Protein Information

General Information of the Protein

Protein ID	PT01007
Protein Name	Alpha-1B adrenergic receptor
Secondarily Protein Name	Alpha-1B adrenoreceptor
Gene Name	ADRA1B
Sequence	MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Adrenergic receptor
Function	This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. Show/Hide
Uniprot ID	Primary ID: P35368 Secondarily ID: B0LPE1 Show/Hide
HGNC ID	HGNC:278
Subcellular Location	Nucleus membrane Cell membrane Cytoplasm Membrane Caveola

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0386331 Compound Info	2-[4-(1H-pyrazol-5-yl)-2,3-dihydro-1H-inden-1-yl]-1H-imidazole Show/Hide	C15H14N4	1
1	EC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0094131 Compound Info	(S)-6-(2-(pyridin-3-yl)phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C17H15N3	1
1	EC50 = 760 nM Bioactivity Info	TI LI LO TS
CP0394382 Compound Info	2-(1,2,3,4-tetrahydronaphthalen-1-yl)-1H-imidazole Show/Hide	C13H14N2	1
1	EC50 = 791 nM Bioactivity Info	TI LI LO TS
CP0432099 Compound Info	4-[1-(1H-imidazol-2-yl)-2,3-dihydro-1H-inden-4-yl]-5-methyl-1H-pyrazole Show/Hide	C16H16N4	1
1	EC50 = 902 nM Bioactivity Info	TI LI LO TS
CP0374408 Compound Info	2-(2-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-yl)-4-fluorophenyl)oxazole Show/Hide	C15H12FN3O	1
1	EC50 = 990 nM Bioactivity Info	TI LI LO TS
CP0387538 Compound Info	6-(2-chlorophenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C12H11ClN2	1
1	EC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0443477 Compound Info	6-(2-fluorophenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C12H11FN2	1
1	EC50 = 1770 nM Bioactivity Info	TI LI LO TS
CP0070621 Compound Info	2-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-yl)benzonitrile Show/Hide	C13H11N3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0372415 Compound Info	6-phenyl-6,7-di hydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C12H12N2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0372416 Compound Info	6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-1H-benzo[d]imidazole Show/Hide	C14H16N2O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0372418 Compound Info	2-(2,3-dihydro-1H-inden-2-yl)-1H-imidazole Show/Hide	C12H12N2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0381834 Compound Info	6-phenyl-4,5,6,7-tetra hydro-1H-benzo[d]imidazole Show/Hide	C13H14N2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0381836 Compound Info	6-(2-(methoxy methyl)phenyl)-4,5,6,7-tetrahydro-1H-benzo[d]imidazole Show/Hide	C15H18N2O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0387536 Compound Info	6-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine Show/Hide	C13H14N2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0387537 Compound Info	6-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-benzo[d]imidazole Show/Hide	C13H13ClN2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0388057 Compound Info	6-(2-methoxyphenyl)-4,5,6,7-tetrahydro-1H-benzo[d]imidazole Show/Hide	C14H16N2O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0388099 Compound Info	6-(4-chlorophenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C12H11ClN2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0394386 Compound Info	2-(2,3-dihydro-1H-inden-1-yl)-1H-imidazole Show/Hide	C12H12N2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0427948 Compound Info	6-(3-methoxyphenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C13H14N2O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0428546 Compound Info	6-(3-methoxyphenyl)-4,5,6,7-tetrahydro-1H-benzo[d]imidazole Show/Hide	C14H16N2O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0431172 Compound Info	6-(3-chlorophenyl)-4,5,6,7-tetrahydro-1H-benzo[d]imidazole Show/Hide	C13H13ClN2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0443475 Compound Info	6-(2-chlorophenyl)-4,5,6,7-tetrahydro-1H-benzo[d]imidazole Show/Hide	C13H13ClN2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0497555 Compound Info	6-(2-(methoxymethyl)phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C14H16N2O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0040617 Compound Info	6-(4-fluoro-2-(pyrimidin-5-yl)phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C16H13FN4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0040622 Compound Info	6-(5-fluoro-2-(pyrimidin-5-yl)phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C16H13FN4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0070307 Compound Info	(S)-6-(biphenyl-2-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C18H16N2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0070312 Compound Info	(S)-6-(2-(1H-pyrazol-1-yl)phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C15H14N4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0086900 Compound Info	(S)-N-(2'-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-yl)biphenyl-3-yl)methanesulfonamide Show/Hide	C19H19N3O2S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0094129 Compound Info	(R)-2-(2-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-yl)phenyl)oxazole Show/Hide	C15H13N3O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0094133 Compound Info	(S)-2-(2-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-yl)phenyl)-N-methylethanesulfonamide Show/Hide	C15H19N3O2S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0148986 Compound Info	(R)-2-(5-chloro-4-(methoxymethyl)-2,3-dihydro-1H-inden-1-yl)-1H-imidazole Show/Hide	C14H15ClN2O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0152026 Compound Info	6-(4-fluoro-2-(1H-pyrazol-1-yl)phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C15H13FN4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0174601 Compound Info	(S)-2-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-yl)benzonitrile Show/Hide	C13H11N3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0234407 Compound Info	6-(5-fluoro-2-(1H-pyrazol-5-yl)phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C15H13FN4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0278671 Compound Info	6-(5-fluoro-2-(1H-pyrazol-1-yl)phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C15H13FN4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0280468 Compound Info	(S)-2'-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-yl)-N-methylbiphenyl-3-carboxamide Show/Hide	C20H19N3O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0297367 Compound Info	6-(2-fluoro-6-(pyrimidin-5-yl)phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C16H13FN4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0307853 Compound Info	(S)-6-(2-(pyridin-4-yl)phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C17H15N3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0308471 Compound Info	6-(4-fluoro-2-(1H-pyrazol-5-yl)phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C15H13FN4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0374403 Compound Info	2-(2-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-yl)-5-fluorophenyl)oxazole Show/Hide	C15H12FN3O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0039841 Compound Info	ABT-866 Show/Hide	C12H15N3O2S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0162054 Compound Info	N-[2-chloro-5-(1H-imidazol-2-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide Show/Hide	C14H16ClN3O2S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0386328 Compound Info	2-(5-chloro-4-methoxy-2,3-dihydro-1H-inden-1-yl)-1H-imidazole Show/Hide	C13H13ClN2O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0386330 Compound Info	N-[5-(1H-imidazol-2-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide Show/Hide	C14H17N3O2S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0386334 Compound Info	N-[1-(1H-imidazol-2-yl)-2,3-dihydro-1H-inden-4-yl]ethanesulfonamide Show/Hide	C14H17N3O2S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0386335 Compound Info	N-[1-(1H-imidazol-2-yl)-2,3-dihydro-1H-inden-4-yl]methanesulfonamide Show/Hide	C13H15N3O2S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0386337 Compound Info	1-(1H-imidazol-2-yl)-N-methyl-2,3-dihydro-1H-indene-4-carboxamide Show/Hide	C14H15N3O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0386339 Compound Info	2-[5-chloro-4-(1H-pyrazol-5-yl)-2,3-dihydro-1H-inden-1-yl]-1H-imidazole Show/Hide	C15H13ClN4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0386341 Compound Info	2-(5-chloro-4-(1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-yl)-1H-imidazole Show/Hide	C15H13ClN4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0386402 Compound Info	N-[1-(1H-imidazol-2-yl)-2,3-dihydro-1H-inden-4-yl]propane-1-sulfonamide Show/Hide	C15H19N3O2S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0394385 Compound Info	2-[1-(1H-imidazol-2-yl)-2,3-dihydro-1H-inden-4-yl]pyridine Show/Hide	C17H15N3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0394388 Compound Info	2-[1-(1H-imidazol-2-yl)-2,3-dihydro-1H-inden-4-yl]-1,3-oxazole Show/Hide	C15H13N3O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0394391 Compound Info	3-[1-(1H-imidazol-2-yl)-2,3-dihydro-1H-inden-4-yl]pyridine Show/Hide	C17H15N3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0399603 Compound Info	2-[4-(1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-yl]-1H-imidazole Show/Hide	C15H14N4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0412851 Compound Info	4-[1-(1H-imidazol-2-yl)-2,3-dihydro-1H-inden-4-yl]-1-methylpyrazole Show/Hide	C16H16N4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0412854 Compound Info	3-[1-(1H-imidazol-2-yl)-2,3-dihydro-1H-inden-4-yl]-1-methylpyrazole Show/Hide	C16H16N4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0412855 Compound Info	5-[1-(1H-imidazol-2-yl)-2,3-dihydro-1H-inden-4-yl]-1-methylpyrazole Show/Hide	C16H16N4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0412856 Compound Info	N-[1-(1H-imidazol-2-yl)-5-methyl-2,3-dihydro-1H-inden-4-yl]methanesulfonamide Show/Hide	C14H17N3O2S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0412857 Compound Info	N-[6-chloro-3-(4,5-dihydro-1H-imidazol-2-ylmethoxy)-2-methylphenyl]methanesulfonamide Show/Hide	C12H16ClN3O3S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0412860 Compound Info	2-[1-(1H-imidazol-2-yl)-2,3-dihydro-1H-inden-4-yl]-1,3-thiazole Show/Hide	C15H13N3S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0432098 Compound Info	2-(4-methoxy-2,3-dihydro-1H-inden-1-yl)-1H-imidazole Show/Hide	C13H14N2O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0433560 Compound Info	4-[1-(1H-imidazol-2-yl)-2,3-dihydro-1H-inden-4-yl]-5-methyl-1,2-oxazole Show/Hide	C16H15N3O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0433564 Compound Info	2-(4-methoxy-5-methyl-2,3-dihydro-1H-inden-1-yl)-1H-imidazole Show/Hide	C14H16N2O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0316893 Compound Info	(S)-2-(2-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-yl)phenyl)oxazole Show/Hide	C15H13N3O	1
1	EC50 > 1400 nM Bioactivity Info	TI LI LO TS
CP0148987 Compound Info	(S)-6-(2-(pyrimidin-5-yl)phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole Show/Hide	C16H14N4	1
1	EC50 > 6500 nM Bioactivity Info	TI LI LO TS
CP0381815 Compound Info	3-[4-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazine-1-carbonyl]triazol-1-yl]-7-(diethylamino)chromen-2-one Show/Hide	C30H33N9O5	2
1	IC50 = 1.2 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.1 nM Bioactivity Info	TI LI LO TS
CP0381526 Compound Info	3-[4-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazine-1-carbonyl]triazol-1-yl]-7-hydroxychromen-2-one Show/Hide	C26H24N8O6	1
1	IC50 < 5 nM Bioactivity Info	TI LI LO TS
CP0415132 Compound Info	3-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazine-1-carbonyl]-7-hydroxychromen-2-one Show/Hide	C24H23N5O6	1
1	IC50 < 5 nM Bioactivity Info	TI LI LO TS
CP0072943 Compound Info	3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)amino]phenol;methanesulfonic acid Show/Hide	C17H19N3O	3
1	IC50 = 10.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 4.8 nM Bioactivity Info	TI LI LO TS
3	Ki = 47.4 nM Bioactivity Info	TI LI LO TS
CP0381531 Compound Info	5-[[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazine-1-carbothioyl]amino]-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid Show/Hide	C35H30N6O7S	2
1	IC50 = 16.3 nM Bioactivity Info	TI LI LO TS
2	Ki = 7.3 nM Bioactivity Info	TI LI LO TS
CP0381529 Compound Info	3-[4-[[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]methyl]triazol-1-yl]-7-(diethylamino)chromen-2-one Show/Hide	C30H35N9O4	2
1	IC50 = 52.4 nM Bioactivity Info	TI LI LO TS
2	Ki = 29.9 nM Bioactivity Info	TI LI LO TS
CP0377739 Compound Info	[(6aR)-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-yl] 5-(dithiolan-3-yl)pentanoate Show/Hide	C27H33NO2S2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0082953 Compound Info	2,3-dihydro-1,4-benzodioxin-3-ylmethyl-[2-(2,6-dimethoxyphenoxy)ethyl]amine;hydrochloride Show/Hide	C19H23NO5	3
1	Ki = 0.038 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.90309 nM Bioactivity Info	TI LI LO TS
3	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0854007 Compound Info	[2-(2,6-Dimethoxy-phenoxy)-ethyl]-(4-phenyl-chroman-2-ylmethyl)-amine Show/Hide	C26H29NO4	1
1	Ki = 0.03981 nM Bioactivity Info	TI LI LO TS
CP0210810 Compound Info	[(4aS,8aR)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(furan-2-yl)methanone Show/Hide	C23H27N5O4	1
1	Ki = 0.07079 nM Bioactivity Info	TI LI LO TS
CP0495472 Compound Info	N-[6-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]hexyl]-N-methylfuran-2-carboxamide Show/Hide	C23H31N5O4	1
1	Ki = 0.1096 nM Bioactivity Info	TI LI LO TS
CP0475365 Compound Info	[(4aS,8aR)-4-[4-(dipropylamino)-6,7-dimethoxyquinazolin-2-yl]-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(furan-2-yl)methanone Show/Hide	C29H39N5O4	1
1	Ki = 0.1288 nM Bioactivity Info	TI LI LO TS
CP0097484 Compound Info	CYCLAZOSIN Show/Hide	C23H27N5O4	2
1	Ki = 0.1349 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.3236 nM Bioactivity Info	TI LI LO TS
CP0519946 Compound Info	1-[(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-2-(2-methoxy-6-propan-2-ylphenoxy)ethanone Show/Hide	C30H39N5O5	1
1	Ki = 0.1514 nM Bioactivity Info	TI LI LO TS
CP0163564 Compound Info	2-[2-[(3-chlorophenyl)methoxy]phenoxy]-N-[2-(2,6-dimethoxyphenoxy)ethyl]ethanamine Show/Hide	C25H28ClNO5	1
1	Ki = 0.1585 nM Bioactivity Info	TI LI LO TS
CP0879010 Compound Info	N-{6-[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]-hexyl}-3-dimethylaminomethyl-N-methyl-benzamide Show/Hide	C28H40N6O3	1
1	Ki = 0.166 nM Bioactivity Info	TI LI LO TS
CP0410683 Compound Info	benzyl (4aS,8aR)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxylate Show/Hide	C26H31N5O4	1
1	Ki = 0.1905 nM Bioactivity Info	TI LI LO TS
CP0882784 Compound Info	(+)-6,7-dimethoxy-2-[(4aS,8aR)-4-(2-thienylcarbonyl)octahydroquinoxalin-1(2H)-yl]quinazolin-4-amine Show/Hide	C23H27N5O3S	1
1	Ki = 0.2399 nM Bioactivity Info	TI LI LO TS
CP0105052 Compound Info	N-[2-(2,6-dimethoxyphenoxy)ethyl]-2-[2-[(4-methylphenyl)methoxy]phenoxy]ethanamine Show/Hide	C26H31NO5	1
1	Ki = 0.2512 nM Bioactivity Info	TI LI LO TS
CP0370354 Compound Info	N-[2-(2,6-dimethoxyphenoxy)ethyl]-2-[2-[(3-methylphenyl)methoxy]phenoxy]ethanamine Show/Hide	C26H31NO5	1
1	Ki = 0.2512 nM Bioactivity Info	TI LI LO TS
CP0040814 Compound Info	[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone Show/Hide	C19H21N5O4	2
1	Ki = 0.28 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.4074 nM Bioactivity Info	TI LI LO TS
CP0386945 Compound Info	N-[(3S)-1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-3-yl]furan-2-carboxamide Show/Hide	C20H23N5O4	1
1	Ki = 0.2818 nM Bioactivity Info	TI LI LO TS
CP0410713 Compound Info	[(4aR,8aS)-4-[4-(dipropylamino)-6,7-dimethoxyquinazolin-2-yl]-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(furan-2-yl)methanone Show/Hide	C29H39N5O4	1
1	Ki = 0.302 nM Bioactivity Info	TI LI LO TS
CP0862789 Compound Info	1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-2-[1,2]dithiolan-3-yl-ethanone Show/Hide	C19H25N5O3S2	1
1	Ki = 0.309 nM Bioactivity Info	TI LI LO TS
CP0872936 Compound Info	(+)-2-[(4aS,8aR)-4-(5-bromo-2-furoyl)octahydroquinoxalin-1(2H)-yl]-6,7-dimethoxyquinazolin-4-amine Show/Hide	C23H26BrN5O4	1
1	Ki = 0.309 nM Bioactivity Info	TI LI LO TS
CP0483083 Compound Info	benzyl (4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxylate Show/Hide	C26H31N5O4	1
1	Ki = 0.3802 nM Bioactivity Info	TI LI LO TS
CP0180112 Compound Info	N-[2-(2,6-dimethoxyphenoxy)ethyl]-2-[2-[(4-nitrophenyl)methoxy]phenoxy]ethanamine Show/Hide	C25H28N2O7	1
1	Ki = 0.3981 nM Bioactivity Info	TI LI LO TS
CP0316444 Compound Info	N-[2-(2,6-dimethoxyphenoxy)ethyl]-2-[2-[(4-methoxyphenyl)methoxy]phenoxy]ethanamine Show/Hide	C26H31NO6	1
1	Ki = 0.3981 nM Bioactivity Info	TI LI LO TS
CP0327530 Compound Info	[(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone Show/Hide	C27H31N5O5	1
1	Ki = 0.4169 nM Bioactivity Info	TI LI LO TS
CP0872837 Compound Info	(+)-2-[(4aS,8aR)-4-benzoyloctahydroquinoxalin-1(2H)-yl]-6,7-dimethoxyquinazolin-4-amine Show/Hide	C25H29N5O3	1
1	Ki = 0.4898 nM Bioactivity Info	TI LI LO TS
CP0375896 Compound Info	N-[2-(2,6-dimethoxyphenyl)sulfanylethyl]-2-(2-phenylmethoxyphenoxy)ethanamine Show/Hide	C25H29NO4S	1
1	Ki = 0.5012 nM Bioactivity Info	TI LI LO TS
CP0412412 Compound Info	2-[[(3S)-1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-3-yl]amino]naphthalene-1,4-dione Show/Hide	C25H25N5O4	1
1	Ki = 0.5248 nM Bioactivity Info	TI LI LO TS
CP0847183 Compound Info	[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-[1,2]dithiolan-3-yl-methanone Show/Hide	C18H23N5O3S2	1
1	Ki = 0.537 nM Bioactivity Info	TI LI LO TS
CP0316443 Compound Info	N-[2-(2,6-dimethoxyphenoxy)ethyl]-2-(2-phenylmethoxyphenoxy)ethanamine Show/Hide	C25H29NO5	2
1	Ki = 0.537 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.96708 nM Bioactivity Info	TI LI LO TS
CP0184026 Compound Info	2-[2-[(2-chlorophenyl)methoxy]phenoxy]-N-[2-(2,6-dimethoxyphenoxy)ethyl]ethanamine Show/Hide	C25H28ClNO5	1
1	Ki = 0.5623 nM Bioactivity Info	TI LI LO TS
CP0035002 Compound Info	(R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide Show/Hide	C20H28N2O5S	1
1	Ki = 0.631 nM Bioactivity Info	TI LI LO TS
CP0048996 Compound Info	CAS_74191-85-8 Show/Hide	C23H25N5O5	2
1	Ki = 0.631 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.8128 nM Bioactivity Info	TI LI LO TS
CP0247776 Compound Info	2-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-[1,4]naphthoquinone Show/Hide	C24H23N5O4	1
1	Ki = 0.6761 nM Bioactivity Info	TI LI LO TS
CP0519947 Compound Info	1-[(4aS,8aR)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]ethanone Show/Hide	C20H27N5O3	1
1	Ki = 0.7413 nM Bioactivity Info	TI LI LO TS
CP0446806 Compound Info	1-[(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-2,2-dimethylpropan-1-one Show/Hide	C23H33N5O3	1
1	Ki = 0.7762 nM Bioactivity Info	TI LI LO TS
CP0404407 Compound Info	2-[[2-(2,6-dimethoxyphenoxy)ethylamino]methyl]-3-phenyl-3,4-dihydro-2H-naphthalen-1-one Show/Hide	C27H29NO4	1
1	Ki = 0.786041 nM Bioactivity Info	TI LI LO TS
CP0105050 Compound Info	N-[2-(2,6-dimethoxyphenoxy)ethyl]-2-[2-[(3-nitrophenyl)methoxy]phenoxy]ethanamine Show/Hide	C25H28N2O7	1
1	Ki = 0.7943 nM Bioactivity Info	TI LI LO TS
CP0254827 Compound Info	N-[2-(2,6-dimethoxyphenoxy)ethyl]-2-[2-[(2-methylphenyl)methoxy]phenoxy]ethanamine Show/Hide	C26H31NO5	1
1	Ki = 0.7943 nM Bioactivity Info	TI LI LO TS
CP0416569 Compound Info	N-[2-(2,6-diethoxyphenoxy)ethyl]-2-(2-phenylmethoxyphenoxy)ethanamine Show/Hide	C27H33NO5	1
1	Ki = 0.7943 nM Bioactivity Info	TI LI LO TS
CP0404393 Compound Info	2-(2,6-dimethoxyphenoxy)-N-[(3-phenyl-3,4-dihydro-2H-chromen-2-yl)methyl]ethanamine Show/Hide	C26H29NO4	1
1	Ki = 0.818226 nM Bioactivity Info	TI LI LO TS
CP0441147 Compound Info	3-[[2-(2,6-dimethoxyphenoxy)ethylamino]methyl]-2-phenyl-2,3-dihydrochromen-4-one Show/Hide	C26H27NO5	1
1	Ki = 0.835056 nM Bioactivity Info	TI LI LO TS
CP0475824 Compound Info	2-(2,6-dimethoxyphenoxy)-N-[(2-phenyl-2H-chromen-3-yl)methyl]ethanamine Show/Hide	C26H27NO4	1
1	Ki = 0.835056 nM Bioactivity Info	TI LI LO TS
CP0872835 Compound Info	(+)-6,7-dimethoxy-2-[(4aS,8aR)-4-(5-methoxy-2-furoyl)octahydroquinoxalin-1(2H)-yl]quinazolin-4-amine Show/Hide	C24H29N5O5	1
1	Ki = 0.871 nM Bioactivity Info	TI LI LO TS
CP0882785 Compound Info	(+)-6,7-dimethoxy-2-[(4aS,8aR)-4-(5-methyl-2-furoyl)octahydroquinoxalin-1(2H)-yl]quinazolin-4-amine Show/Hide	C24H29N5O4	1
1	Ki = 0.871 nM Bioactivity Info	TI LI LO TS
CP0390476 Compound Info	1-[(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]hexan-1-one Show/Hide	C24H35N5O3	1
1	Ki = 0.912 nM Bioactivity Info	TI LI LO TS
CP0421980 Compound Info	N-[6-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]hexyl]-N-methyl-2,3-dihydro-1,4-benzodioxine-3-carboxamide Show/Hide	C27H35N5O5	1
1	Ki = 0.9333 nM Bioactivity Info	TI LI LO TS
CP0042265 Compound Info	2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-isoindole-1,3-dione Show/Hide	C23H27N3O3	1
1	Ki = 0.96 nM Bioactivity Info	TI LI LO TS
CP0184024 Compound Info	Clopenphendioxan Show/Hide	C25H28ClNO5	1
1	Ki = 1 nM Bioactivity Info	TI LI LO TS
CP0422260 Compound Info	N-[2-[2-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]ethyldisulfanyl]ethyl]-N-methylfuran-2-carboxamide Show/Hide	C21H27N5O4S2	1
1	Ki = 1.072 nM Bioactivity Info	TI LI LO TS
CP0845244 Compound Info	[2-(2,6-Dimethoxy-phenoxy)-ethyl]-(4-phenyl-thiochroman-2-ylmethyl)-amine Show/Hide	C26H29NO3S	1
1	Ki = 1.148 nM Bioactivity Info	TI LI LO TS
CP0495611 Compound Info	1-[(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-2-naphthalen-2-ylethanone Show/Hide	C30H33N5O3	1
1	Ki = 1.175 nM Bioactivity Info	TI LI LO TS
CP0505188 Compound Info	3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid (3-{4-[2-(3-nitrooxy-propoxy)-phenyl]-piperazin-1-yl}-propyl)-amide Show/Hide	C33H36N4O7	1
1	Ki = 1.2 nM Bioactivity Info	TI LI LO TS
CP0861076 Compound Info	2-{[2-(2,6-Dimethoxy-phenoxy)-ethylamino]-methyl}-4-phenyl-3,4-dihydro-2H-naphthalen-1-one Show/Hide	C27H29NO4	1
1	Ki = 1.23 nM Bioactivity Info	TI LI LO TS
CP0855768 Compound Info	1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-5-[1,2]dithiolan-3-yl-pentan-1-one Show/Hide	C22H31N5O3S2	1
1	Ki = 1.259 nM Bioactivity Info	TI LI LO TS
CP0882786 Compound Info	(+)-1-(5-{[(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)octahydroquinoxalin-1(2H)-yl]carbonyl}-2-furyl)ethanone Show/Hide	C25H29N5O5	1
1	Ki = 1.38 nM Bioactivity Info	TI LI LO TS
CP0421978 Compound Info	[(4aS,8aR)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone Show/Hide	C27H31N5O5	1
1	Ki = 1.413 nM Bioactivity Info	TI LI LO TS
CP0437539 Compound Info	2-methoxy-5-[(2R)-2-[2-(2-propan-2-yloxyphenoxy)ethylamino]propyl]benzenesulfonamide Show/Hide	C21H30N2O5S	1
1	Ki = 1.905 nM Bioactivity Info	TI LI LO TS
CP0126496 Compound Info	N-[2-(2,6-dimethoxyphenoxy)ethyl]-2-[2-[(3-methoxyphenyl)methoxy]phenoxy]ethanamine Show/Hide	C26H31NO6	1
1	Ki = 1.995 nM Bioactivity Info	TI LI LO TS
CP0376824 Compound Info	2-methoxy-5-[(2R)-2-[2-(2-phenylmethoxyphenoxy)ethylamino]propyl]benzenesulfonamide Show/Hide	C25H30N2O5S	1
1	Ki = 2.089 nM Bioactivity Info	TI LI LO TS
CP0912440 Compound Info	(S)-2-[((2-(2,6-Dimethoxyphenoxy)ethyl)amino)methyl]-8-chloro-1,4-benzodioxane hydrochloride Show/Hide	C19H23Cl2NO5	1
1	Ki = 2.188 nM Bioactivity Info	TI LI LO TS
CP0910843 Compound Info	(S)-2-(2,6-dimethoxyphenoxy)-N-((8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)ethanamine hydrochloride Show/Hide	C19H23ClFNO5	1
1	Ki = 2.399 nM Bioactivity Info	TI LI LO TS
CP0289979 Compound Info	N-[2-(2,6-dimethoxyphenoxy)ethyl]-2-[2-[(2-nitrophenyl)methoxy]phenoxy]ethanamine Show/Hide	C25H28N2O7	1
1	Ki = 2.512 nM Bioactivity Info	TI LI LO TS
CP0943167 Compound Info	(S)-2-(2,6-dimethoxyphenoxy)-N-((8-methoxy-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)ethanamine hydrochloride Show/Hide	C20H26ClNO6	1
1	Ki = 2.754 nM Bioactivity Info	TI LI LO TS
CP0892862 Compound Info	[2-(2-Benzyl-phenoxy)-ethyl]-[2-(2,6-dimethoxy-phenoxy)-ethyl]-amine Show/Hide	C25H29NO4	1
1	Ki = 2.818 nM Bioactivity Info	TI LI LO TS
CP0882783 Compound Info	(+)-6,7-dimethoxy-2-[(4aS,8aR)-4-(1H-pyrrol-2-ylcarbonyl)octahydroquinoxalin-1(2H)-yl]quinazolin-4-amine Show/Hide	C23H28N6O3	1
1	Ki = 3.162 nM Bioactivity Info	TI LI LO TS
CP0405415 Compound Info	5-[(1S,1aR,6aS)-1-propyl-1a,6-dihydro-1H-cyclopropa[a]inden-6a-yl]-1H-imidazole Show/Hide	C16H18N2	1
1	Ki = 3.548 nM Bioactivity Info	TI LI LO TS
CP0345915 Compound Info	3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid {3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-amide Show/Hide	C31H33N3O4	1
1	Ki = 3.9 nM Bioactivity Info	TI LI LO TS
CP0442589 Compound Info	3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid (3-{4-[2-(4-methyl-5-oxy-furazan-3-ylmethoxy)-phenyl]-piperazin-1-yl}-propyl)-amide Show/Hide	C34H35N5O6	1
1	Ki = 4.7 nM Bioactivity Info	TI LI LO TS
CP0386458 Compound Info	N-[2-(2-methoxy-6-nitrophenoxy)ethyl]-2-(2-phenylmethoxyphenoxy)ethanamine Show/Hide	C24H26N2O6	1
1	Ki = 5.012 nM Bioactivity Info	TI LI LO TS
CP0416570 Compound Info	N-[2-(2-methoxy-6-methylphenoxy)ethyl]-2-(2-phenylmethoxyphenoxy)ethanamine Show/Hide	C25H29NO4	1
1	Ki = 5.012 nM Bioactivity Info	TI LI LO TS
CP0068100 Compound Info	1-[2-(1,3-benzodioxol-5-yl)ethyl]-4-(2-methoxyphenyl)piperazine Show/Hide	C20H24N2O3	1
1	Ki = 5.248 nM Bioactivity Info	TI LI LO TS
CP0307245 Compound Info	1-[2-(1,3-benzodioxol-5-yl)ethyl]-4-(2-ethoxyphenyl)piperazine Show/Hide	C21H26N2O3	1
1	Ki = 5.37 nM Bioactivity Info	TI LI LO TS
CP0472991 Compound Info	2-methoxy-5-[(2R)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]benzenesulfonamide Show/Hide	C20H25F3N2O5S	1
1	Ki = 5.495 nM Bioactivity Info	TI LI LO TS
CP0847195 Compound Info	(S)-N-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-2-(2,6-dimethoxyphenoxy)ethanamine hydrochloride Show/Hide	C19H24ClNO5	1
1	Ki = 5.754 nM Bioactivity Info	TI LI LO TS
CP0433386 Compound Info	N-[[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-2-(2,6-dimethoxyphenoxy)ethanamine Show/Hide	C19H23NO5	1
1	Ki = 5.754 nM Bioactivity Info	TI LI LO TS
CP0846086 Compound Info	(S)-N-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-2-(2,6-dimethoxyphenoxy)ethanamine oxalate Show/Hide	C21H25NO9	1
1	Ki = 5.754 nM Bioactivity Info	TI LI LO TS
CP0858962 Compound Info	(+)-6,7-dimethoxy-2-[(4aS,8aR)-4-(pyridin-2-ylcarbonyl)octahydroquinoxalin-1(2H)-yl]quinazolin-4-amine Show/Hide	C24H28N6O3	1
1	Ki = 5.888 nM Bioactivity Info	TI LI LO TS
CP0411936 Compound Info	5-[(1aR,6S,6aR)-6-methyl-1a,6-dihydro-1H-cyclopropa[a]inden-6a-yl]-1H-imidazole Show/Hide	C14H14N2	1
1	Ki = 6.166 nM Bioactivity Info	TI LI LO TS
CP0254826 Compound Info	N-[2-(2,6-dimethoxyphenoxy)ethyl]-2-[2-[(2-methoxyphenyl)methoxy]phenoxy]ethanamine Show/Hide	C26H31NO6	1
1	Ki = 6.31 nM Bioactivity Info	TI LI LO TS
CP0494781 Compound Info	3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid (3-{4-[2-(4-cyano-5-oxy-furazan-3-ylmethoxy)-phenyl]-piperazin-1-yl}-propyl)-amide Show/Hide	C34H32N6O6	1
1	Ki = 6.5 nM Bioactivity Info	TI LI LO TS
CP0288408 Compound Info	1-[(4,4-diphenyl-1,3-dioxolan-2-yl)methyl]-4-(2-methoxyphenyl)piperazine Show/Hide	C27H30N2O3	1
1	Ki = 6.761 nM Bioactivity Info	TI LI LO TS
CP0859288 Compound Info	1-((2,2-diphenyl-1,3-dioxolan-4-yl)methyl)-4-(2-methoxyphenyl)piperazine oxalate Show/Hide	C29H32N2O7	1
1	Ki = 6.761 nM Bioactivity Info	TI LI LO TS
CP0375932 Compound Info	3-(2,6-dimethoxyphenyl)-N-[2-(2-phenylmethoxyphenoxy)ethyl]propan-1-amine Show/Hide	C26H31NO4	1
1	Ki = 6.918 nM Bioactivity Info	TI LI LO TS
CP0460833 Compound Info	N-[(9-amino-6,7-dimethoxy-1,2,3,4-tetrahydroacridin-3-yl)methyl]-2-(trifluoromethyl)benzamide Show/Hide	C24H24F3N3O3	1
1	Ki = 7.413 nM Bioactivity Info	TI LI LO TS
CP0558773 Compound Info	(3S)-N-[(3S)-1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-3-yl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide Show/Hide	C24H27N5O5	1
1	Ki = 7.413 nM Bioactivity Info	TI LI LO TS
CP0411964 Compound Info	N-[2-(2-chloro-6-methoxyphenoxy)ethyl]-2-(2-phenylmethoxyphenoxy)ethanamine Show/Hide	C24H26ClNO4	1
1	Ki = 7.943 nM Bioactivity Info	TI LI LO TS
CP0688480 Compound Info	2-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}-8-(4-methylbenzenesulfonyl)-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C26H35N3O5S	1
1	Ki = 8.318 nM Bioactivity Info	TI LI LO TS
CP0126495 Compound Info	N-[(9-amino-6,7-dimethoxy-1,2,3,4-tetrahydroacridin-3-yl)methyl]-4-(trifluoromethyl)benzamide Show/Hide	C24H24F3N3O3	1
1	Ki = 8.913 nM Bioactivity Info	TI LI LO TS
CP0374188 Compound Info	5-[(1aR,6S,6aS)-6-propyl-1a,6-dihydro-1H-cyclopropa[a]inden-6a-yl]-1H-imidazole Show/Hide	C16H18N2	1
1	Ki = 8.913 nM Bioactivity Info	TI LI LO TS
CP0905131 Compound Info	1-[(5,5-Diphenyloxolan-2-yl)methyl]-4-(2-methoxyphenyl)-piperazine Oxalate Salt Show/Hide	C30H34N2O6	1
1	Ki = 8.913 nM Bioactivity Info	TI LI LO TS
CP0446804 Compound Info	1-[(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]ethanone Show/Hide	C20H27N5O3	1
1	Ki = 9.12 nM Bioactivity Info	TI LI LO TS
CP0421705 Compound Info	8-[[(2S,4S)-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2-phenyl-1,3-dioxolan-2-yl]methyl]-8-azaspiro[4.5]decane-7,9-dione Show/Hide	C31H39N3O5	1
1	Ki = 9.333 nM Bioactivity Info	TI LI LO TS
CP0489482 Compound Info	8-[[(2S,4R)-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2-phenyl-1,3-dioxolan-2-yl]methyl]-8-azaspiro[4.5]decane-7,9-dione Show/Hide	C31H39N3O5	1
1	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0132460 Compound Info	1-(2-ethoxyphenyl)-4-[2-(4-methoxyphenyl)ethyl]piperazine Show/Hide	C21H28N2O2	1
1	Ki = 10.23 nM Bioactivity Info	TI LI LO TS
CP0068101 Compound Info	1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(2-propan-2-yloxyphenyl)piperazine Show/Hide	C23H32N2O3	1
1	Ki = 10.47 nM Bioactivity Info	TI LI LO TS
CP0889460 Compound Info	(S)-2-[((2-(2-methoxy-5-phenylphenoxy)ethyl)amino)methyl]-1,4-benzodioxane hydrochloride Show/Hide	C24H26ClNO4	1
1	Ki = 10.96 nM Bioactivity Info	TI LI LO TS
CP0388614 Compound Info	5-[(1aR,6S,6aR)-6-propoxy-1a,6-dihydro-1H-cyclopropa[a]inden-6a-yl]-1H-imidazole Show/Hide	C16H18N2O	1
1	Ki = 11.48 nM Bioactivity Info	TI LI LO TS
CP0894510 Compound Info	[2-(2,6-Dimethoxy-phenoxy)-ethyl]-(4-phenyl-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-amine Show/Hide	C27H31NO3	1
1	Ki = 12.3 nM Bioactivity Info	TI LI LO TS
CP0393190 Compound Info	N-[(9-amino-6,7-dimethoxy-1,2,3,4-tetrahydroacridin-3-yl)methyl]furan-2-carboxamide Show/Hide	C21H23N3O4	1
1	Ki = 12.3 nM Bioactivity Info	TI LI LO TS
CP0459890 Compound Info	N-[(9-amino-6,7-dimethoxy-1,2,3,4-tetrahydroacridin-3-yl)methyl]-3-(trifluoromethyl)benzamide;hydrochloride Show/Hide	C24H25ClF3N3O3	1
1	Ki = 12.59 nM Bioactivity Info	TI LI LO TS
CP0375895 Compound Info	2-(2-ethoxyphenoxy)-N-[2-(2-phenylmethoxyphenoxy)ethyl]ethanamine Show/Hide	C25H29NO4	1
1	Ki = 12.59 nM Bioactivity Info	TI LI LO TS
CP0132465 Compound Info	1-[2-(1,3-benzodioxol-5-yl)ethyl]-4-(2-propan-2-yloxyphenyl)piperazine Show/Hide	C22H28N2O3	1
1	Ki = 12.88 nM Bioactivity Info	TI LI LO TS
CP0403966 Compound Info	8-Chloro-2-{2-[4-(2-chloro-phenyl)-piperazin-1-yl]-ethylamino}-6-methyl-6H-1,6,7,9a-tetraaza-fluoren-5-one Show/Hide	C22H23Cl2N7O	1
1	Ki = 13.6 nM Bioactivity Info	TI LI LO TS
CP0154868 Compound Info	1-[2-(3-methoxyphenyl)ethyl]-4-(2-propan-2-yloxyphenyl)piperazine Show/Hide	C22H30N2O2	1
1	Ki = 13.8 nM Bioactivity Info	TI LI LO TS
CP0454587 Compound Info	1-[2-(4-methoxyphenyl)ethyl]-4-(2-propan-2-yloxyphenyl)piperazine Show/Hide	C22H30N2O2	1
1	Ki = 14.79 nM Bioactivity Info	TI LI LO TS
CP0234085 Compound Info	2-(2,2-diphenyl-1,3-dioxolan-4-yl)-N-[2-(2-methoxyphenoxy)ethyl]ethanamine;oxalic acid Show/Hide	C28H31NO8	1
1	Ki = 14.79 nM Bioactivity Info	TI LI LO TS
CP0394919 Compound Info	2-(4-(4-(2-isopropoxyphenyl)piperazin-1-yl)cyclohexyl)-2H-benzo[e]isoindole-1,3-dione Show/Hide	C31H35N3O3	1
1	Ki = 15 nM Bioactivity Info	TI LI LO TS
CP0447962 Compound Info	8-Chloro-2-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethylamino}-6-methyl-6H-1,6,7,9a-tetraaza-fluoren-5-one Show/Hide	C23H26ClN7O2	1
1	Ki = 15.2 nM Bioactivity Info	TI LI LO TS
CP0519411 Compound Info	8-Chloro-6-methyl-2-[2-(4-phenyl-piperazin-1-yl)-ethylamino]-6H-1,6,7,9a-tetraaza-fluoren-5-one Show/Hide	C22H24ClN7O	1
1	Ki = 15.6 nM Bioactivity Info	TI LI LO TS
CP0861255 Compound Info	(S)-N-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-2-(2-methoxynaphthalen-1-yloxy)ethanamine hydrochloride Show/Hide	C22H24ClNO4	1
1	Ki = 15.85 nM Bioactivity Info	TI LI LO TS
CP0373939 Compound Info	N-[2-(2,6-dimethoxyphenyl)sulfinylethyl]-2-(2-phenylmethoxyphenoxy)ethanamine Show/Hide	C25H29NO5S	1
1	Ki = 15.85 nM Bioactivity Info	TI LI LO TS
CP0132464 Compound Info	1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(2-ethoxyphenyl)piperazine Show/Hide	C22H30N2O3	1
1	Ki = 15.85 nM Bioactivity Info	TI LI LO TS
CP0350499 Compound Info	N-[(2,2-diphenyl-1,3-dioxan-4-yl)methyl]-2-(2-methoxyphenoxy)ethanamine;oxalic acid Show/Hide	C28H31NO8	1
1	Ki = 15.85 nM Bioactivity Info	TI LI LO TS
CP0453508 Compound Info	4-[2-(4-{3-[(3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carbonyl)-amino]-propyl}-piperazin-1-yl)-phenoxymethyl]-2-oxy-furazan-3-carboxylic acid amide Show/Hide	C34H34N6O7	1
1	Ki = 15.9 nM Bioactivity Info	TI LI LO TS
CP0374191 Compound Info	5-[(1S,1aR,6aS)-1-ethyl-1a,6-dihydro-1H-cyclopropa[a]inden-6a-yl]-1H-imidazole Show/Hide	C15H16N2	1
1	Ki = 16.6 nM Bioactivity Info	TI LI LO TS
CP0116923 Compound Info	8-benzyl-3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C26H35N3O3	1
1	Ki = 16.6 nM Bioactivity Info	TI LI LO TS
CP0881025 Compound Info	(S)-2-[((2-(2-methoxy-6-phenylphenoxy)ethyl)amino)methyl]-1,4-benzodioxane hydrochloride Show/Hide	C24H26ClNO4	1
1	Ki = 17.78 nM Bioactivity Info	TI LI LO TS
CP0415318 Compound Info	1-[[(2S,4R)-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2-phenyl-1,3-dioxolan-2-yl]methyl]azepan-2-one Show/Hide	C28H37N3O4	1
1	Ki = 18.2 nM Bioactivity Info	TI LI LO TS
CP0933240 Compound Info	(S)-2-[((2-(2-methoxy-5,6,7,8-tetrahydronaphthoxy)ethyl)amino)methyl]-1,4-benzodioxane hydrochloride Show/Hide	C22H28ClNO4	1
1	Ki = 19.05 nM Bioactivity Info	TI LI LO TS
CP0382789 Compound Info	N-[(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]-2-(2-propan-2-yloxyphenoxy)ethanamine Show/Hide	C27H31NO4	1
1	Ki = 19.95 nM Bioactivity Info	TI LI LO TS
CP0411965 Compound Info	2-(2-methoxyphenoxy)-N-[2-(2-phenylmethoxyphenoxy)ethyl]ethanamine Show/Hide	C24H27NO4	1
1	Ki = 19.95 nM Bioactivity Info	TI LI LO TS
CP0847727 Compound Info	Carboxy-methanecarboxylate(2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-dimethyl-(2-phenoxy-ethyl)-ammonium Show/Hide	C28H31NO7	1
1	Ki = 20.42 nM Bioactivity Info	TI LI LO TS
CP0402212 Compound Info	N-[[(2R)-6,6-diphenyl-1,4-dioxan-2-yl]methyl]-2-(2-methoxyphenoxy)ethanamine Show/Hide	C26H29NO4	2
1	Ki = 21.88 nM Bioactivity Info	TI LI LO TS
2	Ki = 56.23 nM Bioactivity Info	TI LI LO TS
CP0087722 Compound Info	N-[[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-2-[(6-methoxy-2,3-dihydro-1-benzofuran-7-yl)oxy]ethanamine;hydrochloride Show/Hide	C20H24ClNO5	1
1	Ki = 21.88 nM Bioactivity Info	TI LI LO TS
CP0437121 Compound Info	5-Acetyl-4-amino-2-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-6-phenyl-2H-pyridazin-3-one Show/Hide	C25H29N5O3	1
1	Ki = 22.1 nM Bioactivity Info	TI LI LO TS
CP0496434 Compound Info	[(4aS,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone Show/Hide	C27H31N5O5	1
1	Ki = 22.39 nM Bioactivity Info	TI LI LO TS
CP0394914 Compound Info	2-(4-(4-(2-isopropoxyphenyl)piperazin-1-yl)cyclohexyl)-2H-pyrrolo[3,4-c]pyridine-1,3-dione Show/Hide	C26H32N4O3	1
1	Ki = 22.4 nM Bioactivity Info	TI LI LO TS
CP0421822 Compound Info	1-[(6,6-diphenyl-1,4-dioxan-2-yl)methyl]-4-(2-methoxyphenyl)piperazine Show/Hide	C28H32N2O3	1
1	Ki = 22.91 nM Bioactivity Info	TI LI LO TS
CP0240495 Compound Info	1-(2-ethoxyphenyl)-4-[2-(3-methoxyphenyl)ethyl]piperazine Show/Hide	C21H28N2O2	1
1	Ki = 25.12 nM Bioactivity Info	TI LI LO TS
CP0482650 Compound Info	2-[[(3R)-1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-3-yl]amino]naphthalene-1,4-dione Show/Hide	C25H25N5O4	1
1	Ki = 25.12 nM Bioactivity Info	TI LI LO TS
CP0222921 Compound Info	N-(2-benzhydryloxyethyl)-2-phenoxyethanamine;oxalic acid Show/Hide	C25H27NO6	1
1	Ki = 25.12 nM Bioactivity Info	TI LI LO TS
CP0869545 Compound Info	[2-(2,6-Dimethoxy-phenoxy)-ethyl]-(4-phenyl-thiochroman-2-ylmethyl)-amine Show/Hide	C26H29NO3S	1
1	Ki = 27.54 nM Bioactivity Info	TI LI LO TS
CP0326120 Compound Info	N-[[(2S,4S)-2-benzhydryl-1,3-dioxolan-4-yl]methyl]-2-(2-methoxyphenoxy)ethanamine;oxalic acid Show/Hide	C28H31NO8	1
1	Ki = 27.54 nM Bioactivity Info	TI LI LO TS
CP0108664 Compound Info	N-[[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-2-[(6-methoxy-1-benzofuran-7-yl)oxy]ethanamine;hydrochloride Show/Hide	C20H22ClNO5	1
1	Ki = 28.84 nM Bioactivity Info	TI LI LO TS
CP0917590 Compound Info	(S)-2-[((2-(2,6-Dimethoxyphenoxy)ethyl)amino)methyl]-8-hydroxy-1,4-benzodioxane hydrochloride Show/Hide	C19H24ClNO6	1
1	Ki = 30.9 nM Bioactivity Info	TI LI LO TS
CP0204599 Compound Info	2-[(2S,4S)-2-benzhydryl-1,3-dioxolan-4-yl]-N-[2-(2-methoxyphenoxy)ethyl]ethanamine;oxalic acid Show/Hide	C29H33NO8	1
1	Ki = 30.9 nM Bioactivity Info	TI LI LO TS
CP0394897 Compound Info	2-methoxy-5-[(2R)-2-[[(2R,3S)-2-methyl-2,3-dihydro-1,4-benzodioxin-3-yl]methylamino]propyl]benzenesulfonamide Show/Hide	C20H26N2O5S	1
1	Ki = 31.62 nM Bioactivity Info	TI LI LO TS
CP0230606 Compound Info	N-[(2,2-diphenyl-1,3-dioxan-5-yl)methyl]-2-(2-methoxyphenoxy)ethanamine;oxalic acid Show/Hide	C28H31NO8	1
1	Ki = 31.62 nM Bioactivity Info	TI LI LO TS
CP0375630 Compound Info	5-[(1S,1aR,6aS)-1-methyl-1a,6-dihydro-1H-cyclopropa[a]inden-6a-yl]-1H-imidazole Show/Hide	C14H14N2	1
1	Ki = 33.11 nM Bioactivity Info	TI LI LO TS
CP0860648 Compound Info	(R)-2-[((2-(2,6-Dimethoxyphenoxy)ethyl)amino)methyl]-8-chloro-1,4-benzodioxane hydrochloride Show/Hide	C19H23Cl2NO5	1
1	Ki = 33.88 nM Bioactivity Info	TI LI LO TS
CP0243183 Compound Info	N-[[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-2-[(6-methoxy-2,3-dihydro-1H-indol-7-yl)oxy]ethanamine;dihydrochloride Show/Hide	C20H26Cl2N2O4	1
1	Ki = 35.48 nM Bioactivity Info	TI LI LO TS
CP0356931 Compound Info	N-[[(2S,4R)-2-benzhydryl-1,3-dioxolan-4-yl]methyl]-2-(2-methoxyphenoxy)ethanamine;oxalic acid Show/Hide	C28H31NO8	1
1	Ki = 37.15 nM Bioactivity Info	TI LI LO TS
CP0483388 Compound Info	3-[[2-(2,6-dimethoxyphenoxy)ethylamino]methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroacridin-9-amine Show/Hide	C26H33N3O5	1
1	Ki = 39.81 nM Bioactivity Info	TI LI LO TS
CP0374189 Compound Info	5-[(1aR,6aR)-1a-methyl-1,6-dihydrocyclopropa[a]inden-6a-yl]-1H-imidazole Show/Hide	C14H14N2	1
1	Ki = 39.81 nM Bioactivity Info	TI LI LO TS
CP0405414 Compound Info	5-[(1aR,6S,6aR)-6-ethoxy-1a,6-dihydro-1H-cyclopropa[a]inden-6a-yl]-1H-imidazole Show/Hide	C15H16N2O	1
1	Ki = 39.81 nM Bioactivity Info	TI LI LO TS
CP0894525 Compound Info	[(5,5-Diphenyloxolan-2-yl)methyl][2-(2-methoxyphenoxy)-ethyl]amine Oxalate Salt Show/Hide	C28H31NO7	1
1	Ki = 39.81 nM Bioactivity Info	TI LI LO TS
CP0386135 Compound Info	5-[(1aR,6S,6aS)-6-ethyl-1a,6-dihydro-1H-cyclopropa[a]inden-6a-yl]-1H-imidazole Show/Hide	C15H16N2	1
1	Ki = 40.74 nM Bioactivity Info	TI LI LO TS
CP0390411 Compound Info	N-[(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]-3-(2-methoxyphenyl)propan-1-amine Show/Hide	C26H29NO3	1
1	Ki = 41.69 nM Bioactivity Info	TI LI LO TS
CP0688481 Compound Info	2-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C19H29N3O3	1
1	Ki = 42.66 nM Bioactivity Info	TI LI LO TS
CP0566392 Compound Info	N-[(3R)-1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-3-yl]furan-2-carboxamide Show/Hide	C20H23N5O4	1
1	Ki = 42.66 nM Bioactivity Info	TI LI LO TS
CP0405465 Compound Info	6-(4-(4-(2-isopropoxyphenyl)piperazin-1-yl)cyclohexyl)-6H-pyrrolo[3,4-b]pyridine-5,7-dione Show/Hide	C26H32N4O3	1
1	Ki = 44.6 nM Bioactivity Info	TI LI LO TS
CP0750872 Compound Info	N-((2,2-diphenyl-1,3-dioxolan-4-yl)methyl)-2-(2-methoxyphenoxy)ethanamine oxalate Show/Hide	C27H29NO8	2
1	Ki = 45.71 nM Bioactivity Info	TI LI LO TS
2	Ki = 46.77 nM Bioactivity Info	TI LI LO TS
CP0390409 Compound Info	N-[(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]-2-(2-methoxyphenoxy)ethanamine Show/Hide	C25H27NO4	1
1	Ki = 46.77 nM Bioactivity Info	TI LI LO TS
CP0416404 Compound Info	1-[[(2S,4S)-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2-phenyl-1,3-dioxolan-2-yl]methyl]piperidine-2,6-dione Show/Hide	C27H33N3O5	1
1	Ki = 46.77 nM Bioactivity Info	TI LI LO TS
CP0464900 Compound Info	(3R)-N-[(3R)-1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-3-yl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide Show/Hide	C24H27N5O5	1
1	Ki = 46.77 nM Bioactivity Info	TI LI LO TS
CP0408404 Compound Info	N-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-2-[(2-methoxy-5,6,7,8-tetrahydronaphthalen-1-yl)oxy]ethanamine;hydrochloride Show/Hide	C22H27NO4	1
1	Ki = 48.98 nM Bioactivity Info	TI LI LO TS
CP0411877 Compound Info	1-[[(2S,4R)-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2-phenyl-1,3-dioxolan-2-yl]methyl]piperidin-2-one Show/Hide	C27H35N3O4	1
1	Ki = 51.29 nM Bioactivity Info	TI LI LO TS
CP0409005 Compound Info	N-[[(2R)-6,6-diphenyl-1,4-dioxan-2-yl]methyl]-2-phenoxyethanamine Show/Hide	C25H27NO3	2
1	Ki = 52.48 nM Bioactivity Info	TI LI LO TS
2	Ki = 120.23 nM Bioactivity Info	TI LI LO TS
CP0373754 Compound Info	N-[(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]-2-(2-ethoxyphenoxy)ethanamine Show/Hide	C26H29NO4	1
1	Ki = 53.7 nM Bioactivity Info	TI LI LO TS
CP0412413 Compound Info	2-[(3S)-3-aminopiperidin-1-yl]-6,7-dimethoxyquinazolin-4-amine Show/Hide	C15H21N5O2	1
1	Ki = 54.95 nM Bioactivity Info	TI LI LO TS
CP0414228 Compound Info	N-[(6,6-diphenyl-1,4-dioxan-2-yl)methyl]-2-(2-methoxyphenoxy)ethanamine Show/Hide	C26H29NO4	1
1	Ki = 56.23 nM Bioactivity Info	TI LI LO TS
CP0350497 Compound Info	N-[(2,2-diphenyl-1,3-dioxan-4-yl)methyl]-2-phenoxyethanamine;oxalic acid Show/Hide	C27H29NO7	1
1	Ki = 56.23 nM Bioactivity Info	TI LI LO TS
CP0382790 Compound Info	N-[(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]-2-(3-methoxyphenoxy)ethanamine Show/Hide	C25H27NO4	1
1	Ki = 58.88 nM Bioactivity Info	TI LI LO TS
CP0408405 Compound Info	[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl-[2-(2-methoxy-5-phenylphenoxy)ethyl]azanium;chloride Show/Hide	C24H25NO4	1
1	Ki = 61.66 nM Bioactivity Info	TI LI LO TS
CP0746429 Compound Info	N-((2,2-diphenyl-1,3-dioxolan-4-yl)methyl)-2-phenoxyethanamine oxalate Show/Hide	C26H27NO7	1
1	Ki = 63.1 nM Bioactivity Info	TI LI LO TS
CP0400291 Compound Info	N-[(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]-2-phenoxyethanamine Show/Hide	C24H25NO3	1
1	Ki = 63.1 nM Bioactivity Info	TI LI LO TS
CP0763928 Compound Info	2-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}-8-[4-(trifluoromethyl)benzoyl]-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C27H32F3N3O4	1
1	Ki = 63.1 nM Bioactivity Info	TI LI LO TS
CP0464898 Compound Info	(3R)-N-[(3S)-1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-3-yl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide Show/Hide	C24H27N5O5	1
1	Ki = 63.1 nM Bioactivity Info	TI LI LO TS
CP0061623 Compound Info	8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-azaspiro[4.5]decane-7,9-dione Show/Hide	C22H31N3O3	2
1	Ki = 64.57 nM Bioactivity Info	TI LI LO TS
2	Ki = 707.95 nM Bioactivity Info	TI LI LO TS
CP0356932 Compound Info	2-[(2S,4R)-2-benzhydryl-1,3-dioxolan-4-yl]-N-[2-(2-methoxyphenoxy)ethyl]ethanamine;oxalic acid Show/Hide	C29H33NO8	1
1	Ki = 64.57 nM Bioactivity Info	TI LI LO TS
CP0037866 Compound Info	CAS_146714-97-8 Show/Hide	C25H34N4O2	1
1	Ki = 66.07 nM Bioactivity Info	TI LI LO TS
CP0780574 Compound Info	N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-cyclohexanecarboxamide tri hydrochloride Show/Hide	C25H35ClN4O2	1
1	Ki = 66.07 nM Bioactivity Info	TI LI LO TS
CP0394967 Compound Info	2-methoxy-5-[(2R)-2-[[(2S,3R)-2-methyl-2,3-dihydro-1,4-benzodioxin-3-yl]methylamino]propyl]benzenesulfonamide Show/Hide	C20H26N2O5S	1
1	Ki = 67.61 nM Bioactivity Info	TI LI LO TS
CP0657012 Compound Info	8-Benzoyl-2-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C26H33N3O4	1
1	Ki = 67.61 nM Bioactivity Info	TI LI LO TS
CP0535381 Compound Info	N-[(3,3-diphenyl-1,4-dioxan-2-yl)methyl]-2-(2-methoxyphenoxy)ethanamine Show/Hide	C26H29NO4	1
1	Ki = 67.61 nM Bioactivity Info	TI LI LO TS
CP0455988 Compound Info	3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-8-(3-nitrophenyl)sulfonyl-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C25H32N4O7S	1
1	Ki = 69.18 nM Bioactivity Info	TI LI LO TS
CP0697681 Compound Info	8-(4-Chlorobenzenesulfonyl)-2-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C25H32ClN3O5S	1
1	Ki = 69.18 nM Bioactivity Info	TI LI LO TS
CP0415317 Compound Info	1-[[(2R,4R)-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2-phenyl-1,3-dioxolan-2-yl]methyl]pyrrolidin-2-one Show/Hide	C26H33N3O4	1
1	Ki = 70.79 nM Bioactivity Info	TI LI LO TS
CP0904595 Compound Info	(R)-N-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-2-(2,6-dimethoxyphenoxy)ethanamine hydrochloride Show/Hide	C19H24ClNO5	1
1	Ki = 72.44 nM Bioactivity Info	TI LI LO TS
CP0415319 Compound Info	1-[[(2S,4S)-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2-phenyl-1,3-dioxolan-2-yl]methyl]azepan-2-one Show/Hide	C28H37N3O4	1
1	Ki = 72.44 nM Bioactivity Info	TI LI LO TS
CP0118815 Compound Info	N-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-2-(2,6-dimethoxyphenoxy)ethanamine Show/Hide	C19H23NO5	1
1	Ki = 72.44 nM Bioactivity Info	TI LI LO TS
CP0846429 Compound Info	(R)-N-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-2-(2,6-dimethoxyphenoxy)ethanamine oxalate Show/Hide	C21H25NO9	1
1	Ki = 72.44 nM Bioactivity Info	TI LI LO TS
CP0435761 Compound Info	N-[[(2R)-5,5-diphenyl-1,4-dioxan-2-yl]methyl]-2-(2-methoxyphenoxy)ethanamine Show/Hide	C26H29NO4	1
1	Ki = 74.13 nM Bioactivity Info	TI LI LO TS
CP0854278 Compound Info	trans-5-({[2-(2-Methoxyphenoxy)ethyl]amino}methyl)-2,2-diphenylcyclopentan-1-ol Oxalate Salt Show/Hide	C29H33NO7	1
1	Ki = 74.13 nM Bioactivity Info	TI LI LO TS
CP0232093 Compound Info	1-[3-(4-phenylpiperazin-1-yl)propyl]-3,4-dihydroquinolin-2-one Show/Hide	C22H27N3O	1
1	Ki = 74.13 nM Bioactivity Info	TI LI LO TS
CP0373783 Compound Info	2-(2,6-dimethoxyphenoxy)-N-[(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]ethanamine Show/Hide	C26H29NO5	1
1	Ki = 75.86 nM Bioactivity Info	TI LI LO TS
CP0067759 Compound Info	1-(2-phenylethyl)-4-(2-propan-2-yloxyphenyl)piperazine Show/Hide	C21H28N2O	1
1	Ki = 77.62 nM Bioactivity Info	TI LI LO TS
CP0440492 Compound Info	N-[(9-amino-6,7-dimethoxy-2,3-dihydro-1H-cyclopenta[b]quinolin-2-yl)methyl]furan-2-carboxamide Show/Hide	C20H21N3O4	1
1	Ki = 79.43 nM Bioactivity Info	TI LI LO TS
CP0416571 Compound Info	N-[2-(2,6-dichlorophenoxy)ethyl]-2-(2-phenylmethoxyphenoxy)ethanamine Show/Hide	C23H23Cl2NO3	1
1	Ki = 79.43 nM Bioactivity Info	TI LI LO TS
CP0912439 Compound Info	(R)-2-(2,6-dimethoxyphenoxy)-N-((8-methoxy-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)ethanamine hydrochloride Show/Hide	C20H26ClNO6	1
1	Ki = 79.43 nM Bioactivity Info	TI LI LO TS
CP0705393 Compound Info	{[(4R)-2,2-diphenyl-1,3-dioxolan-4-yl]methyl}(2-phenoxyethyl)amine oxalate Show/Hide	C26H27NO7	1
1	Ki = 79.43 nM Bioactivity Info	TI LI LO TS
CP0147893 Compound Info	3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-N-phenyl-1,4-dioxa-8-azaspiro[4.5]decane-8-carboxamide Show/Hide	C26H34N4O4	1
1	Ki = 81.28 nM Bioactivity Info	TI LI LO TS
CP0846825 Compound Info	(R)-N-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-2-(2-methoxynaphthalen-1-yloxy)ethanaminium chloride Show/Hide	C22H24ClNO4	1
1	Ki = 85.11 nM Bioactivity Info	TI LI LO TS
CP0374560 Compound Info	1-[[(2S,4S)-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2-phenyl-1,3-dioxolan-2-yl]methyl]pyrrolidine-2,5-dione Show/Hide	C26H31N3O5	1
1	Ki = 85.11 nM Bioactivity Info	TI LI LO TS
CP0250925 Compound Info	3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-8-thiophen-2-ylsulfonyl-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C23H31N3O5S2	1
1	Ki = 85.11 nM Bioactivity Info	TI LI LO TS
CP0433574 Compound Info	8-(benzenesulfonyl)-3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C25H33N3O5S	1
1	Ki = 85.11 nM Bioactivity Info	TI LI LO TS
CP0154869 Compound Info	1-(2-methoxyphenyl)-4-(2-phenylethyl)piperazine Show/Hide	C19H24N2O	1
1	Ki = 91.2 nM Bioactivity Info	TI LI LO TS
CP0366049 Compound Info	2-benzhydryloxy-3-[2-(2-methoxyphenoxy)ethylamino]propan-1-ol;oxalic acid Show/Hide	C27H31NO8	1
1	Ki = 91.2 nM Bioactivity Info	TI LI LO TS
CP0230604 Compound Info	2-(2,2-diphenyl-1,3-dioxolan-4-yl)-N-(2-phenoxyethyl)ethanamine;oxalic acid Show/Hide	C27H29NO7	1
1	Ki = 95.5 nM Bioactivity Info	TI LI LO TS
CP0390410 Compound Info	N-[(2,2-diphenyl-1,3-oxathiolan-5-yl)methyl]-2-(2-methoxyphenoxy)ethanamine Show/Hide	C25H27NO3S	1
1	Ki = 100 nM Bioactivity Info	TI LI LO TS
CP0373940 Compound Info	N-[2-(2,6-dimethylphenoxy)ethyl]-2-(2-phenylmethoxyphenoxy)ethanamine Show/Hide	C25H29NO3	1
1	Ki = 100 nM Bioactivity Info	TI LI LO TS
CP0439525 Compound Info	2-[2-[2-(2-phenylmethoxyphenoxy)ethylamino]ethoxy]benzene-1,3-diol Show/Hide	C23H25NO5	1
1	Ki = 100 nM Bioactivity Info	TI LI LO TS
CP0497240 Compound Info	2-phenoxy-N-[2-(2-phenylmethoxyphenoxy)ethyl]ethanamine Show/Hide	C23H25NO3	1
1	Ki = 100 nM Bioactivity Info	TI LI LO TS
CP0912441 Compound Info	(R)-2-(2,6-dimethoxyphenoxy)-N-((8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)ethanamine hydrochloride Show/Hide	C19H23ClFNO5	1
1	Ki = 102.33 nM Bioactivity Info	TI LI LO TS
CP0361338 Compound Info	N-[[(2S,4R)-2-benzhydryl-1,3-dioxolan-4-yl]methyl]-2-phenoxyethanamine;oxalic acid Show/Hide	C27H29NO7	1
1	Ki = 102.33 nM Bioactivity Info	TI LI LO TS
CP0459292 Compound Info	N-[[(2S,4S)-2-benzhydryl-1,3-dioxolan-4-yl]methyl]-2-phenoxyethanamine;oxalic acid Show/Hide	C27H29NO7	1
1	Ki = 102.33 nM Bioactivity Info	TI LI LO TS
CP0464670 Compound Info	2-(4,5-dihydro-1H-imidazol-2-yl)-1-(3-methoxyphenyl)-1-(4-methylphenyl)hydrazine Show/Hide	C17H20N4O	1
1	Ki = 102.8 nM Bioactivity Info	TI LI LO TS
CP0350496 Compound Info	2-[(2S,4R)-2-benzhydryl-1,3-dioxolan-4-yl]-N-(2-phenoxyethyl)ethanamine;oxalic acid Show/Hide	C28H31NO7	1
1	Ki = 107.15 nM Bioactivity Info	TI LI LO TS
CP0272023 Compound Info	3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-8-(4-nitrophenyl)sulfonyl-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C25H32N4O7S	1
1	Ki = 109.65 nM Bioactivity Info	TI LI LO TS
CP0802344 Compound Info	8-Cyclohexanecarbonyl-2-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C26H39N3O4	1
1	Ki = 109.65 nM Bioactivity Info	TI LI LO TS
CP0751060 Compound Info	{[(4S)-2,2-diphenyl-1,3-dioxolan-4-yl]methyl}(2-phenoxyethyl)amine oxalate Show/Hide	C26H27NO7	1
1	Ki = 114.82 nM Bioactivity Info	TI LI LO TS
CP0396049 Compound Info	N-[(6,6-diphenyl-1,4-dioxan-2-yl)methyl]-2-pyridin-2-yloxyethanamine Show/Hide	C24H26N2O3	1
1	Ki = 114.82 nM Bioactivity Info	TI LI LO TS
CP0373753 Compound Info	N-[(2,2-diphenyl-1,3-dithiolan-4-yl)methyl]-2-(2-methoxyphenoxy)ethanamine Show/Hide	C25H27NO2S2	1
1	Ki = 117.49 nM Bioactivity Info	TI LI LO TS
CP0408073 Compound Info	N-[(6,6-diphenyl-1,4-dioxan-2-yl)methyl]-2-phenoxyethanamine Show/Hide	C25H27NO3	1
1	Ki = 120.23 nM Bioactivity Info	TI LI LO TS
CP0396050 Compound Info	2-(2-chlorophenoxy)-N-[(6,6-diphenyl-1,4-dioxan-2-yl)methyl]ethanamine Show/Hide	C25H26ClNO3	1
1	Ki = 120.23 nM Bioactivity Info	TI LI LO TS
CP0859341 Compound Info	[(5,5-Diphenyloxolan-2-yl)methyl](2-phenoxyethyl)amine Oxalate Salt Show/Hide	C27H29NO6	1
1	Ki = 123.03 nM Bioactivity Info	TI LI LO TS
CP0378503 Compound Info	2-(2,6-dimethoxyphenoxy)-N-[[(2R)-5,5-diphenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C27H31NO5	1
1	Ki = 125.89 nM Bioactivity Info	TI LI LO TS
CP0406705 Compound Info	N-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-2-[(6-methoxy-1-benzofuran-7-yl)oxy]ethanamine;hydrochloride Show/Hide	C20H22ClNO5	1
1	Ki = 125.89 nM Bioactivity Info	TI LI LO TS
CP0121063 Compound Info	1-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)-4-(2-methoxyphenyl)piperazine Show/Hide	C20H30N2O3	1
1	Ki = 125.89 nM Bioactivity Info	TI LI LO TS
CP0406086 Compound Info	1-[[(2S,4S)-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2-phenyl-1,3-dioxolan-2-yl]methyl]piperidin-2-one Show/Hide	C27H35N3O4	1
1	Ki = 128.82 nM Bioactivity Info	TI LI LO TS
CP0311688 Compound Info	N-tert-butyl-3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-1,4-dioxa-8-azaspiro[4.5]decane-8-carboxamide Show/Hide	C24H38N4O4	1
1	Ki = 128.82 nM Bioactivity Info	TI LI LO TS
CP0489497 Compound Info	1-[[(2S,4R)-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2-phenyl-1,3-dioxolan-2-yl]methyl]piperidine-2,6-dione Show/Hide	C27H33N3O5	1
1	Ki = 131.83 nM Bioactivity Info	TI LI LO TS
CP0382788 Compound Info	2-(3,4-dimethoxyphenoxy)-N-[(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]ethanamine Show/Hide	C26H29NO5	1
1	Ki = 138.04 nM Bioactivity Info	TI LI LO TS
CP0374257 Compound Info	N-[[(2R)-5,5-diphenyl-1,4-dioxan-2-yl]methyl]-2-phenoxyethanamine Show/Hide	C25H27NO3	1
1	Ki = 141.25 nM Bioactivity Info	TI LI LO TS
CP0859289 Compound Info	5-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}-2,2-diphenylcyclopentan-1-one Oxalate Salt Show/Hide	C31H34N2O6	1
1	Ki = 141.25 nM Bioactivity Info	TI LI LO TS
CP0250926 Compound Info	1-(1,4-dioxa-8-thiaspiro[4.5]decan-3-ylmethyl)-4-(2-methoxyphenyl)piperazine Show/Hide	C19H28N2O3S	1
1	Ki = 141.25 nM Bioactivity Info	TI LI LO TS
CP0772147 Compound Info	2-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}-8-[4(trifluoromethoxy)benzenesulfonyl]-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C26H32F3N3O6S	1
1	Ki = 147.91 nM Bioactivity Info	TI LI LO TS
CP0405158 Compound Info	N-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-2-(2-methoxy-6-phenylphenoxy)ethanamine;hydrochloride Show/Hide	C24H25NO4	1
1	Ki = 151.36 nM Bioactivity Info	TI LI LO TS
CP0657011 Compound Info	2-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}-8-phenyl-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C25H33N3O3	1
1	Ki = 154.88 nM Bioactivity Info	TI LI LO TS
CP0115843 Compound Info	[3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-pyrrolidin-2-ylmethanone Show/Hide	C24H36N4O4	1
1	Ki = 158.49 nM Bioactivity Info	TI LI LO TS
CP0763926 Compound Info	8-(Furan-2-carbonyl)-2-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C24H31N3O5	1
1	Ki = 158.49 nM Bioactivity Info	TI LI LO TS
CP0500849 Compound Info	N-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-2-[(6-methoxy-2,3-dihydro-1-benzofuran-7-yl)oxy]ethanamine;hydrochloride Show/Hide	C20H24ClNO5	1
1	Ki = 162.18 nM Bioactivity Info	TI LI LO TS
CP0854275 Compound Info	cis-5-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}-2,2-diphenylcyclopentan-1-ol Oxalate salt Show/Hide	C31H36N2O6	1
1	Ki = 165.96 nM Bioactivity Info	TI LI LO TS
CP0471912 Compound Info	2-[(2S,4S)-2-benzhydryl-1,3-dioxolan-4-yl]-N-(2-phenoxyethyl)ethanamine;oxalic acid Show/Hide	C28H31NO7	1
1	Ki = 165.96 nM Bioactivity Info	TI LI LO TS
CP0477118 Compound Info	N-[[(2S)-6,6-diphenyl-1,4-dioxan-2-yl]methyl]-2-phenoxyethanamine Show/Hide	C25H27NO3	1
1	Ki = 169.82 nM Bioactivity Info	TI LI LO TS
CP0373784 Compound Info	2-(2,3-dimethoxyphenoxy)-N-[(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]ethanamine Show/Hide	C26H29NO5	1
1	Ki = 173.78 nM Bioactivity Info	TI LI LO TS
CP0415316 Compound Info	1-[[(2R,4S)-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2-phenyl-1,3-dioxolan-2-yl]methyl]pyrrolidin-2-one Show/Hide	C26H33N3O4	1
1	Ki = 173.78 nM Bioactivity Info	TI LI LO TS
CP0374190 Compound Info	5-[(1aR,6aR)-1,1-dimethyl-1a,6-dihydrocyclopropa[a]inden-6a-yl]-1H-imidazole Show/Hide	C15H16N2	1
1	Ki = 177.83 nM Bioactivity Info	TI LI LO TS
CP0389458 Compound Info	N-[(6,6-diphenyl-1,4-dioxan-2-yl)methyl]-2-(2-methylphenoxy)ethanamine Show/Hide	C26H29NO3	1
1	Ki = 177.83 nM Bioactivity Info	TI LI LO TS
CP0386946 Compound Info	2-[(3R)-3-aminopiperidin-1-yl]-6,7-dimethoxyquinazolin-4-amine Show/Hide	C15H21N5O2	1
1	Ki = 177.83 nM Bioactivity Info	TI LI LO TS
CP0862493 Compound Info	(S)-2-[((2-(2-methoxy-4-phenylphenoxy)ethyl)amino)methyl]-1,4-benzodioxane hydrochloride Show/Hide	C24H26ClNO4	1
1	Ki = 186.21 nM Bioactivity Info	TI LI LO TS
CP0445299 Compound Info	1-(2-methoxyphenyl)-4-(1-oxa-4-thiaspiro[4.5]decan-2-ylmethyl)piperazine Show/Hide	C20H30N2O2S	1
1	Ki = 190.55 nM Bioactivity Info	TI LI LO TS
CP0384764 Compound Info	2-(2,6-dimethoxyphenoxy)-N-[[(2R)-6,6-diphenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C27H31NO5	2
1	Ki = 194.98 nM Bioactivity Info	TI LI LO TS
2	Ki = 323.59 nM Bioactivity Info	TI LI LO TS
CP0503951 Compound Info	N-(1,4-dithiaspiro[4.5]decan-3-ylmethyl)-2-(2-methoxyphenoxy)ethanamine Show/Hide	C18H27NO2S2	1
1	Ki = 194.98 nM Bioactivity Info	TI LI LO TS
CP0853819 Compound Info	(E)-N-(2-Dimethylamino-ethyl)-N-[4'-(phenethylamino-methyl)-biphenyl-4-ylmethyl]-3-phenyl-acrylamide TFA Show/Hide	C37H40F3N3O3	1
1	Ki = 199.53 nM Bioactivity Info	TI LI LO TS
CP0415073 Compound Info	3-[[2-(2,6-dimethoxyphenoxy)ethylamino]methyl]-6,7-dimethoxy-2,3,4,10-tetrahydro-1H-acridin-9-one Show/Hide	C26H32N2O6	1
1	Ki = 218.78 nM Bioactivity Info	TI LI LO TS
CP0503955 Compound Info	2-(2-methoxyphenoxy)-N-(1-oxa-4-thiaspiro[4.5]decan-2-ylmethyl)ethanamine Show/Hide	C18H27NO3S	1
1	Ki = 218.78 nM Bioactivity Info	TI LI LO TS
CP0406100 Compound Info	1-[[(2S,4R)-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2-phenyl-1,3-dioxolan-2-yl]methyl]pyrrolidine-2,5-dione Show/Hide	C26H31N3O5	1
1	Ki = 223.87 nM Bioactivity Info	TI LI LO TS
CP0116478 Compound Info	1-[3-(4-benzylpiperidin-1-yl)propyl]-3,4-dihydroquinolin-2-one Show/Hide	C24H30N2O	1
1	Ki = 223.87 nM Bioactivity Info	TI LI LO TS
CP0373781 Compound Info	N-[(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]-2-(2-methylphenoxy)ethanamine Show/Hide	C25H27NO3	1
1	Ki = 239.88 nM Bioactivity Info	TI LI LO TS
CP0802345 Compound Info	N-butyl-2-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-1,4-dioxa-8-azaspiro[4.5]decane-8-carboxamide Show/Hide	C24H38N4O4	1
1	Ki = 239.88 nM Bioactivity Info	TI LI LO TS
CP0854276 Compound Info	trans-5-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}-2,2-diphenylcyclopentan-1-ol Oxalate Show/Hide	C31H36N2O6	1
1	Ki = 245.47 nM Bioactivity Info	TI LI LO TS
CP0389457 Compound Info	N-[(6,6-diphenyl-1,4-dioxan-2-yl)methyl]-2-(2-nitrophenoxy)ethanamine Show/Hide	C25H26N2O5	1
1	Ki = 251.19 nM Bioactivity Info	TI LI LO TS
CP0848345 Compound Info	Carboxy-methanecarboxylate(2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-methyl-(2-phenoxy-ethyl)-ammonium Show/Hide	C27H29NO7	1
1	Ki = 257.04 nM Bioactivity Info	TI LI LO TS
CP0378505 Compound Info	2-(2-methoxyphenoxy)-N-[[(2R,5R)-5-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C20H25NO4	1
1	Ki = 263.03 nM Bioactivity Info	TI LI LO TS
CP0378504 Compound Info	2-(2-methoxyphenoxy)-N-[[(2R,6S)-6-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C20H25NO4	1
1	Ki = 269.15 nM Bioactivity Info	TI LI LO TS
CP0402211 Compound Info	2-(2-methoxyphenoxy)-N-[[(2R,5S)-5-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C20H25NO4	1
1	Ki = 281.84 nM Bioactivity Info	TI LI LO TS
CP0347659 Compound Info	N-[(2,2-diphenyl-1,3-dioxan-5-yl)methyl]-2-phenoxyethanamine;oxalic acid Show/Hide	C27H29NO7	1
1	Ki = 281.84 nM Bioactivity Info	TI LI LO TS
CP0854274 Compound Info	trans-5-{[(2-Phenoxyethyl)amino]methyl}-2,2-diphenylcyclopentan-1-ol Oxalate Salt Show/Hide	C28H31NO6	1
1	Ki = 288.4 nM Bioactivity Info	TI LI LO TS
CP0688479 Compound Info	2-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}-1,4-dioxa-8lambda6-thiaspiro[4.5]decane-8,8-dione Show/Hide	C19H28N2O5S	1
1	Ki = 288.4 nM Bioactivity Info	TI LI LO TS
CP0389448 Compound Info	N-[(6,6-diphenyl-1,4-dioxan-2-yl)methyl]-2-[2-(methoxymethoxy)phenoxy]ethanamine Show/Hide	C27H31NO5	1
1	Ki = 288.4 nM Bioactivity Info	TI LI LO TS
CP0382852 Compound Info	N-[(6,7-dimethoxy-9-oxo-2,3,4,10-tetrahydro-1H-acridin-3-yl)methyl]furan-2-carboxamide Show/Hide	C21H22N2O5	1
1	Ki = 295.12 nM Bioactivity Info	TI LI LO TS
CP0371702 Compound Info	2-(2-methoxyphenoxy)-N-[[(2R,6R)-6-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C20H25NO4	1
1	Ki = 302 nM Bioactivity Info	TI LI LO TS
CP0847634 Compound Info	(E)-N-[4'-(Phenethylamino-methyl)-biphenyl-4-ylmethyl]-3-phenyl-N-pyridin-3-ylmethyl-acrylamide TFA Show/Hide	C39H36F3N3O3	1
1	Ki = 316.23 nM Bioactivity Info	TI LI LO TS
CP0861232 Compound Info	3-Cyclopentyl-N-(2-dimethylamino-ethyl)-N-[4'-(phenethylamino-methyl)-biphenyl-4-ylmethyl]-propionamide with di TFA Show/Hide	C38H47F6N3O5	1
1	Ki = 316.23 nM Bioactivity Info	TI LI LO TS
CP0405413 Compound Info	5-[(1aR,6S,6aR)-6-propan-2-yloxy-1a,6-dihydro-1H-cyclopropa[a]inden-6a-yl]-1H-imidazole Show/Hide	C16H18N2O	1
1	Ki = 316.23 nM Bioactivity Info	TI LI LO TS
CP0464899 Compound Info	(3S)-N-[(3R)-1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-3-yl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide Show/Hide	C24H27N5O5	1
1	Ki = 316.23 nM Bioactivity Info	TI LI LO TS
CP0415219 Compound Info	2-(2,6-dimethoxyphenoxy)-N-[(6,6-diphenyl-1,4-dioxan-2-yl)methyl]ethanamine Show/Hide	C27H31NO5	1
1	Ki = 323.59 nM Bioactivity Info	TI LI LO TS
CP0068597 Compound Info	1-(2-methoxyphenyl)-4-(1,4,8-trioxaspiro[4.5]decan-3-ylmethyl)piperazine Show/Hide	C19H28N2O4	1
1	Ki = 323.59 nM Bioactivity Info	TI LI LO TS
CP0115835 Compound Info	3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-8-methylsulfonyl-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C20H31N3O5S	1
1	Ki = 363.08 nM Bioactivity Info	TI LI LO TS
CP0949094 Compound Info	(S)-2-[((2-(2-methoxy-1-naphthoxy)ethyl)amino)methyl]-2,3,6,7,8,9-hexahydronaphtho[2,3-b][1,4]dioxine hydrochloride Show/Hide	C26H30ClNO4	1
1	Ki = 371.54 nM Bioactivity Info	TI LI LO TS
CP0404054 Compound Info	N-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-2-[(6-methoxy-2,3-dihydro-1H-indol-7-yl)oxy]ethanamine;dihydrochloride Show/Hide	C20H26Cl2N2O4	1
1	Ki = 371.54 nM Bioactivity Info	TI LI LO TS
CP0396051 Compound Info	2-[2-[(6,6-diphenyl-1,4-dioxan-2-yl)methylamino]ethoxy]phenol Show/Hide	C25H27NO4	1
1	Ki = 371.54 nM Bioactivity Info	TI LI LO TS
CP0426667 Compound Info	1-[[(2R)-3,3-diphenyl-1,4-dioxan-2-yl]methyl]-4-(2-methoxyphenyl)piperazine Show/Hide	C28H32N2O3	1
1	Ki = 380.19 nM Bioactivity Info	TI LI LO TS
CP0464374 Compound Info	N-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)-2-(2-methoxyphenoxy)ethanamine Show/Hide	C18H27NO4	1
1	Ki = 389.05 nM Bioactivity Info	TI LI LO TS
CP0453599 Compound Info	2-(2,6-dimethoxyphenoxy)-N-[[(3R)-2,3,6,7,8,9-hexahydrobenzo[g][1,4]benzodioxin-3-yl]methyl]ethanamine;hydrochloride Show/Hide	C23H29NO5	1
1	Ki = 398.11 nM Bioactivity Info	TI LI LO TS
CP0943168 Compound Info	(R)-2-[((2-(2,6-Dimethoxyphenoxy)ethyl)amino)methyl]-8-hydroxy-1,4-benzodioxane hydrochloride Show/Hide	C19H24ClNO6	1
1	Ki = 398.11 nM Bioactivity Info	TI LI LO TS
CP0468298 Compound Info	1-(1,4-dithiaspiro[4.5]decan-3-ylmethyl)-4-(2-methoxyphenyl)piperazine Show/Hide	C20H30N2OS2	1
1	Ki = 407.38 nM Bioactivity Info	TI LI LO TS
CP0396500 Compound Info	N-[[(2S)-6,6-diphenyl-1,4-dioxan-2-yl]methyl]-2-(2-methoxyphenoxy)ethanamine Show/Hide	C26H29NO4	1
1	Ki = 416.87 nM Bioactivity Info	TI LI LO TS
CP0485314 Compound Info	N-[[(3R)-2,3-dihydrobenzo[g][1,4]benzodioxin-3-yl]methyl]-2-(2,6-dimethoxyphenoxy)ethanamine;hydrochloride Show/Hide	C23H26ClNO5	1
1	Ki = 426.58 nM Bioactivity Info	TI LI LO TS
CP0500270 Compound Info	N-(1-oxa-4-thiaspiro[4.5]decan-2-ylmethyl)-2-phenoxyethanamine Show/Hide	C17H25NO2S	1
1	Ki = 436.52 nM Bioactivity Info	TI LI LO TS
CP0373782 Compound Info	2-(3,5-dimethoxyphenoxy)-N-[(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]ethanamine Show/Hide	C26H29NO5	1
1	Ki = 446.68 nM Bioactivity Info	TI LI LO TS
CP0892038 Compound Info	(S)-2-(2,6-dimethoxyphenoxy)-N-((5-methoxy-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)ethanamine hydrochloride Show/Hide	C20H26ClNO6	1
1	Ki = 446.68 nM Bioactivity Info	TI LI LO TS
CP0121059 Compound Info	3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-1,4-dioxa-8lambda4-thiaspiro[4.5]decane 8-oxide Show/Hide	C19H28N2O4S	1
1	Ki = 478.63 nM Bioactivity Info	TI LI LO TS
CP0155898 Compound Info	N-[[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-2-[(6-methoxy-1H-indol-7-yl)oxy]ethanamine Show/Hide	C20H22N2O4	1
1	Ki = 489.78 nM Bioactivity Info	TI LI LO TS
CP0512065 Compound Info	N-[[(3R)-2,3,6,7,8,9-hexahydrobenzo[g][1,4]benzodioxin-3-yl]methyl]-2-(2-methoxynaphthalen-1-yl)oxyethanamine;hydrochloride Show/Hide	C26H29NO4	1
1	Ki = 549.54 nM Bioactivity Info	TI LI LO TS
CP0522904 Compound Info	N-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-2-(2-methoxy-4-phenylphenoxy)ethanamine;hydrochloride Show/Hide	C24H25NO4	1
1	Ki = 549.54 nM Bioactivity Info	TI LI LO TS
CP0500278 Compound Info	N-(1,4-dithiaspiro[4.5]decan-3-ylmethyl)-2-phenoxyethanamine Show/Hide	C17H25NOS2	1
1	Ki = 549.54 nM Bioactivity Info	TI LI LO TS
CP0399906 Compound Info	N-[5-[(5-chloro-6-oxo-4-piperazin-1-ylpyridazin-1-yl)methyl]-2-methylphenyl]-4-phenylbenzamide Show/Hide	C29H28ClN5O2	1
1	Ki = 562.34 nM Bioactivity Info	TI LI LO TS
CP0889459 Compound Info	(S)-2-(2,6-dimethoxyphenoxy)-N-((2,3,6,7,8,9-hexahydronaphtho[2,3-b][1,4]dioxin-2-yl)methyl)ethanaminium chloride Show/Hide	C23H30ClNO5	1
1	Ki = 575.44 nM Bioactivity Info	TI LI LO TS
CP0388359 Compound Info	N-[3-[(5-chloro-6-oxo-4-piperazin-1-ylpyridazin-1-yl)methyl]phenyl]-4-phenylbenzamide Show/Hide	C28H26ClN5O2	1
1	Ki = 630.96 nM Bioactivity Info	TI LI LO TS
CP0860647 Compound Info	(R)-2-(2,6-dimethoxyphenoxy)-N-((5-methoxy-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)ethanamine hydrochloride Show/Hide	C20H26ClNO6	1
1	Ki = 645.65 nM Bioactivity Info	TI LI LO TS
CP0714031 Compound Info	SID50105948 Show/Hide	C22H33Cl2N3O3	1
1	Ki = 707.95 nM Bioactivity Info	TI LI LO TS
CP0232092 Compound Info	1-[3-(4-butylpiperidin-1-yl)propyl]-3,4-dihydroquinolin-2-one Show/Hide	C21H32N2O	1
1	Ki = 776.25 nM Bioactivity Info	TI LI LO TS
CP0485217 Compound Info	3-[N'-(4,5-Dihydro-1H-imidazol-2-yl)-N-p-tolyl-hydrazino]-phenol Show/Hide	C16H18N4O	1
1	Ki = 843 nM Bioactivity Info	TI LI LO TS
CP0917489 Compound Info	(S)-N-((2,3-dihydronaphtho[2,3-b][1,4]dioxin-2-yl)methyl)-2-(2,6-dimethoxyphenoxy)ethanaminium chloride Show/Hide	C23H26ClNO5	1
1	Ki = 891.25 nM Bioactivity Info	TI LI LO TS
CP0379393 Compound Info	5-[(1aR,6R,6aR)-6-methoxy-1a,6-dihydro-1H-cyclopropa[a]inden-6a-yl]-1H-imidazole Show/Hide	C14H14N2O	1
1	Ki = 912.01 nM Bioactivity Info	TI LI LO TS
CP0468296 Compound Info	N-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)-2-phenoxyethanamine Show/Hide	C17H25NO3	1
1	Ki = 977.24 nM Bioactivity Info	TI LI LO TS
CP0131832 Compound Info	1-[3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]ethanone Show/Hide	C21H31N3O4	1
1	Ki = 1000 nM Bioactivity Info	TI LI LO TS
CP0763927 Compound Info	2,2,2-Trifluoro-1-(2-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)ethan-1-one Show/Hide	C21H28F3N3O4	1
1	Ki = 1000 nM Bioactivity Info	TI LI LO TS
CP0775946 Compound Info	2-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}-8-(pyridin-2-yl)-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C24H32N4O3	1
1	Ki = 1000 nM Bioactivity Info	TI LI LO TS
CP0444701 Compound Info	5,6-dichloro-2-(4-(4-(2-isopropoxyphenyl)piperazin-1-yl)cyclohexyl)isoindoline-1,3-dione Show/Hide	C27H31Cl2N3O3	1
1	Ki = 1082 nM Bioactivity Info	TI LI LO TS
CP0388360 Compound Info	N-[3-[(5-chloro-6-oxo-4-piperazin-1-ylpyridazin-1-yl)methyl]-2-methylphenyl]-4-phenylbenzamide Show/Hide	C29H28ClN5O2	1
1	Ki = 1445.44 nM Bioactivity Info	TI LI LO TS
CP0414234 Compound Info	2-(2,6-dimethoxyphenoxy)-N-[[(2S)-6,6-diphenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C27H31NO5	1
1	Ki = 1659.59 nM Bioactivity Info	TI LI LO TS
CP0444051 Compound Info	N-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-2-[(6-methoxy-1H-indol-7-yl)oxy]ethanamine Show/Hide	C20H22N2O4	1
1	Ki = 1905.46 nM Bioactivity Info	TI LI LO TS
CP0379392 Compound Info	ATIPAMEZOLE Show/Hide	C14H16N2	1
1	Ki = 1949.84 nM Bioactivity Info	TI LI LO TS
CP0417233 Compound Info	FIPAMEZOLE Show/Hide	C14H15FN2	1
1	Ki = 2089.3 nM Bioactivity Info	TI LI LO TS
CP0350498 Compound Info	2-benzhydryloxy-3-(2-phenoxyethylamino)propan-1-ol;oxalic acid Show/Hide	C26H29NO7	1
1	Ki = 2290.87 nM Bioactivity Info	TI LI LO TS
CP0230607 Compound Info	N-(2-benzhydryloxyethyl)-2-(2-methoxyphenoxy)ethanamine;oxalic acid Show/Hide	C26H29NO7	1
1	Ki = 3019.95 nM Bioactivity Info	TI LI LO TS
CP0394915 Compound Info	4,5,6,7-tetrafluoro-2-(4-(4-(2-isopropoxyphenyl)piperazin-1-yl)cyclohexyl)isoindoline-1,3-dione Show/Hide	C27H29F4N3O3	1
1	Ki = 4108 nM Bioactivity Info	TI LI LO TS
CP0135923 Compound Info	CHEBI:6956 Show/Hide	C23H30N2O4	1
1	Ki = 4770 nM Bioactivity Info	TI LI LO TS
CP0037227 Compound Info	7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol Show/Hide	C16H25NO	2
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
2	Ki < 1000000 nM Bioactivity Info	TI LI LO TS
CP0371704 Compound Info	2-(2,6-dimethoxyphenoxy)-N-[[(2R,5S)-5-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C21H27NO5	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0374167 Compound Info	2-phenoxy-N-[[(2R,6S)-6-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C19H23NO3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0374168 Compound Info	2-(2,6-dimethoxyphenoxy)-N-[[(2R,6S)-6-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C21H27NO5	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0384754 Compound Info	2-phenoxy-N-[[(2R,5S)-5-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C19H23NO3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0423054 Compound Info	2-(2,6-dimethoxyphenoxy)-N-[[(2R,5R)-5-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C21H27NO5	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0435760 Compound Info	2-phenoxy-N-[[(2R,5R)-5-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C19H23NO3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0439399 Compound Info	2-phenoxy-N-[[(2R,6R)-6-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C19H23NO3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0439400 Compound Info	2-(2,6-dimethoxyphenoxy)-N-[[(2R,6R)-6-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C21H27NO5	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0373751 Compound Info	N-[(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]-2-(2-phenylphenoxy)ethanamine Show/Hide	C30H29NO3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0373752 Compound Info	N-[(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]-2-(4-phenylphenoxy)ethanamine Show/Hide	C30H29NO3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0400292 Compound Info	N-[(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]-2-(3-phenylphenoxy)ethanamine Show/Hide	C30H29NO3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0854273 Compound Info	5-{[(2-Phenoxyethyl)amino]methyl}-2,2-diphenylcyclopentan-1-one Oxalate Salt Show/Hide	C28H29NO6	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0854277 Compound Info	5-({[2-(2-Methoxyphenoxy)ethyl]amino}methyl)-2,2-diphenylcyclopentan-1-one Oxalate Salt Show/Hide	C29H31NO7	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0859496 Compound Info	cis-5-{[(2-Phenoxyethyl)amino]methyl}-2,2-diphenylcyclopentan-1-ol Oxalate Salt Show/Hide	C28H31NO6	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0500267 Compound Info	2-(2,6-dimethoxyphenoxy)-N-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)ethanamine Show/Hide	C19H29NO5	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0402933 Compound Info	2-(2-methoxyphenoxy)-N-[[(2R,3S)-3-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C20H25NO4	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0416975 Compound Info	2-(2,6-dimethoxyphenoxy)-N-[[(2R,3R)-3-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C21H27NO5	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0421814 Compound Info	N-[(3,3-diphenyl-1,4-dioxan-2-yl)methyl]-2-phenoxyethanamine Show/Hide	C25H27NO3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0421815 Compound Info	1-(2-methoxyphenyl)-4-[(2-phenyl-1,4-dioxan-2-yl)methyl]piperazine Show/Hide	C22H28N2O3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0421816 Compound Info	1-(2-methoxyphenyl)-4-[[(2R,3S)-3-phenyl-1,4-dioxan-2-yl]methyl]piperazine Show/Hide	C22H28N2O3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0421818 Compound Info	2-phenoxy-N-[(2-phenyl-1,4-dioxan-2-yl)methyl]ethanamine Show/Hide	C19H23NO3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0421820 Compound Info	2-(2-methoxyphenoxy)-N-[(2-phenyl-1,4-dioxan-2-yl)methyl]ethanamine Show/Hide	C20H25NO4	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0421821 Compound Info	2-(2-methoxyphenoxy)-N-[[(2R,3R)-3-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C20H25NO4	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0434677 Compound Info	2-(2,6-dimethoxyphenoxy)-N-[(3,3-diphenyl-1,4-dioxan-2-yl)methyl]ethanamine Show/Hide	C27H31NO5	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0434680 Compound Info	2-(2,6-dimethoxyphenoxy)-N-[(2-phenyl-1,4-dioxan-2-yl)methyl]ethanamine Show/Hide	C21H27NO5	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0484174 Compound Info	2-phenoxy-N-[[(2R,3R)-3-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C19H23NO3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0484175 Compound Info	2-phenoxy-N-[[(2R,3S)-3-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C19H23NO3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0538009 Compound Info	2-(2,6-dimethoxyphenoxy)-N-[[(2R,3S)-3-phenyl-1,4-dioxan-2-yl]methyl]ethanamine Show/Hide	C21H27NO5	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0538010 Compound Info	1-(2-methoxyphenyl)-4-[[(2R,3R)-3-phenyl-1,4-dioxan-2-yl]methyl]piperazine Show/Hide	C22H28N2O3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0372320 Compound Info	3-[[2-(2,6-dimethoxyphenoxy)ethylamino]methyl]-2-phenyl-2,3-dihydrothiochromen-4-one Show/Hide	C26H27NO4S	1
1	Ki < 1000000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000880 , COS

Cell Line Info

Cell Line ID: CL000109 , COS-1

Cell Line Info

Cell Line ID: CL000053 , COS-7

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000065 , HEK293-EBNA

Cell Line Info

Cell Line ID: CL000440 , LM

Cell Line Info

Cell Line ID: CL000019 , Rat1

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0049024 Compound Info	1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine Show/Hide	C19H25N5O4	8
1	EC50 = 0.5 nM
2	Ki = 1.2 nM
3	Ki = 1.95 nM
4	Ki = 2.2 nM
5	Ki = 2.512 nM
6	Ki = 2.6 nM
7	Ki = 2.68 nM
8	Ki = 30 nM
CP0147996 Compound Info	CHEBI:8093 Show/Hide	C9H13NO2	1
1	EC50 = 5.9 nM
CP0049357 Compound Info	1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-2-(2-isopropyl-6-methoxy-phenoxy)-ethanone Show/Hide	C26H33N5O5	1
1	IC50 = 1.2 nM
CP0043740 Compound Info	1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphthalenyloxy)-2-propanol;hydrochloride Show/Hide	C24H28N2O3	1
1	IC50 = 634 nM
CP0097484 Compound Info	CYCLAZOSIN Show/Hide	C23H27N5O4	3
1	Ki = 0.1995 nM
2	Ki = 0.309 nM
3	Ki = 0.6918 nM
CP0040814 Compound Info	[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone Show/Hide	C19H21N5O4	6
1	Ki = 0.21 nM
2	Ki = 0.2512 nM
3	Ki = 0.32 nM
4	Ki = 0.42 nM
5	Ki = 0.4571 nM
6	Ki = 0.55 nM
CP0189141 Compound Info	17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic acid methyl ester Show/Hide	C21H26N2O3	2
1	Ki = 0.6 nM
2	Ki = 4.6 nM
CP0035002 Compound Info	(R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide Show/Hide	C20H28N2O5S	3
1	Ki = 0.61 nM
2	Ki = 1.92 nM
3	Ki = 2 nM
CP0210810 Compound Info	[(4aS,8aR)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(furan-2-yl)methanone Show/Hide	C23H27N5O4	1
1	Ki = 0.6918 nM
CP0048996 Compound Info	CAS_74191-85-8 Show/Hide	C23H25N5O5	2
1	Ki = 0.74 nM
2	Ki = 1 nM
CP0069692 Compound Info	(+)-yohimbine Show/Hide	C21H26N2O3	2
1	Ki = 1.1 nM
2	Ki = 7.2 nM
CP0327530 Compound Info	[(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone Show/Hide	C27H31N5O5	1
1	Ki = 1.413 nM
CP0055045 Compound Info	2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,9-dihydro-2,4,9-triaza-fluorene-1,3-dione Show/Hide	C23H25N5O3	1
1	Ki = 1.82 nM
CP0082953 Compound Info	2,3-dihydro-1,4-benzodioxin-3-ylmethyl-[2-(2,6-dimethoxyphenoxy)ethyl]amine;hydrochloride Show/Hide	C19H23NO5	5
1	Ki = 2.512 nM
2	Ki = 9.9 nM
3	Ki = 10 nM
4	Ki = 37 nM
5	Ki = 57.34 nM
CP0013593 Compound Info	1-(3-Hydroxy-propyl)-5-((R)-2-{2-[2-(2,2,2-trifluoro-ethoxy)-phenoxy]-ethylamino}-propyl)-2,3-dihydro-1H-indole-7-carboxylic acid amide Show/Hide	C25H32F3N3O4	1
1	Ki = 19.95 nM
CP0048998 Compound Info	5-Chloro-8-methyl-1-vinyl-6,7,8,9-tetrahydro-2-thia-8-aza-benzo[cd]azulene Show/Hide	C14H14ClNS	2
1	Ki = 19.95 nM
2	Ki = 23 nM
CP0096821 Compound Info	CHEMBL99142 Show/Hide	C24H27N5O2	1
1	Ki = 20.89 nM
CP0087323 Compound Info	Niguldipine Show/Hide	C36H39N3O6	2
1	Ki = 25.01 nM
2	Ki = 55 nM
CP0345915 Compound Info	3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid {3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-amide Show/Hide	C31H33N3O4	1
1	Ki = 31.62 nM
CP0714031 Compound Info	SID50105948 Show/Hide	C22H33Cl2N3O3	2
1	Ki = 50.12 nM
2	Ki = 630.96 nM
CP0061623 Compound Info	8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-azaspiro[4.5]decane-7,9-dione Show/Hide	C22H31N3O3	4
1	Ki = 69.18 nM
2	Ki = 94.3 nM
3	Ki = 191 nM
4	Ki = 631 nM
CP0117550 Compound Info	6,7-Dibromo-3-[(2S,5R)-5-(6-bromo-1H-indol-3-yl)-4-methyl-piperazin-2-yl]-1H-indol-4-ol Show/Hide	C21H19Br3N4O	1
1	Ki = 78 nM
CP0192450 Compound Info	3-(3-{3-[4-Fluoro-2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl)-5-methyl-1H-pyrimidine-2,4-dione Show/Hide	C20H24F4N4O3	1
1	Ki = 79.43 nM
CP0645895 Compound Info	SID50112869 Show/Hide	C36H40N4O5	3
1	Ki = 180 nM
2	Ki = 218.78 nM
3	Ki = 220 nM
CP0037866 Compound Info	CAS_146714-97-8 Show/Hide	C25H34N4O2	1
1	Ki = 322 nM
CP0654918 Compound Info	rac-N3-(3-(4,4-diphenylpiperidin-1-yl)propyl)-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide Show/Hide	C35H39N5O4	1
1	Ki = 330 nM
CP0040436 Compound Info	5-N-[3-(4,4-diphenylpiperidin-1-yl)propyl]-3-N,2,6-trimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide Show/Hide	C36H41N5O4	2
1	Ki = 416.87 nM
2	Ki = 489.78 nM
CP0037227 Compound Info	7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol Show/Hide	C16H25NO	2
1	Ki = 5975 nM
2	Ki < 1000 nM
CP0002071 Compound Info	N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-prop-2-enylprop-2-en-1-amine Show/Hide	C17H22N2O	1
1	Ki < 10000 nM

Clinical Information about the Protein

Target 1 ( Adrenergic receptor alpha-1B (ADRA1B) )

Target Type	Successful Target
Disease	4 Target-related Diseases				4
1	Pain [ICD-11: MG30-MG3Z]
2	Hypertension [ICD-11: BA00-BA04]
3	Obesity [ICD-11: 5B81]
4	Psychiatric disorder [ICD-11: 6E8Z]
Approved Drug(s)	4 Approved Drugs				4
1	Methamphetamine	Drug Info	Approved	Pain
2	Methoxamine	Drug Info	Approved	Hypertension
3	Phendimetrazine	Drug Info	Approved	Obesity
4	Propericiazine	Drug Info	Approved	Psychiatric disorder
Clinical Trial Drug(s)	1 Clinical Trial Drug				1
1	MEDETOMIDINE	Drug Info	Phase 2	Pain

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT01849	Alpha-1B adrenergic receptor	Mesocricetus auratus, Golden hamster	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han