General Information of the Compound
Compound ID
CP0015504
Compound Name
2-(4-{2-[(4-chlorophenyl)formamido]ethyl}phenoxy)-2-methylpropanoic acid
    Show/Hide
Synonyms
2-(4-{2-[(4-chlorobenzoyl)amino]ethyl}phenoxy)-2-methylpropanoic acid
2-(p-(2-(p-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid
2-[4-(2-[4-Chlorobenzamido]ethyl)-phenoxy]-2-methylpropanoic acid
2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid
2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]isobutyric Acid
2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid
A-[4-(4-chlorobenzoylaminoethyl)phenoxy]isobutyric acid
Azufibrat
Azupharma Brand of Bezafibrate
BF-759
BM 15.075
BM 15075
BM-15.075
BM-15075
BM15.075
Bayer Brand of Bezafibrate
Befibrat
Befizal
Berlin Chemie Brand of Bezafibrate
Berlin-Chemie Brand of Bezafibrate
Betapharm Brand of Bezafibrate
Beza Lande
Beza Puren
Beza-Lande
Beza-Puren
BezaLande
BezaPuren
Bezabeta
Bezacur
Bezafibrat
Bezafibrat PB
Bezafibrate
Bezafibrate (JP15/USAN/INN)
Bezafibrate Azupharma Brand
Bezafibrate Bayer Brand
Bezafibrate Berlin-Chemie Brand
Bezafibrate Betapharm Brand
Bezafibrate Cryopharma Brand
Bezafibrate Elfar Brand
Bezafibrate Hennig Brand
Bezafibrate Hexal Brand
Bezafibrate Isis Brand
Bezafibrate Lakeside Brand
Bezafibrate Merckle Brand
Bezafibrate Roche Brand
Bezafibrate Synthelabo Brand
Bezafibrate TAD Brand
Bezafibrate Teva Brand
Bezafibrate [USAN:BAN:INN:JAN]
Bezafibrato
Bezafibrato [INN-Spanish]
Bezafibrato [Spanish]
Bezafibratum
Bezafibratum [INN-Latin]
Bezafisal;Bezalip
Bezalip (TN)
Bezalip Retard
Bezamerck
Bezatol
Bezatol SR
Bezatol SR (TN)
Boehringer Mannheim Brand of Bezafibrate
Cedur
Cryopharma Brand of Bezafibrate
Difaterol
Durabezur
Elfar Brand of Bezafibrate;Hennig Brand of Bezafibrate
Eulitop
Hexal Brand of Bezafibrate
Isis Brand of Bezafibrate
LO 44
Lakeside Brand of Bezafibrate
Lipox
Merckle Brand of Bezafibrate
PB, Bezafibrat
Reducterol
Regadrin B
Roche Brand of Bezafibrate
Sklerofibrat
Solibay
Synthelabo Brand of Bezafibrate
TAD Brand of Bezafibrate
Teva Brand of Bezafibrate
    Show/Hide
Structure
Formula
C19H20ClNO4
Molecular Weight
361.825
Canonical SMILES
CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(O)=O
    Show/Hide
InChI
InChI=1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24)
    Show/Hide
InChIKey
IIBYAHWJQTYFKB-UHFFFAOYSA-N
CAS
41859-67-0
Physicochemical Property
logP
3.5545
Rotatable Bonds
7
Heavy Atom Count
25
Polar Areas
75.63
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 39042
SID: 12015374
ChEMBL ID
CHEMBL264374
DrugBank ID
DB01393
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00910, Peroxisome proliferator-activated receptor alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000044 CV-1 Chlorocebus aethiops (Green monkey)  2
1
EC50 = 30000 nM
   TI
   LI
   LO
   TS
2
EC50 = 50000 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 31700 nM
   TI
   LI
   LO
   TS
2
EC50 = 46580 nM
   TI
   LI
   LO
   TS
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 42500 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
EC50 > 78000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 50000 nM
Protein ID: PT01919, Peroxisome proliferator-activated receptor alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000044 CV-1 Chlorocebus aethiops (Green monkey)  1
1
EC50 = 90000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00909, Peroxisome proliferator-activated receptor delta
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 18900 nM
   TI
   LI
   LO
   TS
CL000044 CV-1 Chlorocebus aethiops (Green monkey)  2
1
EC50 = 20000 nM
   TI
   LI
   LO
   TS
2
EC50 = 30000 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 35740 nM
   TI
   LI
   LO
   TS
Protein ID: PT00915, Peroxisome proliferator-activated receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000044 CV-1 Chlorocebus aethiops (Green monkey)  3
1
EC50 = 3000 nM
   TI
   LI
   LO
   TS
2
EC50 = 60000 nM
   TI
   LI
   LO
   TS
3
EC50 = 100000 nM
   TI
   LI
   LO
   TS
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 57200 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 70360 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 60000 nM
Protein ID: PT02973, Peroxisome proliferator-activated receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000044 CV-1 Chlorocebus aethiops (Green monkey)  1
1
EC50 = 55000 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Bezafibrate )
Drug Name Bezafibrate
Indication
Hyperlipidaemia
Approved
Target(s)
Peroxisome proliferator-activated receptor alpha (PPARA)
Agonist