Brief Information of the Cell Line and Protein
Cell Line ID: CL000053 , COS-7
Synonyms
Cos-7
COS 7
Cos 7
COS7
Cos7
CV-1 in Origin Simian-7
Category Transformed cell line
Organism
Chlorocebus aethiops (Green monkey)
Cellosaurus ID
CVCL_0224
Protein ID: PT00914 , Melanocortin receptor 4
Gene Name MC4R
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P32245
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000053  Protein ID: PT00914
 
Compound ID Compound Name Compound Formula
CP0955395
(+/-)-1-[3-(40-fluorobiphenyl-2-yl)propyl]-4-[2-(4-fluorophenyl)-2-(1-isopropylpiperidin-4-yl)ethyl]piperazine trihydrochloride
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C35H46ClF2N3
 1
1
IC50 = 14.5 nM
   TI
   LI
   LO
   TS
CP0950478
(+/-)-1-[3-(3-fluorobiphenyl-2-yl)propyl]-4-[2-(4-fluorophenyl)-2-(1-isopropylpiperidin-4-yl)ethyl]piperazine trihydrochloride
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C35H46ClF2N3
 1
1
IC50 = 18.3 nM
   TI
   LI
   LO
   TS
CP0890157
(+/-)-1-(3-biphenyl-2-ylpropyl)-4-[2-(4-fluorophenyl)-2-(1-isopropylpiperidin-4-yl)ethyl]piperazine tri hydrochloride
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C35H47ClFN3
 1
1
IC50 = 19.7 nM
   TI
   LI
   LO
   TS
CP0890156
(+/-)-1-[3-(6-fluorobiphenyl-2-yl)propyl]-4-[2-(4-fluorophenyl)-2-(1-isopropylpiperidin-4-yl)ethyl]piperazine trihydrochloride
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C35H46ClF2N3
 1
1
IC50 = 19.8 nM
   TI
   LI
   LO
   TS
CP0880108
(+/-)-1-[3-(30-fluorobiphenyl-2-yl)propyl]-4-[2-(4-fluorophenyl)-2-(1-isopropylpiperidin-4-yl)ethyl]piperazine trihydrochloride
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C35H46ClF2N3
 1
1
IC50 = 23.4 nM
   TI
   LI
   LO
   TS
CP0860900
(+/-)-1-[2-(4-fluorophenyl)-2-(1-isopropylpiperidin-4-yl)ethyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine trihydrochloride
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C35H49ClFN3O
 1
1
IC50 = 40.3 nM
   TI
   LI
   LO
   TS
CP0873561
(+/-)-1-[3-(4-fluorobiphenyl-2-yl)propyl]-4-[2-(4-fluorophenyl)-2-(1-isopropylpiperidin-4-yl)ethyl]piperazine trihydrochloride
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C35H46ClF2N3
 1
1
IC50 = 52.2 nM
   TI
   LI
   LO
   TS
CP0873563
(+/-)-1-[3-(5-fluorobiphenyl-2-yl)propyl]-4-[2-(4-fluorophenyl)-2-(1-isopropylpiperidin-4-yl)ethyl]piperazinetrihydrochloride
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C35H46ClF2N3
 1
1
IC50 = 52.7 nM
   TI
   LI
   LO
   TS
CP0921990
(+/-)-1-[3-(20-fluorobiphenyl-2-yl)propyl]-4-[2-(4-fluorophenyl)-2-(1-isopropylpiperidin-4-yl)ethyl]piperazinetri hydrochloride
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C35H46ClF2N3
 1
1
IC50 = 98.6 nM
   TI
   LI
   LO
   TS
CP0948497
(+/-)-1-[2-(4-fluorophenyl)-2-(1-methylpiperidin-4-yl)ethyl]-4-[4-(1-naphthyl)butyl]piperazine tri hydrochloride
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C32H43ClFN3
 1
1
IC50 = 333 nM
   TI
   LI
   LO
   TS