General Information of the Protein
Protein ID
PT06620
Protein Name
Sodium/nucleoside cotransporter 2
Secondarily
Protein Name
Concentrative nucleoside transporter 2
Na(+)/nucleoside cotransporter 2
Sodium-coupled nucleoside transporter 2
Sodium/purine nucleoside cotransporter
Solute carrier family 28 member 2
Gene Name
SLC28A2
Secondarily
Gene Name
Cnt2
Spnt
Sequence
MAKSEGRKSASQDTSENGMENPGLELMEVGNLEQGKTLEEVTQGHSLKDGLGHSSLWRRILQPFTKARSFYQRHAGLFKKILLGLLCLAYAAYLLAACILNFRRALALFVITCLVIFILACHFLKKFFAKKSIRCLKPLKNTRLRLWLKRVFMGAAVVGLILWLALDTAQRPEQLISFAGICMFILILFACSKHHSAVSWRTVFWGLGLQFVFGILVIRTEPGFNAFQWLGDQIQIFLAYTVEGSSFVFGDTLVQSVFAFQSLPIIIFFGCVMSILYYLGLVQWVIQKIAWFLQITMGTTAAETLAVAGNIFVGMTEAPLLIRPYLADMTLSEIHAVMTGGFATIAGTVLGAFISFGIDASSLISASVMAAPCALALSKLVYPEVEESKFKSKEGVKLPRGEERNILEAASNGATDAIALVANVAANLIAFLAVLAFINSTLSWLGEMVDIHGLTFQVICSYVLRPMVFMMGVQWADCPLVAEIVGVKFFINEFVAYQQLSQYKNKRLSGVEEWINGEKQWISVKAEIIATFSLCGFANLTSIGITLGGLTSMVPQRKSDLCKLVVRALFTGACVSFISACMAGILYVPRGAETDCVSFLNTNFTNRTYETYVCCRELFQSTLLNGTNMPSFSGPWQDKESSLRNLAKCCDLYTSTVCA
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Organism
Rattus norvegicus, Rat
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC28 and SLC29 families of nucleoside transporters
>
SLC28 Na+-coupled nucleoside transport family
Function
Sodium-dependent and purine-selective (PubMed:7775409, PubMed:8967974, PubMed:1315767). Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (PubMed:7775409, PubMed:8967974, PubMed:1315767). Accepts purine, analogs of purine nucleosides and uridine, and exhibits high affinity for adenosine (PubMed:7775409). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity).
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Uniprot ID
Primary ID:
Q62773

Secondarily ID:
Q9QWI3
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Ensembl ID
ENSG00000137860
Subcellular Location
Membrane
Apicolateral cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0420092
 Compound Info 
(2R,3R,4S,5R)-2-[2-[[3-(4-hydroxybutoxy)-4-phenylphenyl]methylamino]benzimidazol-1-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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C29H33N3O6
  1
1
IC50 = 1500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0464430
 Compound Info 
(2R,3R,4S,5R)-2-[6-amino-8-[[3-(4-hydroxybutoxy)-4-phenylphenyl]methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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C27H32N6O6
  1
1
IC50 = 38000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420048
 Compound Info 
(2R,3R,4S,5R)-2-[6-amino-8-[[3-(3-hydroxypropoxy)-4-phenylphenyl]methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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C26H30N6O6
  1
1
IC50 = 45100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420093
 Compound Info 
(2R,3R,4S,5R)-2-[6-amino-8-[[3-(5-hydroxypentoxy)-4-phenylphenyl]methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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C28H34N6O6
  1
1
IC50 = 60000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420026
 Compound Info 
(2R,3R,4S,5R)-2-[6-amino-8-[(4-pyridin-3-ylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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C22H23N7O4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420088
 Compound Info 
2-[5-[[[6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-8-yl]amino]methyl]-2-phenylphenoxy]acetamide
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C25H27N7O6
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0420153
 Compound Info 
(2R,3R,4S,5R)-2-[6-amino-8-[[3-(2-hydroxyethoxy)-4-phenylphenyl]methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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C25H28N6O6
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT05357 Sodium/nucleoside cotransporter 2 Homo sapiens, Human
 Protein Info