General Information of the Compound
Compound ID
CP0434680
Compound Name
2-(2,6-dimethoxyphenoxy)-N-[(2-phenyl-1,4-dioxan-2-yl)methyl]ethanamine
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Structure
Formula
C21H27NO5
Molecular Weight
373.449
Canonical SMILES
COc1cccc(OC)c1OCCNCC1(COCCO1)c1ccccc1
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InChI
InChI=1S/C21H27NO5/c1-23-18-9-6-10-19(24-2)20(18)26-12-11-22-15-21(16-25-13-14-27-21)17-7-4-3-5-8-17/h3-10,22H,11-16H2,1-2H3
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InChIKey
HMEASZSDPGDKQU-UHFFFAOYSA-N
Physicochemical Property
logP
2.6145
Rotatable Bonds
9
Heavy Atom Count
27
Polar Areas
58.18
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155512508
ChEMBL ID
CHEMBL4437817
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00819, 5-hydroxytryptamine receptor 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000017 HeLa Homo sapiens (Human)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01089, Alpha-1A adrenergic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01007, Alpha-1B adrenergic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01004, Alpha-1D adrenergic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS