Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[[2-methoxyethyl(methyl)amino]methyl]-3-(4-methoxyphenyl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea
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 PubChem ID
CID: 10100930
SID: 15088329
Canonical SMILES
COCCN(C)Cc1c(sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccc(OC)cc3)c(=O)c12)-c1ccc(NC(=O)NOC)cc1
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Compound Formula C33H33F2N5O6S
Compound Structure
Protein Name
 Protein Info 
Gonadotropin-releasing hormone receptor
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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GnRH receptor
Uniprot ID
P30968
Gene Name
GNRHR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  4
1
IC50 = 0.07 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.17 nM
   TI
   LI
   LO
   TS
3
IC50 = 0.29 nM
   TI
   LI
   LO
   TS
4
IC50 = 0.43 nM
   TI
   LI
   LO
   TS