Protein Information

General Information of the Protein

Protein ID	PT01494
Protein Name	Beta-2 adrenergic receptor
Secondarily Protein Name	Beta-2 adrenoreceptor
Gene Name	ADRB2
Secondarily Gene Name	ADRB2R B2AR
Sequence	MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Adrenergic receptor
Function	Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Show/Hide
Uniprot ID	Primary ID: P07550 Secondarily ID: B0LPE4 B2R7X2 O14823 O14824 O14825 O14826 Q4JG18 Q53GA6 Q6GMT4 Q6P4D8 Q8NEQ9 Q96EC3 Q9UCZ0 Q9UCZ1 Q9UCZ2 Q9UCZ3 Q9UH95 Q9UHA1 Q9UMZ5 Show/Hide
HGNC ID	HGNC:286
Subcellular Location	Cell membrane Early endosome Golgi apparatus

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000901 , 661W

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0391154 Compound Info	(3aS,9bS)-7,9-dimethoxy-3a-methyl-2,3,4,9b-tetrahydro-1H-chromeno[3,4-b]pyrrole Show/Hide	C14H19NO3	1
1	Ki = 575.44 nM Bioactivity Info	TI LI LO TS
CP0391120 Compound Info	(1S,2R)-1-ethyl-7-methoxy-2-methyl-3,4-dihydro-1H-naphthalen-2-amine Show/Hide	C14H21NO	1
1	Ki = 5011.87 nM Bioactivity Info	TI LI LO TS
CP0387083 Compound Info	(3aS,9bS)-3a-methyl-5-phenyl-2,3,4,9b-tetrahydro-1H-pyrrolo[2,3-c]quinoline Show/Hide	C18H20N2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0391121 Compound Info	(3S,4S)-4-ethyl-3,6-dimethyl-2,4-dihydrochromen-3-amine Show/Hide	C13H19NO	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0411059 Compound Info	(3S,4S)-4-ethyl-3-methyl-1-phenyl-2,4-dihydroquinolin-3-amine Show/Hide	C18H22N2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000052 , A-431

Cell Line Info

Cell Line ID: CL000612 , BEAS-2B

Cell Line Info

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000053 , COS-7

Cell Line Info

Cell Line ID: CL000088 , Flp-In-293

Cell Line Info

Cell Line ID: CL000386 , Flp-In-CHO

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000246 , NCI-H292

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Cell Line ID: CL000102 , U-87MG ATCC

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0088670 Compound Info	Batefenterol Show/Hide	C40H42ClN5O7	1
1	EC50 = 0.2512 nM
CP0734482 Compound Info	US9315463, 12 Show/Hide	C39H43ClN4O9S2	1
1	EC50 = 0.2512 nM
CP0227843 Compound Info	ARFORMOTEROL TARTRATE Show/Hide	C19H24N2O4	1
1	EC50 = 0.3162 nM
CP0039163 Compound Info	[3-[(2R)-2-[[(2R)-2-hydroxy-2-[3-(thiophen-2-ylsulfonylamino)phenyl]ethyl]amino]propyl]-1H-indol-7-yl] octane-1-sulfonate Show/Hide	C31H41N3O6S3	1
1	EC50 = 20 nM
CP0103438 Compound Info	[3-[(2R)-2-[[(2R)-2-hydroxy-2-[3-(thiophen-2-ylsulfonylamino)phenyl]ethyl]amino]propyl]-1H-indol-7-yl] pyridine-3-sulfonate Show/Hide	C28H28N4O6S3	1
1	EC50 = 22 nM
CP0198066 Compound Info	(R)-1-((R)-3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1-methyl-ethylamino]-ethanol Show/Hide	C19H21ClN2O	1
1	EC50 = 25 nM
CP0279836 Compound Info	Butane-1-sulfonic acid 3-(2-{(R)-(R)-2-hydroxy-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester Show/Hide	C27H33N3O6S3	1
1	EC50 = 26 nM
CP0071878 Compound Info	N-[3-[(1R)-1-hydroxy-2-[[(2R)-1-(7-methoxy-1H-indol-3-yl)propan-2-yl]amino]ethyl]phenyl]thiophene-2-sulfonamide Show/Hide	C24H27N3O4S2	2
1	EC50 = 29 nM
2	Ki = 25 nM
CP0118799 Compound Info	[3-[(2R)-2-[[(2R)-2-hydroxy-2-[3-(thiophen-2-ylsulfonylamino)phenyl]ethyl]amino]propyl]-1H-indol-7-yl] propane-2-sulfonate Show/Hide	C26H31N3O6S3	1
1	EC50 = 40 nM
CP0039168 Compound Info	[3-[(2R)-2-[[(2R)-2-hydroxy-2-[3-(thiophen-2-ylsulfonylamino)phenyl]ethyl]amino]propyl]-1H-indol-7-yl] methanesulfonate Show/Hide	C24H27N3O6S3	2
1	EC50 = 44 nM
2	Ki = 48 nM
CP0198056 Compound Info	[3-[(2R)-2-[[(2R)-2-hydroxy-2-[3-(naphthalen-2-ylmethylamino)phenyl]ethyl]amino]propyl]-1H-indol-7-yl] methanesulfonate Show/Hide	C31H33N3O4S	1
1	EC50 = 44 nM
CP0058497 Compound Info	[3-[(2R)-2-[[(2R)-2-hydroxy-2-[3-(prop-2-ynylamino)phenyl]ethyl]amino]propyl]-1H-indol-7-yl] methanesulfonate Show/Hide	C23H27N3O4S	1
1	EC50 = 45 nM
CP0118781 Compound Info	[3-[(2R)-2-[[(2R)-2-hydroxy-2-[3-(thiophen-2-ylsulfonylamino)phenyl]ethyl]amino]propyl]-1H-indol-7-yl] thiophene-2-sulfonate Show/Hide	C27H27N3O6S4	1
1	EC50 = 49 nM
CP0071879 Compound Info	N-[3-[(1R)-1-hydroxy-2-[[(2R)-1-(7-phenylmethoxy-1H-indol-3-yl)propan-2-yl]amino]ethyl]phenyl]thiophene-2-sulfonamide Show/Hide	C30H31N3O4S2	1
1	EC50 = 54 nM
CP0071873 Compound Info	N-[3-[(1R)-1-hydroxy-2-[[(2R)-1-(1H-indol-3-yl)propan-2-yl]amino]ethyl]phenyl]thiophene-2-sulfonamide Show/Hide	C23H25N3O3S2	2
1	EC50 = 66 nM
2	Ki = 51 nM
CP0103437 Compound Info	Benzenesulfonic acid 3-(2-{(R)-(R)-2-hydroxy-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester Show/Hide	C29H29N3O6S3	1
1	EC50 = 72 nM
CP0039161 Compound Info	[3-[(2R)-2-[[(2R)-2-hydroxy-2-[3-(3-methylbut-2-enylamino)phenyl]ethyl]amino]propyl]-1H-indol-7-yl] methanesulfonate Show/Hide	C25H33N3O4S	1
1	EC50 = 160 nM
CP0039162 Compound Info	[3-[(2R)-2-[[(2R)-2-[3-[[(E)-but-2-enyl]amino]phenyl]-2-hydroxyethyl]amino]propyl]-1H-indol-7-yl] methanesulfonate Show/Hide	C24H31N3O4S	1
1	EC50 = 170 nM
CP0075978 Compound Info	2-[[3-[(2R)-2-[[(2R)-2-hydroxy-2-[3-(thiophen-2-ylsulfonylamino)phenyl]ethyl]amino]propyl]-1H-indol-7-yl]oxy]acetic acid Show/Hide	C25H27N3O6S2	2
1	EC50 = 180 nM
2	Ki = 160 nM
CP0071877 Compound Info	(+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydroxyethylamino)propyl)phenoxy)acetic acid Show/Hide	C19H22ClNO4	1
1	EC50 = 290 nM
CP0039165 Compound Info	(S)-1-((R)-3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1-methyl-ethylamino]-ethanol Show/Hide	C19H21ClN2O	1
1	EC50 = 330 nM
CP0077033 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[4-[(2-phenylpropylamino)methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C27H31N3O3S	1
1	IC50 = 0.1995 nM
CP0106241 Compound Info	7-[(1R)-2-[2-[3-[[2-(2,6-dichlorophenyl)ethylamino]methyl]phenyl]ethylamino]-1-hydroxyethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C26H27Cl2N3O3S	1
1	IC50 = 0.1995 nM
CP0068490 Compound Info	1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-(propan-2-ylamino)butan-2-ol Show/Hide	C17H27NO2	8
1	IC50 = 0.49 nM
2	IC50 = 1.2 nM
3	IC50 = 2.3 nM
4	IC50 = 2.5 nM
5	Kd = 0.63 nM
6	Ki = 0.13 nM
7	Ki = 0.16 nM
8	Ki = 0.5 nM
CP0079349 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[3-[(3-pyridin-2-ylpropylamino)methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C26H30N4O3S	1
1	IC50 = 0.5012 nM
CP0099673 Compound Info	7-[(1R)-2-[2-[3-[[2-(2-fluorophenyl)ethylamino]methyl]phenyl]ethylamino]-1-hydroxyethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C26H28FN3O3S	1
1	IC50 = 0.5012 nM
CP0079346 Compound Info	7-[(1R)-2-[2-[3-[[2-(2-chlorophenyl)ethylamino]methyl]phenyl]ethylamino]-1-hydroxyethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C26H28ClN3O3S	1
1	IC50 = 0.631 nM
CP0094737 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[3-[[2-(7-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C29H32N4O3S	1
1	IC50 = 0.631 nM
CP0105170 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[3-[[2-(2-methoxyphenyl)ethylamino]methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C27H31N3O4S	1
1	IC50 = 0.7943 nM
CP0164759 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[3-[(3-phenylpropylamino)methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C27H31N3O3S	1
1	IC50 = 0.7943 nM
CP0248384 Compound Info	7-[(1R)-2-[2-[3-[[(2-fluorophenyl)methylamino]methyl]phenyl]ethylamino]-1-hydroxyethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C25H26FN3O3S	1
1	IC50 = 1 nM
CP0667268 Compound Info	(6aR,7R)-1,2-Dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-7-ol Show/Hide	C18H19NO3	2
1	IC50 = 1.4 nM
2	Ki = 13 nM
CP0093926 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[3-[2-[(2-methoxyphenyl)methylamino]ethyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C27H31N3O4S	1
1	IC50 = 1.585 nM
CP0106289 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[4-[[2-(7-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C29H32N4O3S	1
1	IC50 = 1.995 nM
CP0164685 Compound Info	7-[(1R)-2-[2-[4-[[2-(2-fluorophenyl)ethylamino]methyl]phenyl]ethylamino]-1-hydroxyethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C26H28FN3O3S	1
1	IC50 = 1.995 nM
CP0200935 Compound Info	7-[(1R)-2-[2-[3-[[(2-chlorophenyl)methylamino]methyl]phenyl]ethylamino]-1-hydroxyethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C25H26ClN3O3S	1
1	IC50 = 1.995 nM
CP0200938 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[4-[(2-phenylethylamino)methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C26H29N3O3S	1
1	IC50 = 1.995 nM
CP0248376 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[4-[2-[[[(1R)-1-phenylethyl]amino]methyl]phenyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C32H33N3O3S	1
1	IC50 = 1.995 nM
CP0248383 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[4-[[2-(2-methoxyphenyl)ethylamino]methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C27H31N3O4S	1
1	IC50 = 1.995 nM
CP0099740 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[3-[(2-pyridin-2-ylethylamino)methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C25H28N4O3S	1
1	IC50 = 2.512 nM
CP0079347 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[4-[(2-pyridin-2-ylethylamino)methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C25H28N4O3S	1
1	IC50 = 3.162 nM
CP0164760 Compound Info	7-[(1R)-2-[2-[4-[[2-(2,6-dichlorophenyl)ethylamino]methyl]phenyl]ethylamino]-1-hydroxyethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C26H27Cl2N3O3S	1
1	IC50 = 3.981 nM
CP0205373 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[3-(pyrrolidin-1-ylmethyl)phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C22H27N3O3S	1
1	IC50 = 3.981 nM
CP0267948 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[3-[(4-phenylpiperidin-1-yl)methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C29H33N3O3S	1
1	IC50 = 3.981 nM
CP0065062 Compound Info	1-hydroxy-2-naphthoic acid;4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]-2-methylol-phenol Show/Hide	C25H37NO4	3
1	IC50 = 5.012 nM
2	Ki = 1 nM
3	Ki = 3.2 nM
CP0077034 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[3-[[(4-methoxyphenyl)methylamino]methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C26H29N3O4S	1
1	IC50 = 5.012 nM
CP0093924 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[3-[[(2-methoxyphenyl)methylamino]methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C26H29N3O4S	1
1	IC50 = 6.31 nM
CP0106238 Compound Info	7-[(1R)-2-[3-[3-[[2-(2,6-dichlorophenyl)ethylamino]methyl]phenyl]propylamino]-1-hydroxyethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C27H29Cl2N3O3S	1
1	IC50 = 6.31 nM
CP0200936 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[3-[[(3-methoxyphenyl)methylamino]methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C26H29N3O4S	1
1	IC50 = 6.31 nM
CP0079351 Compound Info	7-[(1R)-2-[2-[3-[[2-(2-fluorophenyl)ethylamino]methyl]phenoxy]ethylamino]-1-hydroxyethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C26H28FN3O4S	1
1	IC50 = 7.943 nM
CP0164758 Compound Info	7-[(1R)-2-[2-[3-[3-[(benzylamino)methyl]phenyl]phenyl]ethylamino]-1-hydroxyethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C31H31N3O3S	1
1	IC50 = 10 nM
CP0099742 Compound Info	7-[(1R)-2-[2-[2-[[2-(2-fluorophenyl)ethylamino]methyl]phenyl]ethylamino]-1-hydroxyethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C26H28FN3O3S	1
1	IC50 = 12.59 nM
CP0164757 Compound Info	4-hydroxy-7-[2-[2-[3-[[[(1S,2R)-2-phenylcyclopropyl]amino]methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C27H29N3O2S	1
1	IC50 = 12.59 nM
CP0238383 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[3-[(pyridin-2-ylmethylamino)methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C24H26N4O3S	1
1	IC50 = 15.85 nM
CP0093925 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[3-[(2-methoxyethylamino)methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C21H27N3O4S	1
1	IC50 = 25.12 nM
CP0106236 Compound Info	7-[(1R)-2-[2-[3-[[(2-ethoxyphenyl)methylamino]methyl]phenyl]ethylamino]-1-hydroxyethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C27H31N3O4S	1
1	IC50 = 25.12 nM
CP0282923 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[3-[[(2-methoxyphenyl)methyl-methylamino]methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C27H31N3O4S	1
1	IC50 = 25.12 nM
CP0248375 Compound Info	7-[(1R)-2-[2-[4-[3-(1,3-dihydroisoindol-2-ylmethyl)phenyl]phenyl]ethylamino]-1-hydroxyethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C32H31N3O3S	1
1	IC50 = 63.1 nM
CP0282691 Compound Info	8-hydroxy-5-[(1R)-1-hydroxy-2-[2-[3-[(2-pyridin-2-ylethylamino)methyl]phenyl]ethylamino]ethyl]-1H-quinolin-2-one Show/Hide	C27H30N4O3	1
1	IC50 = 63.1 nM
CP0200932 Compound Info	4-hydroxy-7-[2-[2-[4-[(2-pyridin-2-ylethylamino)methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C25H28N4O2S	1
1	IC50 = 100 nM
CP0267946 Compound Info	7-[2-[2-[4-[[(3R)-3-(4-chlorophenoxy)pyrrolidin-1-yl]methyl]phenyl]ethylamino]ethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C28H30ClN3O3S	1
1	IC50 = 125.89 nM
CP0276059 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[4-[[(2-methoxyphenyl)methylamino]methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C26H29N3O4S	1
1	IC50 = 125.89 nM
CP0047480 Compound Info	(S)-4-(3-hexylureido)-N-(4-(2-(1-hydroxy-2-(4-hydroxyphenoxy)ethylamino)ethyl)phenyl)benzenesulfonamide Show/Hide	C30H40N4O6S	2
1	IC50 = 190 nM
2	Ki = 160 nM
CP0106240 Compound Info	4-hydroxy-7-[(1S)-1-hydroxy-2-[2-[4-[[(2-methoxyphenyl)methylamino]methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C26H29N3O4S	1
1	IC50 = 251.19 nM
CP0079350 Compound Info	4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[4-[(2-methoxyethylamino)methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one Show/Hide	C21H27N3O4S	1
1	IC50 = 316.23 nM
CP0275729 Compound Info	7-[2-[2-[4-[[2-(2,6-dichlorophenyl)ethylamino]methyl]phenyl]ethylamino]ethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C26H27Cl2N3O2S	1
1	IC50 = 501.19 nM
CP0275143 Compound Info	2-(hydroxymethyl)-4-[(1R)-1-hydroxy-2-[2-[4-[(2-phenylethylamino)methyl]phenyl]ethylamino]ethyl]phenol Show/Hide	C26H32N2O3	1
1	IC50 = 630.96 nM
CP0156740 Compound Info	(R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)ethyl)phenyl)-4-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)benzenesulfonamide Show/Hide	C31H27F3N4O3S2	1
1	IC50 = 670 nM
CP0106288 Compound Info	7-[2-[2-[4-[3-[[ethyl(pyridin-4-ylmethyl)amino]methyl]phenyl]phenyl]ethylamino]ethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C32H34N4O2S	1
1	IC50 = 794.33 nM
CP0200931 Compound Info	7-[2-[2-[4-[[2-(2-fluorophenyl)ethylamino]methyl]phenyl]ethylamino]ethyl]-4-hydroxy-3H-1,3-benzothiazol-2-one Show/Hide	C26H28FN3O2S	1
1	IC50 = 1258.93 nM
CP0065922 Compound Info	4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol Show/Hide	C13H21NO3	1
1	IC50 = 1995.26 nM
CP0076111 Compound Info	(4-pyrimidin-2-ylphenyl)methanamine Show/Hide	C11H11N3	1
1	IC50 = 10000 nM
CP0051719 Compound Info	2-(2-aminothiazol-4-yl)-N-(4-(((2S,5R)-5-((R)-hydroxy(phenyl)methyl)pyrrolidin-2-yl)methyl)phenyl)acetamide Show/Hide	C23H26N4O2S	1
1	IC50 > 20000 nM
CP0105651 Compound Info	(6S)-N-[4-[[(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-6-carboxamide Show/Hide	C24H27N5O2	1
1	IC50 > 20000 nM
CP0135426 Compound Info	(4R)-N-[4-[[(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-cyclopenta[d][1,3]thiazole-4-carboxamide Show/Hide	C24H26N4O2S	1
1	IC50 > 20000 nM
CP0041613 Compound Info	Anapriline Show/Hide	C16H21NO2	1
1	Kd = 0.79 nM
CP0066323 Compound Info	CAS_73573-87-2 Show/Hide	C19H24N2O4	2
1	Kd = 2.512 nM
2	Ki = 2.6 nM
CP0042046 Compound Info	1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethan-1-ol Show/Hide	C12H18Cl2N2O	1
1	Kd = 15.85 nM
CP0068209 Compound Info	4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;hydrochloride Show/Hide	C11H17NO3	2
1	Kd = 50 nM
2	Kd = 251.19 nM
CP0295726 Compound Info	Procaterol Show/Hide	C16H22N2O3	1
1	Kd = 79.43 nM
CP0041553 Compound Info	5-(1-hydroxy-2-(1-(4-hydroxyphenyl)propan-2-ylamino)ethyl)benzene-1,3-diol Show/Hide	C17H21NO4	1
1	Kd = 100 nM
CP0042352 Compound Info	2,3-bis(oxidanyl)butanedioic acid;4-[(1R)-2-(methylamino)-1-oxidanyl-ethyl]benzene-1,2-diol Show/Hide	C9H13NO3	2
1	Kd = 630 nM
2	Kd = 630.96 nM
CP0075433 Compound Info	5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol Show/Hide	C12H19NO3	2
1	Kd = 2510 nM
2	Kd = 2511.89 nM
CP0039930 Compound Info	(-)-arterenol Show/Hide	C8H11NO3	2
1	Kd = 3980 nM
2	Kd = 3981.07 nM
CP0036921 Compound Info	3-HYDROXYTYRAMINE HYDROCHLORIDE Show/Hide	C8H11NO2	1
1	Kd = 64560 nM
CP0156994 Compound Info	1-(9H-Carbazol-4-yloxy)-3-isopropylamino-propan-2-ol Show/Hide	C18H22N2O2	1
1	Ki = 0.114 nM
CP0036702 Compound Info	1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol Show/Hide	C14H20N2O2	1
1	Ki = 0.4 nM
CP0308246 Compound Info	7-((R)-2-((1R,2R)-2-(benzyloxy)cyclopentylamino)-1-hydroxyethyl)-4-hydroxybenzo[d]thiazol-2(3H)-one Show/Hide	C21H24N2O4S	1
1	Ki = 0.5 nM
CP0062567 Compound Info	ALPRENOLOL,(+) Show/Hide	C15H23NO2	1
1	Ki = 0.5 nM
CP0258990 Compound Info	7-((R)-2-((cis)-bi(cyclopentan)-2-ylamino)-1-hydroxyethyl)-4-hydroxybenzo[d]thiazol-2(3H)-one Show/Hide	C19H26N2O3S	1
1	Ki = 0.6 nM
CP0665630 Compound Info	N-(2-(2-(2-Aminoethoxy)ethoxy)ethyl)-2-((3-(2-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)propyl)thio)acetamide Show/Hide	C23H41N3O5S	1
1	Ki = 2.9 nM
CP0665629 Compound Info	Tert-butyl (15-(2-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)-10-oxo-3,6-dioxa-12-thia-9-azapentadecyl)carbamate Show/Hide	C28H49N3O7S	1
1	Ki = 3.2 nM
CP0715545 Compound Info	Tert-butyl (18-(2-allylphenoxy)-17-hydroxy-3,6,9,12-tetraoxa-15-azaoctadecyl)carbamate Show/Hide	C27H46N2O8	1
1	Ki = 3.7 nM
CP0042468 Compound Info	4-Hydroxy-7-{2-[2-(3-phenethyloxy-propane-1-sulfonyl)-ethylamino]-ethyl}-3H-benzothiazol-2-one Show/Hide	C22H28N2O5S2	1
1	Ki = 4 nM
CP0187238 Compound Info	7-((R)-2-((1S,2S)-2-(benzyloxy)cyclopentylamino)-1-hydroxyethyl)-4-hydroxybenzo[d]thiazol-2(3H)-one Show/Hide	C21H24N2O4S	1
1	Ki = 6.1 nM
CP0700254 Compound Info	18-(2-allylphenoxy)-1-amino-3,6,9,12-tetraoxa-15-azaoctadecan-17-ol Show/Hide	C22H38N2O6	1
1	Ki = 10.3 nM
CP0732169 Compound Info	Methyl 2-((3-(2-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)propyl)thio)acetate Show/Hide	C18H29NO4S	1
1	Ki = 15 nM
CP0010653 Compound Info	2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-2,2-diphenyl-acetamide (Darifenacin) Show/Hide	C28H30N2O2	1
1	Ki = 15.9 nM
CP0707834 Compound Info	18-(2-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)-2,13-dioxo-6,9-dioxa-15-thia-3,12-diazaoctadecane-1-sulfonic acid Show/Hide	C25H43N3O9S2	1
1	Ki = 16.4 nM
CP0133061 Compound Info	3-Amino-N-(3-{(R)-1-hydroxy-2-[(R)-2-(7-methanesulfonyl-1H-indol-3-yl)-1-methyl-ethylamino]-ethyl}-phenyl)-benzenesulfonamide Show/Hide	C26H30N4O5S2	1
1	Ki = 20 nM
CP0159295 Compound Info	8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one Show/Hide	C24H28N2O3	1
1	Ki = 20.6 nM
CP0715546 Compound Info	3-(2-((1E,3E)-5-((E)-3,3-Dimethyl-5-sulfo-1-(3-sulfopropyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3-(1-(2-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)-6,17-dioxo-10,13-dioxa-4-thia-7,16-diazadocosan-22-yl)-3-methyl-5-sulfo-3H-indol-1-ium-1-yl)propane-1-sulfonate Show/Hide	C59H85N5O18S5	1
1	Ki = 26 nM
CP0834374 Compound Info	4-((15-(2-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)-10-oxo-3,6-dioxa-12-thia-9-azapentadecyl)carbamoyl)cyclobutane-1,2,3-tricarboxylic acid Show/Hide	C31H47N3O12S	1
1	Ki = 78.6 nM
CP0189834 Compound Info	N-[4-[4-[[[(2R)-2-hydroxy-2-[4-hydroxy-3-(methanesulfonamido)phenyl]ethyl]amino]methyl]piperidin-1-yl]sulfonylphenyl]nonanamide Show/Hide	C30H46N4O7S2	1
1	Ki = 140 nM
CP0318599 Compound Info	2-[1-[4-[4-[[[(2R)-2-hydroxy-2-[4-hydroxy-3-(methanesulfonamido)phenyl]ethyl]amino]methyl]piperidin-1-yl]sulfonylphenyl]indol-3-yl]acetic acid Show/Hide	C31H36N4O8S2	1
1	Ki = 180 nM
CP0136837 Compound Info	2-(4-{4-[2-Hydroxy-2-(4-hydroxy-3-methanesulfonylamino-phenyl)-ethylamino]-piperidin-1-yl}-benzoylamino)-3-phenyl-propionic acid Show/Hide	C30H36N4O7S	1
1	Ki = 480 nM
CP0665628 Compound Info	4-((18-(2-allylphenoxy)-17-hydroxy-3,6,9,12-tetraoxa-15-azaoctadecyl)carbamoyl)cyclobutane-1,2,3-tricarboxylic acid Show/Hide	C30H44N2O13	1
1	Ki = 512 nM
CP0700117 Compound Info	3-(3-(1-(2-Allylphenoxy)-2-hydroxy-20-oxo-7,10,13,16-tetraoxa-4,19-diazapentacosan-25-yl)-2-((1E,3E)-5-((E)-3,3-dimethyl-5-sulfo-1-(3-sulfopropyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3-methyl-5-sulfo-3H-indol-1-ium-1-yl)propane-1-sulfonate Show/Hide	C58H82N4O19S4	1
1	Ki = 547 nM
CP0692947 Compound Info	21-(2-allylphenoxy)-20-hydroxy-2-oxo-6,9,12,15-tetraoxa-3,18-diazahenicosane-1-sulfonic acid Show/Hide	C24H40N2O10S	1
1	Ki = 752 nM
CP0077949 Compound Info	6-[2-[3-(1H-indol-4-yloxy)propylamino]ethoxy]-4H-1,4-benzoxazin-3-one Show/Hide	C21H23N3O4	1
1	Ki = 1000 nM
CP0208046 Compound Info	2-(4-{4-[2-Hydroxy-2-(4-hydroxy-3-methanesulfonylamino-phenyl)-ethylamino]-piperidin-1-yl}-benzoylamino)-4-methyl-pentanoic acid Show/Hide	C27H38N4O7S	1
1	Ki = 3400 nM
CP0345975 Compound Info	2-(4-{4-[2-Hydroxy-2-(4-hydroxy-3-methanesulfonylamino-phenyl)-ethylamino]-piperidin-1-yl}-benzoylamino)-3-methyl-butyric acid Show/Hide	C26H36N4O7S	1
1	Ki = 3600 nM
CP0135421 Compound Info	(4-{4-[2-Hydroxy-2-(4-hydroxy-3-methanesulfonylamino-phenyl)-ethylamino]-piperidin-1-yl}-benzoylamino)-acetic acid Show/Hide	C23H30N4O7S	1
1	Ki = 11600 nM
CP0718208 Compound Info	SID50106054 Show/Hide	C20H18ClNNa2O7	1
1	Ki = 79200 nM
CP0213665 Compound Info	3-[N-butyl-4-[4-[[(2R)-2-hydroxy-2-[4-hydroxy-3-(methanesulfonamido)phenyl]ethyl]amino]piperidin-1-yl]anilino]-3-oxopropanoic acid Show/Hide	C27H38N4O7S	1
1	Ki > 100000 nM

Clinical Information about the Protein

Target 1 ( Adrenergic receptor beta-2 (ADRB2) )

Target Type	Successful Target
Disease	10 Target-related Diseases				10
1	Chronic obstructive pulmonary disease [ICD-11: CA22]
2	Asthma [ICD-11: CA23]
3	Chronic breathing disorder [ICD-11: 7A4Z]
4	Heart block [ICD-11: BC63]
5	Premature labour [ICD-11: JB00]
6	Acute asthma [ICD-11: CA23]
7	Gastric adenocarcinoma [ICD-11: 2B72]
8	Atrial fibrillation [ICD-11: BC81.3]
9	Obesity [ICD-11: 5B81]
10	Cardiovascular disease [ICD-11: BA00-BE2Z]
Approved Drug(s)	17 Approved Drugs				17
1	Arformoterol	Drug Info	Approved	Chronic obstructive pulmonary disease
2	Bambuterol	Drug Info	Approved	Asthma
3	Clenbuterol	Drug Info	Approved	Chronic breathing disorder
4	Fenoterol	Drug Info	Approved	Asthma
5	Formoterol	Drug Info	Approved	Asthma
6	Indacaterol	Drug Info	Approved	Chronic obstructive pulmonary disease
7	Isoetharine	Drug Info	Approved	Asthma
8	Isoproterenol	Drug Info	Approved	Heart block
9	Levalbuterol	Drug Info	Approved	Asthma
10	Olodaterol	Drug Info	Approved	Chronic obstructive pulmonary disease
11	Pirbuterol	Drug Info	Approved	Asthma
12	Procaterol	Drug Info	Approved	Asthma
13	Ritodrine	Drug Info	Approved	Premature labour
14	Salbutamol	Drug Info	Approved	Acute asthma
15	Salmeterol	Drug Info	Approved	Chronic obstructive pulmonary disease
16	Terbutaline	Drug Info	Approved	Asthma
17	Vilanterol	Drug Info	Approved	Chronic obstructive pulmonary disease
Clinical Trial Drug(s)	7 Clinical Trial Drugs				7
1	GSK642444	Drug Info	Phase 3	Chronic obstructive pulmonary disease
2	ICI 118,551	Drug Info	Phase 3	Gastric adenocarcinoma
3	BUCINDOLOL	Drug Info	Phase 2/3	Atrial fibrillation
4	Carmoterol	Drug Info	Phase 2	Chronic obstructive pulmonary disease
5	GSK961081	Drug Info	Phase 2	Chronic obstructive pulmonary disease
6	LAS 100977	Drug Info	Phase 2	Chronic obstructive pulmonary disease
7	L-796568	Drug Info	Phase 1	Obesity
Discontinued Drug(s)	5 Discontinued Drugs				5
1	Broxaterol	Drug Info	Discontinued in Phase 3	Asthma
2	Sibenadet	Drug Info	Discontinued in Phase 3	Chronic obstructive pulmonary disease
3	Milveterol	Drug Info	Discontinued in Phase 2	Asthma
4	PF-610355	Drug Info	Discontinued in Phase 2	Chronic obstructive pulmonary disease
5	DPI-201-106	Drug Info	Terminated	Cardiovascular disease

Target 2 ( ADRB2 messenger RNA (ADRB2 mRNA) )

Target Type	Clinical trial Target

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han