Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[[2-methoxyethyl(methyl)amino]methyl]-2,4-dioxo-3-pyridin-2-ylthieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea
    Show/Hide
 PubChem ID
CID: 9895596
SID: 14863370
Canonical SMILES
COCCN(C)Cc1c(sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccccn3)c(=O)c12)-c1ccc(NC(=O)NOC)cc1
    Show/Hide
Compound Formula C31H30F2N6O5S
Compound Structure
Protein Name
 Protein Info 
Gonadotropin-releasing hormone receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
GnRH receptor
Uniprot ID
P30968
Gene Name
GNRHR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  4
1
IC50 = 0.2 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.3 nM
   TI
   LI
   LO
   TS
3
IC50 = 0.83 nM
   TI
   LI
   LO
   TS
4
IC50 = 13 nM
   TI
   LI
   LO
   TS