Brief Information of the Cell Line and Protein
Cell Line ID: CL000053 , COS-7
Synonyms
Cos-7
COS 7
Cos 7
COS7
Cos7
CV-1 in Origin Simian-7
Category Transformed cell line
Organism
Chlorocebus aethiops (Green monkey)
Cellosaurus ID
CVCL_0224
Protein ID: PT01953 , Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Gene Name ENPP1
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P22413
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000053  Protein ID: PT01953
 
Compound ID Compound Name Compound Formula
CP0573617
N-[3-[3-(3-chloro-4-methoxyphenyl)-4-pyridin-4-ylpyrazol-1-yl]phenyl]-4-methylbenzenesulfonamide
   Show/Hide
C28H23ClN4O3S
 1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
CP0457528
[4-[6-(4-tert-butylphenyl)sulfonyloxy-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-2-yl]phenyl] 4-tert-butylbenzenesulfonate
   Show/Hide
C48H51NO8S3
 1
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
CP0455865
[4-[6-(4-methoxyphenyl)sulfonyloxy-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-2-yl]phenyl] 4-methoxybenzenesulfonate
   Show/Hide
C42H39NO10S3
 1
1
IC50 = 420 nM
   TI
   LI
   LO
   TS
CP0421361
[4-[6-(4-methylphenyl)sulfonyloxy-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-2-yl]phenyl] 4-methylbenzenesulfonate
   Show/Hide
C42H39NO8S3
 1
1
IC50 = 450 nM
   TI
   LI
   LO
   TS
CP0554610
N-(3-nitrophenyl)sulfonylpyrrolo[2,3-b]pyridine-1-carboxamide
   Show/Hide
C14H10N4O5S
 1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
CP0573434
N-(benzenesulfonyl)-4-chloropyrrolo[2,3-b]pyridine-1-carboxamide
   Show/Hide
C14H10ClN3O3S
 1
1
IC50 = 1080 nM
   TI
   LI
   LO
   TS
CP0549034
5-bromo-N-(3-nitrophenyl)sulfonylpyrrolo[2,3-b]pyridine-1-carboxamide
   Show/Hide
C14H9BrN4O5S
 1
1
IC50 = 1150 nM
   TI
   LI
   LO
   TS
CP0569545
5-bromo-N-(4-methylphenyl)sulfonylpyrrolo[2,3-b]pyridine-1-carboxamide
   Show/Hide
C15H12BrN3O3S
 1
1
IC50 = 1550 nM
   TI
   LI
   LO
   TS
CP0393057
(4-chlorophenyl)-[3,5-dimethyl-4-(4-methylphenoxy)pyrazol-1-yl]methanone
   Show/Hide
C19H17ClN2O2
 1
1
IC50 = 2530 nM
   TI
   LI
   LO
   TS
CP0451225
N-(benzenesulfonyl)-4-(dimethylamino)pyrrolo[2,3-b]pyridine-1-carboxamide
   Show/Hide
C16H16N4O3S
 1
1
IC50 = 2770 nM
   TI
   LI
   LO
   TS
CP0569547
4-chloro-N-naphthalen-2-ylsulfonylpyrrolo[2,3-b]pyridine-1-carboxamide
   Show/Hide
C18H12ClN3O3S
 1
1
IC50 = 3290 nM
   TI
   LI
   LO
   TS
CP0466473
[4-[3-[4-(2-piperidin-1-ylethoxy)benzoyl]-6-[4-(trifluoromethyl)phenyl]sulfonyloxy-1-benzothiophen-2-yl]phenyl] 4-(trifluoromethyl)benzenesulfonate
   Show/Hide
C42H33F6NO8S3
 1
1
IC50 = 4010 nM
   TI
   LI
   LO
   TS
CP0455851
[4-[6-(dimethylsulfamoyloxy)-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-2-yl]phenyl] N,N-dimethylsulfamate
   Show/Hide
C32H37N3O8S3
 1
1
IC50 = 4240 nM
   TI
   LI
   LO
   TS
CP0248022
(4-aminophenyl)-(4-chloro-3,5-dimethylpyrazol-1-yl)methanone
   Show/Hide
C12H12ClN3O
 1
1
IC50 = 4350 nM
   TI
   LI
   LO
   TS
CP0554612
N-(benzenesulfonyl)pyrrolo[2,3-b]pyridine-1-carboxamide
   Show/Hide
C14H11N3O3S
 1
1
IC50 = 4500 nM
   TI
   LI
   LO
   TS
CP0213064
4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl-1H-pyrazole
   Show/Hide
C12H10Cl2N2O
 1
1
IC50 = 5340 nM
   TI
   LI
   LO
   TS
CP0360392
(4-chloro-3,5-dimethylpyrazol-1-yl)-pyridin-4-ylmethanone
   Show/Hide
C11H10ClN3O
 1
1
IC50 = 5420 nM
   TI
   LI
   LO
   TS
CP0014670
CHEMBL3040216
   Show/Hide
C51H40N6O23S6
 3
1
IC50 = 7770 nM
   TI
   LI
   LO
   TS
2
IC50 = 8670 nM
   TI
   LI
   LO
   TS
3
Ki = 260 nM
   TI
   LI
   LO
   TS
CP0392815
3,5-dimethyl-4-naphthalen-2-yloxy-1H-pyrazole
   Show/Hide
C15H14N2O
 1
1
IC50 = 8040 nM
   TI
   LI
   LO
   TS
CP0569546
N-(benzenesulfonyl)-5-bromopyrrolo[2,3-b]pyridine-1-carboxamide
   Show/Hide
C14H10BrN3O3S
 1
1
IC50 = 8300 nM
   TI
   LI
   LO
   TS
CP0487595
[4-[6-(4-fluorophenyl)sulfonyloxy-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-2-yl]phenyl] 4-fluorobenzenesulfonate
   Show/Hide
C40H33F2NO8S3
 1
1
IC50 = 8880 nM
   TI
   LI
   LO
   TS
CP0554611
N-(4-chlorophenyl)sulfonylpyrrolo[2,3-b]pyridine-1-carboxamide
   Show/Hide
C14H10ClN3O3S
 1
1
IC50 = 10360 nM
   TI
   LI
   LO
   TS
CP0847177
pentasodium {[({[(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl phosphonato}methyl)phosphinato]oxy}(boranuidyl)phosphoryl ({[(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl phosphonato}methyl)phosphonate
   Show/Hide
C22H31BN10Na5O17P5
 2
1
IC50 = 13000 nM
   TI
   LI
   LO
   TS
2
Ki = 9000 nM
   TI
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   TS
CP0847499
sodium bis(((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)oxidophosphoryl)methyl)diphosphonate
   Show/Hide
C22H28N10Na4O17P4
 2
1
IC50 = 33000 nM
   TI
   LI
   LO
   TS
2
Ki = 13000 nM
   TI
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   TS
CP0847178
sodium bis(((((2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)oxidophosphoryl)methyl)diphosphonate
   Show/Hide
C22H28N10Na4O15P4
 3
1
IC50 = 50000 nM
   TI
   LI
   LO
   TS
2
Ki = 51000 nM
   TI
   LI
   LO
   TS
3
Ki = 80000 nM
   TI
   LI
   LO
   TS
CP0847500
pentasodium {[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}methyl)phosphinato]oxy}(boranuidyl)phosphoryl ({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}methyl)phosphonate
   Show/Hide
C22H31BN10Na5O19P5
 3
1
IC50 = 63000 nM
   TI
   LI
   LO
   TS
2
Ki = 20000 nM
   TI
   LI
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   TS
3
Ki = 31000 nM
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   LI
   LO
   TS
CP0068517
(4-aminophenyl)-(3,5-dimethylpyrazol-1-yl)methanone
   Show/Hide
C12H13N3O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0068518
(4-chloro-3,5-dimethylpyrazol-1-yl)-naphthalen-2-ylmethanone
   Show/Hide
C16H13ClN2O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0080092
(3,5-dimethylpyrazol-1-yl)-(3-methylphenyl)methanone
   Show/Hide
C13H14N2O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0080093
(2R)-1-(4-chloro-3,5-dimethylpyrazol-1-yl)-2-[4-(2-methylpropyl)phenyl]propan-1-one
   Show/Hide
C18H23ClN2O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0080094
2-(4-aminobenzoyl)-5-methyl-1H-pyrazol-3-one
   Show/Hide
C11H11N3O2
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0197995
(3,5-dimethylpyrazol-1-yl)-naphthalen-2-ylmethanone
   Show/Hide
C16H14N2O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0249219
(4-chlorophenyl)-(3,5-dimethylpyrazol-1-yl)methanone
   Show/Hide
C12H11ClN2O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0271237
(4-chloro-3,5-dimethylpyrazol-1-yl)-(3-methylphenyl)methanone
   Show/Hide
C13H13ClN2O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0346103
5-methyl-2-(4-methylbenzoyl)-1H-pyrazol-3-one
   Show/Hide
C12H12N2O2
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0360393
(E)-1-(4-chloro-3,5-dimethylpyrazol-1-yl)-3-phenylprop-2-en-1-one
   Show/Hide
C14H13ClN2O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0360394
(4-aminophenyl)-[3,5-dimethyl-4-(4-methylphenoxy)pyrazol-1-yl]methanone
   Show/Hide
C19H19N3O2
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0386814
(4-chloro-3,5-dimethylpyrazol-1-yl)-(4-methylphenyl)methanone
   Show/Hide
C13H13ClN2O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0386818
(3,5-Dimethyl-pyrazol-1-yl)-pyridin-4-yl-methanone
   Show/Hide
C11H11N3O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0393064
(4-chloro-3,5-dimethylpyrazol-1-yl)-(2-methylphenyl)methanone
   Show/Hide
C13H13ClN2O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0393067
(3,5-dimethylpyrazol-1-yl)-(2-methylphenyl)methanone
   Show/Hide
C13H14N2O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0073082
6,7-dimethoxy-2-[(E)-2-pyridin-3-ylethenyl]-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline
   Show/Hide
C24H30N6O4S
 1
1
Ki = 58 nM
   TI
   LI
   LO
   TS
CP0046920
6,7-dimethoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline
   Show/Hide
C17H25N5O4S
 1
1
Ki = 59 nM
   TI
   LI
   LO
   TS
CP0389840
6,7-dimethoxy-2-[(E)-2-pyridin-2-ylethenyl]-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline
   Show/Hide
C24H30N6O4S
 1
1
Ki = 71 nM
   TI
   LI
   LO
   TS
CP0533325
6,7-dimethoxy-2-[(3-oxo-1H-2-benzofuran-1-yl)methyl]-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline
   Show/Hide
C26H31N5O6S
 1
1
Ki = 90 nM
   TI
   LI
   LO
   TS
CP0545978
6,7-dimethoxy-2-[(E)-2-(3-methoxyphenyl)ethenyl]-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline
   Show/Hide
C26H33N5O5S
 1
1
Ki = 101 nM
   TI
   LI
   LO
   TS
CP0393268
2-[(E)-2-(2-fluorophenyl)ethenyl]-6,7-dimethoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline
   Show/Hide
C25H30FN5O4S
 1
1
Ki = 211 nM
   TI
   LI
   LO
   TS
CP0393272
6,7-dimethoxy-2-[(E)-2-pyridin-4-ylethenyl]-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline
   Show/Hide
C24H30N6O4S
 1
1
Ki = 218 nM
   TI
   LI
   LO
   TS
CP0533324
6,7-dimethoxy-2-[(E)-2-(4-methoxyphenyl)ethenyl]-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline
   Show/Hide
C26H33N5O5S
 1
1
Ki = 231 nM
   TI
   LI
   LO
   TS
CP0521481
6-methoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline
   Show/Hide
C16H23N5O3S
 1
1
Ki = 242 nM
   TI
   LI
   LO
   TS
CP0389804
methyl 3-[(E)-2-[6,7-dimethoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazolin-2-yl]ethenyl]benzoate
   Show/Hide
C27H33N5O6S
 1
1
Ki = 297 nM
   TI
   LI
   LO
   TS
CP0412039
6,7-dimethoxy-2-[(E)-2-(2-methoxyphenyl)ethenyl]-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline
   Show/Hide
C26H33N5O5S
 1
1
Ki = 302 nM
   TI
   LI
   LO
   TS
CP0529297
2-[2-(4-fluorophenyl)ethyl]-6,7-dimethoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline
   Show/Hide
C25H32FN5O4S
 1
1
Ki = 366 nM
   TI
   LI
   LO
   TS
CP0523452
2-[(E)-2-(4-fluorophenyl)ethenyl]-6,7-dimethoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline
   Show/Hide
C25H30FN5O4S
 1
1
Ki = 465 nM
   TI
   LI
   LO
   TS
CP0143975
CHEMBL3087158
   Show/Hide
C11H19BN5O11P3
 1
1
Ki = 500 nM
   TI
   LI
   LO
   TS
CP0178522
CHEBI:34946
   Show/Hide
C29H20ClN7O11S3
 1
1
Ki = 520 nM
   TI
   LI
   LO
   TS
CP0462173
2-[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]ethanamine
   Show/Hide
C17H24N4O2
 1
1
Ki = 699 nM
   TI
   LI
   LO
   TS
CP0422437
[dichloro-[[2-[(2,4-dioxopyrimidin-1-yl)methoxy]ethoxy-sulfanylphosphinothioyl]oxy-hydroxyphosphoryl]methyl]phosphonic acid
   Show/Hide
C8H13Cl2N2O10P3S2
 1
1
Ki = 730 nM
   TI
   LI
   LO
   TS
CP0391149
[[2-[(2,4-dioxopyrimidin-1-yl)methoxy]ethoxy-sulfanylphosphinothioyl]oxy-hydroxyphosphoryl]methylphosphonic acid
   Show/Hide
C8H15N2O10P3S2
 1
1
Ki = 940 nM
   TI
   LI
   LO
   TS
CP0408021
[2-[(2,4-dioxopyrimidin-1-yl)methoxy]ethoxy-sulfanylphosphinothioyl] phosphono hydrogen phosphate
   Show/Hide
C7H13N2O11P3S2
 1
1
Ki = 1280 nM
   TI
   LI
   LO
   TS
CP0518911
4-chloro-6-ethoxy-7-methoxyquinazoline
   Show/Hide
C11H11ClN2O2
 1
1
Ki = 1311 nM
   TI
   LI
   LO
   TS
CP0462171
methyl 4-[(E)-2-[6,7-dimethoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazolin-2-yl]ethenyl]benzoate
   Show/Hide
C27H33N5O6S
 1
1
Ki = 1340 nM
   TI
   LI
   LO
   TS
CP0412038
6,7-dimethoxy-2-[(E)-2-phenylethenyl]-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline
   Show/Hide
C25H31N5O4S
 1
1
Ki = 1840 nM
   TI
   LI
   LO
   TS
CP0408022
[2-[(2,4-dioxopyrimidin-1-yl)methoxy]ethoxy-sulfanylphosphinothioyl] dihydrogen phosphate
   Show/Hide
C7H12N2O8P2S2
 1
1
Ki = 2830 nM
   TI
   LI
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   TS
CP0521480
4-chloro-7-methoxy-6-propoxyquinazoline
   Show/Hide
C12H13ClN2O2
 1
1
Ki = 3241 nM
   TI
   LI
   LO
   TS
CP0462172
2-[(E)-2-(3-fluorophenyl)ethenyl]-6,7-dimethoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline
   Show/Hide
C25H30FN5O4S
 1
1
Ki = 3583 nM
   TI
   LI
   LO
   TS
CP0242592
CHEMBL3087159
   Show/Hide
C11H19BN5O11P3
 1
1
Ki = 7000 nM
   TI
   LI
   LO
   TS
CP0389806
[(E)-3-(4-chloro-7-methoxyquinazolin-6-yl)oxyprop-1-enyl]-pentafluoro-lambda6-sulfane
   Show/Hide
C12H10ClF5N2O2S
 1
1
Ki = 7965 nM
   TI
   LI
   LO
   TS
CP0084216
CHEMBL3087166
   Show/Hide
C11H17BCl2N5O11P3
 1
1
Ki = 18000 nM
   TI
   LI
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   TS
CP0242590
[[[(2R,3S,4R,5R)-5-(6-amino-2-methylsulfanylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]-difluoromethyl]phosphonic acid
   Show/Hide
C12H17F2N5O9P2S
 1
1
Ki = 26000 nM
   TI
   LI
   LO
   TS
CP0478932
CHEMBL3087167
   Show/Hide
C11H17BCl2N5O11P3
 1
1
Ki = 28000 nM
   TI
   LI
   LO
   TS
CP0426716
({[({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}difluoromethyl)phosphonic acid
   Show/Hide
C12H18F2N5O12P3S
 1
1
Ki = 37000 nM
   TI
   LI
   LO
   TS
CP0084217
CHEMBL3087160
   Show/Hide
C12H21BN5O11P3S
 1
1
Ki = 56000 nM
   TI
   LI
   LO
   TS