General Information of the Compound
Compound ID
CP0219136
Compound Name
4-[(3,5-dihydroxyphenyl)methyl]-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]piperazine-1-carboxamide
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Structure
Formula
C32H35N7O4
Molecular Weight
581.677
Canonical SMILES
Cc1cc(ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1)C(=O)N1Cc2cnn(C)c2Nc2ccccc12
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InChI
InChI=1S/C32H35N7O4/c1-21-13-23(31(42)39-20-25-18-34-36(2)30(25)35-28-5-3-4-6-29(28)39)7-8-24(21)17-33-32(43)38-11-9-37(10-12-38)19-22-14-26(40)16-27(41)15-22/h3-8,13-16,18,35,40-41H,9-12,17,19-20H2,1-2H3,(H,33,43)
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InChIKey
HWPGRFRXZNLZEX-UHFFFAOYSA-N
Physicochemical Property
logP
4.07112
Rotatable Bonds
5
Heavy Atom Count
43
Polar Areas
126.2
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
8
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 135506374
SID: 14911401
ChEMBL ID
CHEMBL3763342
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01658, Oxytocin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  8
1
EC50 = 3 nM
   TI
   LI
   LO
   TS
2
EC50 = 420 nM
   TI
   LI
   LO
   TS
3
EC50 = 880 nM
   TI
   LI
   LO
   TS
4
EC50 = 881 nM
   TI
   LI
   LO
   TS
5
IC50 > 10000 nM
   TI
   LI
   LO
   TS
6
Ki = 30.5 nM
   TI
   LI
   LO
   TS
7
Ki = 230 nM
   TI
   LI
   LO
   TS
8
Ki = 978 nM
   TI
   LI
   LO
   TS
CL000524 HEK293-FT Homo sapiens (Human)  2
1
EC50 = 24 nM
   TI
   LI
   LO
   TS
2
EC50 = 150 nM
   TI
   LI
   LO
   TS
CL000941 CHO-DUKX-A2 Cricetulus griseus (Chinese hamster)  4
1
EC50 = 61 nM
   TI
   LI
   LO
   TS
2
EC50 = 61.3 nM
   TI
   LI
   LO
   TS
3
Ki = 58 nM
   TI
   LI
   LO
   TS
4
Ki = 58.4 nM
   TI
   LI
   LO
   TS
Protein ID: PT05873, Oxytocin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000524 HEK293-FT Homo sapiens (Human)  1
1
EC50 = 78 nM
   TI
   LI
   LO
   TS
Protein ID: PT01839, Vasopressin V1a receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  6
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
IC50 = 7 nM
   TI
   LI
   LO
   TS
3
IC50 = 613 nM
   TI
   LI
   LO
   TS
4
Ki = 12.5 nM
   TI
   LI
   LO
   TS
5
Ki = 27 nM
   TI
   LI
   LO
   TS
6
Ki = 113 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 113 nM
2 Ki > 1000 nM
Protein ID: PT01648, Vasopressin V2 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000524 HEK293-FT Homo sapiens (Human)  1
1
EC50 = 2300 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki >= 58.4 nM