Compound Info	Trifluoro-acetate2-{2-[7-chloro-6-(2-cyclopropyl-pyrimidin-4-ylcarbamoyl)-3-(3,5-dimethyl-phenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C34H35ClF3N5O5	2
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
2	IC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0299802 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-1-(2,5-dimethyl-pyrrolidin-1-yl)-2-methyl-propan-1-one Show/Hide	C37H48N4O	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0332602 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid cyclooctyl-ethyl-amide Show/Hide	C38H50N4O	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0309400 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid cyclohexyl-ethyl-amide Show/Hide	C36H46N4O	1
1	IC50 = 16 nM Bioactivity Info	TI LI LO TS
CP0236982 Compound Info	1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C37H46N4O	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0255311 Compound Info	1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{2-[methyl-(4-pyridin-4-yl-butyl)-amino]-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C38H48N4O	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0055695 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-2-[2-(2-ethyl-pyridin-4-yl)-ethylamino]-1-methyl-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C39H50N4O	1
1	IC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0460098 Compound Info	2-(4-Benzoylamino-phenyl)-3-[(benzyl-methyl-amino)-methyl]-8-(2,6-difluoro-benzyl)-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester Show/Hide	C38H33F2N5O4	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0215042 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-[2-(3,5-dimethyl-phenyl)-3-((S)-2-{2-[2-(1-hydroxy-ethyl)-pyridin-4-yl]-ethylamino}-1-methyl-ethyl)-1H-indol-5-yl]-2-methyl-propan-1-one Show/Hide	C39H50N4O2	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0401406 Compound Info	N-[4-[5-[[benzyl(methyl)amino]methyl]-1-[(2,6-difluorophenyl)methyl]-3-(3-methoxyphenyl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-N-methylpropanamide Show/Hide	C39H36F2N4O4S	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0508595 Compound Info	5-[(Benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-3-(3-methoxy-phenyl)-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione; HCL.0.8H2O Show/Hide	C36H31F2N3O4S	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0534533 Compound Info	5-[(Benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-3-(3-methoxy-phenyl)-6-(4-nitro-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione; HCL8.H2O Show/Hide	C35H28F2N4O5S	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0136681 Compound Info	1-(3,3-Dimethyl-azetidin-1-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C37H48N4O	1
1	IC50 = 21 nM Bioactivity Info	TI LI LO TS
CP0868282 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-6-([1,3,4]thiadiazol-2-ylcarbamoyl)-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C29H29ClF3N5O5S	2
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
2	IC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0190899 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indol-5-yl}-N,N-diisobutyl-isobutyramide Show/Hide	C39H54N4O	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0288623 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid cyclohexyl-ethyl-amide Show/Hide	C36H46N4O	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0299579 Compound Info	Acetic acid 4-(2-{(S)-2-[5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-pyridin-2-ylmethyl ester Show/Hide	C40H50N4O3	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0874971 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-6-(3-methyl-isoxazol-5-ylcarbamoyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C31H32ClF3N4O6	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0115024 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-2-[2-(2,6-dimethyl-pyridin-4-yl)-ethylamino]-1-methyl-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C39H50N4O	1
1	IC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0082419 Compound Info	4-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-pyridine-2-carboxylic acid methyl ester Show/Hide	C39H48N4O3	1
1	IC50 = 25 nM Bioactivity Info	TI LI LO TS
CP0215181 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-1-methyl-2-[2-(3-methyl-1-oxy-pyridin-4-yl)-ethylamino]-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C38H48N4O2	1
1	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0917751 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-6-(5-methyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C30H31ClF3N5O5S	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0535333 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-2-(4-butyrylamino-phenyl)-8-(2,6-difluoro-benzyl)-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester Show/Hide	C35H35F2N5O4	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0464281 Compound Info	ethyl 7-benzyl-3-[[benzyl(methyl)amino]methyl]-4-oxo-2-[4-(phenylcarbamoylamino)phenyl]thieno[2,3-b]pyridine-5-carboxylate Show/Hide	C39H36N4O4S	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0501953 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-7-[(2-fluorophenyl)methyl]-2-(4-methoxyphenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C33H31FN2O4S	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0531940 Compound Info	5-[(Benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-3,6-bis-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione; HCL.0.0.5H2O Show/Hide	C36H31F2N3O4S	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0149717 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-1-(dodecahydro-carbazol-9-yl)-2-methyl-propan-1-one Show/Hide	C44H58N4O	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0850063 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-6-(pyridin-3-ylcarbamoyl)-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C32H32ClF3N4O5	2
1	IC50 = 32 nM Bioactivity Info	TI LI LO TS
2	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0150494 Compound Info	1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-butan-1-one Show/Hide	C38H48N4O	1
1	IC50 = 38 nM Bioactivity Info	TI LI LO TS
CP0331985 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-1-piperidin-1-yl-propan-1-one Show/Hide	C36H46N4O	1
1	IC50 = 38 nM Bioactivity Info	TI LI LO TS
CP0223103 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-1-(4,4-dimethyl-piperidin-1-yl)-2-methyl-propan-1-one Show/Hide	C39H52N4O	1
1	IC50 = 39 nM Bioactivity Info	TI LI LO TS
CP0880605 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-6-(2,6-dimethyl-pyrimidin-4-ylcarbamoyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C33H35ClF3N5O5	2
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
2	IC50 = 486 nM Bioactivity Info	TI LI LO TS
CP0310600 Compound Info	1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-ethyl-butan-1-one Show/Hide	C39H50N4O	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0439642 Compound Info	ethyl 2-(4-aminophenyl)-7-benzyl-3-[[benzyl(methyl)amino]methyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C32H31N3O3S	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0853700 Compound Info	Trifluoro-acetate2-{2-[7-chloro-6-(di-sec-butyl-carbamoyl)-3-(3,5-dimethyl-phenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C35H45ClF3N3O5	1
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0172193 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-1-methyl-2-[2-(3-methyl-pyridin-4-yl)-ethylamino]-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C38H48N4O	1
1	IC50 = 48 nM Bioactivity Info	TI LI LO TS
CP0384674 Compound Info	5-[(Benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-6-(4-methoxy-phenyl)-3-phenyl-1H-thieno[2,3-d]pyrimidine-2,4-dione; HCL.0.5H2O Show/Hide	C35H29F2N3O3S	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0290421 Compound Info	N-cyclohexyl-2-[2-(3,5-dimethylphenyl)-3-[2-(4-pyridin-4-ylbutylamino)ethyl]-1H-indol-5-yl]-N-ethyl-2-methylpropanamide Show/Hide	C39H52N4O	1
1	IC50 = 54 nM Bioactivity Info	TI LI LO TS
CP0155115 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-2-[2-(2-methoxymethyl-pyridin-4-yl)-ethylamino]-1-methyl-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C39H50N4O2	1
1	IC50 = 55 nM Bioactivity Info	TI LI LO TS
CP0214051 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-N,N-diethyl-isobutyramide Show/Hide	C35H46N4O	1
1	IC50 = 58 nM Bioactivity Info	TI LI LO TS
CP0352069 Compound Info	2-(3,5-Dimethyl-phenyl)-3-{2-[methyl-(4-pyridin-4-yl-butyl)-amino]-ethyl}-1H-indole-5-carboxylic acid diethylamide Show/Hide	C33H42N4O	1
1	IC50 = 58 nM Bioactivity Info	TI LI LO TS
CP0138177 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-1-morpholin-4-yl-propan-1-one Show/Hide	C35H44N4O2	1
1	IC50 = 59 nM Bioactivity Info	TI LI LO TS
CP0369348 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-1-pyrrolidin-1-yl-propan-1-one Show/Hide	C35H44N4O	1
1	IC50 = 61 nM Bioactivity Info	TI LI LO TS
CP0207774 Compound Info	1-(3,3-Dimethyl-azetidin-1-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C36H46N4O	1
1	IC50 = 62 nM Bioactivity Info	TI LI LO TS
CP0286926 Compound Info	[2-(3,5-dimethylphenyl)-3-[2-(4-pyridin-3-ylbutylamino)ethyl]-1H-indol-5-yl]-(2,5-dimethylpyrrolidin-1-yl)methanone Show/Hide	C34H42N4O	1
1	IC50 = 62 nM Bioactivity Info	TI LI LO TS
CP0193348 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-1-methyl-2-[2-(2-propyl-pyridin-4-yl)-ethylamino]-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C40H52N4O	1
1	IC50 = 62 nM Bioactivity Info	TI LI LO TS
CP0225806 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-1-(3aR,7aS)-octahydro-isoindol-2-yl-propan-1-one Show/Hide	C40H52N4O	1
1	IC50 = 66 nM Bioactivity Info	TI LI LO TS
CP0246348 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-1-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-2-methyl-propan-1-one Show/Hide	C39H50N4O3	1
1	IC50 = 66 nM Bioactivity Info	TI LI LO TS
CP0182886 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-7-(2-methoxy-benzyl)-2-(4-methoxy-phenyl)-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester Show/Hide	C34H34N2O5S	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0054992 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid diisobutylamide Show/Hide	C36H48N4O	1
1	IC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0453601 Compound Info	5-[(Benzyl-methyl-amino)-methyl]-3-(2-chloro-phenyl)-1-(2,6-difluoro-benzyl)-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione; HCL.0.5H2O Show/Hide	C35H28ClF2N3O3S	1
1	IC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0299531 Compound Info	3-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-1-methyl-1H-pyridin-2-one Show/Hide	C38H48N4O2	1
1	IC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0252860 Compound Info	1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{2-[ethyl-(4-pyridin-4-yl-butyl)-amino]-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C39H50N4O	1
1	IC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0297942 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid bis-(2,2,2-trifluoro-ethyl)-amide Show/Hide	C32H34F6N4O	1
1	IC50 = 91 nM Bioactivity Info	TI LI LO TS
CP0524086 Compound Info	1-(8-Aza-spiro[4.5]dec-8-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C41H54N4O	1
1	IC50 = 93 nM Bioactivity Info	TI LI LO TS
CP0184382 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indol-5-yl}-N,N-diethyl-isobutyramide Show/Hide	C35H46N4O	1
1	IC50 = 94 nM Bioactivity Info	TI LI LO TS
CP0386028 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-7-[(2-cyanophenyl)methyl]-2-(4-methoxyphenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C34H31N3O4S	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0551304 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-2-(4-methoxyphenyl)-7-[(2-nitrophenyl)methyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C33H31N3O6S	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0194543 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-[2-(3,5-dimethyl-phenyl)-3-((S)-2-{2-[2-(1-hydroxy-1-methyl-ethyl)-pyridin-4-yl]-ethylamino}-1-methyl-ethyl)-1H-indol-5-yl]-2-methyl-propan-1-one Show/Hide	C40H52N4O2	1
1	IC50 = 106 nM Bioactivity Info	TI LI LO TS
CP0849296 Compound Info	Trifluoro-acetate2-{2-[6-[(benzo[1,3]dioxol-5-ylmethyl)-carbamoyl]-7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C35H35ClF3N3O7	2
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
2	IC50 = 591 nM Bioactivity Info	TI LI LO TS
CP0368048 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid ethyl-isopropyl-amide Show/Hide	C33H42N4O	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0045709 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid diisobutylamide Show/Hide	C36H48N4O	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0223421 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-1-(4-ethanesulfonyl-piperazin-1-yl)-2-methyl-propan-1-one Show/Hide	C38H51N5O3S	1
1	IC50 = 124 nM Bioactivity Info	TI LI LO TS
CP0163117 Compound Info	(7-Aza-bicyclo[2.2.1]hept-7-yl)-(1-{2-(3,5-dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-cyclobutyl)-methanone Show/Hide	C38H46N4O	1
1	IC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0916409 Compound Info	Trifluoro-acetate2-{2-[7-chloro-6-diethylcarbamoyl-3-(3,5-dimethyl-phenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C31H37ClF3N3O5	1
1	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0105024 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid diethylamide Show/Hide	C32H40N4O	1
1	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0244439 Compound Info	1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{2-[isopropyl-(4-pyridin-4-yl-butyl)-amino]-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C40H52N4O	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0436282 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-7-[(2-methoxyphenyl)methyl]-4-oxo-2-phenylthieno[2,3-b]pyridine-5-carboxylate Show/Hide	C33H32N2O4S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0500544 Compound Info	ethyl 7-benzyl-3-[[benzyl(methyl)amino]methyl]-2-(4-methoxyphenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C33H32N2O4S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0384670 Compound Info	5-[(Benzyl-methyl-amino)-methyl]-3-(3-chloro-phenyl)-1-(2,6-difluoro-benzyl)-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione; HCL.H2O Show/Hide	C35H28ClF2N3O3S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0405427 Compound Info	5-[(Benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-3-(2-methoxy-phenyl)-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione; HCL.1.5H2O Show/Hide	C36H31F2N3O4S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0531947 Compound Info	5-[(Benzyl-methyl-amino)-methyl]-3-(4-chloro-phenyl)-1-(2,6-difluoro-benzyl)-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione; HCL.H2O Show/Hide	C35H28ClF2N3O3S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0196914 Compound Info	4-(2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propionyl)-piperazine-1-carboxylic acid tert-butyl ester Show/Hide	C41H55N5O3	1
1	IC50 = 220 nM Bioactivity Info	TI LI LO TS
CP0445880 Compound Info	7-Chloro-4-(2-cyclopentyl-ethoxy)-2-oxo-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid [1,2,5]thiadiazol-3-ylamide Show/Hide	C28H29ClN4O3S	2
1	IC50 = 243 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1150 nM Bioactivity Info	TI LI LO TS
CP0041665 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid ethyl-(2-hydroxy-ethyl)-amide Show/Hide	C32H40N4O2	1
1	IC50 = 260 nM Bioactivity Info	TI LI LO TS
CP0214050 Compound Info	(7-Aza-bicyclo[2.2.1]hept-7-yl)-{2-(3,5-dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-methanone Show/Hide	C34H40N4O	1
1	IC50 = 260 nM Bioactivity Info	TI LI LO TS
CP0847491 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-6-(pyrimidin-2-ylcarbamoyl)-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C31H31ClF3N5O5	2
1	IC50 = 290 nM Bioactivity Info	TI LI LO TS
2	IC50 > 3200 nM Bioactivity Info	TI LI LO TS
CP0300561 Compound Info	1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{2-[isobutyl-(4-pyridin-4-yl-butyl)-amino]-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C41H54N4O	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0449533 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-2-(4-methoxyphenyl)-7-[(4-methoxyphenyl)methyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C34H34N2O5S	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0485573 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-7-[(3-fluorophenyl)methyl]-2-(4-methoxyphenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C33H31FN2O4S	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0551305 Compound Info	ethyl 3-[[benzyl(ethyl)amino]methyl]-2-(4-methoxyphenyl)-7-[(2-methoxyphenyl)methyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C35H36N2O5S	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0373317 Compound Info	ethyl 3-[[benzyl-[2-[[1-[2-[2-[2-[2-[2-[4-[[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methylamino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C86H94F4N20O14	2
1	IC50 = 309.03 nM Bioactivity Info	TI LI LO TS
2	Ki = 194.98 nM Bioactivity Info	TI LI LO TS
CP0847053 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-6-(4H-[1,2,4]triazol-3-ylcarbamoyl)-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C29H30ClF3N6O5	2
1	IC50 = 320 nM Bioactivity Info	TI LI LO TS
2	IC50 = 775 nM Bioactivity Info	TI LI LO TS
CP0376521 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indol-5-yl}-isobutyramide Show/Hide	C31H38N4O	1
1	IC50 = 350 nM Bioactivity Info	TI LI LO TS
CP0535910 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-2-[4-[[1-[2-[2-[2-[2-[4-[[[4-[3-[[benzyl(methyl)amino]methyl]-8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-5-oxoimidazo[1,2-a]pyrimidin-2-yl]phenyl]carbamoylamino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methylcarbamoylamino]phenyl]-8-[(2,6-difluorophenyl)methyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C78H80F4N18O11	2
1	IC50 = 354.81 nM Bioactivity Info	TI LI LO TS
2	Ki = 29.51 nM Bioactivity Info	TI LI LO TS
CP0363826 Compound Info	4-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-pyridine-2-carboxylic acid Show/Hide	C38H46N4O3	1
1	IC50 = 371 nM Bioactivity Info	TI LI LO TS
CP0464282 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-7-[(4-fluorophenyl)methyl]-2-(4-methoxyphenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C33H31FN2O4S	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0529753 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-2-(4-methoxyphenyl)-7-[(3-methoxyphenyl)methyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C34H34N2O5S	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0461051 Compound Info	3-Benzyl-5-[(benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione; HCL.0.5H2O Show/Hide	C36H31F2N3O3S	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0522471 Compound Info	5-[(Benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-3-isobutyl-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione; HCL Show/Hide	C33H33F2N3O3S	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0373316 Compound Info	ethyl 3-[[[2-[[1-[2-[2-(2-azidoethoxy)ethoxy]ethyl]triazol-4-yl]methylamino]-2-oxoethyl]-benzylamino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C44H49F2N13O7	1
1	IC50 = 467.74 nM Bioactivity Info	TI LI LO TS
CP0464285 Compound Info	ethyl 3-[(dimethylamino)methyl]-2-(4-methoxyphenyl)-7-[(2-methoxyphenyl)methyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C28H30N2O5S	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0486699 Compound Info	ethyl 7-benzyl-3-[[benzyl(methyl)amino]methyl]-2-(3-methoxyphenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C33H32N2O4S	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0374809 Compound Info	ethyl 3-[[[2-[[1-[2-(2-azidoethoxy)ethyl]triazol-4-yl]methylamino]-2-oxoethyl]-benzylamino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C42H45F2N13O6	1
1	IC50 = 524.81 nM Bioactivity Info	TI LI LO TS
CP0258027 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid bis-(2-methoxy-ethyl)-amide Show/Hide	C34H44N4O3	1
1	IC50 = 610 nM Bioactivity Info	TI LI LO TS
CP0435797 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-8-[(2,6-difluorophenyl)methyl]-5-oxo-2-[4-(prop-2-ynylcarbamoylamino)phenyl]imidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C35H32F2N6O4	2
1	IC50 = 676.08 nM Bioactivity Info	TI LI LO TS
2	Ki = 1.349 nM Bioactivity Info	TI LI LO TS
CP0436605 Compound Info	ethyl 2-[4-[[1-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methylcarbamoylamino]phenyl]-3-[[benzyl(methyl)amino]methyl]-8-[(2,6-difluorophenyl)methyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C45H52F2N12O8	1
1	IC50 = 676.08 nM Bioactivity Info	TI LI LO TS
CP0538123 Compound Info	ethyl 7-benzyl-3-[[benzyl(methyl)amino]methyl]-2-(2-methoxyphenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C33H32N2O4S	1
1	IC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0439698 Compound Info	5-[(Benzyl-methyl-amino)-methyl]-3-cyclohexyl-1-(2,6-difluoro-benzyl)-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione; HCL.0.5H2O Show/Hide	C35H35F2N3O3S	1
1	IC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0373318 Compound Info	ethyl 3-[[[2-[[1-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]triazol-4-yl]methylamino]-2-oxoethyl]-benzylamino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C46H53F2N13O8	1
1	IC50 = 724.44 nM Bioactivity Info	TI LI LO TS
CP0445447 Compound Info	ethyl 3-[[[2-[[1-(2-azidoethyl)triazol-4-yl]methylamino]-2-oxoethyl]-benzylamino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C40H41F2N13O5	1
1	IC50 = 724.44 nM Bioactivity Info	TI LI LO TS
CP0373315 Compound Info	ethyl 3-[[benzyl-[2-[[1-[2-[2-[2-[4-[[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]methyl]triazol-1-yl]ethoxy]ethoxy]ethyl]triazol-4-yl]methylamino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C82H86F4N20O12	2
1	IC50 = 831.76 nM Bioactivity Info	TI LI LO TS
2	Ki = 58.88 nM Bioactivity Info	TI LI LO TS
CP0509408 Compound Info	ethyl 3-[[[2-[[1-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methylamino]-2-oxoethyl]-benzylamino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C48H57F2N13O9	1
1	IC50 = 831.76 nM Bioactivity Info	TI LI LO TS
CP0874996 Compound Info	Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-6-(2-ethyl-2H-pyrazol-3-ylcarbamoyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium Show/Hide	C32H35ClF3N5O5	2
1	IC50 = 860 nM Bioactivity Info	TI LI LO TS
2	IC50 = 977 nM Bioactivity Info	TI LI LO TS
CP0530448 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-2-[4-[[1-[2-[2-[2-[4-[[[4-[3-[[benzyl(methyl)amino]methyl]-8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-5-oxoimidazo[1,2-a]pyrimidin-2-yl]phenyl]carbamoylamino]methyl]triazol-1-yl]ethoxy]ethoxy]ethyl]triazol-4-yl]methylcarbamoylamino]phenyl]-8-[(2,6-difluorophenyl)methyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C76H76F4N18O10	2
1	IC50 = 954.99 nM Bioactivity Info	TI LI LO TS
2	Ki = 23.44 nM Bioactivity Info	TI LI LO TS
CP0541694 Compound Info	ethyl 3-[[benzyl-[2-oxo-2-(prop-2-ynylamino)ethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C38H37F2N7O5	2
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
2	Ki = 5.248 nM Bioactivity Info	TI LI LO TS
CP0256086 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid isopropylamide Show/Hide	C31H38N4O	1
1	IC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0405362 Compound Info	ethyl 3-[[benzyl-[2-[[1-[2-[2-[2-[2-[4-[[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methylamino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C84H90F4N20O13	2
1	IC50 = 1318.26 nM Bioactivity Info	TI LI LO TS
2	Ki = 69.18 nM Bioactivity Info	TI LI LO TS
CP0435279 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-2-[4-[[1-[2-[2-[2-[2-[2-[4-[[[4-[3-[[benzyl(methyl)amino]methyl]-8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-5-oxoimidazo[1,2-a]pyrimidin-2-yl]phenyl]carbamoylamino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methylcarbamoylamino]phenyl]-8-[(2,6-difluorophenyl)methyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C80H84F4N18O12	1
1	IC50 = 1348.96 nM Bioactivity Info	TI LI LO TS
CP0442969 Compound Info	ethyl 3-[[benzyl-[2-[[1-[2-[2-[4-[[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]methyl]triazol-1-yl]ethoxy]ethyl]triazol-4-yl]methylamino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C80H82F4N20O11	1
1	IC50 = 1548.82 nM Bioactivity Info	TI LI LO TS
CP0435798 Compound Info	ethyl 3-[[benzyl-[2-[[1-[2-[4-[[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]methyl]triazol-1-yl]ethyl]triazol-4-yl]methylamino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C78H78F4N20O10	1
1	IC50 = 1905.46 nM Bioactivity Info	TI LI LO TS
CP0500896 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-2-[4-[[1-[2-[4-[[[4-[3-[[benzyl(methyl)amino]methyl]-8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-5-oxoimidazo[1,2-a]pyrimidin-2-yl]phenyl]carbamoylamino]methyl]triazol-1-yl]ethyl]triazol-4-yl]methylcarbamoylamino]phenyl]-8-[(2,6-difluorophenyl)methyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C72H68F4N18O8	1
1	IC50 = 1905.46 nM Bioactivity Info	TI LI LO TS
CP0076365 Compound Info	7-(2-Methoxy-benzyl)-2-(4-methoxy-phenyl)-3-methylaminomethyl-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester Show/Hide	C27H28N2O5S	1
1	IC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0523763 Compound Info	ethyl 3-[(benzylamino)methyl]-2-(4-methoxyphenyl)-7-[(2-methoxyphenyl)methyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C33H32N2O5S	1
1	IC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0504053 Compound Info	ethyl 2-[4-[[1-[2-[2-(2-azidoethoxy)ethoxy]ethyl]triazol-4-yl]methylcarbamoylamino]phenyl]-3-[[benzyl(methyl)amino]methyl]-8-[(2,6-difluorophenyl)methyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C41H44F2N12O6	1
1	IC50 = 2398.83 nM Bioactivity Info	TI LI LO TS
CP0464694 Compound Info	ethyl 2-[4-[[1-(2-azidoethyl)triazol-4-yl]methylcarbamoylamino]phenyl]-3-[[benzyl(methyl)amino]methyl]-8-[(2,6-difluorophenyl)methyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C37H36F2N12O4	1
1	IC50 = 2570.4 nM Bioactivity Info	TI LI LO TS
CP0480378 Compound Info	ethyl 2-[4-[[1-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]triazol-4-yl]methylcarbamoylamino]phenyl]-3-[[benzyl(methyl)amino]methyl]-8-[(2,6-difluorophenyl)methyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C43H48F2N12O7	1
1	IC50 = 3019.95 nM Bioactivity Info	TI LI LO TS
CP0437227 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-2-[4-[[1-[2-[2-[4-[[[4-[3-[[benzyl(methyl)amino]methyl]-8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-5-oxoimidazo[1,2-a]pyrimidin-2-yl]phenyl]carbamoylamino]methyl]triazol-1-yl]ethoxy]ethyl]triazol-4-yl]methylcarbamoylamino]phenyl]-8-[(2,6-difluorophenyl)methyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C74H72F4N18O9	1
1	IC50 = 3162.28 nM Bioactivity Info	TI LI LO TS
CP0437872 Compound Info	ethyl 2-[4-[[1-[2-(2-azidoethoxy)ethyl]triazol-4-yl]methylcarbamoylamino]phenyl]-3-[[benzyl(methyl)amino]methyl]-8-[(2,6-difluorophenyl)methyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C39H40F2N12O5	1
1	IC50 = 3630.78 nM Bioactivity Info	TI LI LO TS
CP0501954 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-2-(4-methoxyphenyl)-7-methyl-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C27H28N2O4S	1
1	IC50 = 5000 nM Bioactivity Info	TI LI LO TS
CP0542982 Compound Info	ethyl 3-[[acetyl(benzyl)amino]methyl]-2-(4-methoxyphenyl)-7-[(2-methoxyphenyl)methyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C35H34N2O6S	1
1	IC50 = 7000 nM Bioactivity Info	TI LI LO TS
CP0435772 Compound Info	3-[[benzyl(methyl)amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxo-N-prop-2-ynylimidazo[1,2-a]pyrimidine-6-carboxamide Show/Hide	C35H33F2N7O3	2
1	IC50 = 7079.46 nM Bioactivity Info	TI LI LO TS
2	Ki = 162.18 nM Bioactivity Info	TI LI LO TS
CP0515771 Compound Info	ethyl 2-(4-methoxyphenyl)-7-[(2-methoxyphenyl)methyl]-3-methyl-4-oxothieno[2,3-b]pyridine-5-carboxylate Show/Hide	C26H25NO5S	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0501955 Compound Info	ethyl 3-[[benzyl(methyl)amino]methyl]-2-(4-methoxyphenyl)-4-oxo-7H-thieno[2,3-b]pyridine-5-carboxylate Show/Hide	C26H26N2O4S	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0871618 Compound Info	3-{[benzyl(methyl)amino]methyl}-N-{[1-(2-{2-[2-(4-{[(3-{[benzyl(methyl)amino]methyl}-8-[(2,6-difluorophenyl)methyl]-2-{4-[(ethylcarbamoyl)amino]phenyl}-5-oxo-5H,8H-imidazo[1,2-a]pyrimidin-6-yl)formamido]methyl}-1H-1,2,3-triazol-1-yl)ethoxy]ethoxy}ethyl)-1H-1,2,3-triazol-4-yl]methyl}-8-[(2,6-difluorophenyl)methyl]-2-{4-[(methylcarbamoyl)amino]phenyl}-5-oxo-5H,8H-imidazo[1,2-a]pyrimidine-6-carboxamide Show/Hide	C75H76F4N20O8	1
1	IC50 < 10000 nM Bioactivity Info	TI LI LO TS
CP0877635 Compound Info	3-{[benzyl(methyl)amino]methyl}-N-({1-[2-(2-{2-[2-(4-{[(3-{[benzyl(methyl)amino]methyl}-8-[(2,6-difluorophenyl)methyl]-2-{4-[(ethylcarbamoyl)amino]phenyl}-5-oxo-5H,8H-imidazo[1,2-a]pyrimidin-6-yl)formamido]methyl}-1H-1,2,3-triazol-1-yl)ethoxy]ethoxy}ethoxy)ethyl]-1H-1,2,3-triazol-4-yl}methyl)-8-[(2,6-difluorophenyl)methyl]-2-{4-[(ethylcarbamoyl)amino]phenyl}-5-oxo-5H,8H-imidazo[1,2-a]pyrimidine-6-carboxamide Show/Hide	C78H82F4N20O9	1
1	IC50 < 10000 nM Bioactivity Info	TI LI LO TS
CP0877638 Compound Info	1-(4-(8-(2,6-difluorobenzyl)-6-(((1-(2-(2-azidoethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methyl)carbamoyl)-3-((benzyl(methyl)amino)methyl)-5-oxo-5,8-dihydroimidazo[1,2-a]pyrimidin-2-yl)phenyl)-3-ethylurea Show/Hide	C39H41F2N13O4	1
1	IC50 < 10000 nM Bioactivity Info	TI LI LO TS
CP0878009 Compound Info	1-(4-(8-(2,6-difluorobenzyl)-6-(((1-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methyl)carbamoyl)-3-((benzyl(methyl)amino)methyl)-5-oxo-5,8-dihydroimidazo[1,2-a]pyrimidin-2-yl)phenyl)-3-ethylurea Show/Hide	C43H49F2N13O6	1
1	IC50 < 10000 nM Bioactivity Info	TI LI LO TS
CP0878010 Compound Info	3-{[benzyl(methyl)amino]methyl}-N-({1-[2-(4-{[(3-{[benzyl(methyl)amino]methyl}-8-[(2,6-difluorophenyl)methyl]-2-{4-[(ethylcarbamoyl)amino]phenyl}-5-oxo-5H,8H-imidazo[1,2-a]pyrimidin-6-yl)formamido]methyl}-1H-1,2,3-triazol-1-yl)ethyl]-1H-1,2,3-triazol-4-yl}methyl)-8-[(2,6-difluorophenyl)methyl]-2-{4-[(ethylcarbamoyl)amino]phenyl}-5-oxo-5H,8H-imidazo[1,2-a]pyrimidine-6-carboxamide Show/Hide	C72H70F4N20O6	1
1	IC50 < 10000 nM Bioactivity Info	TI LI LO TS
CP0878011 Compound Info	1-(4-(8-(2,6-difluorobenzyl)-6-(((1-(2-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methyl)carbamoyl)-3-((benzyl(methyl)amino)methyl)-5-oxo-5,8-dihydroimidazo[1,2-a]pyrimidin-2-yl)phenyl)-3-ethylurea Show/Hide	C45H53F2N13O7	1
1	IC50 < 10000 nM Bioactivity Info	TI LI LO TS
CP0883044 Compound Info	1-(4-(8-(2,6-difluorobenzyl)-6-(((1-(2-azidoethyl)-1H-1,2,3-triazol-4-yl)methyl)carbamoyl)-3-((benzyl(methyl)amino)methyl)-5-oxo-5,8-dihydroimidazo[1,2-a]pyrimidin-2-yl)phenyl)-3-ethylurea Show/Hide	C37H37F2N13O3	1
1	IC50 < 10000 nM Bioactivity Info	TI LI LO TS
CP0886316 Compound Info	3-{[benzyl(methyl)amino]methyl}-N-[(1-{2-[2-(4-{[(3-{[benzyl(methyl)amino]methyl}-8-[(2,6-difluorophenyl)methyl]-2-{4-[(ethylcarbamoyl)amino]phenyl}-5-oxo-5H,8H-imidazo[1,2-a]pyrimidin-6-yl)formamido]methyl}-1H-1,2,3-triazol-1-yl)ethoxy]ethyl}-1H-1,2,3-triazol-4-yl)methyl]-8-[(2,6-difluorophenyl)methyl]-2-{4-[(ethylcarbamoyl)amino]phenyl}-5-oxo-5H,8H-imidazo[1,2-a]pyrimidine-6-carboxamide Show/Hide	C74H74F4N20O7	1
1	IC50 < 10000 nM Bioactivity Info	TI LI LO TS
CP0886560 Compound Info	3-{[benzyl(methyl)amino]methyl}-N-({1-[14-(4-{[(3-{[benzyl(methyl)amino]methyl}-8-[(2,6-difluorophenyl)methyl]-2-{4-[(ethylcarbamoyl)amino]phenyl}-5-oxo-5H,8H-imidazo[1,2-a]pyrimidin-6-yl)formamido]methyl}-1H-1,2,3-triazol-1-yl)-3,6,9,12-tetraoxatetradecan-1-yl]-1H-1,2,3-triazol-4-yl}methyl)-8-[(2,6-difluorophenyl)methyl]-2-{4-[(ethylcarbamoyl)amino]phenyl}-5-oxo-5H,8H-imidazo[1,2-a]pyrimidine-6-carboxamide Show/Hide	C80H86F4N20O10	1
1	IC50 < 10000 nM Bioactivity Info	TI LI LO TS
CP0941391 Compound Info	1-(4-(8-(2,6-difluorobenzyl)-6-(((1-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methyl)carbamoyl)-3-((benzyl(methyl)amino)methyl)-5-oxo-5,8-dihydroimidazo[1,2-a]pyrimidin-2-yl)phenyl)-3-ethylurea Show/Hide	C41H45F2N13O5	1
1	IC50 < 10000 nM Bioactivity Info	TI LI LO TS
CP0403789 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(3-chloro-4-fluorophenyl)ethyl]-8-[(3R,4S,6R)-4-[cyclopropylmethyl(methyl)amino]-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] (4S)-4-methyl-2-oxo-1,3-oxazolidine-3-carboxylate Show/Hide	C47H69ClFN3O13	1
1	Ki = 0.3311 nM Bioactivity Info	TI LI LO TS
CP0480685 Compound Info	(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-8-[(3R,4S,6R)-4-[bis(cyclopropylmethyl)amino]-3-hydroxy-6-methyloxan-2-yl]oxy-15-[2-(3-chloro-4-fluorophenyl)ethyl]-2-ethyl-6-[(4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,12,16-trione Show/Hide	C53H82ClFN2O13	1
1	Ki = 0.8511 nM Bioactivity Info	TI LI LO TS
CP0533022 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-8-[(3R,4S,6R)-4-[bis(cyclopropylmethyl)amino]-3-hydroxy-6-methyloxan-2-yl]oxy-15-[2-(3,4-dichlorophenyl)ethyl]-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] (4S)-4-methyl-2-oxo-1,3-oxazolidine-3-carboxylate Show/Hide	C50H73Cl2N3O13	1
1	Ki = 1.288 nM Bioactivity Info	TI LI LO TS
CP0522002 Compound Info	(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-8-[(3R,4S,6R)-4-[cyclopentyl(methyl)amino]-3-hydroxy-6-methyloxan-2-yl]oxy-15-[2-(3,4-dichlorophenyl)ethyl]-2-ethyl-6-[(4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,12,16-trione Show/Hide	C51H80Cl2N2O13	1
1	Ki = 1.514 nM Bioactivity Info	TI LI LO TS
CP0211775 Compound Info	A-198401 Show/Hide	C47H69Cl2N3O13	1
1	Ki = 1.862 nM Bioactivity Info	TI LI LO TS
CP0403723 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-8-[(3R,4S,6R)-4-[cyclopentyl(methyl)amino]-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] (4S)-4-methyl-2-oxo-1,3-oxazolidine-3-carboxylate Show/Hide	C48H72ClN3O13	2
1	Ki = 3.89 nM Bioactivity Info	TI LI LO TS
2	Ki = 38.02 nM Bioactivity Info	TI LI LO TS
CP0453836 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-8-[(3R,4S,6R)-4-[cyclopentyl(methyl)amino]-3-hydroxy-6-methyloxan-2-yl]oxy-15-[2-(3,4-dichlorophenyl)ethyl]-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] (4S)-4-methyl-2-oxo-1,3-oxazolidine-3-carboxylate Show/Hide	C48H71Cl2N3O13	1
1	Ki = 5.623 nM Bioactivity Info	TI LI LO TS
CP0375492 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-8-[(3R,4S,6R)-4-[cyclohexyl(methyl)amino]-3-hydroxy-6-methyloxan-2-yl]oxy-15-[2-(3,4-dichlorophenyl)ethyl]-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] (4S)-4-methyl-2-oxo-1,3-oxazolidine-3-carboxylate Show/Hide	C49H73Cl2N3O13	1
1	Ki = 7.244 nM Bioactivity Info	TI LI LO TS
CP0514478 Compound Info	(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-8-[(3R,4S,6R)-4-[cyclopentyl(methyl)amino]-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-6-[(4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,12,16-trione Show/Hide	C51H81ClN2O13	1
1	Ki = 7.586 nM Bioactivity Info	TI LI LO TS
CP0520257 Compound Info	(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-8-[(3R,4S,6R)-4-[cyclopropylmethyl(methyl)amino]-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-6-[(4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,12,16-trione Show/Hide	C50H79ClN2O13	1
1	Ki = 13.18 nM Bioactivity Info	TI LI LO TS
CP0374667 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(3,4-dichlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] (4S)-4-methyl-2-oxo-1,3-oxazolidine-3-carboxylate Show/Hide	C46H69Cl2N3O13	1
1	Ki = 15.14 nM Bioactivity Info	TI LI LO TS
CP0430480 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-8-[(3R,4S,6R)-4-[cyclopropylmethyl(methyl)amino]-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] (4S)-4-methyl-2-oxo-1,3-oxazolidine-3-carboxylate Show/Hide	C47H70ClN3O13	1
1	Ki = 18.62 nM Bioactivity Info	TI LI LO TS
CP0448714 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] (4S)-4-methyl-2-oxo-1,3-oxazolidine-3-carboxylate Show/Hide	C46H70ClN3O13	1
1	Ki = 18.62 nM Bioactivity Info	TI LI LO TS
CP0394212 Compound Info	(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-6-[(4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,12,16-trione Show/Hide	C49H79ClN2O13	1
1	Ki = 22.39 nM Bioactivity Info	TI LI LO TS
CP0410101 Compound Info	(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-8-[(3R,4S,6R)-4-[butan-2-yl(cyclopropylmethyl)amino]-3-hydroxy-6-methyloxan-2-yl]oxy-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-6-[(4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,12,16-trione Show/Hide	C53H85ClN2O13	1
1	Ki = 27.54 nM Bioactivity Info	TI LI LO TS
CP0445667 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] 5-methyl-2-oxo-1,3-oxazolidine-3-carboxylate Show/Hide	C46H70ClN3O13	1
1	Ki = 36.31 nM Bioactivity Info	TI LI LO TS
CP0430277 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] (4R)-4-methyl-2-oxo-1,3-oxazolidine-3-carboxylate Show/Hide	C46H70ClN3O13	1
1	Ki = 48.98 nM Bioactivity Info	TI LI LO TS
CP0511367 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] (4S)-4-ethyl-2-oxo-1,3-oxazolidine-3-carboxylate Show/Hide	C47H72ClN3O13	1
1	Ki = 66.07 nM Bioactivity Info	TI LI LO TS
CP0381079 Compound Info	(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-6-[(4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-(methylamino)oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,12,16-trione Show/Hide	C46H73ClN2O13	1
1	Ki = 79.43 nM Bioactivity Info	TI LI LO TS
CP0381021 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] 4,4-dimethyl-2-oxo-1,3-oxazolidine-3-carboxylate Show/Hide	C47H72ClN3O13	1
1	Ki = 79.43 nM Bioactivity Info	TI LI LO TS
CP0502052 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] (4S,5R)-4,5-dimethyl-2-oxo-1,3-oxazolidine-3-carboxylate Show/Hide	C47H72ClN3O13	1
1	Ki < 100 nM Bioactivity Info	TI LI LO TS
CP0504856 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] 2-oxo-1,3-oxazolidine-3-carboxylate Show/Hide	C45H68ClN3O13	1
1	Ki = 114.82 nM Bioactivity Info	TI LI LO TS
CP0436307 Compound Info	ethyl 3-[[benzyl-[2-oxo-2-[4-(3-phenylprop-2-ynylcarbamoyl)piperidin-1-yl]ethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C50H50F2N8O6	1
1	Ki = 140 nM Bioactivity Info	TI LI LO TS
CP0427984 Compound Info	ethyl 3-[[benzyl-[2-oxo-2-[[2-oxo-2-(3-phenylprop-2-ynylamino)ethyl]amino]ethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C46H44F2N8O6	1
1	Ki = 170 nM Bioactivity Info	TI LI LO TS
CP0438999 Compound Info	(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-8-[(3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-6-[(4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,12,16-trione Show/Hide	C47H75ClN2O13	1
1	Ki = 190.55 nM Bioactivity Info	TI LI LO TS
CP0507096 Compound Info	(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-8-[(3R,4S,6R)-4-[cyclohexyl(methyl)amino]-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-6-[(4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,12,16-trione Show/Hide	C52H83ClN2O13	1
1	Ki = 204.17 nM Bioactivity Info	TI LI LO TS
CP0448712 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] oxolane-3-carboxylate Show/Hide	C46H71ClN2O12	1
1	Ki = 213.8 nM Bioactivity Info	TI LI LO TS
CP0436306 Compound Info	ethyl 3-[[benzyl-[2-oxo-2-[(2S)-2-(3-phenylprop-2-ynylcarbamoyl)pyrrolidin-1-yl]ethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C49H48F2N8O6	1
1	Ki = 260 nM Bioactivity Info	TI LI LO TS
CP0403913 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] (4R)-4-(2-methylpropyl)-2-oxo-1,3-oxazolidine-3-carboxylate Show/Hide	C49H76ClN3O13	1
1	Ki = 275.42 nM Bioactivity Info	TI LI LO TS
CP0436308 Compound Info	ethyl 3-[[benzyl-[2-oxo-2-[[6-oxo-6-(3-phenylprop-2-ynylamino)hexyl]amino]ethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C50H52F2N8O6	1
1	Ki = 380 nM Bioactivity Info	TI LI LO TS
CP0507827 Compound Info	ethyl 3-[[benzyl-[2-[4-[3-[3-[3-[[1-[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]piperidine-4-carbonyl]amino]prop-1-ynyl]phenyl]prop-2-ynylcarbamoyl]piperidin-1-yl]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C94H94F4N16O12	1
1	Ki = 400 nM Bioactivity Info	TI LI LO TS
CP0436303 Compound Info	ethyl 3-[[benzyl-[2-[[(2S)-1-[3-[4-[3-[[(2S)-2-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]propanoyl]amino]prop-1-ynyl]phenyl]prop-2-ynylamino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C88H86F4N16O12	1
1	Ki = 480 nM Bioactivity Info	TI LI LO TS
CP0507828 Compound Info	ethyl 3-[[benzyl-[2-[4-[3-[2-[3-[[1-[2-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]acetyl]piperidine-4-carbonyl]amino]prop-1-ynyl]phenyl]prop-2-ynylcarbamoyl]piperidin-1-yl]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C93H93F4N17O11	1
1	Ki = 500 nM Bioactivity Info	TI LI LO TS
CP0449200 Compound Info	ethyl 3-[[benzyl-[2-[4-[3-[4-[3-[[1-[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]piperidine-4-carbonyl]amino]prop-1-ynyl]phenyl]prop-2-ynylcarbamoyl]piperidin-1-yl]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C94H94F4N16O12	1
1	Ki = 510 nM Bioactivity Info	TI LI LO TS
CP0433399 Compound Info	ethyl 3-[[benzyl-[2-[[2-[3-[4-[3-[[2-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]acetyl]amino]prop-1-ynyl]phenyl]prop-2-ynylamino]-2-oxoethyl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C86H82F4N16O12	1
1	Ki = 530 nM Bioactivity Info	TI LI LO TS
CP0508616 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] 5-ethyl-2-oxo-1,3-oxazolidine-3-carboxylate Show/Hide	C47H72ClN3O13	1
1	Ki = 562.34 nM Bioactivity Info	TI LI LO TS
CP0436309 Compound Info	ethyl 3-[[benzyl-[2-oxo-2-[[4-oxo-4-(3-phenylprop-2-ynylamino)butyl]amino]ethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C48H48F2N8O6	1
1	Ki = 580 nM Bioactivity Info	TI LI LO TS
CP0444487 Compound Info	ethyl 3-[[benzyl-[2-[[4-[3-[4-[3-[4-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]butanoylamino]prop-1-ynyl]phenyl]prop-2-ynylamino]-4-oxobutyl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C90H90F4N16O12	1
1	Ki = 600 nM Bioactivity Info	TI LI LO TS
CP0436310 Compound Info	ethyl 3-[[benzyl-[2-[[6-[3-[4-[3-[6-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]hexanoylamino]prop-1-ynyl]phenyl]prop-2-ynylamino]-6-oxohexyl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C94H98F4N16O12	1
1	Ki = 620 nM Bioactivity Info	TI LI LO TS
CP0391374 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] cyclopentanecarboxylate Show/Hide	C47H73ClN2O11	1
1	Ki = 630.96 nM Bioactivity Info	TI LI LO TS
CP0507830 Compound Info	ethyl 3-[[benzyl-[2-[[6-[3-[2-[3-[6-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]hexanoylamino]prop-1-ynyl]phenyl]prop-2-ynylamino]-6-oxohexyl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C91H94F4N16O10	1
1	Ki = 700 nM Bioactivity Info	TI LI LO TS
CP0386687 Compound Info	ethyl 3-[[benzyl-[2-[[(2S)-1-[3-[4-[3-[[(2S)-2-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]-3-methylbutanoyl]amino]prop-1-ynyl]phenyl]prop-2-ynylamino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C92H94F4N16O12	1
1	Ki = 720 nM Bioactivity Info	TI LI LO TS
CP0427978 Compound Info	ethyl 3-[[benzyl-[2-[(2S)-2-[3-[4-[3-[[(2S)-1-[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]prop-1-ynyl]phenyl]prop-2-ynylcarbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C92H90F4N16O12	1
1	Ki = 740 nM Bioactivity Info	TI LI LO TS
CP0490573 Compound Info	ethyl 3-[[benzyl-[2-[[(2S)-3-methyl-1-oxo-1-(3-phenylprop-2-ynylamino)butan-2-yl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C49H50F2N8O6	1
1	Ki = 770 nM Bioactivity Info	TI LI LO TS
CP0375305 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] 2-methyl-1,3-oxazolidine-3-carboxylate Show/Hide	C46H72ClN3O12	1
1	Ki = 794.33 nM Bioactivity Info	TI LI LO TS
CP0427979 Compound Info	ethyl 3-[[benzyl-[2-[[4-[3-[3-[3-[4-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]butanoylamino]prop-1-ynyl]phenyl]prop-2-ynylamino]-4-oxobutyl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C90H90F4N16O12	1
1	Ki = 820 nM Bioactivity Info	TI LI LO TS
CP0449135 Compound Info	ethyl 3-[[benzyl-[2-[[4-[3-[2-[3-[4-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]butanoylamino]prop-1-ynyl]phenyl]prop-2-ynylamino]-4-oxobutyl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C87H86F4N16O10	1
1	Ki = 840 nM Bioactivity Info	TI LI LO TS
CP0436304 Compound Info	ethyl 3-[[benzyl-[2-[[2-[(2S)-2-[3-[2-[3-[[(2S)-1-[2-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]prop-1-ynyl]phenyl]prop-2-ynylcarbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C93H92F4N18O12	1
1	Ki = 850 nM Bioactivity Info	TI LI LO TS
CP0427987 Compound Info	ethyl 3-[[benzyl-[2-[[6-[3-[3-[3-[6-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]hexanoylamino]prop-1-ynyl]phenyl]prop-2-ynylamino]-6-oxohexyl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C94H98F4N16O12	1
1	Ki = 930 nM Bioactivity Info	TI LI LO TS
CP0436311 Compound Info	ethyl 3-[[benzyl-[2-[(2S)-2-[3-[3-[3-[[(2S)-1-[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]prop-1-ynyl]phenyl]prop-2-ynylcarbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C92H90F4N16O12	1
1	Ki = 930 nM Bioactivity Info	TI LI LO TS
CP0427988 Compound Info	ethyl 3-[[benzyl-[2-[[2-[3-[2-[3-[[2-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]acetyl]amino]prop-1-ynyl]phenyl]prop-2-ynylamino]-2-oxoethyl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C83H78F4N16O10	1
1	Ki = 1000 nM Bioactivity Info	TI LI LO TS
CP0433400 Compound Info	ethyl 3-[[benzyl-[2-[[2-[3-[3-[3-[[2-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]acetyl]amino]prop-1-ynyl]phenyl]prop-2-ynylamino]-2-oxoethyl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C86H82F4N16O12	1
1	Ki = 1100 nM Bioactivity Info	TI LI LO TS
CP0427983 Compound Info	ethyl 3-[[benzyl-[2-oxo-2-[[(2S)-1-oxo-1-(3-phenylprop-2-ynylamino)propan-2-yl]amino]ethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C47H46F2N8O6	1
1	Ki = 1600 nM Bioactivity Info	TI LI LO TS
CP0375096 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] pyrrolidine-1-carboxylate Show/Hide	C46H72ClN3O11	1
1	Ki = 1621.81 nM Bioactivity Info	TI LI LO TS
CP0455132 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] 3-methylbutanoate Show/Hide	C46H73ClN2O11	1
1	Ki = 2041.74 nM Bioactivity Info	TI LI LO TS
CP0494596 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] 2-oxoimidazolidine-1-carboxylate Show/Hide	C45H69ClN4O12	1
1	Ki = 2041.74 nM Bioactivity Info	TI LI LO TS
CP0436312 Compound Info	ethyl 3-[[benzyl-[2-[[(2S)-1-[3-[3-[3-[[(2S)-2-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]-3-methylbutanoyl]amino]prop-1-ynyl]phenyl]prop-2-ynylamino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C92H94F4N16O12	1
1	Ki = 2200 nM Bioactivity Info	TI LI LO TS
CP0449136 Compound Info	ethyl 3-[[benzyl-[2-[[2-[[(2S)-1-[3-[2-[3-[[(2S)-2-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]propanoyl]amino]prop-1-ynyl]phenyl]prop-2-ynylamino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C87H85F4N17O11	1
1	Ki = 3000 nM Bioactivity Info	TI LI LO TS
CP0436305 Compound Info	ethyl 3-[[benzyl-[2-[[2-[[(2S)-1-[3-[2-[3-[[(2S)-2-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]-3-methylbutanoyl]amino]prop-1-ynyl]phenyl]prop-2-ynylamino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C91H93F4N17O11	1
1	Ki = 3300 nM Bioactivity Info	TI LI LO TS
CP0381020 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] 3-methyl-2-oxoimidazolidine-1-carboxylate Show/Hide	C46H71ClN4O12	1
1	Ki = 4677.35 nM Bioactivity Info	TI LI LO TS
CP0490571 Compound Info	ethyl 3-[[benzyl-[2-[[(2S)-1-[3-[3-[3-[[(2S)-2-[[2-[benzyl-[[8-[(2,6-difluorophenyl)methyl]-6-ethoxycarbonyl-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidin-3-yl]methyl]amino]acetyl]amino]propanoyl]amino]prop-1-ynyl]phenyl]prop-2-ynylamino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(ethylcarbamoylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate Show/Hide	C88H86F4N16O12	1
1	Ki = 5300 nM Bioactivity Info	TI LI LO TS
CP0415934 Compound Info	[(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl] morpholine-4-carboxylate Show/Hide	C46H72ClN3O12	1
1	Ki = 5623.41 nM Bioactivity Info	TI LI LO TS
CP0430671 Compound Info	(1S,2R,5R,6S,7S,8R,9S,11R,13R,14R)-15-[2-(4-chlorophenyl)ethyl]-2-ethyl-6-hydroxy-8-[(3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,12,16-trione Show/Hide	C41H65ClN2O10	1
1	Ki = 10000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000053 , COS-7

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000194 , RBL-1

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0037858 Compound Info	(S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(pyrimidin-4-yl)-3-(3,4,5-trimethylphenyl)-1,2-dihydroquinoline-6-carboxamide Show/Hide	C28H28ClN5O3	6
1	Activity = 0.4 nM
2	IC50 = 0.44 nM
3	IC50 = 0.5 nM
4	IC50 = 1 nM
5	IC50 = 60 nM
6	Ki = 0.4 nM
CP0039875 Compound Info	1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)amino)methyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea Show/Hide	C36H31F2N5O4S	38
1	IC50 = 0.1 nM
2	IC50 = 0.3 nM
3	IC50 = 0.4 nM
4	IC50 = 0.5 nM
5	IC50 = 0.6 nM
6	IC50 = 0.7 nM
7	IC50 = 0.8 nM
8	IC50 = 0.9 nM
9	IC50 = 1.1 nM
10	IC50 = 1.2 nM
11	IC50 = 1.3 nM
12	IC50 = 1.4 nM
13	IC50 = 1.8 nM
14	IC50 = 1.9 nM
15	IC50 = 2 nM
16	IC50 = 2.3 nM
17	IC50 = 2.5 nM
18	IC50 = 3 nM
19	IC50 = 4.3 nM
20	IC50 = 5.2 nM
21	IC50 = 6.3 nM
22	IC50 = 8.5 nM
23	IC50 = 9.7 nM
24	IC50 = 10 nM
25	IC50 = 12.1 nM
26	IC50 = 23.4 nM
27	IC50 = 24.4 nM
28	IC50 = 94.9 nM
29	IC50 = 108 nM
30	IC50 = 115 nM
31	IC50 = 148 nM
32	IC50 = 192 nM
33	IC50 = 193 nM
34	IC50 = 240 nM
35	IC50 = 242 nM
36	IC50 = 470 nM
37	IC50 = 1070 nM
38	Ki = 0.2 nM
CP0778924 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-7-(2,6-difluoro-benzyl)-2-(4-isobutyrylamino-phenyl)-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid isopropyl ester hydrochloride Show/Hide	C37H38ClF2N3O4S	1
1	IC50 = 0.2 nM
CP0227902 Compound Info	5-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-1-methyl-1H-pyridin-2-one Show/Hide	C38H48N4O2	1
1	IC50 = 0.2 nM
CP0039874 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-7-(2,6-difluoro-benzyl)-2-(4-isobutyrylamino-phenyl)-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid isopropyl ester; hydrochloride Show/Hide	C37H37F2N3O4S	4
1	IC50 = 0.2 nM
2	IC50 = 4 nM
3	IC50 = 60 nM
4	Ki = 0.2 nM
CP0091820 Compound Info	ELIGARD Show/Hide	C59H84N16O12	2
1	IC50 = 0.3 nM
2	IC50 = 0.8 nM
CP0095035 Compound Info	7-Chloro-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide Show/Hide	C30H32ClN5O3	1
1	IC50 = 0.3 nM
CP0213550 Compound Info	5-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-1H-pyridin-2-one Show/Hide	C37H46N4O2	1
1	IC50 = 0.3 nM
CP0122740 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-1-methyl-2-[2-(1-oxy-pyridin-4-yl)-ethylamino]-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C37H46N4O2	1
1	IC50 = 0.3 nM
CP0361002 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-1-methyl-2-[2-(2-methyl-1-oxy-pyridin-4-yl)-ethylamino]-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C38H48N4O2	1
1	IC50 = 0.3 nM
CP0076599 Compound Info	1-(1S,4R)-2-Aza-bicyclo[2.2.1]hept-2-yl-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C38H48N4O	1
1	IC50 = 0.4 nM
CP0272840 Compound Info	5-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-1-methyl-piperidin-2-one Show/Hide	C38H52N4O2	1
1	IC50 = 0.4 nM
CP0522236 Compound Info	5-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-1-methoxymethyl-1H-pyridin-2-one Show/Hide	C39H50N4O3	1
1	IC50 = 0.4 nM
CP0115024 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-2-[2-(2,6-dimethyl-pyridin-4-yl)-ethylamino]-1-methyl-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C39H50N4O	1
1	IC50 = 0.4 nM
CP0299579 Compound Info	Acetic acid 4-(2-{(S)-2-[5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-pyridin-2-ylmethyl ester Show/Hide	C40H50N4O3	1
1	IC50 = 0.4 nM
CP0464146 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-2-[2-(2-hydroxymethyl-pyridin-4-yl)-ethylamino]-1-methyl-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C38H48N4O2	1
1	IC50 = 0.4 nM
CP0257614 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-[3-{(S)-2-[2-(2,6-dimethyl-1-oxy-pyridin-4-yl)-ethylamino]-1-methyl-ethyl}-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-2-methyl-propan-1-one Show/Hide	C39H50N4O2	1
1	IC50 = 0.5 nM
CP0046868 Compound Info	(R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione Show/Hide	C27H24F3N3O3	48
1	IC50 = 0.5 nM
2	IC50 = 0.6 nM
3	IC50 = 0.7 nM
4	IC50 = 0.8 nM
5	IC50 = 0.9 nM
6	IC50 = 1 nM
7	IC50 = 1.1 nM
8	IC50 = 1.2 nM
9	IC50 = 1.3 nM
10	IC50 = 1.4 nM
11	IC50 = 1.5 nM
12	IC50 = 1.6 nM
13	IC50 = 1.7 nM
14	IC50 = 1.8 nM
15	IC50 = 2.3 nM
16	IC50 = 2.4 nM
17	IC50 = 2.5 nM
18	IC50 = 2.6 nM
19	IC50 = 2.7 nM
20	IC50 = 2.8 nM
21	IC50 = 3 nM
22	IC50 = 3.1 nM
23	IC50 = 3.2 nM
24	IC50 = 3.4 nM
25	IC50 = 3.7 nM
26	IC50 = 5.5 nM
27	IC50 = 5.7 nM
28	IC50 = 6.6 nM
29	IC50 = 7.5 nM
30	IC50 = 8 nM
31	IC50 = 8.9 nM
32	IC50 = 9.2 nM
33	IC50 = 11.4 nM
34	IC50 = 13.9 nM
35	IC50 = 15.2 nM
36	IC50 = 24.2 nM
37	IC50 = 42.7 nM
38	IC50 = 80 nM
39	IC50 = 123 nM
40	IC50 = 182 nM
41	IC50 = 262 nM
42	IC50 = 980 nM
43	IC50 = 4200 nM
44	IC50 = 5000 nM
45	IC50 = 5030 nM
46	IC50 = 5200 nM
47	Ki = 0.56 nM
48	Ki = 3.5 nM
CP0135587 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(2-pyridin-3-yl-ethylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C37H46N4O	1
1	IC50 = 0.6 nM
CP0213240 Compound Info	(S)-1-(2-aza-bicyclo[2.2.2]octan-2-yl)-2-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-1H-indol-5-yl)-2-methylpropan-1-one Show/Hide	C37H46N4O	1
1	IC50 = 0.6 nM
CP0246348 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-1-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-2-methyl-propan-1-one Show/Hide	C39H50N4O3	1
1	IC50 = 0.6 nM
CP0371321 Compound Info	5-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-1,3-dimethyl-1H-pyridin-2-one Show/Hide	C39H50N4O2	1
1	IC50 = 0.6 nM
CP0215042 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-[2-(3,5-dimethyl-phenyl)-3-((S)-2-{2-[2-(1-hydroxy-ethyl)-pyridin-4-yl]-ethylamino}-1-methyl-ethyl)-1H-indol-5-yl]-2-methyl-propan-1-one Show/Hide	C39H50N4O2	1
1	IC50 = 0.6 nM
CP0463978 Compound Info	2-[3-{(S)-2-[2-(2-Acetyl-pyridin-4-yl)-ethylamino]-1-methyl-ethyl}-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-1-(2-aza-bicyclo[2.2.2]oct-2-yl)-2-methyl-propan-1-one Show/Hide	C39H48N4O2	1
1	IC50 = 0.6 nM
CP0063211 Compound Info	1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C38H48N4O	1
1	IC50 = 0.7 nM
CP0136681 Compound Info	1-(3,3-Dimethyl-azetidin-1-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C37H48N4O	1
1	IC50 = 0.7 nM
CP0155115 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-2-[2-(2-methoxymethyl-pyridin-4-yl)-ethylamino]-1-methyl-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C39H50N4O2	1
1	IC50 = 0.7 nM
CP0194543 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-[2-(3,5-dimethyl-phenyl)-3-((S)-2-{2-[2-(1-hydroxy-1-methyl-ethyl)-pyridin-4-yl]-ethylamino}-1-methyl-ethyl)-1H-indol-5-yl]-2-methyl-propan-1-one Show/Hide	C40H52N4O2	1
1	IC50 = 0.7 nM
CP0221205 Compound Info	4-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-pyridine-2-carbonitrile Show/Hide	C38H45N5O	1
1	IC50 = 0.7 nM
CP0196863 Compound Info	1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(2-pyridin-4-yl-ethylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C36H44N4O	1
1	IC50 = 0.8 nM
CP0334675 Compound Info	1-(8-Aza-bicyclo[3.2.1]oct-8-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C39H50N4O	1
1	IC50 = 0.8 nM
CP0172193 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-1-methyl-2-[2-(3-methyl-pyridin-4-yl)-ethylamino]-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C38H48N4O	1
1	IC50 = 0.8 nM
CP0215181 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-1-methyl-2-[2-(3-methyl-1-oxy-pyridin-4-yl)-ethylamino]-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C38H48N4O2	1
1	IC50 = 0.8 nM
CP0082419 Compound Info	4-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-pyridine-2-carboxylic acid methyl ester Show/Hide	C39H48N4O3	1
1	IC50 = 0.9 nM
CP0208585 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-1-methyl-2-[2-(2-methyl-pyridin-4-yl)-ethylamino]-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C38H48N4O	1
1	IC50 = 0.9 nM
CP0216361 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C39H50N4O	1
1	IC50 = 1 nM
CP0219557 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-2-[2-(6-methoxy-pyridin-3-yl)-ethylamino]-1-methyl-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C38H48N4O2	1
1	IC50 = 1 nM
CP0327922 Compound Info	1-(1R,4S)-2-Aza-bicyclo[2.2.1]hept-2-yl-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C38H48N4O	1
1	IC50 = 1 nM
CP0299019 Compound Info	1-(1R,4S)-2-Aza-bicyclo[2.2.1]hept-2-yl-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(2-pyridin-4-yl-ethylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C36H44N4O	1
1	IC50 = 1.2 nM
CP0223103 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-1-(4,4-dimethyl-piperidin-1-yl)-2-methyl-propan-1-one Show/Hide	C39H52N4O	1
1	IC50 = 1.3 nM
CP0225806 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-1-(3aR,7aS)-octahydro-isoindol-2-yl-propan-1-one Show/Hide	C40H52N4O	1
1	IC50 = 1.4 nM
CP0236982 Compound Info	1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C37H46N4O	1
1	IC50 = 1.4 nM
CP0070855 Compound Info	(S)-1-(3-(1-(4-(1H-tetrazol-5-yl)phenethylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone Show/Hide	C36H37F4N7O	1
1	IC50 = 1.5 nM
CP0202958 Compound Info	5-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-4-yl)piperazin-1-yl)methyl)-1-ethylpyrimidine-2,4(1H,3H)-dione Show/Hide	C28H34N6O2	2
1	IC50 = 1.6 nM
2	IC50 = 1.7 nM
CP0332602 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid cyclooctyl-ethyl-amide Show/Hide	C38H50N4O	1
1	IC50 = 1.9 nM
CP0196182 Compound Info	1-(3-Aza-bicyclo[3.2.2]non-3-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C40H52N4O	1
1	IC50 = 2.1 nM
CP0309400 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid cyclohexyl-ethyl-amide Show/Hide	C36H46N4O	1
1	IC50 = 2.3 nM
CP0524086 Compound Info	1-(8-Aza-spiro[4.5]dec-8-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C41H54N4O	1
1	IC50 = 2.7 nM
CP0288623 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid cyclohexyl-ethyl-amide Show/Hide	C36H46N4O	1
1	IC50 = 2.8 nM
CP0055695 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-2-[2-(2-ethyl-pyridin-4-yl)-ethylamino]-1-methyl-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C39H50N4O	1
1	IC50 = 3.3 nM
CP0286926 Compound Info	[2-(3,5-dimethylphenyl)-3-[2-(4-pyridin-3-ylbutylamino)ethyl]-1H-indol-5-yl]-(2,5-dimethylpyrrolidin-1-yl)methanone Show/Hide	C34H42N4O	1
1	IC50 = 3.6 nM
CP0223421 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-1-(4-ethanesulfonyl-piperazin-1-yl)-2-methyl-propan-1-one Show/Hide	C38H51N5O3S	1
1	IC50 = 4.4 nM
CP0193348 Compound Info	1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethyl-phenyl)-3-{(S)-1-methyl-2-[2-(2-propyl-pyridin-4-yl)-ethylamino]-ethyl}-1H-indol-5-yl)-2-methyl-propan-1-one Show/Hide	C40H52N4O	1
1	IC50 = 4.6 nM
CP0336314 Compound Info	1-(6-Aza-bicyclo[3.2.1]oct-6-yl)-2-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propan-1-one Show/Hide	C39H50N4O	1
1	IC50 = 4.8 nM
CP0364803 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-1-(1,3,3-trimethyl-6-aza-bicyclo[3.2.1]oct-6-yl)-propan-1-one Show/Hide	C42H56N4O	1
1	IC50 = 4.8 nM
CP0045709 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid diisobutylamide Show/Hide	C36H48N4O	1
1	IC50 = 5 nM
CP0299531 Compound Info	3-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-1-methyl-1H-pyridin-2-one Show/Hide	C38H48N4O2	1
1	IC50 = 5.3 nM
CP0219252 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-N,N-diisobutyl-isobutyramide Show/Hide	C40H56N4O	1
1	IC50 = 5.6 nM
CP0091943 Compound Info	2-(4-tert-butylphenyl)-4-(4-((1-ethyl-5-methyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-1H-benzo[d]imidazole Show/Hide	C28H36N6	2
1	IC50 = 5.8 nM
2	IC50 = 7 nM
CP0112281 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-7-(2,6-difluoro-benzyl)-2-(4-methoxy-phenyl)-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester Show/Hide	C33H30F2N2O4S	1
1	IC50 = 6 nM
CP0110348 Compound Info	(S)-1-((S)-2-((S)-2-(2-((S)-2-((S)-2-((S)-2-((S)-3-(1H-imidazol-5-yl)-2-((S)-2-oxopyrrolidine-5-carboxamido)propanamido)-3-(1H-indol-2-yl)propanamido)-3-hydroxypropanamido)-3-(4-hydroxyphenyl)propanamido)acetamido)-4-methylpentanamido)-5-(diaminomethylene Show/Hide	C53H72N16O12	1
1	IC50 = 6 nM
CP0196914 Compound Info	4-(2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propionyl)-piperazine-1-carboxylic acid tert-butyl ester Show/Hide	C41H55N5O3	1
1	IC50 = 6.1 nM
CP0080593 Compound Info	3-((R)-2-Amino-2-cyclohexyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione Show/Hide	C27H30F3N3O3	3
1	IC50 = 6.5 nM
2	Ki = 6.5 nM
3	Ki = 120 nM
CP0054992 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid diisobutylamide Show/Hide	C36H48N4O	1
1	IC50 = 7.1 nM
CP0070868 Compound Info	2-(4-tert-butylphenyl)-4-(4-((2-methyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-1H-benzo[d]imidazole Show/Hide	C26H32N6	1
1	IC50 = 7.5 nM
CP0211626 Compound Info	2-(4-tert-butylphenyl)-4-(4-((1,2-diethyl-5-methyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-1H-benzo[d]imidazole Show/Hide	C30H40N6	1
1	IC50 = 8 nM
CP0363826 Compound Info	4-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-pyridine-2-carboxylic acid Show/Hide	C38H46N4O3	1
1	IC50 = 8.2 nM
CP0191989 Compound Info	2-(4-tert-butylphenyl)-4-(4-((1,2-dimethyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-1H-benzo[d]imidazole Show/Hide	C27H34N6	1
1	IC50 = 10 nM
CP0368048 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid ethyl-isopropyl-amide Show/Hide	C33H42N4O	1
1	IC50 = 11 nM
CP0043368 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid diethylamide Show/Hide	C32H40N4O	1
1	IC50 = 18 nM
CP0152863 Compound Info	2-(4-tert-butylphenyl)-4-(4-((2-methyl-1-propyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-1H-benzo[d]imidazole Show/Hide	C29H38N6	1
1	IC50 = 18 nM
CP0167736 Compound Info	(S)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyl-3-(2-(methylamino)-3-phenylpropyl)pyrimidine-2,4(1H,3H)-dione Show/Hide	C29H28F3N3O3	3
1	IC50 = 20 nM
2	Ki = 8.1 nM
3	Ki = 200 nM
CP0149717 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-1-(dodecahydro-carbazol-9-yl)-2-methyl-propan-1-one Show/Hide	C44H58N4O	1
1	IC50 = 21 nM
CP0105024 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid diethylamide Show/Hide	C32H40N4O	1
1	IC50 = 23 nM
CP0342019 Compound Info	5-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-4-yl)piperazin-1-yl)methyl)quinoxaline Show/Hide	C30H32N6	1
1	IC50 = 26 nM
CP0033448 Compound Info	BAY-784 Show/Hide	C29H26ClF4N3O5S2	2
1	IC50 = 27 nM
2	IC50 ~ 27 nM
CP0214050 Compound Info	(7-Aza-bicyclo[2.2.1]hept-7-yl)-{2-(3,5-dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-methanone Show/Hide	C34H40N4O	1
1	IC50 = 32 nM
CP0376521 Compound Info	2-{2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indol-5-yl}-isobutyramide Show/Hide	C31H38N4O	1
1	IC50 = 32 nM
CP0041665 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid ethyl-(2-hydroxy-ethyl)-amide Show/Hide	C32H40N4O2	1
1	IC50 = 36 nM
CP0297942 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid bis-(2,2,2-trifluoro-ethyl)-amide Show/Hide	C32H34F6N4O	1
1	IC50 = 36 nM
CP0352069 Compound Info	2-(3,5-Dimethyl-phenyl)-3-{2-[methyl-(4-pyridin-4-yl-butyl)-amino]-ethyl}-1H-indole-5-carboxylic acid diethylamide Show/Hide	C33H42N4O	1
1	IC50 = 36 nM
CP0258027 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid bis-(2-methoxy-ethyl)-amide Show/Hide	C34H44N4O3	1
1	IC50 = 45 nM
CP0071049 Compound Info	4-(4-((1-butyl-5-methyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-2-(4-tert-butylphenyl)-1H-benzo[d]imidazole Show/Hide	C30H40N6	1
1	IC50 = 46 nM
CP0256086 Compound Info	2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid isopropylamide Show/Hide	C31H38N4O	1
1	IC50 = 55 nM
CP0182886 Compound Info	3-[(Benzyl-methyl-amino)-methyl]-7-(2-methoxy-benzyl)-2-(4-methoxy-phenyl)-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester Show/Hide	C34H34N2O5S	1
1	IC50 = 70 nM
CP0076365 Compound Info	7-(2-Methoxy-benzyl)-2-(4-methoxy-phenyl)-3-methylaminomethyl-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester Show/Hide	C27H28N2O5S	1
1	IC50 = 2000 nM
CP0061893 Compound Info	1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)amino)methyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-ethylurea Show/Hide	C37H33F2N5O3S	1
1	Ki = 0.4 nM
CP0158198 Compound Info	(R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione Show/Hide	C28H24F5N3O3	1
1	Ki = 0.5 nM
CP0061892 Compound Info	1-(2,6-Difluoro-benzyl)-5-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-6-(4-nitro-phenyl)-3-phenyl-1H-thieno[2,3-d]pyrimidine-2,4-dione Show/Hide	C34H27F2N5O4S	1
1	Ki = 0.6 nM
CP0043839 Compound Info	(R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione Show/Hide	C27H22F5N3O3	1
1	Ki = 0.64 nM
CP0272654 Compound Info	N-[4-[5-[[benzyl(methyl)amino]methyl]-1-[(2,6-difluorophenyl)methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]propanamide Show/Hide	C37H32F2N4O3S	1
1	Ki = 0.8 nM
CP0288327 Compound Info	(R)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyl-3-(2-(pyridin-2-ylmethylamino)propyl)pyrimidine-2,4(1H,3H)-dione Show/Hide	C28H27F3N4O3	1
1	Ki = 1.1 nM
CP0080596 Compound Info	1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-((R)-4-methyl-2-methylamino-pentyl)-1H-pyrimidine-2,4-dione Show/Hide	C26H30F3N3O3	1
1	Ki = 1.2 nM
CP0211775 Compound Info	A-198401 Show/Hide	C47H69Cl2N3O13	1
1	Ki = 1.995 nM
CP0124091 Compound Info	(R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(5-chlorothiophen-2-yl)-6-methylpyrimidine-2,4(1H,3H)-dione Show/Hide	C24H20ClF2N3O2S	1
1	Ki = 2 nM
CP0182660 Compound Info	7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 1-ethyl-propyl ester Show/Hide	C39H44FN5O4	1
1	Ki = 2.7 nM
CP0193577 Compound Info	N-[4-[5-[[benzyl(methyl)amino]methyl]-1-[(2,6-difluorophenyl)methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-2-methylpropanamide Show/Hide	C38H34F2N4O3S	1
1	Ki = 2.9 nM
CP0176635 Compound Info	(R)-1-(2,6-difluorobenzyl)-3-(1-(2-methoxybenzylamino)propan-2-yl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione Show/Hide	C30H30F3N3O4	1
1	Ki = 3.7 nM
CP0061901 Compound Info	N-[4-[5-[[benzyl(methyl)amino]methyl]-1-[(2,6-difluorophenyl)methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]acetamide Show/Hide	C36H30F2N4O3S	1
1	Ki = 4.1 nM
CP0156900 Compound Info	(S)-1-(2,6-difluorobenzyl)-3-(2-(cyclopentylamino)propyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione Show/Hide	C27H30F3N3O3	1
1	Ki = 4.5 nM
CP0439838 Compound Info	(R)-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyl-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)propyl)pyrimidine-2,4(1H,3H)-dione Show/Hide	C30H32F2N4O3	1
1	Ki = 5.2 nM
CP0124188 Compound Info	(R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione Show/Hide	C26H22F3N3O3	1
1	Ki = 5.3 nM
CP0088206 Compound Info	(R)-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyl-3-(2-(methyl(pyridin-2-ylmethyl)amino)propyl)pyrimidine-2,4(1H,3H)-dione Show/Hide	C29H30F2N4O3	2
1	Ki = 5.5 nM
2	Ki = 102 nM
CP0165712 Compound Info	5-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl)-N-(2,4,6-trimethoxyphenyl)furan-2-carboxamide Show/Hide	C30H37NO5	1
1	Ki = 6 nM
CP0290843 Compound Info	3-((R)-2-Amino-4-methyl-pentyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione Show/Hide	C25H28F3N3O3	1
1	Ki = 6.4 nM
CP0367573 Compound Info	1-(2,6-Difluoro-benzyl)-3-((S)-2-dimethylamino-3-phenyl-propyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione Show/Hide	C30H30F3N3O3	1
1	Ki = 7.9 nM
CP0292322 Compound Info	(R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)-1,3,5-triazinane-2,4,6-trione Show/Hide	C25H21F3N4O4	1
1	Ki = 9 nM
CP0288326 Compound Info	(R)-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyl-3-(2-(pyridin-2-ylmethylamino)propyl)pyrimidine-2,4(1H,3H)-dione Show/Hide	C28H28F2N4O3	1
1	Ki = 15 nM
CP0306971 Compound Info	1-(2,6-difluorobenzyl)-6-(4-(methylthio)benzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione Show/Hide	C32H35F2N5O2S	1
1	Ki = 15 nM
CP0046850 Compound Info	3-((S)-2-Amino-3-phenyl-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione Show/Hide	C28H26F3N3O3	1
1	Ki = 16 nM
CP0276324 Compound Info	1-(2,6-difluoro-benzyl)-5-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione Show/Hide	C30H30F2N4O4	1
1	Ki = 24 nM
CP0167737 Compound Info	1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-bromo-6-fluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione Show/Hide	C25H21BrF2N4O4	1
1	Ki = 24 nM
CP0124192 Compound Info	(R)-methyl 4-(2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(2-fluoro-3-methoxyphenyl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethylamino)butanoate Show/Hide	C32H30F5N3O5	1
1	Ki = 32 nM
CP0257980 Compound Info	1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-[2-(2-pyridin-2-yl-ethylamino)-ethyl]-1H-pyrimidine-2,4-dione Show/Hide	C28H28F2N4O3	1
1	Ki = 34 nM
CP0061891 Compound Info	1-(2,6-difluorobenzyl)-6-(4-aminophenyl)-5-((benzyl(methyl)amino)methyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Show/Hide	C34H28F2N4O2S	1
1	Ki = 36 nM
CP0039878 Compound Info	(R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(3-methoxyphenyl)-1,3,5-triazinane-2,4,6-trione Show/Hide	C25H22F2N4O4	1
1	Ki = 37 nM
CP0266590 Compound Info	5-Benzo[1,3]dioxol-5-yl-1-(2,6-difluoro-benzyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione Show/Hide	C29H28F2N4O4	1
1	Ki = 38 nM
CP0167734 Compound Info	3-((S)-2-Amino-4-methyl-pentyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione Show/Hide	C25H28F3N3O3	1
1	Ki = 39 nM
CP0344191 Compound Info	6-[(Benzyl-methyl-amino)-methyl]-1-(2-fluoro-benzyl)-7-(4-isobutyrylamino-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester Show/Hide	C36H37FN4O4	1
1	Ki = 44 nM
CP0363522 Compound Info	3-((S)-2-Amino-2-cyclohexyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione Show/Hide	C27H30F3N3O3	1
1	Ki = 46 nM
CP0167735 Compound Info	3-((R)-2-Amino-3-methyl-butyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione Show/Hide	C24H26F3N3O3	1
1	Ki = 51 nM
CP0057956 Compound Info	1-(2-Fluoro-benzyl)-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester Show/Hide	C33H33FN4O4	1
1	Ki = 55 nM
CP0363519 Compound Info	3-((R)-2-Amino-3-phenyl-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione Show/Hide	C28H26F3N3O3	1
1	Ki = 66 nM
CP0263178 Compound Info	2-[3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-3-methoxy-phenyl)-2,4,6-trioxo-[1,3,5]triazinan-1-ylmethyl]-benzonitrile Show/Hide	C26H22FN5O4	1
1	Ki = 86 nM
CP0112996 Compound Info	8-Cyano-1-(2-fluoro-benzyl)-7-(4-isobutoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester Show/Hide	C37H38FN5O4	1
1	Ki = 100 nM
CP0137688 Compound Info	(R)-ethyl 2-(4-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzylamino)acetate Show/Hide	C31H30F4N4O4	1
1	Ki = 110 nM
CP0061904 Compound Info	1-(2,6-Difluoro-benzyl)-5-[(methyl-phenethyl-amino)-methyl]-6-(4-nitro-phenyl)-3-phenyl-1H-thieno[2,3-d]pyrimidine-2,4-dione Show/Hide	C35H28F2N4O4S	1
1	Ki = 170 nM
CP0220826 Compound Info	1-(2,6-difluorobenzyl)-5-((benzyl(methyl)amino)methyl)-6-(4-nitrophenyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Show/Hide	C34H26F2N4O4S	1
1	Ki = 180 nM
CP0186211 Compound Info	1-(2,6-Difluoro-benzyl)-5-(4-methoxy-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione Show/Hide	C29H30F2N4O3	1
1	Ki = 230 nM
CP0370351 Compound Info	1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-fluoro-3-methoxy-phenyl)-5-(2-trifluoromethoxy-benzyl)-[1,3,5]triazinane-2,4,6-trione Show/Hide	C26H22F4N4O5	1
1	Ki = 240 nM
CP0190830 Compound Info	1-(2,6-Difluoro-benzyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-5-phenyl-1H-pyrimidine-2,4-dione Show/Hide	C28H28F2N4O2	1
1	Ki = 400 nM
CP0288325 Compound Info	(S)-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyl-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)propyl)pyrimidine-2,4(1H,3H)-dione Show/Hide	C30H32F2N4O3	1
1	Ki = 470 nM
CP0080594 Compound Info	3-((R)-2-Amino-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione Show/Hide	C22H22F3N3O3	1
1	Ki = 600 nM
CP0363523 Compound Info	3-((S)-2-Amino-3-methyl-butyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione Show/Hide	C24H26F3N3O3	1
1	Ki = 970 nM
CP0137685 Compound Info	(R)-2-(4-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzylamino)acetic acid Show/Hide	C29H26F4N4O4	1
1	Ki = 3900 nM
CP0080595 Compound Info	3-((S)-2-Amino-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione Show/Hide	C22H22F3N3O3	1
1	Ki > 10000 nM
CP0267018 Compound Info	(R)-2-(4-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzyloxy)acetic acid Show/Hide	C29H25F4N3O5	1
1	Ki > 10000 nM

Clinical Information about the Protein

Target 1 ( Gonadotropin-releasing hormone receptor (GNRHR) )

Target Type	Successful Target
Disease	9 Target-related Diseases				9
1	Prostate cancer [ICD-11: 2C82.0]
2	Ovarian stimulation [ICD-11: LB45.1]
3	Endometriosis [ICD-11: GA10]
4	Ovulation dysfunction [ICD-11: 5A80]
5	Hypothalamic hypogonadism [ICD-11: 5A61.2]
6	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
7	Uterine fibroids [ICD-11: 2E86.0]
8	Hormone deficiency [ICD-11: 5A61.1]
9	Coronavirus infection [ICD-11: 1D92]
Approved Drug(s)	10 Approved Drugs				10
1	Abarelix	Drug Info	Approved	Prostate cancer
2	Cetrorelix	Drug Info	Approved	Ovarian stimulation
3	Degarelix	Drug Info	Approved	Prostate cancer
4	Elagolix sodium	Drug Info	Approved	Endometriosis
5	Ganirelix	Drug Info	Approved	Ovulation dysfunction
6	Gonadorelin	Drug Info	Approved	Hypothalamic hypogonadism
7	Leuprorelin acetate	Drug Info	Approved	Prostate cancer
8	Nafarelin	Drug Info	Approved	Endometriosis
9	Triptorelin	Drug Info	Approved	Solid tumour/cancer
10	Relugolix	Drug Info	Approved	Prostate cancer
Clinical Trial Drug(s)	2 Clinical Trial Drugs				2
1	ACYLINE	Drug Info	Phase 2	Prostate cancer
2	KLH-2109	Drug Info	Phase 2	Endometriosis
Discontinued Drug(s)	3 Discontinued Drugs				3
1	TAK-013	Drug Info	Discontinued in Phase 2	Uterine fibroids
2	A-75998	Drug Info	Discontinued in Phase 1	Hormone deficiency
3	NBI-42902	Drug Info	Discontinued in Phase 1	Prostate cancer
Preclinical Drug(s)	1 Preclinical Drug				1
1	5-(N,N-hexamethylene)-amiloride	Drug Info	Preclinical	Coronavirus infection

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT01997	Gonadotropin-releasing hormone receptor	Rattus norvegicus, Rat	Protein Info
PT02079	Gonadotropin-releasing hormone receptor	Macaca mulatta, Rhesus macaque	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han