General Information of the Compound
Compound ID
CP0267948
Compound Name
4-hydroxy-7-[(1R)-1-hydroxy-2-[2-[3-[(4-phenylpiperidin-1-yl)methyl]phenyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one
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Structure
Formula
C29H33N3O3S
Molecular Weight
503.668
Canonical SMILES
O[C@@H](CNCCc1cccc(CN2CCC(CC2)c2ccccc2)c1)c1ccc(O)c2[nH]c(=O)sc12
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InChI
InChI=1S/C29H33N3O3S/c33-25-10-9-24(28-27(25)31-29(35)36-28)26(34)18-30-14-11-20-5-4-6-21(17-20)19-32-15-12-23(13-16-32)22-7-2-1-3-8-22/h1-10,17,23,26,30,33-34H,11-16,18-19H2,(H,31,35)/t26-/m0/s1
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InChIKey
QLAUZPPGGRVYJJ-SANMLTNESA-N
Physicochemical Property
logP
4.5405
Rotatable Bonds
9
Heavy Atom Count
36
Polar Areas
88.59
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
6
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24901140
SID: 53785538
ChEMBL ID
CHEMBL1947153
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01494, Beta-2 adrenergic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000246 NCI-H292 Homo sapiens (Human)  1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3.981 nM