General Information of the Compound
Compound ID
CP0125122
Compound Name
(S)Methamphetamine
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Synonyms
Crank
(+)-(S)-Deoxyephedrine
(+)-(S)-N-alpha-Dimethylphenethylamine
(+)-2-(N-Methylamino)-1-phenylpropane
(+)-Methylamphetamine
(+)-N,alpha-Dimethyl-beta-phenylethylamine
(+)-N,alpha-Dimethylphenethylamine
(+)-N-Methylamphetamine
(+)-methamphetamine
(2S)-N-methyl-1-phenylpropan-2-amine
(S)-(+)-Deoxyephedrine
(S)-(+)-Methamphetamine
(S)-(+)-N,alpha,dimethylphenethylamine
(S)-Methamphetamine
(S)-Methylamphetamine
(S)-N,alpha-Dimethylbenzeneethanamine
(S)-N,alpha-Dimethylbenzeneethanoamine
(alphaS)-N,alpha-dimethylbenzeneethanamine
1-Phenyl-2-methylamino-propan
1-Phenyl-2-methylamino-propan [German]
1-Phenyl-2-methylaminopropane
2S-(+)-Methamphetamine
Benzeneethanamine, N,alpha-dimethyl-, (S)-(9CI)
Benzeneethanamine, N,alpha-dimethyl-, (alphaS)-(9CI)
Crank [Street Name]
Crystal Meth
Crystal Meth [Street Name]
D-(S)-Methamphetamine
D-1-Phenyl-2-methylaminopropan
D-1-Phenyl-2-methylaminopropan [German]
D-1-Phenyl-2-methylaminopropane
D-Deoxyephedrine
D-Desoxyephedrine
D-Methamphetamine
D-Methylamphetamine
D-N,alpha-Dimethylphenethylamine
D-N,alpha-dimethylphenethylamine
D-N-Methylamphetamine
D-Phenylisopropylmethylamine;Desoxyn (TN)
Desohyephedrine
Desyphed
Desyphed hydrochloride
ICE [Street Name]
L-Methamphetamine
METHAMPHETAMINE
Metamfetamina
Metamfetamina [INN-Spanish]
Metamfetamine
Metamfetamine (INN)
Metamfetamine [INN];Metamfetaminum [Latin]
Metamfetamine-m
Metamfetaminum
Metamfetaminum [INN-Latin]
Metamphetamine
Metanfetamina [INN-Spanish]
Metanfetamina [Spanish]
Meth
Meth (Street Name)
Methamfetamine
Methamphetamine
Methamphetamine, its salts, isomers, and salts of its isomers
Methamphetaminum
Methamphetaminum [INN-Latin]
Methamphetaminum [JP]
Methyl-beta-phenylisopropylamine
Methylamphetamine
N-Methyl-1-phenyl-2-propanamine
N-Methyl-beta-phenylisopropylamin
N-Methyl-beta-phenylisopropylamin [German]
N-Methyl-beta-phenylisopropylamine
N-Methylamphetamine
Norodin
Phenethylamine, N,alpha-dimethyl-, (S)-(+)-(8CI)
S-(+)-Methamphetamine
Speed
Speed [Street Name]
Stimulex
d-(S)-Methamphetamine
d-Deoxyephedrine
d-Desoxyephedrine
d-Methamphetamine
d-Methylamphetamine
d-N-Methylamphetamine
d-Phenylisopropylmethylamine
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Structure
Formula
C10H15N
Molecular Weight
149.237
Canonical SMILES
CN[C@@H](C)Cc1ccccc1
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InChI
InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3/t9-/m0/s1
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InChIKey
MYWUZJCMWCOHBA-VIFPVBQESA-N
CAS
14611-50-8
1690-86-4
45952-89-4
139-47-9
537-46-2
Physicochemical Property
logP
1.837
Rotatable Bonds
3
Heavy Atom Count
11
Polar Areas
12.03
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
1
Complexity
11

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10836
SID: 15194699
ChEMBL ID
CHEMBL1201201
DrugBank ID
DB01577
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03226, Trace amine-associated receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  5
1
EC50 = 17.81 nM
   TI
   LI
   LO
   TS
2
EC50 = 70 nM
   TI
   LI
   LO
   TS
3
EC50 = 278.9 nM
   TI
   LI
   LO
   TS
4
EC50 = 920 nM
   TI
   LI
   LO
   TS
5
EC50 = 1822 nM
   TI
   LI
   LO
   TS
Protein ID: PT03501, Trace amine-associated receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  4
1
EC50 = 133.3 nM
   TI
   LI
   LO
   TS
2
EC50 = 201.8 nM
   TI
   LI
   LO
   TS
3
EC50 = 890 nM
   TI
   LI
   LO
   TS
4
EC50 = 2044 nM
   TI
   LI
   LO
   TS
Protein ID: PT04763, Trace amine-associated receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
EC50 = 1300 nM
   TI
   LI
   LO
   TS
CL000076 CHO/Galpha16 Cricetulus griseus (Chinese hamster)  1
1
EC50 = 1500 nM
   TI
   LI
   LO
   TS
Protein ID: PT06422, Trace amine-associated receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000076 CHO/Galpha16 Cricetulus griseus (Chinese hamster)  1
1
EC50 = 5300 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Methamphetamine )
Drug Name Methamphetamine
Company Ovation Pharma
Indication
Pain
Approved
Attention deficit hyperactivity disorder
Approved
Target(s)
Dopamine D2 receptor (D2R)
Agonist
Adrenergic receptor alpha-1B (ADRA1B)
Antagonist