Brief Information of the Cell Line and Protein
Cell Line ID: CL000053 , COS-7
Synonyms
Cos-7
COS 7
Cos 7
COS7
Cos7
CV-1 in Origin Simian-7
Category Transformed cell line
Organism
Chlorocebus aethiops (Green monkey)
Cellosaurus ID
CVCL_0224
Protein ID: PT00909 , Peroxisome proliferator-activated receptor delta
Gene Name PPARD
Organism Homo sapiens, Human
Protein Classification Transcription factor
Uniprot ID Q03181
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000053  Protein ID: PT00909
 
Compound ID Compound Name Compound Formula
CP0039118
2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid
   Show/Hide
C21H18F3NO3S2
 2
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
2
EC50 = 1050 nM
   TI
   LI
   LO
   TS
CP0408561
2-(2-methyl-4-(3-(2-propyl-4-(trifluoromethyl)phenoxy)propoxy)phenoxy)acetic acid
   Show/Hide
C22H25F3O5
 1
1
EC50 = 7 nM
   TI
   LI
   LO
   TS
CP0431821
2-(2-methyl-4-(3-(4-propyl-6-(trifluoromethyl)pyridin-3-yloxy)propoxy)phenoxy)acetic acid
   Show/Hide
C21H24F3NO5
 1
1
EC50 = 15 nM
   TI
   LI
   LO
   TS
CP0395321
methyl 2-[2-methyl-4-[3-[2-propyl-4-(trifluoromethyl)phenoxy]propoxy]phenoxy]acetate
   Show/Hide
C23H27F3O5
 1
1
EC50 = 16 nM
   TI
   LI
   LO
   TS
CP0060839
2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid
   Show/Hide
C21H17F4NO3S2
 1
1
EC50 = 26.9 nM
   TI
   LI
   LO
   TS
CP0041706
2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy)phenoxy)acetic acid
   Show/Hide
C22H26O7
 2
1
EC50 = 39 nM
   TI
   LI
   LO
   TS
2
EC50 = 125 nM
   TI
   LI
   LO
   TS
CP0376354
methyl 2-[4-[3-(6-acetyl-5-hydroxy-4-propylpyridin-3-yl)oxypropoxy]phenoxy]acetate
   Show/Hide
C22H27NO7
 1
1
EC50 = 82 nM
   TI
   LI
   LO
   TS
CP0528133
(E)-3-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methoxy]phenyl]prop-2-enoic acid
   Show/Hide
C21H15F4NO3S
 1
1
EC50 = 95.9 nM
   TI
   LI
   LO
   TS
CP0408562
methyl 2-[4-[3-[2-propyl-4-(trifluoromethyl)phenoxy]propoxy]phenoxy]acetate
   Show/Hide
C22H25F3O5
 1
1
EC50 = 98 nM
   TI
   LI
   LO
   TS
CP0571518
(E)-3-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]phenyl]prop-2-enoic acid
   Show/Hide
C21H15F4NO2S2
 1
1
EC50 = 134 nM
   TI
   LI
   LO
   TS
CP0540303
(E)-3-[4-[methyl-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methyl]amino]phenyl]prop-2-enoic acid
   Show/Hide
C22H19F3N2O2S
 1
1
EC50 = 199 nM
   TI
   LI
   LO
   TS
CP0534026
(E)-3-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methoxy]phenyl]prop-2-enoic acid
   Show/Hide
C21H16F3NO3S
 1
1
EC50 = 274 nM
   TI
   LI
   LO
   TS
CP0575915
(E)-3-[2-methyl-4-[methyl-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methyl]amino]phenyl]prop-2-enoic acid
   Show/Hide
C23H21F3N2O2S
 1
1
EC50 = 335 nM
   TI
   LI
   LO
   TS
CP0457137
4-[5-chloro-1-[(2-methyl-1,3-benzothiazol-6-yl)sulfonyl]indol-2-yl]butanoic acid
   Show/Hide
C20H17ClN2O4S2
 1
1
EC50 = 441 nM
   TI
   LI
   LO
   TS
CP0376355
methyl 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]acetate
   Show/Hide
C23H28O7
 1
1
EC50 = 457 nM
   TI
   LI
   LO
   TS
CP0444072
2-[2,6-dimethyl-4-[[(2Z)-3-oxo-2-[[4-(trifluoromethyl)phenyl]methylidene]-1-benzofuran-6-yl]oxymethyl]phenoxy]-2-methylpropanoic acid
   Show/Hide
C29H25F3O6
 1
1
EC50 = 500 nM
   TI
   LI
   LO
   TS
CP0568632
2-[2,6-dimethyl-4-[[(2Z)-3-oxo-2-[(4-propan-2-ylphenyl)methylidene]-1-benzofuran-6-yl]oxymethyl]phenoxy]-2-methylpropanoic acid
   Show/Hide
C31H32O6
 1
1
EC50 = 520 nM
   TI
   LI
   LO
   TS
CP0488748
(E)-3-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenyl]prop-2-enoic acid
   Show/Hide
C21H16F3NO2S2
 1
1
EC50 = 535 nM
   TI
   LI
   LO
   TS
CP0457133
4-[1-(benzenesulfonyl)-5-chloroindol-2-yl]butanoic acid
   Show/Hide
C18H16ClNO4S
 1
1
EC50 = 645 nM
   TI
   LI
   LO
   TS
CP0458506
4-[5-chloro-1-[(4-methyl-2,3-dihydro-1,4-benzoxazin-6-yl)sulfonyl]indol-2-yl]butanoic acid
   Show/Hide
C21H21ClN2O5S
 1
1
EC50 = 697 nM
   TI
   LI
   LO
   TS
CP0076831
Elafibranor
   Show/Hide
C22H24O4S
 1
1
EC50 = 730 nM
   TI
   LI
   LO
   TS
CP0261934
4-[1-(1,3-benzothiazol-6-ylsulfonyl)-5-chloroindol-2-yl]butanoic acid
   Show/Hide
C19H15ClN2O4S2
 1
1
EC50 = 866 nM
   TI
   LI
   LO
   TS
CP0479763
4-[1-[(2-amino-1,3-benzothiazol-6-yl)sulfonyl]-5-chloroindol-2-yl]butanoic acid
   Show/Hide
C19H16ClN3O4S2
 1
1
EC50 = 919 nM
   TI
   LI
   LO
   TS
CP0412236
4-[1-(1,3-benzodioxol-5-ylsulfonyl)-5-chloroindol-2-yl]butanoic acid
   Show/Hide
C19H16ClNO6S
 1
1
EC50 = 977 nM
   TI
   LI
   LO
   TS
CP0558902
2-[2,6-dimethyl-4-[[(2Z)-2-(naphthalen-2-ylmethylidene)-3-oxo-1-benzofuran-6-yl]oxymethyl]phenoxy]-2-methylpropanoic acid
   Show/Hide
C32H28O6
 1
1
EC50 = 980 nM
   TI
   LI
   LO
   TS
CP0395319
methyl 2-[4-[3-(2-propylphenoxy)propoxy]phenoxy]acetate
   Show/Hide
C21H26O5
 1
1
EC50 = 1046 nM
   TI
   LI
   LO
   TS
CP0412241
4-[5-chloro-1-(4-methylphenyl)sulfonylindol-2-yl]butanoic acid
   Show/Hide
C19H18ClNO4S
 1
1
EC50 = 1085 nM
   TI
   LI
   LO
   TS
CP0457054
4-[5-chloro-1-[(2-methyl-1,3-benzothiazol-5-yl)sulfonyl]indol-2-yl]butanoic acid
   Show/Hide
C20H17ClN2O4S2
 1
1
EC50 = 1098 nM
   TI
   LI
   LO
   TS
CP0447366
4-[1-(1,3-benzothiazol-5-ylsulfonyl)-5-(trifluoromethyl)indol-2-yl]butanoic acid
   Show/Hide
C20H15F3N2O4S2
 1
1
EC50 = 1120 nM
   TI
   LI
   LO
   TS
CP0507033
4-[1-[3-(trifluoromethoxy)phenyl]sulfonyl-5-(trifluoromethyl)indol-2-yl]butanoic acid
   Show/Hide
C20H15F6NO5S
 1
1
EC50 = 1140 nM
   TI
   LI
   LO
   TS
CP0450948
2-[2,6-dimethyl-4-[[(2Z)-3-oxo-2-[[4-(trifluoromethoxy)phenyl]methylidene]-1-benzofuran-6-yl]oxymethyl]phenoxy]-2-methylpropanoic acid
   Show/Hide
C29H25F3O7
 1
1
EC50 = 1170 nM
   TI
   LI
   LO
   TS
CP0486453
(E)-3-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylamino]phenyl]prop-2-enoic acid
   Show/Hide
C21H17F3N2O2S
 1
1
EC50 = 1220 nM
   TI
   LI
   LO
   TS
CP0412239
4-[5-chloro-1-(3-methoxyphenyl)sulfonylindol-2-yl]butanoic acid
   Show/Hide
C19H18ClNO5S
 1
1
EC50 = 1230 nM
   TI
   LI
   LO
   TS
CP0412247
4-[1-(4-methoxyphenyl)sulfonyl-5-(trifluoromethyl)indol-2-yl]butanoic acid
   Show/Hide
C20H18F3NO5S
 1
1
EC50 = 1259 nM
   TI
   LI
   LO
   TS
CP0484170
2-[2,6-dimethyl-4-[[(2Z)-3-oxo-2-[[4-(trifluoromethylsulfanyl)phenyl]methylidene]-1-benzofuran-6-yl]oxymethyl]phenoxy]-2-methylpropanoic acid
   Show/Hide
C29H25F3O6S
 1
1
EC50 = 1260 nM
   TI
   LI
   LO
   TS
CP0387205
2-[3-[[2-(naphthalene-2-carbonylamino)benzoyl]amino]phenyl]acetic acid
   Show/Hide
C26H20N2O4
 1
1
EC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0457135
4-[5-chloro-1-(3-methylphenyl)sulfonylindol-2-yl]butanoic acid
   Show/Hide
C19H18ClNO4S
 1
1
EC50 = 1347 nM
   TI
   LI
   LO
   TS
CP0457136
4-[1-[(2-amino-1,3-benzoxazol-6-yl)sulfonyl]-5-chloroindol-2-yl]butanoic acid
   Show/Hide
C19H16ClN3O5S
 1
1
EC50 = 1387 nM
   TI
   LI
   LO
   TS
CP0241890
2-(4-(3-(2,3-dimethylphenoxy)propoxy)phenylthio)acetic acid
   Show/Hide
C19H22O4S
 1
1
EC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0520738
2-[4-[[(2Z)-2-benzylidene-3-oxo-1-benzofuran-6-yl]oxymethyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid
   Show/Hide
C28H26O6
 1
1
EC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0457134
4-[1-(3-methoxyphenyl)sulfonyl-5-(trifluoromethyl)indol-2-yl]butanoic acid
   Show/Hide
C20H18F3NO5S
 1
1
EC50 = 1607 nM
   TI
   LI
   LO
   TS
CP0558901
2-[2,6-dimethyl-4-[[(2Z)-3-oxo-2-[[2-(trifluoromethyl)phenyl]methylidene]-1-benzofuran-6-yl]oxymethyl]phenoxy]-2-methylpropanoic acid
   Show/Hide
C29H25F3O6
 1
1
EC50 = 1630 nM
   TI
   LI
   LO
   TS
CP0479762
4-[1-(4-chlorophenyl)sulfonyl-5-(trifluoromethyl)indol-2-yl]butanoic acid
   Show/Hide
C19H15ClF3NO4S
 1
1
EC50 = 1650 nM
   TI
   LI
   LO
   TS
CP0559506
2-[4-[[(2Z)-2-[(4-bromophenyl)methylidene]-3-oxo-1-benzofuran-6-yl]oxymethyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid
   Show/Hide
C28H25BrO6
 1
1
EC50 = 1720 nM
   TI
   LI
   LO
   TS
CP0432116
2-[2,6-dimethyl-4-[[(2Z)-2-[(4-methylsulfanylphenyl)methylidene]-3-oxo-1-benzofuran-6-yl]oxymethyl]phenoxy]-2-methylpropanoic acid
   Show/Hide
C29H28O6S
 1
1
EC50 = 1800 nM
   TI
   LI
   LO
   TS
CP0457055
3-[1-(benzenesulfonyl)-5-chloroindol-2-yl]propanoic acid
   Show/Hide
C17H14ClNO4S
 1
1
EC50 = 1912 nM
   TI
   LI
   LO
   TS
CP0559505
2-[4-[[(2Z)-2-[(4-chlorophenyl)methylidene]-3-oxo-1-benzofuran-6-yl]oxymethyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid
   Show/Hide
C28H25ClO6
 1
1
EC50 = 1980 nM
   TI
   LI
   LO
   TS
CP0412235
4-[1-(3-chlorophenyl)sulfonyl-5-(trifluoromethyl)indol-2-yl]butanoic acid
   Show/Hide
C19H15ClF3NO4S
 1
1
EC50 = 2026 nM
   TI
   LI
   LO
   TS
CP0447390
4-[1-[4-(trifluoromethoxy)phenyl]sulfonyl-5-(trifluoromethyl)indol-2-yl]butanoic acid
   Show/Hide
C20H15F6NO5S
 1
1
EC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0445061
2-[3-[[2-[[4-(trifluoromethyl)benzoyl]amino]benzoyl]amino]phenyl]acetic acid
   Show/Hide
C23H17F3N2O4
 1
1
EC50 = 2200 nM
   TI
   LI
   LO
   TS
CP0559509
2-[4-[[(2Z)-2-[(4-methoxyphenyl)methylidene]-3-oxo-1-benzofuran-6-yl]oxymethyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid
   Show/Hide
C29H28O7
 1
1
EC50 = 2250 nM
   TI
   LI
   LO
   TS
CP0396062
2-[3-[[2-[[4-(trifluoromethylsulfanyl)benzoyl]amino]benzoyl]amino]phenyl]acetic acid
   Show/Hide
C23H17F3N2O4S
 1
1
EC50 = 2300 nM
   TI
   LI
   LO
   TS
CP0444071
2-[4-[[(2Z)-2-[(4-ethoxyphenyl)methylidene]-3-oxo-1-benzofuran-6-yl]oxymethyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid
   Show/Hide
C30H30O7
 1
1
EC50 = 2310 nM
   TI
   LI
   LO
   TS
CP0484171
2-[2,6-dimethyl-4-[[(2Z)-3-oxo-2-[(4-phenylphenyl)methylidene]-1-benzofuran-6-yl]oxymethyl]phenoxy]-2-methylpropanoic acid
   Show/Hide
C34H30O6
 1
1
EC50 = 2450 nM
   TI
   LI
   LO
   TS
CP0379834
3-[[2-[(4-tert-butylbenzoyl)amino]-4-methoxybenzoyl]amino]benzoic acid
   Show/Hide
C26H26N2O5
 1
1
EC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0387068
3-[[2-[[3-fluoro-4-(trifluoromethyl)benzoyl]amino]benzoyl]amino]benzoic acid
   Show/Hide
C22H14F4N2O4
 1
1
EC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0387067
3-[[2-[[4-(trifluoromethyl)benzoyl]amino]benzoyl]amino]benzoic acid
   Show/Hide
C22H15F3N2O4
 1
1
EC50 = 3200 nM
   TI
   LI
   LO
   TS
CP0396063
3-[[4-chloro-2-[[4-(trifluoromethyl)benzoyl]amino]benzoyl]amino]benzoic acid
   Show/Hide
C22H14ClF3N2O4
 1
1
EC50 = 3400 nM
   TI
   LI
   LO
   TS
CP0568976
2-[2,6-dimethyl-4-[[(2Z)-2-[(4-methylphenyl)methylidene]-3-oxo-1-benzofuran-6-yl]oxymethyl]phenoxy]-2-methylpropanoic acid
   Show/Hide
C29H28O6
 1
1
EC50 = 3930 nM
   TI
   LI
   LO
   TS
CP0387227
3-[[2-(naphthalene-2-carbonylamino)benzoyl]amino]benzoic acid
   Show/Hide
C25H18N2O4
 1
1
EC50 = 4700 nM
   TI
   LI
   LO
   TS
CP0419731
2-[3-[[2-[(4-tert-butylbenzoyl)amino]benzoyl]amino]phenyl]acetic acid
   Show/Hide
C26H26N2O4
 1
1
EC50 = 5400 nM
   TI
   LI
   LO
   TS
CP0388904
2-[3-[[2-[(4-methoxybenzoyl)amino]benzoyl]amino]phenyl]acetic acid
   Show/Hide
C23H20N2O5
 1
1
EC50 = 5900 nM
   TI
   LI
   LO
   TS
CP0388903
3-[[5-chloro-2-[[4-(trifluoromethyl)benzoyl]amino]benzoyl]amino]benzoic acid
   Show/Hide
C22H14ClF3N2O4
 1
1
EC50 = 6300 nM
   TI
   LI
   LO
   TS
CP0387204
2-[3-[[2-[(4-phenylbenzoyl)amino]benzoyl]amino]phenyl]acetic acid
   Show/Hide
C28H22N2O4
 1
1
EC50 = 6400 nM
   TI
   LI
   LO
   TS
CP0398732
3-[3-[[2-[[4-(trifluoromethyl)benzoyl]amino]benzoyl]amino]phenyl]propanoic acid
   Show/Hide
C24H19F3N2O4
 1
1
EC50 = 6800 nM
   TI
   LI
   LO
   TS
CP0387203
2-[3-[[2-[(4-methylsulfanylbenzoyl)amino]benzoyl]amino]phenyl]acetic acid
   Show/Hide
C23H20N2O4S
 1
1
EC50 = 7400 nM
   TI
   LI
   LO
   TS
CP0005387
Avandamet
   Show/Hide
C18H19N3O3S
 1
1
EC50 = 8890 nM
   TI
   LI
   LO
   TS
CP0559507
2-[4-[[(2Z)-2-[(4-cyanophenyl)methylidene]-3-oxo-1-benzofuran-6-yl]oxymethyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid
   Show/Hide
C29H25NO6
 1
1
EC50 = 8940 nM
   TI
   LI
   LO
   TS
CP0431820
2-(4-(3-(4-acetyl-3-hydroxyphenoxy)propoxy)phenoxy)acetic acid
   Show/Hide
C19H20O7
 1
1
EC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0450947
2-[4-[[(2Z)-2-[(4-fluorophenyl)methylidene]-3-oxo-1-benzofuran-6-yl]oxymethyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid
   Show/Hide
C28H25FO6
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0140959
3-(4-(3-(2,3-dimethylphenoxy)propoxy)phenyl)propanoic acid
   Show/Hide
C20H24O4
 1
1
EC50 = 11200 nM
   TI
   LI
   LO
   TS
CP0387232
3-[[2-[(4-bromobenzoyl)amino]benzoyl]amino]benzoic acid
   Show/Hide
C21H15BrN2O4
 1
1
EC50 = 12000 nM
   TI
   LI
   LO
   TS
CP0412233
4-[1-(benzenesulfonyl)-5-(trifluoromethyl)indol-2-yl]butanoic acid
   Show/Hide
C19H16F3NO4S
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0412234
4-[1-(benzenesulfonyl)-5-methylindol-2-yl]butanoic acid
   Show/Hide
C19H19NO4S
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0412244
4-[1-(3H-benzimidazol-5-ylsulfonyl)-5-chloroindol-2-yl]butanoic acid
   Show/Hide
C19H16ClN3O4S
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0447365
4-[1-(2,1,3-benzothiadiazol-5-ylsulfonyl)-5-chloroindol-2-yl]butanoic acid
   Show/Hide
C18H14ClN3O4S2
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS