General Information of the Compound
Compound ID
CP0124192
Compound Name
(R)-methyl 4-(2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(2-fluoro-3-methoxyphenyl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethylamino)butanoate
    Show/Hide
Structure
Formula
C32H30F5N3O5
Molecular Weight
631.598
Canonical SMILES
COC(=O)CCCN[C@@H](Cn1c(=O)c(cn(Cc2c(F)cccc2C(F)(F)F)c1=O)-c1cccc(OC)c1F)c1ccccc1
    Show/Hide
InChI
InChI=1S/C32H30F5N3O5/c1-44-27-14-6-11-21(29(27)34)22-17-39(18-23-24(32(35,36)37)12-7-13-25(23)33)31(43)40(30(22)42)19-26(20-9-4-3-5-10-20)38-16-8-15-28(41)45-2/h3-7,9-14,17,26,38H,8,15-16,18-19H2,1-2H3/t26-/m0/s1
    Show/Hide
InChIKey
FDMBTLJSOVSBHD-SANMLTNESA-N
Physicochemical Property
logP
5.315
Rotatable Bonds
12
Heavy Atom Count
45
Polar Areas
91.56
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44593615
ChEMBL ID
CHEMBL455769
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01836, Gonadotropin-releasing hormone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 32 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 32 nM