General Information of the Protein
Protein ID
PT06288
Protein Name
Vitamin D3 receptor
Secondarily
Protein Name
1,25-dihydroxyvitamin D3 receptor
Nuclear receptor subfamily 1 group I member 1
Gene Name
VDR
Secondarily
Gene Name
Nr1i1
Sequence
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPIRADVSTGSYSPRPTLSFSGDSSSNSDLYTPSLDMMEPASFSTMDLNEEGSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTLDDMSWDCGSQDYKYDITDVSRAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGNEIS
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Organism
Mus musculus, Mouse
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 1
>
Nuclear hormone receptor subfamily 1 group I
>
Nuclear hormone receptor subfamily 1 group I member 1
Function
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (PubMed:32354638). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (PubMed:12016314, PubMed:32354638).
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Uniprot ID
Primary ID:
P48281

Secondarily ID:
Q922X0
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Subcellular Location
Nucleus
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0867864
 Compound Info 
(20R)-1-alpha-25-dihydroxy-2-beta-(2-hydroxyethoxy)-16-ene-22-thia-26,27-dimethyl-19,24-dinorvitamin D3
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C28H46O5S
  1
1
EC50 = 0.024 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0900889
 Compound Info 
(20S)-(2E)-1-alpha-25-Dihydroxy-2-[2-(hydroxy)-ethylidene]-16-ene-22-thia-26,27-dimethyl-19,24-dinorvitamin D3
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C28H44O4S
  1
1
EC50 = 0.026 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0858884
 Compound Info 
(20R)-(2E)-1-alpha-25-Dihydroxy-2-[2-(hydroxy)-ethylidene]-16-ene-22-thia-26,27-dimethyl-19,24-dinorvitamin D3
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C28H44O4S
  1
1
EC50 = 0.029 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0888468
 Compound Info 
(20S)-1-alpha-25-dihydroxy-2-beta-(2-hydroxyethoxy)-16-ene-22-thia-26,27-dimethyl-19-norvitamin D3
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C30H50O4S
  1
1
EC50 = 0.03 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0888467
 Compound Info 
(20S)-1-alpha-25-dihydroxy-2-beta-(2-hydroxyethoxy)-16-ene-22-thia-24-homo-26,27-dimethyl-19-norvitamin D3
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C31H52O4S
  1
1
EC50 = 0.09 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0850262
 Compound Info 
(20S)-1-alpha-2-alpha-25-Trihydroxy-2beta-methyl-16-ene-22-thia-26,27-dimethyl-19,24-dinorvitamin D3
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C27H44O4S
  1
1
EC50 = 1.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0898960
 Compound Info 
(20R)-1-alpha-2-alpha-25-Trihydroxy-2-beta-methyl-16-ene-22-thia-26,27-dimethyl-19,24-dinorvitamin D3
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C27H44O4S
  1
1
EC50 = 4.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02576 Vitamin D3 receptor Rattus norvegicus, Rat
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT02378 Vitamin D3 receptor Homo sapiens, Human
 Protein Info