General Information of the Protein
Protein ID
PT01849
Protein Name
Alpha-1B adrenergic receptor
Secondarily
Protein Name
Alpha-1B adrenoreceptor
Gene Name
ADRA1B
Sequence
MNPDLDTGHNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRSGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLPSASPSPGYLGRGAQPPLELCAYPEWKSGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESPGTEGDASNGGCDATTDLANGQPGFKSNMPLAPGHF
    Show/Hide
Organism
Mesocricetus auratus, Golden hamster
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Adrenergic receptor
Function
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).
    Show/Hide
Uniprot ID
P18841
Subcellular Location
Nucleus membrane
Cell membrane
Cytoplasm
Membrane
Caveola
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000041 , LTK-
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0035002
 Compound Info 
(R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide
   Show/Hide
C20H28N2O5S
  1
1
Ki = 0.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0049024
 Compound Info 
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine
   Show/Hide
C19H25N5O4
  1
1
Ki = 0.69 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0150194
 Compound Info 
3-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-2,4-dioxo-1,2,3,4-tetrahydro-benzo[4,5]thieno[3,2-d]pyrimidine-7-carboxylic acid amide
   Show/Hide
C26H26N4O4S
  1
1
Ki = 0.86 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0181767
 Compound Info 
3-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-2,4-dioxo-1,2,3,4-tetrahydro-benzo[4,5]thieno[3,2-d]pyrimidine-8-carboxylic acid dimethylamide
   Show/Hide
C28H30N4O4S
  1
1
Ki = 1.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0257880
 Compound Info 
8-Chloro-3-[2-(6-methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione
   Show/Hide
C25H24ClN3O3S
  1
1
Ki = 1.91 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0172953
 Compound Info 
(Cis)2-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-4,9-dihydro-2,4,9-triaza-fluorene-1,3-dione
   Show/Hide
C25H26N4O3
  1
1
Ki = 2.25 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0290436
 Compound Info 
6-Methoxy-2-[2-(6-methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-4H-9-thia-2,4,5-triaza-fluorene-1,3-dione
   Show/Hide
C25H26N4O4S
  1
1
Ki = 3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0215114
 Compound Info 
9-Methoxy-3-[2-(6-methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione
   Show/Hide
C26H27N3O4S
  1
1
Ki = 3.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0200627
 Compound Info 
9-Chloro-3-[2-(6-methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione
   Show/Hide
C25H24ClN3O3S
  1
1
Ki = 3.15 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0215556
 Compound Info 
5-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-8-thia-3,5,11-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),10,12-tetraene-4,6-dione
   Show/Hide
C24H24N4O3S
  1
1
Ki = 3.33 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0087515
 Compound Info 
2-[2-((3aR,9bR)-6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-4H-9-thia-2,4,5-triaza-fluorene-1,3-dione
   Show/Hide
C24H24N4O3S
  1
1
Ki = 3.39 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0200691
 Compound Info 
3-Methoxy-7-[2-(6-methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-5H-9-thia-1,4,5,7-tetraaza-fluorene-6,8-dione
   Show/Hide
C24H25N5O4S
  1
1
Ki = 3.73 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0272523
 Compound Info 
6-Chloro-2-[2-(6-methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-4H-9-thia-2,4,5-triaza-fluorene-1,3-dione
   Show/Hide
C24H23ClN4O3S
  1
1
Ki = 4.15 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0208716
 Compound Info 
3-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-8-methyl-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione
   Show/Hide
C26H27N3O3S
  1
1
Ki = 4.26 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0285996
 Compound Info 
2-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-4H-9-thia-2,4,6-triaza-fluorene-1,3-dione
   Show/Hide
C24H24N4O3S
  1
1
Ki = 4.63 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0306109
 Compound Info 
(Cis)3-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-1H-benzo[4,5]furo[3,2-d]pyrimidine-2,4-dione
   Show/Hide
C25H25N3O4
  1
1
Ki = 5.39 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0278691
 Compound Info 
7-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-5H-9-thia-1,5,7-triaza-fluorene-6,8-dione
   Show/Hide
C24H24N4O3S
  1
1
Ki = 6.12 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0111500
 Compound Info 
3-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-2,4-dioxo-1,2,3,4-tetrahydro-benzo[4,5]thieno[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C26H24N4O3S
  1
1
Ki = 6.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0306128
 Compound Info 
3-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-2,4-dioxo-1,2,3,4-tetrahydro-benzo[4,5]thieno[3,2-d]pyrimidine-8-carboxylic acid amide
   Show/Hide
C26H26N4O4S
  1
1
Ki = 6.34 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0244629
 Compound Info 
8-Methoxy-2-[2-(6-methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-4H-9-thia-2,4,5-triaza-fluorene-1,3-dione
   Show/Hide
C25H26N4O4S
  1
1
Ki = 6.69 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0172104
 Compound Info 
3-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-9-methyl-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione
   Show/Hide
C26H27N3O3S
  1
1
Ki = 6.95 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0331914
 Compound Info 
(Cis)3-[2-(9-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione
   Show/Hide
C25H25N3O3S
  1
1
Ki = 7.82 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0107696
 Compound Info 
3-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-8-nitro-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione
   Show/Hide
C25H24N4O5S
  1
1
Ki = 8.49 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0117265
 Compound Info 
(Cis)3-[4-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-butyl]-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione
   Show/Hide
C27H29N3O3S
  1
1
Ki = 9.95 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0193838
 Compound Info 
7-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-5H-9-thia-1,4,5,7-tetraaza-fluorene-6,8-dione
   Show/Hide
C23H23N5O3S
  1
1
Ki = 12.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0251349
 Compound Info 
7-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-2-methyl-5H-9-thia-1,4,5,7-tetraaza-fluorene-6,8-dione
   Show/Hide
C24H25N5O3S
  1
1
Ki = 13.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0278639
 Compound Info 
7-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-2,3-dimethyl-5H-9-thia-1,4,5,7-tetraaza-fluorene-6,8-dione
   Show/Hide
C25H27N5O3S
  1
1
Ki = 13.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0101288
 Compound Info 
3-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-2,4-dioxo-1,2,3,4-tetrahydro-benzo[4,5]thieno[3,2-d]pyrimidine-8-carboxylic acid methyl ester
   Show/Hide
C27H27N3O5S
  1
1
Ki = 14.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0306296
 Compound Info 
3-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-2,4-dioxo-1,2,3,4-tetrahydro-benzo[4,5]thieno[3,2-d]pyrimidine-8-carbonitrile
   Show/Hide
C26H24N4O3S
  1
1
Ki = 14.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0257865
 Compound Info 
(Cis)3-[3-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-propyl]-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione
   Show/Hide
C26H27N3O3S
  1
1
Ki = 14.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0334912
 Compound Info 
7-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-5H-9-thia-1,3,5,7-tetraaza-fluorene-6,8-dione
   Show/Hide
C23H23N5O3S
  1
1
Ki = 15.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0507035
 Compound Info 
2-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-4H-9-thia-2,4,5,7-tetraaza-fluorene-1,3-dione
   Show/Hide
C23H23N5O3S
  1
1
Ki = 15.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0352054
 Compound Info 
3-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-7-trifluoromethyl-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione
   Show/Hide
C26H24F3N3O3S
  1
1
Ki = 23.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0363623
 Compound Info 
3-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-2,4-dioxo-1,2,3,4-tetrahydro-benzo[4,5]thieno[3,2-d]pyrimidine-6-carbonitrile
   Show/Hide
C26H24N4O3S
  1
1
Ki = 26.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0200084
 Compound Info 
3-Chloro-7-[2-(6-methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-5H-9-thia-1,4,5,7-tetraaza-fluorene-6,8-dione
   Show/Hide
C23H22ClN5O3S
  1
1
Ki = 35.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0081691
 Compound Info 
3-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-2,4-dioxo-1,2,3,4-tetrahydro-benzo[4,5]thieno[3,2-d]pyrimidine-9-carbonitrile
   Show/Hide
C26H24N4O3S
  1
1
Ki = 35.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0296008
 Compound Info 
(Cis)3-[2-(8-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione
   Show/Hide
C25H25N3O3S
  1
1
Ki = 37.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0405674
 Compound Info 
8-Chloro-2-[2-(6-methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-4H-9-thia-2,4,5-triaza-fluorene-1,3-dione
   Show/Hide
C24H23ClN4O3S
  1
1
Ki = 61.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0300109
 Compound Info 
(Cis)3-[2-(7-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione
   Show/Hide
C25H25N3O3S
  1
1
Ki = 119 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0299620
 Compound Info 
7-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-3-phenyl-5H-9-thia-1,4,5,7-tetraaza-fluorene-6,8-dione
   Show/Hide
C29H27N5O3S
  1
1
Ki = 120 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0214818
 Compound Info 
6-Chloro-3-[2-(6-methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione
   Show/Hide
C25H24ClN3O3S
  1
1
Ki = 1220 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0307684
 Compound Info 
7-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-2-phenyl-5H-9-thia-1,4,5,7-tetraaza-fluorene-6,8-dione
   Show/Hide
C29H27N5O3S
  1
1
Ki = 1853 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000019 , Rat1
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0046703
 Compound Info 
1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one
   Show/Hide
C24H26ClFN4O
  1
1 Ki = 0.33 nM
CP0228798
 Compound Info 
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C26H29FN8O
  1
1 Ki = 1.1 nM
CP0126862
 Compound Info 
1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine
   Show/Hide
C24H23FN4
  1
1 Ki = 1.9 nM
CP0126860
 Compound Info 
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3]triazol-4-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C27H30FN7O
  1
1 Ki = 6 nM
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01007 Alpha-1B adrenergic receptor Homo sapiens, Human
 Protein Info