Protein Information

General Information of the Protein

Protein ID	PT05357
Protein Name	Sodium/nucleoside cotransporter 2
Secondarily Protein Name	Concentrative nucleoside transporter 2 Na(+)/nucleoside cotransporter 2 Sodium-coupled nucleoside transporter 2 Sodium/purine nucleoside co-transporter Solute carrier family 28 member 2
Gene Name	SLC28A2
Secondarily Gene Name	CNT2
Sequence	MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSRWPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVHSFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGICMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYTVAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTATETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDASSLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLATNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMVAEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLSSIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPNTSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Transporter > Electrochemical transporter > SLC superfamily of solute carriers > SLC28 and SLC29 families of nucleoside transporters > SLC28 Na+-coupled nucleoside transport family
Function	Sodium-dependent and purine-selective transporter (PubMed:9435697, PubMed:10087507). Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (PubMed:9435697, PubMed:10087507, PubMed:21795683). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues (PubMed:9435697). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Show/Hide
Uniprot ID	Primary ID: O43868 Secondarily ID: A8K7F9 O43239 Q52LZ0 Show/Hide
Ensembl ID	ENSG00000137860
HGNC ID	HGNC:11002
Subcellular Location	Membrane Apicolateral cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000053 , COS-7

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0420092 Compound Info	(2R,3R,4S,5R)-2-[2-[[3-(4-hydroxybutoxy)-4-phenylphenyl]methylamino]benzimidazol-1-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C29H33N3O6	1
1	IC50 = 62 nM Bioactivity Info	TI LI LO TS
CP0420091 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C23H24N6O4	1
1	IC50 = 640 nM Bioactivity Info	TI LI LO TS
CP0464430 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[[3-(4-hydroxybutoxy)-4-phenylphenyl]methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C27H32N6O6	1
1	IC50 = 940 nM Bioactivity Info	TI LI LO TS
CP0420026 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(4-pyridin-3-ylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C22H23N7O4	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0402947 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(2-methoxy-4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C24H26N6O5	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0420048 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[[3-(3-hydroxypropoxy)-4-phenylphenyl]methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C26H30N6O6	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0445468 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(3-hydroxy-4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C23H24N6O5	1
1	IC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0420046 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(2-hydroxy-4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C23H24N6O5	1
1	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0420049 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(3-methoxy-4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C24H26N6O5	1
1	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0493658 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(4-pyridin-2-ylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C22H23N7O4	1
1	IC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0420093 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[[3-(5-hydroxypentoxy)-4-phenylphenyl]methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C28H34N6O6	1
1	IC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0420047 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(3-ethoxy-4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C25H28N6O5	1
1	IC50 = 2300 nM Bioactivity Info	TI LI LO TS
CP0542133 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(4-pyridin-4-ylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C22H23N7O4	1
1	IC50 = 2700 nM Bioactivity Info	TI LI LO TS
CP0420153 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[[3-(2-hydroxyethoxy)-4-phenylphenyl]methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C25H28N6O6	1
1	IC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0420090 Compound Info	methyl 2-[5-[[[6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-8-yl]amino]methyl]-2-phenylphenoxy]acetate Show/Hide	C26H28N6O7	1
1	IC50 = 3300 nM Bioactivity Info	TI LI LO TS
CP0402946 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(4-phenyl-3-propoxyphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C26H30N6O5	1
1	IC50 = 5200 nM Bioactivity Info	TI LI LO TS
CP0453707 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-(naphthalen-2-ylmethylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C21H22N6O4	1
1	IC50 = 5300 nM Bioactivity Info	TI LI LO TS
CP0499769 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(3-chlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C17H19ClN6O4	1
1	IC50 = 5400 nM Bioactivity Info	TI LI LO TS
CP0464429 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(2-ethoxy-4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C25H28N6O5	1
1	IC50 = 5400 nM Bioactivity Info	TI LI LO TS
CP0420088 Compound Info	2-[5-[[[6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-8-yl]amino]methyl]-2-phenylphenoxy]acetamide Show/Hide	C25H27N7O6	1
1	IC50 = 5500 nM Bioactivity Info	TI LI LO TS
CP0507960 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-(naphthalen-1-ylmethylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C21H22N6O4	1
1	IC50 = 5700 nM Bioactivity Info	TI LI LO TS
CP0529621 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(2-chlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C17H19ClN6O4	1
1	IC50 = 5700 nM Bioactivity Info	TI LI LO TS
CP0572689 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(4-phenyl-2-propan-2-yloxyphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C26H30N6O5	1
1	IC50 = 9300 nM Bioactivity Info	TI LI LO TS
CP0420094 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(4-phenyl-3-propan-2-yloxyphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C26H30N6O5	1
1	IC50 = 10400 nM Bioactivity Info	TI LI LO TS
CP0174436 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(4-methylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C18H22N6O4	1
1	IC50 = 11000 nM Bioactivity Info	TI LI LO TS
CP0355938 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(4-chlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C17H19ClN6O4	1
1	IC50 = 11000 nM Bioactivity Info	TI LI LO TS
CP0530823 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(3-methoxyphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C18H22N6O5	1
1	IC50 = 13000 nM Bioactivity Info	TI LI LO TS
CP0499770 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(3-methylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C18H22N6O4	1
1	IC50 = 19000 nM Bioactivity Info	TI LI LO TS
CP0407561 Compound Info	9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-[[3-(4-hydroxybutoxy)-4-phenylphenyl]methylamino]-1H-purin-6-one Show/Hide	C27H31N5O7	1
1	IC50 = 20100 nM Bioactivity Info	TI LI LO TS
CP0441649 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(3-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C23H24N6O4	1
1	IC50 = 21000 nM Bioactivity Info	TI LI LO TS
CP0486894 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(4-methoxyphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C18H22N6O5	1
1	IC50 = 36000 nM Bioactivity Info	TI LI LO TS
CP0132050 Compound Info	adenosine-derived inhibitor, 6 Show/Hide	C17H20N6O4	1
1	IC50 = 52000 nM Bioactivity Info	TI LI LO TS
CP0569331 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(2-methylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C18H22N6O4	1
1	IC50 = 65000 nM Bioactivity Info	TI LI LO TS
CP0390514 Compound Info	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-pentylcarbamate Show/Hide	C16H24N6O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0390515 Compound Info	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl ethyl carbonate Show/Hide	C13H17N5O6	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0390516 Compound Info	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hexanoate Show/Hide	C16H23N5O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0390517 Compound Info	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl acetate Show/Hide	C12H15N5O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0390518 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(2-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C23H24N6O4	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0390519 Compound Info	(2R,3R,4S,5R)-2-[6-amino-8-[(2-methoxyphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C18H22N6O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0398080 Compound Info	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-benzylcarbamate Show/Hide	C18H20N6O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0398081 Compound Info	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl pentyl carbonate Show/Hide	C16H23N5O6	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0398082 Compound Info	Ado-5'-ethylcarboxylate Show/Hide	C13H17N5O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0453705 Compound Info	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-methylcarbamate Show/Hide	C12H16N6O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0453706 Compound Info	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl 2-phenylacetate Show/Hide	C18H19N5O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0486893 Compound Info	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl methyl carbonate Show/Hide	C12H15N5O6	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0569330 Compound Info	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl benzyl carbonate Show/Hide	C18H19N5O6	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0858176 Compound Info	5'-O-(Ethylcarbamoyl)adenosine Show/Hide	C13H18N6O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0050531 Compound Info	1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-3-(4-hydroxyphenyl)propan-1-one Show/Hide	C21H24O10	1
1	IC50 = 100000 nM

Clinical Information about the Protein

Target 1 ( Solute carrier family 28 member 2 (SLC28A2) )

Target Type	Literature-reported Target

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT06620	Sodium/nucleoside cotransporter 2	Rattus norvegicus, Rat	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han