General Information of the Protein
Protein ID
PT06100
Protein Name
NADPH oxidase 1
Secondarily
Protein Name
Mitogenic oxidase 1
NADH/NADPH mitogenic oxidase subunit P65-MOX
NOH-1
Gene Name
NOX1
Secondarily
Gene Name
MOX1
NOH1
Sequence
MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF
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Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Transmembrane 1-electron transfer carriers
Function
NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor.
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Uniprot ID
Primary ID:
Q9Y5S8

Secondarily ID:
A8K836
O95691
Q2PP02
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HGNC ID
HGNC:7889
Subcellular Location
Cell projection
Invadopodium membrane
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0891668
 Compound Info 
10-(2-Chlorobenzyl)-2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C23H21Cl3N4O2
  1
1
Ki = 87 nM
 Bioactivity Info 
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CP0917567
 Compound Info 
10-(4-Chlorobenzyl)-2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C23H21Cl3N4O2
  1
1
Ki = 95 nM
 Bioactivity Info 
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CP0676506
 Compound Info 
10-benzyl-2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C23H22Cl2N4O2
  1
1
Ki = 101 nM
 Bioactivity Info 
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CP0855809
 Compound Info 
10-(3-Chlorobenzyl)-2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C23H21Cl3N4O2
  1
1
Ki = 104 nM
 Bioactivity Info 
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CP0868711
 Compound Info 
2-(2-Chloro-phenyl)-9-(3-methoxy-benzyl)-2,3,7,8,9,10-hexahydro-6H-2,3,5a,9-tetraaza-cyclohepta[e]indene-1,5-dione hydrochloride
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C24H24Cl2N4O3
  1
1
Ki = 113 nM
 Bioactivity Info 
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CP0931898
 Compound Info 
2-(2-Chlorophenyl)-10-(pyridin-2-ylmethyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C22H21Cl2N5O2
  1
1
Ki = 113 nM
 Bioactivity Info 
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CP0931896
 Compound Info 
2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C16H16Cl2N4O2
  1
1
Ki = 119 nM
 Bioactivity Info 
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CP0853723
 Compound Info 
2-(2-Chlorophenyl)-10-(2-methoxybenzyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C24H24Cl2N4O3
  1
1
Ki = 133 nM
 Bioactivity Info 
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CP0459997
 Compound Info 
tert-butyl 4-(2-chlorophenyl)-3,8-dioxo-4,5,9,13-tetrazatricyclo[7.5.0.02,6]tetradeca-1,6-diene-13-carboxylate
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C21H23ClN4O4
  1
1
Ki = 148 nM
 Bioactivity Info 
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CP0525079
 Compound Info 
4-(2-chlorophenyl)-12-oxa-4,5,9-triazatricyclo[7.4.0.02,6]trideca-1,6-diene-3,8-dione
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C15H12ClN3O3
  1
1
Ki = 173 nM
 Bioactivity Info 
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CP0855810
 Compound Info 
2-(2-Chlorophenyl)-10-(4-methoxybenzyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C24H24Cl2N4O3
  1
1
Ki = 184 nM
 Bioactivity Info 
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CP0943839
 Compound Info 
2-(2-Chlorophenyl)-10-(furan-3-ylmethyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C21H20Cl2N4O3
  1
1
Ki = 200 nM
 Bioactivity Info 
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CP0937033
 Compound Info 
2-(2-Chlorophenyl)-10-(pyridin-3-ylmethyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C22H21Cl2N5O2
  1
1
Ki = 208 nM
 Bioactivity Info 
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CP0931897
 Compound Info 
10-(3-Methoxybenzyl)-2-(2-methoxyphenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C25H27ClN4O4
  1
1
Ki = 212 nM
 Bioactivity Info 
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CP0910838
 Compound Info 
2-(2-Methoxyphenyl)-10-(pyridin-2-ylmethyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C23H24ClN5O3
  1
1
Ki = 217 nM
 Bioactivity Info 
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CP0919256
 Compound Info 
10-Benzyl-2-(2-methoxyphenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C24H25ClN4O3
  1
1
Ki = 218 nM
 Bioactivity Info 
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CP0859309
 Compound Info 
9-benzyl-2-(2-chlorophenyl)-2,3,7,8,9,10-hexahydropyrazolo[4',3':3,4]pyrido[1,2-a]pyrazine-1,5-dione hydrochloride
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C22H20Cl2N4O2
  1
1
Ki = 398 nM
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Cell Line ID: CL000880 , COS
 Cell Line Info 
Cell Line ID: CL000053 , COS-7
 Cell Line Info