General Information of the Compound
Compound ID
CP0150880
Compound Name
2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy}phenyl)methyl](methoxycarbonyl)amino}acetic acid
    Show/Hide
Synonyms
1000998-59-3
2-[[3-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]phenyl]methyl-methoxycarbonylamino]acetic acid
2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy}phenyl)methyl](methoxycarbonyl)amino}acetic acid
39TL5L7XDX
7HA
AKOS030526188
BCP14808
BDBM28800
BMS 687453
BMS-687453
CHEMBL1089501
CS-5523
DA-48472
EX-A592
FT-0749275
HY-10678
J-690001
N-(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzyl)-N-(methoxycarbonyl)glycine
SCHEMBL2742714
UNII-39TL5L7XDX
ZINC44460341
    Show/Hide
Structure
Formula
C22H21ClN2O6
Molecular Weight
444.871
Canonical SMILES
COC(=O)N(CC(O)=O)Cc1cccc(OCc2nc(oc2C)-c2ccc(Cl)cc2)c1
    Show/Hide
InChI
InChI=1S/C22H21ClN2O6/c1-14-19(24-21(31-14)16-6-8-17(23)9-7-16)13-30-18-5-3-4-15(10-18)11-25(12-20(26)27)22(28)29-2/h3-10H,11-13H2,1-2H3,(H,26,27)
    Show/Hide
InChIKey
UJIBXDMNCMEJAY-UHFFFAOYSA-N
Physicochemical Property
logP
4.53542
Rotatable Bonds
8
Heavy Atom Count
31
Polar Areas
102.1
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 16725047
SID: 26679168
ChEMBL ID
CHEMBL1089501
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00910, Peroxisome proliferator-activated receptor alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 9.6 nM
   TI
   LI
   LO
   TS
2
EC50 = 10 nM
   TI
   LI
   LO
   TS
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 47 nM
   TI
   LI
   LO
   TS
Protein ID: PT01919, Peroxisome proliferator-activated receptor alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 426 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 426 nM
Protein ID: PT00695, Peroxisome proliferator-activated receptor alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 488 nM
   TI
   LI
   LO
   TS
Protein ID: PT00915, Peroxisome proliferator-activated receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 2400 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 4017 nM
   TI
   LI
   LO
   TS
2
EC50 = 4100 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( BMS-687453 )
Drug Name BMS-687453
Target(s)
Peroxisome proliferator-activated receptor alpha (PPARA)
Inhibitor