Protein Information

General Information of the Protein

Protein ID	PT02526
Protein Name	Sodium- and chloride-dependent GABA transporter 3
Secondarily Protein Name	Solute carrier family 6 member 11
Gene Name	SLC6A11
Secondarily Gene Name	GABT3 GAT3
Sequence	MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAKLKSDGTIAAITEKETHF Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Transporter > Electrochemical transporter > SLC superfamily of solute carriers > SLC06 neurotransmitter transporter family
Function	Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:7874447). Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (By similarity). Show/Hide
Uniprot ID	Primary ID: P48066 Secondarily ID: B2R6U6 Q8IYC9 Show/Hide
Ensembl ID	ENSG00000132164
HGNC ID	HGNC:11044
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0081174 Compound Info	(S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piperidine-3-carboxylic acid Show/Hide	C30H35NO6	1
1	IC50 = 1120 nM Bioactivity Info	TI LI LO TS
CP0390468 Compound Info	1-(3-carbazol-9-ylpropyl)-4-(2-methoxyphenyl)piperidin-4-ol Show/Hide	C27H30N2O2	1
1	IC50 = 8920 nM Bioactivity Info	TI LI LO TS
CP0860280 Compound Info	trans-(1S,2R)-2-amino-1-(carboxymethyl)cyclopropane hydrochloride Show/Hide	C5H10ClNO2	1
1	IC50 = 13900 nM Bioactivity Info	TI LI LO TS
CP0386952 Compound Info	2-[(1S,2S)-2-aminocyclopropyl]acetic acid Show/Hide	C5H9NO2	1
1	IC50 = 13900 nM Bioactivity Info	TI LI LO TS
CP0041604 Compound Info	3-aminopropanoic acidbeta-alanine Show/Hide	C3H7NO2	1
1	IC50 = 41200 nM Bioactivity Info	TI LI LO TS
CP0059522 Compound Info	(R)-Piperidine-3-carboxylic acid Show/Hide	C6H11NO2	1
1	IC50 = 51000 nM Bioactivity Info	TI LI LO TS
CP0413260 Compound Info	(1S,2S,5R)-5-aminobicyclo[3.1.0]hexane-2-carboxylic acid Show/Hide	C7H11NO2	1
1	IC50 = 76300 nM Bioactivity Info	TI LI LO TS

Cell Line Info

Cell Line Info

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0081174 Compound Info	(S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piperidine-3-carboxylic acid Show/Hide	C30H35NO6	2
1	IC50 = 5000 nM
2	IC50 = 5011.87 nM
CP0000066 Compound Info	4-amino-n-[2,3-3H]butyric acid Show/Hide	C4H9NO2	1
1	IC50 = 7000 nM
CP0292269 Compound Info	1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid Show/Hide	C30H35NO6	1
1	IC50 = 10000 nM
CP0059522 Compound Info	(R)-Piperidine-3-carboxylic acid Show/Hide	C6H11NO2	1
1	IC50 = 51000 nM

Clinical Information about the Protein

Target 1 ( GABA transporter-3 (SLC6A11) )

Target Type	Clinical trial Target
Disease	1 Target-related Disease				1
1	Inflammatory bowel disease [ICD-11: DD72]
Clinical Trial Drug(s)	1 Clinical Trial Drug				1
1	GSK683699	Drug Info	Phase 2	Inflammatory bowel disease

Target 2 ( Gamma-aminobutyric acid transporter 4 (SLC6A11) )

Target Type	Literature-reported Target