| Compound ID |
Compound Name |
Compound Formula |
|
CP0570783
|
methyl 7-hydroxy-8-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate
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|
C15H19NO3
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0564412
|
3-(4-chlorophenoxy)-8-azabicyclo[3.2.1]octane
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|
C13H16ClNO
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0041749
|
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile
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|
C20H21FN2O
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0573525
|
3-(3-chlorophenoxy)-8-azabicyclo[3.2.1]octane
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|
C13H16ClNO
|
1
|
| 1 |
IC50 = 135 nM
|
|
|
|
CP0538661
|
3-(2-chlorophenoxy)-8-azabicyclo[3.2.1]octane
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|
C13H16ClNO
|
1
|
| 1 |
IC50 = 881 nM
|
|
|
|
CP0435862
|
1-(4-fluorophenyl)-1-[3-[1H-indol-3-ylmethyl(methyl)amino]propyl]-3H-2-benzofuran-5-carbonitrile
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|
C28H26FN3O
|
1
|
| 1 |
IC50 = 3000 nM
|
|
|
|
CP0420949
|
3-[1-(4-fluorophenyl)-5-[(E)-2-phenylethenyl]-3H-2-benzofuran-1-yl]-N,N-dimethylpropan-1-amine
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|
C27H28FNO
|
1
|
| 1 |
IC50 = 3400 nM
|
|
|
|
CP0435297
|
4-[1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-yl]aniline
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|
C25H27FN2O
|
1
|
| 1 |
IC50 = 3600 nM
|
|
|
|
CP0041286
|
(1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile
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|
C20H21FN2O
|
3
|
| 1 |
IC50 = 4600 nM
|
|
|
| 2 |
Kd = 2.6 nM
|
|
|
| 3 |
Ki = 7.4 nM
|
|
|
|
CP0484748
|
1-(4-bromophenyl)-1-[3-(dimethylamino)propyl]-3H-2-benzofuran-5-carbonitrile
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|
C20H21BrN2O
|
1
|
| 1 |
IC50 = 4700 nM
|
|
|
|
CP0471633
|
1-[3-[[1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-yl]methyl-methylamino]propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile
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|
C39H41F2N3O2
|
1
|
| 1 |
IC50 = 4900 nM
|
|
|
|
CP0484195
|
1-(4-fluorophenyl)-1-[3-[methyl(2-phenylethyl)amino]propyl]-3H-2-benzofuran-5-carbonitrile
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|
C27H27FN2O
|
1
|
| 1 |
IC50 = 5300 nM
|
|
|
|
CP0552513
|
methyl 8-(3,4-dichlorophenyl)-7-hydroxy-8-azabicyclo[3.2.1]octane-2-carboxylate
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|
C15H17Cl2NO3
|
1
|
| 1 |
IC50 = 5655 nM
|
|
|
|
CP0569006
|
3-phenoxy-8-azabicyclo[3.2.1]octane
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|
C13H17NO
|
1
|
| 1 |
IC50 = 5655 nM
|
|
|
|
CP0519774
|
1-(4-fluorophenyl)-1-[3-[(5-methoxy-1H-indol-3-yl)methyl-methylamino]propyl]-3H-2-benzofuran-5-carbonitrile
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|
C29H28FN3O2
|
1
|
| 1 |
IC50 = 5800 nM
|
|
|
|
CP0124728
|
2-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]-5-[[6-[[(1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-yl]methylamino]-6-oxohexyl]sulfamoyl]benzenesulfonate
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|
C53H64FN5O8S2
|
2
|
| 1 |
Ki = 3 nM
|
|
|
| 2 |
Ki = 34 nM
|
|
|
|
CP0377666
|
5-[[6-[3-[3-[(1S)-5-cyano-1-(4-fluorophenyl)-3H-2-benzofuran-1-yl]propyl-methylamino]propylamino]-6-oxohexyl]sulfamoyl]-2-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]benzenesulfonate
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|
C55H65FN6O8S2
|
2
|
| 1 |
Ki = 11 nM
|
|
|
| 2 |
Ki = 140 nM
|
|
|
|
CP0400724
|
2-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]-5-[[6-[3-[(1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-yl]propylamino]-6-oxohexyl]sulfamoyl]benzenesulfonate
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|
C55H68FN5O8S2
|
2
|
| 1 |
Ki = 11 nM
|
|
|
| 2 |
Ki = 37 nM
|
|
|
|
CP0135457
|
(2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-8-methyl-8-azonia-bicyclo[3.2.1]octane
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|
C16H19Cl2NO2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0400723
|
2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl)-5-(5-{2-[3-(3,4-dichloro-phenyl)-2-methoxycarbonyl-8-aza-bicyclo[3.2.1]oct-8-yl]-ethylcarbamoyl}-pentylsulfamoyl)-benzenesulfonic acid anion
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|
C50H61Cl2N5O9S2
|
2
|
| 1 |
Ki = 94 nM
|
|
|
| 2 |
Ki = 392 nM
|
|
|
|
CP0389631
|
US10913711, Compound 4b
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|
C15H15Cl2NS
|
2
|
| 1 |
Ki = 170 nM
|
|
|
| 2 |
Ki = 270 nM
|
|
|
|
CP0416048
|
5-[[6-[5-[3-[(1S)-5-cyano-1-(4-fluorophenyl)-3H-2-benzofuran-1-yl]propyl-methylamino]pentylamino]-6-oxohexyl]sulfamoyl]-2-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]benzenesulfonate
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|
C57H69FN6O8S2
|
2
|
| 1 |
Ki = 180 nM
|
|
|
| 2 |
Ki = 250 nM
|
|
|
|
CP0853656
|
[1-(3-{2-[3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-8-azabicyclo[3.2.1]oct-8-yl]-ethylcarbamoyl}-propyl)-11,11-dimethyl-2,3,4,11-tetrahydro-1H-naphtho[2,3-g]quinolin-9-ylidene]-dimethyl-ammonium perchlorate
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|
C42H51Cl3N4O7
|
1
|
| 1 |
Ki = 227 nM
|
|
|
|
CP0046624
|
US10913711, Compound 4a
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|
C15H17NS
|
2
|
| 1 |
Ki = 630 nM
|
|
|
| 2 |
Ki = 690 nM
|
|
|
|
CP0393974
|
2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl)-5-[(4-{2-[3-(3,4-dichloro-phenyl)-2-methoxycarbonyl-8-aza-bicyclo[3.2.1]oct-8-yl]-ethylcarbamoyl}-cyclohexylmethyl)-sulfamoyl]-benzenesulfonic acid anion
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|
C52H63Cl2N5O9S2
|
1
|
| 1 |
Ki = 705 nM
|
|
|
|
CP0393973
|
2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl)-5-(5-{2-[3-(3,4-dichloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carbonyloxy]-ethylcarbamoyl}-pentylsulfamoyl)-benzenesulfonic acid anion
Show/Hide
|
C50H61Cl2N5O9S2
|
1
|
| 1 |
Ki = 1490 nM
|
|
|
|
CP0407053
|
US10913711, Compound 2h
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|
C16H15Cl2NOS
|
2
|
| 1 |
Ki = 8300 nM
|
|
|
| 2 |
Ki = 27000 nM
|
|
|
