General Information of the Compound
Compound ID
CP0196914
Compound Name
4-(2-{2-(3,5-Dimethyl-phenyl)-3-[(S)-1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methyl-propionyl)-piperazine-1-carboxylic acid tert-butyl ester
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Structure
Formula
C41H55N5O3
Molecular Weight
665.923
Canonical SMILES
C[C@H](CNCCCCc1ccncc1)c1c([nH]c2ccc(cc12)C(C)(C)C(=O)N1CCN(CC1)C(=O)OC(C)(C)C)-c1cc(C)cc(C)c1
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InChI
InChI=1S/C41H55N5O3/c1-28-23-29(2)25-32(24-28)37-36(30(3)27-43-16-10-9-11-31-14-17-42-18-15-31)34-26-33(12-13-35(34)44-37)41(7,8)38(47)45-19-21-46(22-20-45)39(48)49-40(4,5)6/h12-15,17-18,23-26,30,43-44H,9-11,16,19-22,27H2,1-8H3/t30-/m1/s1
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InChIKey
YRQYJAAMCSTHMK-SSEXGKCCSA-N
Physicochemical Property
logP
7.91964
Rotatable Bonds
11
Heavy Atom Count
49
Polar Areas
90.56
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
49

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44321497
ChEMBL ID
CHEMBL273390
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01836, Gonadotropin-releasing hormone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 220 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6.1 nM