Protein Information

General Information of the Protein

Protein ID	PT01839
Protein Name	Vasopressin V1a receptor
Secondarily Protein Name	AVPR V1a Antidiuretic hormone receptor 1a Vascular/hepatic-type arginine vasopressin receptor
Gene Name	AVPR1A
Secondarily Gene Name	AVPR1
Sequence	MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Peptide receptor (family A GPCR) > Short peptide receptor (family A GPCR) > Vasopressin and oxytocin receptor
Function	Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. Show/Hide
Uniprot ID	P37288
HGNC ID	HGNC:895
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000094 , 1321N1

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0471688 Compound Info	CHEMBL4799793 Show/Hide	C22H23ClN4O	2
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.8 nM Bioactivity Info	TI LI LO TS
CP0546313 Compound Info	CHEMBL5070261 Show/Hide	C22H23ClN4O2	1
1	IC50 = 1.1 nM Bioactivity Info	TI LI LO TS
CP0576666 Compound Info	(5S)-8-chloro-1-(4-pyridin-2-yloxycyclohexyl)-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepin-5-ol Show/Hide	C22H23ClN4O2	1
1	IC50 = 1.2 nM Bioactivity Info	TI LI LO TS
CP0492304 Compound Info	8-bromo-1-(4-pyridin-2-yloxycyclohexyl)-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepine Show/Hide	C22H23BrN4O	2
1	IC50 = 1.3 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.6 nM Bioactivity Info	TI LI LO TS
CP0496263 Compound Info	3-[4-(8-bromo-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepin-1-yl)cyclohexyl]-5-methyl-1,2-oxazole Show/Hide	C21H23BrN4O	2
1	IC50 = 1.7 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.6 nM Bioactivity Info	TI LI LO TS
CP0575713 Compound Info	CHEMBL5070075 Show/Hide	C22H23ClN4O2	1
1	IC50 = 1.8 nM Bioactivity Info	TI LI LO TS
CP0576681 Compound Info	CHEMBL5081323 Show/Hide	C23H26N4O2	1
1	IC50 = 1.9 nM Bioactivity Info	TI LI LO TS
CP0244529 Compound Info	[6-chloro-1-[2-(dimethylamino)ethyl]indol-3-yl]-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone Show/Hide	C25H28ClN3O2	2
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
2	Ki = 5.5 nM Bioactivity Info	TI LI LO TS
CP0514919 Compound Info	3-[4-(8-chloro-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepin-1-yl)cyclohexyl]-5-methyl-1,2-oxazole Show/Hide	C21H23ClN4O	2
1	IC50 = 2.2 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.7 nM Bioactivity Info	TI LI LO TS
CP0496262 Compound Info	[(3S)-6-chloro-1-[4-(2-methylphenyl)piperazine-1-carbonyl]-3,4-dihydro-2H-quinolin-3-yl]-pyrrolidin-1-ylmethanone Show/Hide	C26H31ClN4O2	2
1	IC50 = 2.4 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.6 nM Bioactivity Info	TI LI LO TS
CP0512154 Compound Info	[(3S)-6-chloro-1-[4-(2-methylphenyl)piperazine-1-carbonyl]-3,4-dihydro-2H-quinolin-3-yl]-cyclopentylmethanone Show/Hide	C27H32ClN3O2	2
1	IC50 = 2.4 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.6 nM Bioactivity Info	TI LI LO TS
CP0569560 Compound Info	8-ethynyl-1-(1-pyridin-2-ylpiperidin-4-yl)-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepine Show/Hide	C23H23N5	2
1	IC50 = 2.7 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.45 nM Bioactivity Info	TI LI LO TS
CP0447818 Compound Info	Balovaptan Show/Hide	C22H24ClN5O	2
1	IC50 = 3 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.7 nM Bioactivity Info	TI LI LO TS
CP0531357 Compound Info	8-chloro-1-(1-pyridin-2-ylpiperidin-4-yl)-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepine Show/Hide	C21H22ClN5	2
1	IC50 = 3.2 nM Bioactivity Info	TI LI LO TS
2	Ki = 1.4 nM Bioactivity Info	TI LI LO TS
CP0559965 Compound Info	[6-chloro-1-[4-(2-methylphenyl)piperazine-1-carbonyl]-2,4-dihydroquinazolin-3-yl]-cyclopropylmethanone Show/Hide	C24H27ClN4O2	2
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.3 nM Bioactivity Info	TI LI LO TS
CP0486121 Compound Info	[6-chloro-1-[4-(2-methylphenyl)piperazine-1-carbonyl]-2,4-dihydroquinazolin-3-yl]-cyclopentylmethanone Show/Hide	C26H31ClN4O2	2
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
2	Ki = 1 nM Bioactivity Info	TI LI LO TS
CP0552838 Compound Info	1-[6-chloro-1-[4-(2-methylphenyl)piperazine-1-carbonyl]-2,4-dihydroquinazolin-3-yl]-2-methylpropan-1-one Show/Hide	C24H29ClN4O2	2
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
2	Ki = 2.6 nM Bioactivity Info	TI LI LO TS
CP0543613 Compound Info	8-bromo-1-(1-pyridin-2-ylpiperidin-4-yl)-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepine Show/Hide	C21H22BrN5	2
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.7 nM Bioactivity Info	TI LI LO TS
CP0492303 Compound Info	1-(4-pyridin-2-yloxycyclohexyl)-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepine Show/Hide	C22H24N4O	2
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
2	Ki = 2.3 nM Bioactivity Info	TI LI LO TS
CP0570581 Compound Info	(6-chloro-3-methylsulfonyl-2,4-dihydroquinazolin-1-yl)-[4-(2-methylphenyl)piperazin-1-yl]methanone Show/Hide	C21H25ClN4O3S	2
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
2	Ki = 5.3 nM Bioactivity Info	TI LI LO TS
CP0531356 Compound Info	3-[4-(5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepin-1-yl)cyclohexyl]-5-methyl-1,2-oxazole Show/Hide	C21H24N4O	2
1	IC50 = 25 nM Bioactivity Info	TI LI LO TS
2	Ki = 1.6 nM Bioactivity Info	TI LI LO TS
CP0572743 Compound Info	[(3R)-6-chloro-1-[4-(2-methylphenyl)piperazine-1-carbonyl]-3,4-dihydro-2H-quinolin-3-yl]-cyclopentylmethanone Show/Hide	C27H32ClN3O2	2
1	IC50 = 25 nM Bioactivity Info	TI LI LO TS
2	Ki = 2.3 nM Bioactivity Info	TI LI LO TS
CP0190845 Compound Info	8-chloro-5-methyl-1-(1-pyridin-2-ylpiperidin-4-yl)-4,6-dihydro-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine Show/Hide	C21H23ClN6	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0512179 Compound Info	1-[6-chloro-1-[4-(2-methylphenyl)piperazine-1-carbonyl]-2,4-dihydroquinazolin-3-yl]-2-hydroxyethanone Show/Hide	C22H25ClN4O3	2
1	IC50 = 35 nM Bioactivity Info	TI LI LO TS
2	Ki = 4 nM Bioactivity Info	TI LI LO TS
CP0546885 Compound Info	[7-chloro-4-[4-(2-methylphenyl)piperazine-1-carbonyl]-3,4-dihydro-1H-isoquinolin-2-yl]-cyclopentylmethanone Show/Hide	C27H32ClN3O2	2
1	IC50 = 35 nM Bioactivity Info	TI LI LO TS
2	Ki = 6 nM Bioactivity Info	TI LI LO TS
CP0572741 Compound Info	[6-chloro-1-[4-(2-methylphenyl)piperazine-1-carbonyl]-2,4-dihydroquinazolin-3-yl]-phenylmethanone Show/Hide	C27H27ClN4O2	2
1	IC50 = 35 nM Bioactivity Info	TI LI LO TS
2	Ki = 3 nM Bioactivity Info	TI LI LO TS
CP0546891 Compound Info	(2R)-4-oxo-2-[(3S,4R)-2-oxo-3-[(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]-4-[(E)-2-phenylethenyl]azetidin-1-yl]-N-[(1S)-1-phenylethyl]-4-(4-piperidin-1-ylpiperidin-1-yl)butanamide Show/Hide	C42H49N5O5	2
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.9 nM Bioactivity Info	TI LI LO TS
CP0559964 Compound Info	(6-chloro-3,4-dihydro-2H-quinazolin-1-yl)-[4-(2-methylphenyl)piperazin-1-yl]methanone Show/Hide	C20H23ClN4O	2
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
2	Ki = 3 nM Bioactivity Info	TI LI LO TS
CP0511983 Compound Info	1-[6-chloro-1-[4-(2-methylphenyl)piperazine-1-carbonyl]-2,4-dihydroquinazolin-3-yl]ethanone Show/Hide	C22H25ClN4O2	2
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
2	Ki = 6 nM Bioactivity Info	TI LI LO TS
CP0563079 Compound Info	(6-chloro-4-methyl-2,3-dihydroquinoxalin-1-yl)-[4-(3-chloropyridin-2-yl)piperazin-1-yl]methanone Show/Hide	C19H21Cl2N5O	2
1	IC50 = 55 nM Bioactivity Info	TI LI LO TS
2	Ki = 2 nM Bioactivity Info	TI LI LO TS
CP0471687 Compound Info	7-chloro-1-(4-pyridin-2-yloxycyclohexyl)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline Show/Hide	C21H21ClN4O	2
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
2	Ki = 9 nM Bioactivity Info	TI LI LO TS
CP0574295 Compound Info	(6-chloro-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2-methylphenyl)piperazin-1-yl]methanone Show/Hide	C20H23ClN4O	2
1	IC50 = 80 nM Bioactivity Info	TI LI LO TS
2	Ki = 4.1 nM Bioactivity Info	TI LI LO TS
CP0512193 Compound Info	(6-chloro-3-methyl-2,4-dihydroquinazolin-1-yl)-[4-(2-methylphenyl)piperazin-1-yl]methanone Show/Hide	C21H25ClN4O	2
1	IC50 = 85 nM Bioactivity Info	TI LI LO TS
2	Ki = 3 nM Bioactivity Info	TI LI LO TS
CP0489622 Compound Info	3-[4-(7-chloro-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-1-yl)cyclohexyl]-5-methyl-1,2-oxazole Show/Hide	C20H21ClN4O	2
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
2	Ki = 13 nM Bioactivity Info	TI LI LO TS
CP0552856 Compound Info	1-(1-pyridin-2-ylpiperidin-4-yl)-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepine Show/Hide	C21H23N5	2
1	IC50 = 117 nM Bioactivity Info	TI LI LO TS
2	Ki = 15 nM Bioactivity Info	TI LI LO TS
CP0511984 Compound Info	1-[7-chloro-4-[4-(2-methylphenyl)piperazine-1-carbonyl]-3,4-dihydro-1H-isoquinolin-2-yl]-2-methylpropan-1-one Show/Hide	C25H30ClN3O2	2
1	IC50 = 135 nM Bioactivity Info	TI LI LO TS
2	Ki = 5 nM Bioactivity Info	TI LI LO TS
CP0471315 Compound Info	(6-chloro-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(3-chloropyridin-2-yl)piperazin-1-yl]methanone Show/Hide	C18H19Cl2N5O	2
1	IC50 = 170 nM Bioactivity Info	TI LI LO TS
2	Ki = 6 nM Bioactivity Info	TI LI LO TS
CP0511985 Compound Info	[7-chloro-4-[4-(2-methylphenyl)piperazine-1-carbonyl]-3,4-dihydro-1H-isoquinolin-2-yl]-cyclopropylmethanone Show/Hide	C25H28ClN3O2	1
1	IC50 = 180 nM Bioactivity Info	TI LI LO TS
CP0486505 Compound Info	(6-chloro-3,4-dihydro-2H-quinolin-1-yl)-[4-(2-methylphenyl)piperazin-1-yl]methanone Show/Hide	C21H24ClN3O	2
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
2	Ki = 4 nM Bioactivity Info	TI LI LO TS
CP0484991 Compound Info	methyl 2-[7-chloro-1-(4-pyridin-2-yloxycyclohexyl)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-4-yl]acetate Show/Hide	C24H25ClN4O3	2
1	IC50 = 220 nM Bioactivity Info	TI LI LO TS
2	Ki = 28 nM Bioactivity Info	TI LI LO TS
CP0514922 Compound Info	8-ethyl-1-(1-pyridin-2-ylpiperidin-4-yl)-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepine Show/Hide	C23H27N5	2
1	IC50 = 252 nM Bioactivity Info	TI LI LO TS
2	Ki = 15 nM Bioactivity Info	TI LI LO TS
CP0484989 Compound Info	(6-chloro-3,4-dihydro-2H-quinoxalin-1-yl)-(1-pyridin-2-ylpiperidin-4-yl)methanone Show/Hide	C19H21ClN4O	2
1	IC50 = 260 nM Bioactivity Info	TI LI LO TS
2	Ki = 1.4 nM Bioactivity Info	TI LI LO TS
CP0512001 Compound Info	(6-chloro-4-methyl-2,3-dihydroquinoxalin-1-yl)-(1-pyridin-2-ylpiperidin-4-yl)methanone Show/Hide	C20H23ClN4O	2
1	IC50 = 260 nM Bioactivity Info	TI LI LO TS
2	Ki = 14 nM Bioactivity Info	TI LI LO TS
CP0546894 Compound Info	(6-chloro-3,4-dihydro-2H-quinoxalin-1-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone Show/Hide	C21H22ClN3O2	2
1	IC50 = 280 nM Bioactivity Info	TI LI LO TS
2	Ki = 4 nM Bioactivity Info	TI LI LO TS
CP0512003 Compound Info	(6-chloro-4-methyl-2,3-dihydroquinoxalin-1-yl)-[4-(2-methylphenyl)piperazin-1-yl]methanone Show/Hide	C21H25ClN4O	2
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
2	Ki = 7 nM Bioactivity Info	TI LI LO TS
CP0573494 Compound Info	(6-chloro-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2-methylphenyl)piperidin-1-yl]methanone Show/Hide	C21H24ClN3O	2
1	IC50 = 380 nM Bioactivity Info	TI LI LO TS
2	Ki = 3 nM Bioactivity Info	TI LI LO TS
CP0512176 Compound Info	(7-chloro-2,3,4,5-tetrahydro-1-benzazepin-1-yl)-[4-(2-methylphenyl)piperazin-1-yl]methanone Show/Hide	C22H26ClN3O	2
1	IC50 = 390 nM Bioactivity Info	TI LI LO TS
2	Ki = 5 nM Bioactivity Info	TI LI LO TS
CP0578723 Compound Info	CHEMBL5085869 Show/Hide	C23H26N4O2	1
1	IC50 = 390 nM Bioactivity Info	TI LI LO TS
CP0564874 Compound Info	(6-chloro-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(3-methylpyridin-2-yl)piperazin-1-yl]methanone Show/Hide	C19H22ClN5O	2
1	IC50 = 450 nM Bioactivity Info	TI LI LO TS
2	Ki = 2 nM Bioactivity Info	TI LI LO TS
CP0392030 Compound Info	N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide Show/Hide	C26H25ClN2O3	1
1	IC50 = 470 nM Bioactivity Info	TI LI LO TS
CP0471169 Compound Info	3-[4-(13-chloro-6,7,9-triazatetracyclo[8.4.0.02,4.05,9]tetradeca-1(10),5,7,11,13-pentaen-8-yl)cyclohexyl]-5-methyl-1,2-oxazole Show/Hide	C21H21ClN4O	2
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
2	Ki = 100 nM Bioactivity Info	TI LI LO TS
CP0514921 Compound Info	3-[4-[(2S,4R)-13-chloro-6,7,9-triazatetracyclo[8.4.0.02,4.05,9]tetradeca-1(10),5,7,11,13-pentaen-8-yl]cyclohexyl]-5-methyl-1,2-oxazole Show/Hide	C21H21ClN4O	2
1	IC50 = 635 nM Bioactivity Info	TI LI LO TS
2	Ki = 55 nM Bioactivity Info	TI LI LO TS
CP0560389 Compound Info	(6-chloro-3,4-dihydro-2H-quinoxalin-1-yl)-[(2R)-2-methyl-4-(3-methylpyridin-2-yl)piperazin-1-yl]methanone Show/Hide	C20H24ClN5O	2
1	IC50 = 750 nM Bioactivity Info	TI LI LO TS
2	Ki = 70 nM Bioactivity Info	TI LI LO TS
CP0512184 Compound Info	N-[2-chloro-5-[4-(2-methylphenyl)piperazine-1-carbonyl]phenyl]thiophene-2-carboxamide Show/Hide	C23H22ClN3O2S	2
1	IC50 = 800 nM Bioactivity Info	TI LI LO TS
2	Ki = 170 nM Bioactivity Info	TI LI LO TS
CP0573493 Compound Info	(5-chloro-2,3-dihydroindol-1-yl)-[4-(2-methylphenyl)piperazin-1-yl]methanone Show/Hide	C20H22ClN3O	2
1	IC50 = 880 nM Bioactivity Info	TI LI LO TS
2	Ki = 15 nM Bioactivity Info	TI LI LO TS
CP0575175 Compound Info	(6-chloro-3,4-dihydro-2H-quinoxalin-1-yl)-[(3S)-3-methyl-4-pyridin-2-ylpiperazin-1-yl]methanone Show/Hide	C19H22ClN5O	2
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
2	Ki = 62 nM Bioactivity Info	TI LI LO TS
CP0514920 Compound Info	7-chloro-1-(1-pyridin-2-ylpiperidin-4-yl)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline Show/Hide	C20H20ClN5	2
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
2	Ki = 71 nM Bioactivity Info	TI LI LO TS
CP0512191 Compound Info	1-[7-chloro-4-[4-(2-methylphenyl)piperazine-1-carbonyl]-2,3-dihydroquinoxalin-1-yl]ethanone Show/Hide	C22H25ClN4O2	2
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
2	Ki = 13 nM Bioactivity Info	TI LI LO TS
CP0574441 Compound Info	(7-chloro-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2-methylphenyl)piperazin-1-yl]methanone Show/Hide	C20H23ClN4O	2
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
2	Ki = 560 nM Bioactivity Info	TI LI LO TS
CP0486122 Compound Info	3,4-dihydro-2H-quinoxalin-1-yl-[4-(2-methylphenyl)piperazin-1-yl]methanone Show/Hide	C20H24N4O	2
1	IC50 = 2800 nM Bioactivity Info	TI LI LO TS
2	Ki = 70 nM Bioactivity Info	TI LI LO TS
CP0568276 Compound Info	(6-chloro-3,4-dihydro-2H-quinoxalin-1-yl)-(4-pyridin-2-ylpiperazin-1-yl)methanone Show/Hide	C18H20ClN5O	2
1	IC50 = 6800 nM Bioactivity Info	TI LI LO TS
2	Ki = 160 nM Bioactivity Info	TI LI LO TS
CP0574435 Compound Info	(4-benzylpiperazin-1-yl)-(6-chloro-3,4-dihydro-2H-quinoxalin-1-yl)methanone Show/Hide	C20H23ClN4O	2
1	IC50 = 8300 nM Bioactivity Info	TI LI LO TS
2	Ki = 164 nM Bioactivity Info	TI LI LO TS
CP0546884 Compound Info	[6-chloro-1-[4-(2-methylphenyl)piperazine-1-carbonyl]-2,4-dihydroquinazolin-3-yl]-cyclohexylmethanone Show/Hide	C27H33ClN4O2	1
1	Ki = 5 nM Bioactivity Info	TI LI LO TS
CP0486504 Compound Info	[6-chloro-1-[4-(2-methylphenyl)piperazine-1-carbonyl]-2,4-dihydroquinazolin-3-yl]-[1-(4-fluorophenyl)cyclopropyl]methanone Show/Hide	C30H30ClFN4O2	1
1	Ki = 23 nM Bioactivity Info	TI LI LO TS
CP0484990 Compound Info	13-chloro-8-(4-pyridin-2-yloxycyclohexyl)-6,7,9-triazatetracyclo[8.4.0.02,4.05,9]tetradeca-1(10),5,7,11,13-pentaene Show/Hide	C22H21ClN4O	1
1	Ki = 180 nM Bioactivity Info	TI LI LO TS
CP0559208 Compound Info	13-chloro-8-(1-pyridin-2-ylpiperidin-4-yl)-6,7,9-triazatetracyclo[8.4.0.02,4.05,9]tetradeca-1(10),5,7,11,13-pentaene Show/Hide	C21H20ClN5	1
1	Ki = 260 nM Bioactivity Info	TI LI LO TS
CP0575174 Compound Info	(6-chloro-3,4-dihydro-2H-quinoxalin-1-yl)-[(3R)-3-methyl-4-pyridin-2-ylpiperazin-1-yl]methanone Show/Hide	C19H22ClN5O	1
1	Ki = 310 nM Bioactivity Info	TI LI LO TS
CP0554973 Compound Info	methyl 13-chloro-8-(4-pyridin-2-yloxycyclohexyl)-6,7,9-triazatetracyclo[8.4.0.02,4.05,9]tetradeca-1(10),5,7,11,13-pentaene-4-carboxylate Show/Hide	C24H23ClN4O3	1
1	Ki = 400 nM Bioactivity Info	TI LI LO TS
CP0575176 Compound Info	1-[7-fluoro-4-[4-(2-methylphenyl)piperazine-1-carbonyl]-2,3-dihydroquinoxalin-1-yl]ethanone Show/Hide	C22H25FN4O2	1
1	Ki = 440 nM Bioactivity Info	TI LI LO TS
CP0489621 Compound Info	3-[4-[(2R,4S)-13-chloro-6,7,9-triazatetracyclo[8.4.0.02,4.05,9]tetradeca-1(10),5,7,11,13-pentaen-8-yl]cyclohexyl]-5-methyl-1,2-oxazole Show/Hide	C21H21ClN4O	1
1	Ki = 570 nM Bioactivity Info	TI LI LO TS
CP0480036 Compound Info	7-chloro-4-methoxy-1-(1-pyridin-2-ylpiperidin-4-yl)-[1,2,4]triazolo[4,3-a]quinoxaline Show/Hide	C20H19ClN6O	1
1	Ki = 700 nM Bioactivity Info	TI LI LO TS
CP0418699 Compound Info	7-chloro-4,4-dimethyl-1-(1-pyridin-2-ylpiperidin-4-yl)-5H-[1,2,4]triazolo[4,3-a]quinoxaline Show/Hide	C21H23ClN6	1
1	Ki = 800 nM Bioactivity Info	TI LI LO TS
CP0553108 Compound Info	1-[7-chloro-4,4-dimethyl-1-(1-pyridin-2-ylpiperidin-4-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-5-yl]ethanone Show/Hide	C23H25ClN6O	1
1	Ki = 2400 nM Bioactivity Info	TI LI LO TS
CP0553881 Compound Info	6-chloro-1-(1-pyridin-2-ylpiperidin-4-yl)-3H-[1,2,4]triazolo[4,3-a]benzimidazole Show/Hide	C18H17ClN6	1
1	Ki = 5200 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000053 , COS-7

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000065 , HEK293-EBNA

Cell Line Info

Cell Line ID: CL000524 , HEK293-FT

Cell Line Info

Cell Line ID: CL000017 , HeLa

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0055934 Compound Info	(2S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(10R,13S,16S,19S,22S)-13-(2-amino-2-oxoethyl)-16-(3-amino-3-oxopropyl)-19-benzyl-22-[(4-methoxyphenyl)methyl]-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentazaspiro[5.19]pentacosane-10-carbonyl]pyrrolidine-2-carboxamide Show/Hide	C52H74N14O12S2	3
1	IC50 = 0.63 nM
2	IC50 = 1.9 nM
3	Ki = 0.39 nM
CP0154510 Compound Info	(4S)-N-[2-(dimethylamino)ethyl]-1-[4-[(2-phenylbenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxamide Show/Hide	C39H40N4O3	1
1	IC50 = 2 nM
CP0206403 Compound Info	1N-{4-[6-chloro-16-methyl-(12S)-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-trien-10-ylcarbonyl]phenyl}-2-trifluoromethylbenzamide Show/Hide	C29H25ClF3N3O2	1
1	IC50 = 4 nM
CP0041307 Compound Info	(4R)-N-[2-(dimethylamino)ethyl]-1-[4-[(2-fluorobenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxamide Show/Hide	C33H35FN4O3	1
1	IC50 = 4 nM
CP0197121 Compound Info	3'N-(2-hydroxyethyl)-1-[4-(2-fluorophenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide Show/Hide	C31H30FN3O4	1
1	IC50 = 4 nM
CP0279457 Compound Info	4-{2-[1-[4-(2-fluorophenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3-ylcarboxamido]ethyl}-1,4-oxazinane Show/Hide	C35H37FN4O4	1
1	IC50 = 4 nM
CP0219489 Compound Info	1N-{4-[6-chloro-16-methyl-(12S)-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-trien-10-ylcarbonyl]phenyl}-2-chlorobenzamide Show/Hide	C28H25Cl2N3O2	1
1	IC50 = 5 nM
CP0056752 Compound Info	3'N-(2-dimethylaminoethyl)-1-[4-(5-fluoro-2-methylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide Show/Hide	C34H37FN4O3	1
1	IC50 = 5 nM
CP0124484 Compound Info	3'N-(2-dimethylaminoethyl)-1-[4-(2-phenylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide Show/Hide	C39H40N4O3	1
1	IC50 = 5 nM
CP0154509 Compound Info	3'N-(3-dimethylaminopropyl)-1-[4-(2-phenylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide Show/Hide	C40H42N4O3	1
1	IC50 = 5 nM
CP0280289 Compound Info	3'N-(3-dimethylaminopropyl)-1-[4-(5-fluoro-2-methylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide Show/Hide	C35H39FN4O3	1
1	IC50 = 5 nM
CP0281438 Compound Info	3'N-(2-hydroxyethyl)-1-[4-(2-phenylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide Show/Hide	C37H35N3O4	1
1	IC50 = 6 nM
CP0289902 Compound Info	methyl 2-[[1-[4-[(5-fluoro-2-methylbenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carbonyl]amino]acetate Show/Hide	C33H32FN3O5	1
1	IC50 = 7 nM
CP0304375 Compound Info	3'N-(2-hexahydro-1-pyridinylethyl)-1-[4-(2-fluorophenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide Show/Hide	C36H39FN4O3	1
1	IC50 = 7 nM
CP0105811 Compound Info	3'N-(2-tetrahydro-1H-1-pyrrolylethyl)-1-[4-(2-fluorophenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide Show/Hide	C35H37FN4O3	1
1	IC50 = 8 nM
CP0194057 Compound Info	3'N-(2-dimethylaminoethyl)-1-[4-(2-fluorophenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide Show/Hide	C33H35FN4O3	1
1	IC50 = 8 nM
CP0042892 Compound Info	3'N-(2-hexahydro-1-pyridinylethyl)-1-[4-(5-fluoro-2-methylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide Show/Hide	C37H41FN4O3	2
1	IC50 = 10 nM
2	IC50 = 16 nM
CP0304035 Compound Info	3'N-(2-tetrahydro-1H-1-pyrrolylethyl)-1-[4-(5-fluoro-2-methylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide Show/Hide	C36H39FN4O3	1
1	IC50 = 19 nM
CP0106503 Compound Info	3-chloro-4-[16-methyl-(12S)-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-trien-10-ylcarbonyl]-1-(2-phenylphenylcarboxamido)benzene Show/Hide	C34H30ClN3O2	1
1	IC50 = 24 nM
CP0196743 Compound Info	1N-{4-[6-chloro-16-methyl-(12S)-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-trien-10-ylcarbonyl]phenyl}-2-(4-methylphenyl)benzamide Show/Hide	C35H32ClN3O2	1
1	IC50 = 24 nM
CP0154159 Compound Info	2-[1-[4-(2-phenylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3-ylcarboxamido]acetic acid Show/Hide	C37H33N3O5	1
1	IC50 = 24 nM
CP0062116 Compound Info	1N-{4-[6-chloro-16-ethyl-(12S)-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-trien-10-ylcarbonyl]phenyl}-2-chlorobenzamide Show/Hide	C29H27Cl2N3O2	1
1	IC50 = 35 nM
CP0104567 Compound Info	1N-{4-[6-chloro-16-methyl-(12S)-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-trien-10-ylcarbonyl]phenyl}-2-fluorobenzamide Show/Hide	C28H25ClFN3O2	1
1	IC50 = 68 nM
CP0040044 Compound Info	3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10-ylcarbonyl)-1-(5-fluoro-2-methylphenylcarboxamido)benzene Show/Hide	C27H21ClFN3O2	4
1	IC50 = 150 nM
2	IC50 = 180 nM
3	IC50 = 230 nM
4	Ki = 44 nM
CP0365138 Compound Info	2-Methyl-N-[4-(2,3,4,5-tetrahydro-benzo[b][1,4]diazepine-1-carbonyl)-phenyl]-benzamide Show/Hide	C24H23N3O2	1
1	IC50 = 250 nM
CP0177122 Compound Info	(2S)-5-amino-2-{[(2S)-1-{[(4R,7S,10S,13S,16R)-13-[(2S)-butan-2-yl]-7-(carbamoylmethyl)-16-[(4-ethoxyphenyl)methyl]-10-[(1R)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}pyrrolidin-2-yl]formamido}-N-(carbamoylmethyl)pentanamide Show/Hide	C43H67N11O12S2	2
1	Ki = 0.15 nM
2	Ki = 4.7 nM
CP0244529 Compound Info	[6-chloro-1-[2-(dimethylamino)ethyl]indol-3-yl]-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone Show/Hide	C25H28ClN3O2	1
1	Ki = 1 nM
CP0162813 Compound Info	(2S)-1-[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-(3,4-dimethoxybenzenesulfonyl)-3-hydroxy-2,3-dihydro-1H-indole-2-carbonyl]-pyrrolidine-2-carboxamide Show/Hide	C28H27Cl2N3O7S	1
1	Ki = 2 nM
CP0246508 Compound Info	(1-benzyl-2-methylindol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone Show/Hide	C29H28N2O2	1
1	Ki = 2 nM
CP0441646 Compound Info	(6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone Show/Hide	C21H19ClN2O2	1
1	Ki = 4 nM
CP0260717 Compound Info	2-phenyl-N-[4-(2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]benzamide Show/Hide	C30H26N2O2	1
1	Ki = 14.1 nM
CP0195952 Compound Info	(2S,4R)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulfonyl)-3-(2-methoxyphenyl)-2-oxoindolin-3-yl)-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide Show/Hide	C30H32ClN3O8S	1
1	Ki = 22 nM
CP0117986 Compound Info	(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide Show/Hide	C43H66N12O12S2	2
1	Ki = 34.9 nM
2	Ki = 120 nM
CP0308266 Compound Info	(2-ethoxynaphthalen-1-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone Show/Hide	C25H25NO3	1
1	Ki = 81 nM
CP0219136 Compound Info	4-[(3,5-dihydroxyphenyl)methyl]-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]piperazine-1-carboxamide Show/Hide	C32H35N7O4	2
1	Ki = 113 nM
2	Ki > 1000 nM
CP0219211 Compound Info	(4-benzyl-4-hydroxypiperidin-1-yl)-(1-benzyl-2-methylindol-3-yl)methanone Show/Hide	C29H30N2O2	1
1	Ki = 295 nM
CP0053149 Compound Info	N-[3-[4-[4-(2-oxo-3,4-dihydroquinolin-1-yl)piperidine-1-carbonyl]phenoxy]propyl]acetamide Show/Hide	C26H31N3O4	1
1	Ki = 350 nM
CP0083253 Compound Info	(5H,11H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10-yl)-[2-chloro-4-(3-methyl-pyrazol-1-yl)-phenyl]-methanone Show/Hide	C23H19ClN4O	1
1	Ki = 465 nM
CP0214389 Compound Info	N-[[5-[4-(2-oxo-4H-3,1-benzoxazin-1-yl)piperidine-1-carbonyl]-1-benzofuran-2-yl]methyl]-2-[2-oxo-5-(trifluoromethyl)pyridin-1-yl]acetamide Show/Hide	C31H27F3N4O6	1
1	Ki = 1258.93 nM
CP0106713 Compound Info	(4-benzyl-4-hydroxypiperidin-1-yl)-(2-ethoxynaphthalen-1-yl)methanone Show/Hide	C25H27NO3	1
1	Ki = 2830 nM
CP0041007 Compound Info	1-(1-(4-(1-acetylpiperidin-4-yloxy)-2-methoxybenzoyl)piperidin-4-yl)-1H-benzo[d][1,3]oxazin-2(4H)-one Show/Hide	C28H33N3O6	2
1	Ki = 3200 nM
2	Ki < 1995.26 nM

Clinical Information about the Protein

Target 1 ( Vasopressin V1a receptor (V1AR) )

Target Type	Successful Target
Disease	10 Target-related Diseases				10
1	Euvolemic hyponatremia [ICD-11: 5C72]
2	Diabetic complication [ICD-11: 5A2Y]
3	Hyponatraemia [ICD-11: 5C72]
4	Autism spectrum disorder [ICD-11: 6A02]
5	Sepsis [ICD-11: 1G40-1G41]
6	Atopic dermatitis [ICD-11: EA80]
7	Anxiety disorder [ICD-11: 6B00-6B0Z]
8	Dysmenorrhea [ICD-11: GA34.3]
9	Cardiac disease [ICD-11: BA00-BE2Z]
10	Female sexual arousal dysfunction [ICD-11: HA01.1]
Approved Drug(s)	4 Approved Drugs				4
1	Conivaptan	Drug Info	Approved	Euvolemic hyponatremia
2	Desmopressin	Drug Info	Approved	Diabetic complication
3	Mozavaptan	Drug Info	Approved	Hyponatraemia
4	Oxytocin	Drug Info	Approved	Autism spectrum disorder
Clinical Trial Drug(s)	5 Clinical Trial Drugs				5
1	FE-202158	Drug Info	Phase 2	Sepsis
2	PMX-53	Drug Info	Phase 2	Atopic dermatitis
3	SRX-246	Drug Info	Phase 2	Anxiety disorder
4	SSR149415	Drug Info	Phase 2	Anxiety disorder
5	SRX-251	Drug Info	Phase 1	Dysmenorrhea
Discontinued Drug(s)	3 Discontinued Drugs				3
1	OPC-21268	Drug Info	Discontinued in Phase 2	Cardiac disease
2	PF-3274167	Drug Info	Discontinued in Phase 1	Female sexual arousal dysfunction
3	JTV-605	Drug Info	Terminated	Dysmenorrhea

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han