General Information of the Protein
Protein ID
PT02973
Protein Name
Peroxisome proliferator-activated receptor gamma
Secondarily
Protein Name
Nuclear receptor subfamily 1 group C member 3
Gene Name
PPARG
Secondarily
Gene Name
Nr1c3
Sequence
MGETLGDSPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKNLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQLLHVIKKTETDMSLHPLLQEIYKDLY
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Organism
Mus musculus, Mouse
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 1
>
Nuclear hormone receptor subfamily 1 group C
>
Nuclear hormone receptor subfamily 1 group C member 3
Function
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels (PubMed:19041764).
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Uniprot ID
P37238
Ensembl ID
ENSG00000132170
Subcellular Location
Nucleus
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000384 , 3T3-L1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0050852
 Compound Info 
2-[(1S)-5-{3-[2-propyl-4-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C30H35NO4S
  1
1
EC50 = 12 nM
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CP0182996
 Compound Info 
2-[(1S)-5-(3-{4-[5-(dimethylcarbamoyl)-4-methyl-1,3-thiazol-2-yl]-2-propylphenoxy}propoxy)-2,3-dihydro-1H-inden-1-yl]acetic acid
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C30H36N2O5S
  1
1
EC50 = 17 nM
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CP0265832
 Compound Info 
2-[(1S)-5-{3-[4-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2-propylphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C29H33NO5S
  1
1
EC50 = 17 nM
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CP0256975
 Compound Info 
2-[(1S)-5-{3-[4-(4-tert-butyl-1,3-thiazol-2-yl)-2-propylphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C30H37NO4S
  1
1
EC50 = 18 nM
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CP0234503
 Compound Info 
2-[(1S)-5-(3-{4-[4-(carboxymethyl)-1,3-thiazol-2-yl]-2-propylphenoxy}propoxy)-2,3-dihydro-1H-inden-1-yl]acetic acid
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C28H31NO6S
  1
1
EC50 = 27 nM
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CP0427747
 Compound Info 
(S)-2-(5-(3-((2-(4-isopropylphenyl)-5-methylpyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C29H35N3O3
  1
1
EC50 = 29 nM
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CP0256972
 Compound Info 
2-[(1S)-5-{3-[4-(4,5-dimethyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C26H29NO5S
  1
1
EC50 = 33 nM
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CP0293628
 Compound Info 
2-[(1S)-5-{3-[4-(4-ethoxy-5-methyl-1,3-thiazol-2-yl)-2-propylphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C29H35NO5S
  1
1
EC50 = 34 nM
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CP0427720
 Compound Info 
2-((S)-5-(3-(5-(5-acetyl-4-methylthiazol-2-yl)pyridin-2-yloxy)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C25H26N2O5S
  1
1
EC50 = 35 nM
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CP0206282
 Compound Info 
2-[(1S)-5-{3-[4-(4-ethoxy-1,3-thiazol-2-yl)-2-propylphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C28H33NO5S
  1
1
EC50 = 41 nM
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CP0436913
 Compound Info 
2-[(1S)-5-(3-{[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy}propoxy)-2,3-dihydro-1H-inden-1-yl]acetic acid
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C25H26F3NO5
  1
1
EC50 = 42 nM
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CP0717529
 Compound Info 
[(1S)-5-{3-[4-(6,7-dihydro-5H-pyrano[2,3-d]1,3thiazol-2-yl)-2-propylphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C29H35NO5S
  1
1
EC50 = 42 nM
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CP0114434
 Compound Info 
2-[(1S)-5-(3-{2-methoxy-4-[4-(propan-2-yloxy)-1,3-thiazol-2-yl]phenoxy}propoxy)-2,3-dihydro-1H-inden-1-yl]acetic acid
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C27H31NO6S
  1
1
EC50 = 44 nM
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CP0050853
 Compound Info 
2-[(1S)-5-{3-[4-(4-ethyl-1,3-thiazol-2-yl)-2-propylphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C28H33NO4S
  1
1
EC50 = 45 nM
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CP0206279
 Compound Info 
2-[(1S)-5-(3-{4-[4-(propan-2-yloxy)-1,3-thiazol-2-yl]-2-propylphenoxy}propoxy)-2,3-dihydro-1H-inden-1-yl]acetic acid
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C29H35NO5S
  1
1
EC50 = 45 nM
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CP0050846
 Compound Info 
2-[(1S)-5-{3-[2-propyl-4-(1,3-thiazol-2-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C26H29NO4S
  1
1
EC50 = 48 nM
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CP0256970
 Compound Info 
2-[(1S)-5-{3-[4-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C27H29NO6S
  1
1
EC50 = 49 nM
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CP0217591
 Compound Info 
2-[(1S)-5-(3-{2-propyl-4-[4-(trifluoromethyl)-1,3-thiazol-2-yl]phenoxy}propoxy)-2,3-dihydro-1H-inden-1-yl]acetic acid
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C27H28F3NO4S
  1
1
EC50 = 55 nM
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CP0293630
 Compound Info 
2-[(1S)-5-{3-[4-(4-ethyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C26H29NO5S
  1
1
EC50 = 65 nM
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CP0144052
 Compound Info 
2-[(1S)-5-{3-[2-methoxy-4-(4-methoxy-1,3-thiazol-2-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C25H27NO6S
  1
1
EC50 = 69 nM
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CP0175947
 Compound Info 
2-[(1S)-5-{3-[2-methoxy-4-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C28H31NO5S
  1
1
EC50 = 84 nM
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CP0256961
 Compound Info 
2-[(1S)-5-[3-(4-{4H,5H,6H-cyclopenta[d][1,3]thiazol-2-yl}-2-propylphenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
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C29H33NO4S
  1
1
EC50 = 94 nM
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CP0323409
 Compound Info 
2-[(1S)-5-[3-(4-{4H,5H,6H-cyclopenta[d][1,3]thiazol-2-yl}-2-methoxyphenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
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C27H29NO5S
  1
1
EC50 = 116 nM
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CP0378531
 Compound Info 
(S)-2-(5-(3-((2-(4-ethylphenyl)-5-methylpyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C28H33N3O3
  1
1
EC50 = 145 nM
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CP0421878
 Compound Info 
(S)-2-(5-(3-((2-(4-tert-butylphenyl)-5-methylpyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C30H37N3O3
  1
1
EC50 = 156 nM
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CP0182244
 Compound Info 
2-[(1S)-5-(3-{2-methyl-4-[3-(trifluoromethyl)-1,2,4-thiadiazol-5-yl]phenoxy}propoxy)-2,3-dihydro-1H-inden-1-yl]acetic acid
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C24H23F3N2O4S
  1
1
EC50 = 158 nM
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CP0371876
 Compound Info 
(S)-2-(5-(3-((2-(4-ethoxyphenyl)-5-methylpyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C28H33N3O4
  1
1
EC50 = 161 nM
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CP0424803
 Compound Info 
2-[(1S)-5-{3-[(3-methyl-7-propyl-1,2-benzoxazol-6-yl)oxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C25H29NO5
  1
1
EC50 = 173 nM
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CP0338234
 Compound Info 
2-[(1S)-5-{3-[4-(4-ethoxy-5-methyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C27H31NO6S
  1
1
EC50 = 177 nM
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CP0120178
 Compound Info 
2-[(1S)-5-[3-(2-methoxy-4-{5H,6H,7H-pyrano[2,3-d][1,3]thiazol-2-yl}phenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
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C27H29NO6S
  1
1
EC50 = 181 nM
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CP0323412
 Compound Info 
2-[(1S)-5-{3-[4-(1,3-benzothiazol-2-yl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C28H27NO5S
  1
1
EC50 = 214 nM
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CP0513839
 Compound Info 
(S)-2-(5-(3-((2-(4-acetylphenyl)-5-methylpyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C28H31N3O4
  1
1
EC50 = 237 nM
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CP0206283
 Compound Info 
2-[4-(3-{[(1S)-1-(carboxymethyl)-2,3-dihydro-1H-inden-5-yl]oxy}propoxy)-3-propylphenyl]-4-methyl-1,3-thiazole-5-carboxylic acid
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C28H31NO6S
  1
1
EC50 = 238 nM
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CP0513838
 Compound Info 
2-((S)-5-(3-(5-(4-ethylthiazol-2-yl)pyridin-2-yloxy)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C24H26N2O4S
  1
1
EC50 = 264 nM
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CP0204181
 Compound Info 
2-[(1S)-5-{3-[4-(4,5-dimethyl-1,3-thiazol-2-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C25H27NO4S
  1
1
EC50 = 280 nM
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CP0485678
 Compound Info 
2-[(1S)-5-{3-[(3,7-dimethyl-1,2-benzoxazol-6-yl)oxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C23H25NO5
  1
1
EC50 = 290 nM
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CP0145989
 Compound Info 
2-[(1S)-5-{3-[4-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C27H29NO4S
  1
1
EC50 = 294 nM
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CP0391118
 Compound Info 
2-[(1S)-5-{3-[4-(2,4-dimethoxypyrimidin-5-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C26H28N2O6
  1
1
EC50 = 300 nM
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CP0483666
 Compound Info 
2-[(1S)-5-{3-[4-(4-methoxy-1,3-thiazol-2-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C24H25NO5S
  1
1
EC50 = 300 nM
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CP0050848
 Compound Info 
2-[(1S)-5-{3-[2-propyl-4-(trifluoromethyl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C24H27F3O4
  1
1
EC50 = 303 nM
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CP0367146
 Compound Info 
2-[4-(3-{[(1S)-1-(carboxymethyl)-2,3-dihydro-1H-inden-5-yl]oxy}propoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid
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C25H25NO6S
  1
1
EC50 = 312 nM
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CP0256973
 Compound Info 
2-[(1S)-5-(3-{2-methoxy-4-[4-(trifluoromethyl)-1,3-thiazol-2-yl]phenoxy}propoxy)-2,3-dihydro-1H-inden-1-yl]acetic acid
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C25H24F3NO5S
  1
1
EC50 = 327 nM
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CP0530287
 Compound Info 
(S)-2-(5-(3-((2-(4-ethylphenyl)-5-fluoropyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C27H30FN3O3
  1
1
EC50 = 360 nM
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CP0114529
 Compound Info 
2-[(1S)-5-{3-[4-(4-ethoxy-5-ethyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C28H33NO6S
  1
1
EC50 = 362 nM
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CP0367143
 Compound Info 
2-[(1S)-5-{3-[2-methoxy-4-(1,3-thiazol-2-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C24H25NO5S
  1
1
EC50 = 374 nM
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CP0421876
 Compound Info 
2-((S)-5-(3-(5-(4-ethoxythiazol-2-yl)pyridin-2-yloxy)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C24H26N2O5S
  1
1
EC50 = 411 nM
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CP0486879
 Compound Info 
2-[(1S)-5-{3-[(4-propyl-1H-indol-5-yl)oxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C25H29NO4
  1
1
EC50 = 460 nM
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CP0256971
 Compound Info 
2-[(1S)-5-{3-[4-(5-acetyl-4-methyl-1,3-thiazol-2-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C26H27NO5S
  1
1
EC50 = 480 nM
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CP0524543
 Compound Info 
2-[(1S)-5-{3-[4-(4-methoxypyridin-3-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C26H27NO5
  1
1
EC50 = 485 nM
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CP0523781
 Compound Info 
2-((S)-5-(3-(5-(4,5-dimethylthiazol-2-yl)pyridin-2-yloxy)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C24H26N2O4S
  1
1
EC50 = 511 nM
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CP0217689
 Compound Info 
2-[(1S)-5-{3-[4-(6-methylpyridin-2-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C26H27NO4
  1
1
EC50 = 550 nM
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CP0265833
 Compound Info 
2-[(1S)-5-{3-[4-(pyridin-3-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C25H25NO4
  1
1
EC50 = 550 nM
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CP0234502
 Compound Info 
2-[(1S)-5-{3-[4-(1H-1,2,4-triazol-1-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C22H23N3O4
  1
1
EC50 = 555 nM
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CP0367144
 Compound Info 
2-[(1S)-5-[3-(4-cyano-2-propylphenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
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C24H27NO4
  1
1
EC50 = 570 nM
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CP0553074
 Compound Info 
2-((S)-5-(3-((2-(3-chlorophenyl)-5-methylpyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C26H28ClN3O3
  1
1
EC50 = 582 nM
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CP0522383
 Compound Info 
(S)-2-(5-(3-((2-(4-ethylphenyl)-6-methylpyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C28H33N3O3
  1
1
EC50 = 600 nM
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CP0144056
 Compound Info 
2-[(1S)-5-[3-(4-cyanophenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C21H21NO4
  1
1
EC50 = 637 nM
 Bioactivity Info 
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CP0256964
 Compound Info 
2-[(1S)-5-{3-[4-(thiophen-3-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C24H24O4S
  1
1
EC50 = 650 nM
 Bioactivity Info 
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CP0490621
 Compound Info 
2-((S)-5-(3-(methyl(5-methyl-2-m-tolylpyrimidin-4-yl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C27H31N3O3
  1
1
EC50 = 670 nM
 Bioactivity Info 
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CP0513837
 Compound Info 
(S)-2-(5-(3-(methyl(5-methyl-2-phenylpyrimidin-4-yl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C26H29N3O3
  1
1
EC50 = 678 nM
 Bioactivity Info 
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CP0256976
 Compound Info 
2-[(1S)-5-[3-(4-cyano-2-methoxyphenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C22H23NO5
  1
1
EC50 = 700 nM
 Bioactivity Info 
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CP0256963
 Compound Info 
2-[(1S)-5-{3-[4-(1H-indol-6-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C28H27NO4
  1
1
EC50 = 740 nM
 Bioactivity Info 
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CP0265831
 Compound Info 
2-[(1S)-5-{3-[4-(4-ethoxy-1,3-thiazol-2-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C25H27NO5S
  1
1
EC50 = 753 nM
 Bioactivity Info 
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CP0409492
 Compound Info 
(S)-2-(5-(3-(methyl(5-methyl-2-p-tolylpyrimidin-4-yl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
   Show/Hide
C27H31N3O3
  1
1
EC50 = 780 nM
 Bioactivity Info 
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CP0522384
 Compound Info 
(S)-2-(5-(3-((2-(4-ethylphenyl)pyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C27H31N3O3
  1
1
EC50 = 800 nM
 Bioactivity Info 
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CP0372278
 Compound Info 
(S)-2-(5-(3-((2-(4-fluorophenyl)-5-methylpyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C26H28FN3O3
  1
1
EC50 = 860 nM
 Bioactivity Info 
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CP0120169
 Compound Info 
2-[(1S)-5-{3-[4-(4-ethyl-1,3-thiazol-2-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C25H27NO4S
  1
1
EC50 = 874 nM
 Bioactivity Info 
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CP0286722
 Compound Info 
2-[4-(3-{[(1S)-1-(carboxymethyl)-2,3-dihydro-1H-inden-5-yl]oxy}propoxy)-3-propylphenyl]-4-(hydroxymethyl)-1,3-thiazole-5-carboxylic acid
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C28H31NO7S
  1
1
EC50 = 891 nM
 Bioactivity Info 
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CP0206281
 Compound Info 
2-[(1S)-5-{3-[4-(4-ethoxy-1,3-thiazol-2-yl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C26H29NO6S
  1
1
EC50 = 920 nM
 Bioactivity Info 
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CP0144041
 Compound Info 
2-[(1S)-5-[3-(4-ethoxyphenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
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C22H26O5
  1
1
EC50 = 940 nM
 Bioactivity Info 
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CP0409490
 Compound Info 
(S)-2-(5-(3-((5-ethyl-2-(4-ethylphenyl)pyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
   Show/Hide
C29H35N3O3
  1
1
EC50 = 950 nM
 Bioactivity Info 
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CP0460121
 Compound Info 
2-[(1S)-5-{3-[2-methoxy-4-(4-methyl-1,3-thiazol-2-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C25H27NO5S
  1
1
EC50 = 960 nM
 Bioactivity Info 
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CP0204183
 Compound Info 
2-[(1S)-5-{3-[4-(pyrimidin-5-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C24H24N2O4
  1
1
EC50 = 970 nM
 Bioactivity Info 
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CP0066347
 Compound Info 
2-[4-(3-{[(1S)-1-(carboxymethyl)-2,3-dihydro-1H-inden-5-yl]oxy}propoxy)-3-methoxyphenyl]-4-methyl-1,3-thiazole-5-carboxylic acid
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C26H27NO7S
  1
1
EC50 = 1000 nM
 Bioactivity Info 
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CP0103016
 Compound Info 
2-[(1S)-5-{3-[4-(trifluoromethoxy)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C21H21F3O5
  1
1
EC50 = 1020 nM
 Bioactivity Info 
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CP0428140
 Compound Info 
2-[(1S)-5-{3-[(1-methyl-1H-indol-5-yl)oxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
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C23H25NO4
  1
1
EC50 = 1030 nM
 Bioactivity Info 
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CP0256962
 Compound Info 
2-[(1S)-5-[3-(4-{4H,5H,6H-cyclopenta[d][1,3]thiazol-2-yl}phenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C26H27NO4S
  1
1
EC50 = 1200 nM
 Bioactivity Info 
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CP0256966
 Compound Info 
2-[(1S)-5-[3-(2-ethoxy-4-methylphenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C23H28O5
  1
1
EC50 = 1240 nM
 Bioactivity Info 
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CP0367145
 Compound Info 
2-[(1S)-5-[3-(2-propylphenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
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C23H28O4
  1
1
EC50 = 1520 nM
 Bioactivity Info 
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CP0053275
 Compound Info 
2-[(1S)-5-[3-(4-ethyl-2-methoxyphenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C23H28O5
  1
1
EC50 = 1650 nM
 Bioactivity Info 
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CP0256967
 Compound Info 
2-[(1S)-5-[3-(2-methoxy-4-methylphenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C22H26O5
  1
1
EC50 = 1670 nM
 Bioactivity Info 
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CP0053274
 Compound Info 
2-[(1S)-5-(3-{4-[5-(trifluoromethyl)pyridin-2-yl]phenoxy}propoxy)-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C26H24F3NO4
  1
1
EC50 = 1800 nM
 Bioactivity Info 
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CP0500449
 Compound Info 
2-[(1S)-5-[3-(1H-indol-5-yloxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C22H23NO4
  1
1
EC50 = 1800 nM
 Bioactivity Info 
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CP0485680
 Compound Info 
2-[(1S)-5-{3-[(3-methyl-1-benzofuran-6-yl)oxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C23H24O5
  1
1
EC50 = 1950 nM
 Bioactivity Info 
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CP0174127
 Compound Info 
2-[(1S)-5-[3-(2,4-dimethylphenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C22H26O4
  1
1
EC50 = 2180 nM
 Bioactivity Info 
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CP0504990
 Compound Info 
(S)-2-(5-(3-((2-(4-chlorophenyl)-5-methylpyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C26H28ClN3O3
  1
1
EC50 = 2800 nM
 Bioactivity Info 
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CP0256968
 Compound Info 
2-[(1S)-5-[3-(4-methoxyphenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
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C21H24O5
  1
1
EC50 = 3000 nM
 Bioactivity Info 
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CP0553742
 Compound Info 
2-[(1S)-5-(3-{[4-(prop-2-en-1-yl)-1H-indol-5-yl]oxy}propoxy)-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C25H27NO4
  1
1
EC50 = 3300 nM
 Bioactivity Info 
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CP0536737
 Compound Info 
2-[(1S)-5-{3-[(2-methyl-1H-indol-5-yl)oxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C23H25NO4
  1
1
EC50 = 3650 nM
 Bioactivity Info 
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CP0500448
 Compound Info 
2-[(1S)-5-{3-[(3-methyl-1,2-benzoxazol-6-yl)oxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C22H23NO5
  1
1
EC50 = 3660 nM
 Bioactivity Info 
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CP0144054
 Compound Info 
2-[(1S)-5-{3-[4-(furan-3-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C24H24O5
  1
1
EC50 = 4100 nM
 Bioactivity Info 
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CP0553740
 Compound Info 
2-[(1S)-5-(3-{[3-hydroxy-3-(trifluoromethyl)-2,3-dihydro-1,2-benzoxazol-6-yl]oxy}propoxy)-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C22H22F3NO6
  1
1
EC50 = 5000 nM
 Bioactivity Info 
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CP0256969
 Compound Info 
2-[(1S)-5-{3-[4-(trifluoromethyl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C21H21F3O4
  1
1
EC50 = 5580 nM
 Bioactivity Info 
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CP0050847
 Compound Info 
2-[(1S)-5-{3-[2-acetamido-4-(1H-1,2,3-triazol-1-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C24H26N4O5
  1
1
EC50 = 5600 nM
 Bioactivity Info 
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CP0103017
 Compound Info 
2-[(1S)-5-[3-(4-ethylphenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
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C22H26O4
  1
1
EC50 = 6200 nM
 Bioactivity Info 
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CP0424804
 Compound Info 
2-[(1S)-5-{3-[(4-methyl-1H-indol-5-yl)oxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C23H25NO4
  1
1
EC50 = 6850 nM
 Bioactivity Info 
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CP0553023
 Compound Info 
2-((S)-5-(3-((2-(3-ethoxyphenyl)-5-methylpyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C28H33N3O4
  1
1
EC50 = 6930 nM
 Bioactivity Info 
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CP0513840
 Compound Info 
(S)-2-(5-(3-((2-(4-methoxyphenyl)-5-methylpyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
   Show/Hide
C27H31N3O4
  1
1
EC50 = 7010 nM
 Bioactivity Info 
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CP0104914
 Compound Info 
2-[(1S)-5-[3-(3-methylphenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C21H24O4
  1
1
EC50 = 8000 nM
 Bioactivity Info 
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CP0256965
 Compound Info 
2-[(1S)-5-{3-[2-chloro-4-(4H-1,2,4-triazol-4-yl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C22H22ClN3O4
  1
1
EC50 = 8700 nM
 Bioactivity Info 
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CP0066406
 Compound Info 
2-[(1S)-5-[3-(3,4-dimethylphenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C22H26O4
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0377039
 Compound Info 
2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C20H22O4
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0486878
 Compound Info 
2-[(1S)-5-{3-[(1-methyl-4-propyl-1H-indol-5-yl)oxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C26H31NO4
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0537917
 Compound Info 
2-[(1S)-5-[3-(1H-indol-6-yloxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C22H23NO4
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0538232
 Compound Info 
2-[(1S)-5-[3-(1,3-benzoxazol-6-yloxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C21H21NO5
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0553741
 Compound Info 
2-[(1S)-5-[3-(1,2-benzoxazol-6-yloxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
   Show/Hide
C21H21NO5
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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Cell Line ID: CL000011 , CHO
 Cell Line Info 
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Cell Line ID: CL000044 , CV-1
 Cell Line Info 
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Cell Line ID: CL000043 , U2OS
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0064613
 Compound Info 
(2S)-2-ethoxy-3-(4-{2-[4-(methanesulfonyloxy)phenyl]ethoxy}phenyl)propanoic acid
   Show/Hide
C20H24O7S
  2
1 EC50 = 250 nM
2 Ki = 200 nM
CP0041219
 Compound Info 
Actos
   Show/Hide
C19H20N2O3S
  1
1 IC50 = 700 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01464 Peroxisome proliferator-activated receptor gamma Rattus norvegicus, Rat
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT00915 Peroxisome proliferator-activated receptor gamma Homo sapiens, Human
 Protein Info