Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea
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 PubChem ID
CID: 10348973
SID: 15360452
Canonical SMILES
CONC(=O)Nc1ccc(cc1)-c1sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccc(OC)nn3)c(=O)c2c1CN(C)C
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Compound Formula C29H27F2N7O5S
Compound Structure
Protein Name
 Protein Info 
Gonadotropin-releasing hormone receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
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GnRH receptor
Uniprot ID
P30968
Gene Name
GNRHR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  4
1
IC50 = 0.08 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.33 nM
   TI
   LI
   LO
   TS
3
IC50 = 0.82 nM
   TI
   LI
   LO
   TS
4
IC50 = 18 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
Kd = 0.372 nM
   TI
   LI
   LO
   TS
2
Kd = 0.84 nM
   TI
   LI
   LO
   TS