Protein Information

General Information of the Protein

Protein ID	PT06084
Protein Name	Very long chain fatty acid elongase 6
Secondarily Protein Name	3-keto acyl-CoA synthase ELOVL6 ELOVL fatty acid elongase 6 Elongation of very long chain fatty acids protein 6 Fatty acid elongase 2 Fatty acyl-CoA elongase Long-chain fatty-acyl elongase Very long chain 3-ketoacyl-CoA synthase 6 Very long chain 3-oxoacyl-CoA synthase 6
Gene Name	ELOVL6
Secondarily Gene Name	FACE LCE
Sequence	MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMVYILMTKGLKQSVCDQGFYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVVNYLVFCWMQHDQCHSHFQNIFWSSLMYLSYLVLFCHFFFEAYIGKMRKTTKAE Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Transferase
Function	Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Show/Hide
Uniprot ID	Primary ID: Q9H5J4 Secondarily ID: Q4W5L0 Q8NCD1 Show/Hide
Ensembl ID	ENSG00000170522
HGNC ID	HGNC:15829
Subcellular Location	Endoplasmic reticulum membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000053 , COS-7

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0495958 Compound Info	3-[2-(4-methyllphenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C28H26F3N3O3	1
1	IC50 = 8.7 nM Bioactivity Info	TI LI LO TS
CP0428615 Compound Info	6,6-dimethyl-3-{5-methyl-3-oxo-2-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-pyrazol-4-yl}-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C28H23F6N3O4	1
1	IC50 = 8.9 nM Bioactivity Info	TI LI LO TS
CP0504385 Compound Info	3-[2-(4-isopropylphenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C30H30F3N3O3	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0480497 Compound Info	3-[2-(4-chlorophenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C27H23ClF3N3O3	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0515764 Compound Info	3-[2-(4-cyanophenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C28H23F3N4O3	1
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0485234 Compound Info	3-[2-(4-methoxyphenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C28H26F3N3O4	1
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0480498 Compound Info	3-[2-(3-methoxyphenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C28H26F3N3O4	1
1	IC50 = 43 nM Bioactivity Info	TI LI LO TS
CP0494642 Compound Info	3-[2-(4-fluorophenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C27H23F4N3O3	1
1	IC50 = 44 nM Bioactivity Info	TI LI LO TS
CP0510537 Compound Info	3-[2-(3-chlorophenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C27H23ClF3N3O3	1
1	IC50 = 44 nM Bioactivity Info	TI LI LO TS
CP0504384 Compound Info	3-[2-(2-methoxyphenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C28H26F3N3O4	1
1	IC50 = 58 nM Bioactivity Info	TI LI LO TS
CP0469714 Compound Info	(1R,4S,6R*)-(+/-)-N-[4-(Propan-2-yloxy)phenyl]-2-(thiophen-3-ylsulfonyl)-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C21H26N2O4S2	1
1	IC50 = 67 nM Bioactivity Info	TI LI LO TS
CP0545688 Compound Info	(1R,4S,6R*)-(+/-)-2-(Phenylsulfonyl)-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C23H28N2O4S	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0491267 Compound Info	(1R,4S,6R*)-(+/-)-N-[4-(Propan-2-yloxy)phenyl]-2-(pyridin-3-ylsulfonyl)-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C22H27N3O4S	1
1	IC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0494638 Compound Info	3-(5-ethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C28H26F3N3O3	1
1	IC50 = 99 nM Bioactivity Info	TI LI LO TS
CP0498775 Compound Info	(1R,4S,6R*)-(+/-)-2-[(3-Fluorophenyl)sulfonyl]-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C23H27FN2O4S	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0447933 Compound Info	(1R,4S,6R*)-(+/-)-2-(Butylsulfonyl)-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C21H32N2O4S	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0508057 Compound Info	(1R,4S,6R*)-(+/-)-N-[4-(Propan-2-yloxy)phenyl]-2-(pyridin-2-ylsulfonyl)-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C22H27N3O4S	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0494640 Compound Info	3'-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1'-phenyl-3'-(trifluoromethyl)-3',7'-dihydrospiro[cyclobutane-1,6'-indole]-2',4'(1'H,5'H)-dione Show/Hide	C28H24F3N3O3	1
1	IC50 = 123 nM Bioactivity Info	TI LI LO TS
CP0541186 Compound Info	(1R,4S,6R*)-(+/-)-2-[(2-Fluorophenyl)sulfonyl]-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C23H27FN2O4S	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0511922 Compound Info	1-cyclopropyl-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C24H24F3N3O3	1
1	IC50 = 144 nM Bioactivity Info	TI LI LO TS
CP0495956 Compound Info	6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-propyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C24H26F3N3O3	1
1	IC50 = 185 nM Bioactivity Info	TI LI LO TS
CP0459206 Compound Info	(1R,4S,6R*)-(+/-)-2-[(4-Fluorophenyl)sulfonyl]-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C23H27FN2O4S	1
1	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0494643 Compound Info	6,6-dimethyl-3-[5-methyl-3-oxo-2-(4-phenoxyphenyl)-2,3-dihydro-1H-pyrazol-4-yl]-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C33H28F3N3O4	1
1	IC50 = 196 nM Bioactivity Info	TI LI LO TS
CP0504381 Compound Info	1-cyclohexyl-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C27H30F3N3O3	1
1	IC50 = 210 nM Bioactivity Info	TI LI LO TS
CP0545687 Compound Info	(1R,4S,6R*)-(+/-)-N-[4-(Propan-2-yloxy)phenyl]-2-(propylsulfonyl)-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C20H30N2O4S	1
1	IC50 = 210 nM Bioactivity Info	TI LI LO TS
CP0494637 Compound Info	1-(3-methoxyphenyl)-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C28H26F3N3O4	1
1	IC50 = 226 nM Bioactivity Info	TI LI LO TS
CP0508058 Compound Info	(1R,4S,6R*)-(+/-)-2-[(1-Methyl-1H-imidazol-4-yl)sulfonyl]-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C21H28N4O4S	1
1	IC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0428613 Compound Info	1-(3-chlorophenyl)-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C27H23ClF3N3O3	1
1	IC50 = 245 nM Bioactivity Info	TI LI LO TS
CP0547253 Compound Info	1-cyclobutyl-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C25H26F3N3O3	1
1	IC50 = 271 nM Bioactivity Info	TI LI LO TS
CP0443407 Compound Info	6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C27H24F3N3O3	1
1	IC50 = 290 nM Bioactivity Info	TI LI LO TS
CP0508056 Compound Info	(1R,4S,6R*)-(+/-)-N-[4-(Propan-2-yloxy)phenyl]-2-(thiophen-2-ylsulfonyl)-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C21H26N2O4S2	1
1	IC50 = 320 nM Bioactivity Info	TI LI LO TS
CP0494635 Compound Info	1-cyclopentyl-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C26H28F3N3O3	1
1	IC50 = 411 nM Bioactivity Info	TI LI LO TS
CP0501454 Compound Info	(1R,4S,6R*)-(+/-)-2-(Butylsulfonyl)-N-[4-(trifluoromethoxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C19H25F3N2O4S	1
1	IC50 = 510 nM Bioactivity Info	TI LI LO TS
CP0547252 Compound Info	1,6,6-trimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C22H22F3N3O3	1
1	IC50 = 520 nM Bioactivity Info	TI LI LO TS
CP0495957 Compound Info	1-ethyl-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C23H24F3N3O3	1
1	IC50 = 550 nM Bioactivity Info	TI LI LO TS
CP0504382 Compound Info	1-(4-methoxyphenyl)-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C28H26F3N3O4	1
1	IC50 = 566 nM Bioactivity Info	TI LI LO TS
CP0502375 Compound Info	1-isopropyl-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C24H26F3N3O3	1
1	IC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0459205 Compound Info	(1R,4S,6R*)-(+/-)-2-[(3-Methoxyphenyl)sulfonyl]-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C24H30N2O5S	1
1	IC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0443406 Compound Info	1-(4-chlorophenyl)-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C27H23ClF3N3O3	1
1	IC50 = 603 nM Bioactivity Info	TI LI LO TS
CP0374000 Compound Info	(1R,4S,6R*)-(+/-)-2-[(4-Methoxyphenyl)sulfonyl]-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C24H30N2O5S	1
1	IC50 = 610 nM Bioactivity Info	TI LI LO TS
CP0459204 Compound Info	(1R,4S,6R*)-(+/-)-N-[4-(Propan-2-yloxy)phenyl]-2-(propan-2-ylsulfonyl)-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C20H30N2O4S	1
1	IC50 = 620 nM Bioactivity Info	TI LI LO TS
CP0505598 Compound Info	6-methyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C26H22F3N3O3	1
1	IC50 = 704 nM Bioactivity Info	TI LI LO TS
CP0496214 Compound Info	(1R,4S,6R*)-(+/-)-2-(Butylsulfonyl)-N-(4-phenoxyphenyl)-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C24H30N2O4S	1
1	IC50 = 710 nM Bioactivity Info	TI LI LO TS
CP0501455 Compound Info	(1R,4S,6R*)-(+/-)-N-(4-Benzylphenyl)-2-(butylsulfonyl)-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C25H32N2O3S	1
1	IC50 = 830 nM Bioactivity Info	TI LI LO TS
CP0437851 Compound Info	1-benzyl-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C28H26F3N3O3	1
1	IC50 = 879 nM Bioactivity Info	TI LI LO TS
CP0373997 Compound Info	(+/-)-1-(Butylsulfonyl)-N-[4-(propan-2-yloxy)phenyl]piperidine-3-carboxamide Show/Hide	C19H30N2O4S	1
1	IC50 = 930 nM Bioactivity Info	TI LI LO TS
CP0373996 Compound Info	(1R,4S,6R*)-(+/-)-2-(Butylsulfonyl)-N-[4-(trifluoromethyl)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C19H25F3N2O3S	1
1	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0502372 Compound Info	6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C21H20F3N3O3	1
1	IC50 = 1710 nM Bioactivity Info	TI LI LO TS
CP0485731 Compound Info	(1R,4S,6R*)-(+/-)-2-(Butylsulfonyl)-N-(4-methoxyphenyl)-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C19H28N2O4S	1
1	IC50 = 1710 nM Bioactivity Info	TI LI LO TS
CP0504383 Compound Info	3-(2,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl)-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C22H22F3N3O3	1
1	IC50 = 2020 nM Bioactivity Info	TI LI LO TS
CP0447938 Compound Info	(1R,4S,6R*)-(+/-)-2-(Butylsulfonyl)-N-(4-methylphenyl)-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C19H28N2O3S	1
1	IC50 = 2300 nM Bioactivity Info	TI LI LO TS
CP0485692 Compound Info	(1R,4S,6R*)-(+/-)-N-[4-(Benzyloxy)phenyl]-2-(butylsulfonyl)-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C25H32N2O4S	1
1	IC50 = 2900 nM Bioactivity Info	TI LI LO TS
CP0500627 Compound Info	(1R,4S,6R*)-(+/-)-2-(Ethylsulfonyl)-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C19H28N2O4S	1
1	IC50 = 2900 nM Bioactivity Info	TI LI LO TS
CP0538104 Compound Info	(1R,4S,6R*)-(+/-)-N-[4-(Propan-2-yloxy)phenyl]-2-{[4-(trifluoromethyl)phenyl]sulfonyl}-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C24H27F3N2O4S	1
1	IC50 = 3500 nM Bioactivity Info	TI LI LO TS
CP0474999 Compound Info	3-[2-(2-chlorophenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C27H23ClF3N3O3	1
1	IC50 = 4330 nM Bioactivity Info	TI LI LO TS
CP0494639 Compound Info	3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C25H20F3N3O3	1
1	IC50 = 4500 nM Bioactivity Info	TI LI LO TS
CP0373999 Compound Info	(1R,2R,5R*)-(+/-)-8-(Butylsulfonyl)-N-[4-(propan-2-yloxy)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxamide Show/Hide	C21H32N2O4S	1
1	IC50 = 5950 nM Bioactivity Info	TI LI LO TS
CP0480495 Compound Info	3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,6-diphenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C31H24F3N3O3	1
1	IC50 = 6260 nM Bioactivity Info	TI LI LO TS
CP0515762 Compound Info	1-(2-methoxyphenyl)-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C28H26F3N3O4	1
1	IC50 = 6340 nM Bioactivity Info	TI LI LO TS
CP0514721 Compound Info	1-(2-chlorophenyl)-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C27H23ClF3N3O3	1
1	IC50 = 6520 nM Bioactivity Info	TI LI LO TS
CP0474998 Compound Info	3-(2-cyclohexyl-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl)-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C27H30F3N3O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0480494 Compound Info	3-(5-isopropyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C29H28F3N3O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0515763 Compound Info	3-(2-isopropyl-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl)-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione Show/Hide	C24H26F3N3O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0374064 Compound Info	(1R,4S,6R*)-(+/-)-2-(Methylsulfonyl)-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C18H26N2O4S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0447936 Compound Info	(1R,4S,6R*)-(+/-)-2-(Butylsulfonyl)-N-(4-fluorophenyl)-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C18H25FN2O3S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0509793 Compound Info	(1R,4S,6R*)-(+/-)-2-[(4-tert-Butylphenyl)sulfonyl]-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide Show/Hide	C27H36N2O4S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000006 , HEK293

Cell Line Info

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT06585	Very long chain fatty acid elongase 6	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han