General Information of the Protein
Protein ID
PT02526
Protein Name
Sodium- and chloride-dependent GABA transporter 3
Secondarily
Protein Name
Solute carrier family 6 member 11
Gene Name
SLC6A11
Secondarily
Gene Name
GABT3
GAT3
Sequence
MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAKLKSDGTIAAITEKETHF
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Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC06 neurotransmitter transporter family
Function
Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:7874447). Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (By similarity).
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Uniprot ID
Primary ID:
P48066

Secondarily ID:
B2R6U6
Q8IYC9
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Ensembl ID
ENSG00000132164
HGNC ID
HGNC:11044
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0081174
 Compound Info 
(S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piperidine-3-carboxylic acid
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C30H35NO6
  1
1
IC50 = 1120 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0390468
 Compound Info 
1-(3-carbazol-9-ylpropyl)-4-(2-methoxyphenyl)piperidin-4-ol
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C27H30N2O2
  1
1
IC50 = 8920 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0860280
 Compound Info 
trans-(1S,2R)-2-amino-1-(carboxymethyl)cyclopropane hydrochloride
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C5H10ClNO2
  1
1
IC50 = 13900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0386952
 Compound Info 
2-[(1S,2S)-2-aminocyclopropyl]acetic acid
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C5H9NO2
  1
1
IC50 = 13900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0041604
 Compound Info 
3-aminopropanoic acidbeta-alanine
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C3H7NO2
  1
1
IC50 = 41200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0059522
 Compound Info 
(R)-Piperidine-3-carboxylic acid
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C6H11NO2
  1
1
IC50 = 51000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0413260
 Compound Info 
(1S,2S,5R)-5-aminobicyclo[3.1.0]hexane-2-carboxylic acid
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C7H11NO2
  1
1
IC50 = 76300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Cell Line ID: CL000386 , Flp-In-CHO
 Cell Line Info 
Cell Line ID: CL000027 , tsA201
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0081174
 Compound Info 
(S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piperidine-3-carboxylic acid
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C30H35NO6
  2
1 IC50 = 5000 nM
2 IC50 = 5011.87 nM
CP0000066
 Compound Info 
4-amino-n-[2,3-3H]butyric acid
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C4H9NO2
  1
1 IC50 = 7000 nM
CP0292269
 Compound Info 
1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid
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C30H35NO6
  1
1 IC50 = 10000 nM
CP0059522
 Compound Info 
(R)-Piperidine-3-carboxylic acid
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C6H11NO2
  1
1 IC50 = 51000 nM
Clinical Information about the Protein
Target 1 ( GABA transporter-3 (SLC6A11) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Inflammatory bowel disease [ICD-11: DD72]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 GSK683699
 Drug Info 
Phase 2
Inflammatory bowel disease
Target 2 ( Gamma-aminobutyric acid transporter 4 (SLC6A11) )
Target Type Literature-reported Target