General Information of the Protein
Protein ID
PT01919
Protein Name
Peroxisome proliferator-activated receptor alpha
Secondarily
Protein Name
Nuclear receptor subfamily 1 group C member 1
Gene Name
PPARA
Secondarily
Gene Name
Nr1c1
Ppar
Sequence
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
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Organism
Mus musculus, Mouse
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 1
>
Nuclear hormone receptor subfamily 1 group C
>
Nuclear hormone receptor subfamily 1 group C member 1
Function
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
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Uniprot ID
P23204
Ensembl ID
ENSG00000186951
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000044 , CV-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0450938
 Compound Info 
2-[4-[3-[4-[(4-methoxyphenyl)methyl]-1-[(4-methylphenyl)methyl]-5-oxo-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid
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C31H35N3O5
  1
1
EC50 = 3 nM
 Bioactivity Info 
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CP0538367
 Compound Info 
2-[4-[3-[1,4-bis[(4-methylphenyl)methyl]-5-oxo-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid
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C31H35N3O4
  1
1
EC50 = 3 nM
 Bioactivity Info 
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CP0170396
 Compound Info 
2-{[4-(2-{[(2,4-difluorophenyl)carbamoyl](heptyl)amino}ethyl)phenyl]sulfanyl}-2-methylpropanoic acid
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C26H34F2N2O3S
  1
1
EC50 = 5 nM
 Bioactivity Info 
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CP0397728
 Compound Info 
2-(4-{2-[3-(2,4-Difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-propionic acid
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C26H34F2N2O4
  1
1
EC50 = 10 nM
 Bioactivity Info 
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CP0450936
 Compound Info 
2-[4-[3-[4-[(4-chlorophenyl)methyl]-1-[(4-methylphenyl)methyl]-5-oxo-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid
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C30H32ClN3O4
  1
1
EC50 = 10 nM
 Bioactivity Info 
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CP0568641
 Compound Info 
2-[4-[3-[4-[(4-fluorophenyl)methyl]-1-[(4-methylphenyl)methyl]-5-oxo-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid
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C30H32FN3O4
  1
1
EC50 = 10 nM
 Bioactivity Info 
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CP0450935
 Compound Info 
2-[4-[3-[4-[(3-methoxyphenyl)methyl]-1-[(4-methylphenyl)methyl]-5-oxo-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid
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C31H35N3O5
  1
1
EC50 = 20 nM
 Bioactivity Info 
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CP0450937
 Compound Info 
2-[4-[3-[1-[(4-ethenylphenyl)methyl]-4-[(4-methylphenyl)methyl]-5-oxo-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid
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C32H35N3O4
  1
1
EC50 = 20 nM
 Bioactivity Info 
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CP0551890
 Compound Info 
2-[4-[3-[4-benzyl-1-[(4-methylphenyl)methyl]-5-oxo-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid
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C30H33N3O4
  1
1
EC50 = 20 nM
 Bioactivity Info 
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CP0372746
 Compound Info 
5-[4-[2-(3,4-dimethylphenyl)-5-methyl-1,3-oxazol-4-yl]butyl]-2-methyl-1,3-dioxane-2-carboxylic acid
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C22H29NO5
  1
1
EC50 = 30 nM
 Bioactivity Info 
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CP0372747
 Compound Info 
(2s,5s)-2-methyl-5-(4-(5-methyl-2-p-tolyloxazol-4-yl)butyl)-1,3-dioxane-2-carboxylic acid
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C21H27NO5
  1
1
EC50 = 30 nM
 Bioactivity Info 
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CP0538368
 Compound Info 
2-methyl-2-[4-[3-[1-[(4-methylphenyl)methyl]-5-oxo-4-[(3,4,5-trimethoxyphenyl)methyl]-1,2,4-triazol-3-yl]propyl]phenoxy]propanoic acid
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C33H39N3O7
  1
1
EC50 = 30 nM
 Bioactivity Info 
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CP0374670
 Compound Info 
2-(4-{2-[3-(4-Fluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-propionic acid
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C26H35FN2O4
  1
1
EC50 = 33 nM
 Bioactivity Info 
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CP0403631
 Compound Info 
2-(4-{2-[1-(5-Cyclohexyl-pentyl)-3-(4-fluoro-phenyl)-ureido]-ethyl}-phenoxy)-2-methyl-propionic acid
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C30H41FN2O4
  1
1
EC50 = 53 nM
 Bioactivity Info 
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CP0372745
 Compound Info 
5-[4-[2-(3-fluoro-4-methylphenyl)-5-methyl-1,3-oxazol-4-yl]butyl]-2-methyl-1,3-dioxane-2-carboxylic acid
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C21H26FNO5
  1
1
EC50 = 100 nM
 Bioactivity Info 
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CP0404578
 Compound Info 
2-(4-{2-[1-Cycloheptyl-3-(2,4-difluoro-phenyl)-ureido]-ethyl}-phenoxy)-2-methyl-propionic acid
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C26H32F2N2O4
  1
1
EC50 = 120 nM
 Bioactivity Info 
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CP0439850
 Compound Info 
2-[4-[[1-methyl-6-(1-phenylpropylcarbamoyl)-2-propylindol-3-yl]methyl]phenyl]benzoic acid
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C36H36N2O3
  1
1
EC50 = 170 nM
 Bioactivity Info 
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CP0432278
 Compound Info 
2-[4-[[6-(1-phenylpropylcarbamoyl)-2-propyl-1H-indol-3-yl]methyl]phenyl]benzoic acid
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C35H34N2O3
  1
1
EC50 = 790 nM
 Bioactivity Info 
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CP0422670
 Compound Info 
2-methyl-5-[4-(5-methyl-2-phenyl-1,3-oxazol-4-yl)butyl]-1,3-dioxane-2-carboxylic acid
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C20H25NO5
  1
1
EC50 = 1000 nM
 Bioactivity Info 
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CP0429811
 Compound Info 
4'-((2,3-dimethyl-5-(1-phenylpropylcarbamoyl)-1H-indol-1-yl)methyl)biphenyl-2-carboxylic acid
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C34H32N2O3
  1
1
EC50 = 5510 nM
 Bioactivity Info 
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CP0083167
 Compound Info 
4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid
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C33H30N4O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0447683
 Compound Info 
4'-((6-(1-phenylpropylcarbamoyl)-2-propyl-1H-benzo[d]imidazol-1-yl)methyl)biphenyl-2-carboxylic acid
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C34H33N3O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0380009
 Compound Info 
2-[4-[[2-propyl-5-(1-propylbenzimidazol-2-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl]phenyl]benzoic acid
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C34H32N4O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0380010
 Compound Info 
2-[4-[[5-(1-butylbenzimidazol-2-yl)-2-propylindazol-3-yl]methyl]phenyl]benzoic acid
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C35H34N4O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0421159
 Compound Info 
2-propyl-5-(1-propylbenzimidazol-2-yl)-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrazolo[1,5-a]pyridine
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C34H32N8
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0425898
 Compound Info 
N-(1-phenylpropyl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrazolo[1,5-a]pyridine-5-carboxamide
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C34H33N7O
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0430042
 Compound Info 
2-[4-[[5-(1-phenylpropylcarbamoyl)-2-propylindazol-3-yl]methyl]phenyl]benzoic acid
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C34H33N3O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0432277
 Compound Info 
5-(1-butylbenzimidazol-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]indazole
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C35H34N8
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0432279
 Compound Info 
2-[4-[[5-(1-phenylpropylcarbamoyl)-2-propylpyrazolo[1,5-a]pyridin-3-yl]methyl]phenyl]benzoic acid
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C34H33N3O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0437799
 Compound Info 
2-[4-[[5-(1-phenylpropylcarbamoyl)-2-propyl-1H-indol-3-yl]methyl]phenyl]benzoic acid
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C35H34N2O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0439849
 Compound Info 
2-[4-[[1-methoxy-5-(1-phenylpropylcarbamoyl)-2-propylindol-3-yl]methyl]phenyl]benzoic acid
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C36H36N2O4
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0042877
 Compound Info 
2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic acid
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C17H15ClO4
  1
1
EC50 = 18000 nM
 Bioactivity Info 
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CP0112318
 Compound Info 
2-(4-chlorophenoxy)-2-methylpropanoic acid
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C10H11ClO3
  2
1
EC50 = 50000 nM
 Bioactivity Info 
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2
EC50 = 51000 nM
 Bioactivity Info 
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CP0154373
 Compound Info 
4-[4-(4-Chloro-phenoxy)-phenyl]-4-oxo-butyric acid
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C16H13ClO4
  1
1
EC50 = 80000 nM
 Bioactivity Info 
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CP0015504
 Compound Info 
2-(4-{2-[(4-chlorophenyl)formamido]ethyl}phenoxy)-2-methylpropanoic acid
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C19H20ClNO4
  1
1
EC50 = 90000 nM
 Bioactivity Info 
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CP0378531
 Compound Info 
(S)-2-(5-(3-((2-(4-ethylphenyl)-5-methylpyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C28H33N3O3
  1
1
IC50 = 670 nM
 Bioactivity Info 
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CP0427747
 Compound Info 
(S)-2-(5-(3-((2-(4-isopropylphenyl)-5-methylpyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C29H35N3O3
  1
1
IC50 = 2530 nM
 Bioactivity Info 
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Cell Line ID: CL000011 , CHO
 Cell Line Info 
Cell Line ID: CL000109 , COS-1
 Cell Line Info 
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Cell Line ID: CL000063 , Hep-G2
 Cell Line Info 
Cell Line ID: CL000043 , U2OS
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0257810
 Compound Info 
(2S)-3-phenyl-2-(4-phenylphenoxy)propanoic acid
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C21H18O3
  1
1 EC50 = 0.2 nM
CP0012720
 Compound Info 
2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl}sulfanyl)acetic acid
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C14H14ClN3O2S
  2
1 EC50 = 40 nM
2 Ki = 100 nM
CP0112318
 Compound Info 
2-(4-chlorophenoxy)-2-methylpropanoic acid
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C10H11ClO3
  1
1 EC50 = 42 nM
CP0150880
 Compound Info 
2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy}phenyl)methyl](methoxycarbonyl)amino}acetic acid
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C22H21ClN2O6
  1
1 EC50 = 426 nM
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT00695 Peroxisome proliferator-activated receptor alpha Mesocricetus auratus, Golden hamster
 Protein Info 
PT03261 Peroxisome proliferator-activated receptor alpha Rattus norvegicus, Rat
 Protein Info