Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-(2,6-Difluoro-benzyl)-5-[(methyl-phenethyl-amino)-methyl]-6-(4-nitro-phenyl)-3-phenyl-1H-thieno[2,3-d]pyrimidine-2,4-dione
    Show/Hide
 PubChem ID
CID: 44346398
Canonical SMILES
CN(CCc1ccccc1)Cc1c(sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccccc3)c(=O)c12)-c1ccc(cc1)[N+]([O-])=O
    Show/Hide
Compound Formula C35H28F2N4O4S
Compound Structure
Protein Name
 Protein Info 
Gonadotropin-releasing hormone receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
GnRH receptor
Uniprot ID
P30968
Gene Name
GNRHR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000053 COS-7
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  8
1
IC50 = 1100 nM
   TI
   LI
   LO
   TS
2
IC50 = 1300 nM
   TI
   LI
   LO
   TS
3
IC50 = 1600 nM
   TI
   LI
   LO
   TS
4
IC50 = 1900 nM
   TI
   LI
   LO
   TS
5
IC50 = 3300 nM
   TI
   LI
   LO
   TS
6
IC50 = 5000 nM
   TI
   LI
   LO
   TS
7
IC50 = 7100 nM
   TI
   LI
   LO
   TS
8
IC50 > 10000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 170 nM