Protein Information

General Information of the Protein

Protein ID	PT01650
Protein Name	Alpha-2A adrenergic receptor
Secondarily Protein Name	Alpha-2 adrenergic receptor subtype C10 Alpha-2A adrenoreceptor
Gene Name	ADRA2A
Secondarily Gene Name	ADRA2R ADRAR
Sequence	MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Adrenergic receptor
Function	Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. Show/Hide
Uniprot ID	Primary ID: P08913 Secondarily ID: B0LPF6 Q2I8G2 Q2XN99 Q86TH8 Q9BZK1 Show/Hide
HGNC ID	HGNC:281
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0108416 Compound Info	(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole Show/Hide	C13H16N2	1
1	EC50 = 1.5 nM Bioactivity Info	TI LI LO TS
CP0066123 Compound Info	6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-phenol;hydrochloride Show/Hide	C16H24N2O	2
1	EC50 = 3.311 nM Bioactivity Info	TI LI LO TS
2	Ki = 16.22 nM Bioactivity Info	TI LI LO TS
CP0416730 Compound Info	5-chloro-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-methylsulfanylaniline Show/Hide	C11H14ClN3S	2
1	EC50 = 6.31 nM Bioactivity Info	TI LI LO TS
2	Ki = 41.69 nM Bioactivity Info	TI LI LO TS
CP0418063 Compound Info	CAS_81447-78-1 Show/Hide	C11H12Cl2N2O	2
1	EC50 = 6.31 nM Bioactivity Info	TI LI LO TS
2	Ki = 4.365 nM Bioactivity Info	TI LI LO TS
CP0041905 Compound Info	2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) Show/Hide	C9H9Cl2N3	4
1	EC50 = 8.318 nM Bioactivity Info	TI LI LO TS
2	EC50 = 28 nM Bioactivity Info	TI LI LO TS
3	Ki = 3.8 nM Bioactivity Info	TI LI LO TS
4	Ki = 8.71 nM Bioactivity Info	TI LI LO TS
CP0372608 Compound Info	2-[1-(2,6-diethylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C15H22N2O	2
1	EC50 = 11.75 nM Bioactivity Info	TI LI LO TS
2	Ki = 31.62 nM Bioactivity Info	TI LI LO TS
CP0915206 Compound Info	3-[(Imidazolidin-2-yl)imino]-4-methylindazole hydrochloride Show/Hide	C11H14ClN5	1
1	EC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0489125 Compound Info	7-Cl-Marsanidine Show/Hide	C10H10ClN5	1
1	EC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0376911 Compound Info	2-[1-(2,6-dimethylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C13H18N2O	2
1	EC50 = 18.62 nM Bioactivity Info	TI LI LO TS
2	Ki = 11.75 nM Bioactivity Info	TI LI LO TS
CP0425305 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-5-fluoro-2-methylsulfanylaniline Show/Hide	C11H14FN3S	2
1	EC50 = 25.12 nM Bioactivity Info	TI LI LO TS
2	Ki = 18.2 nM Bioactivity Info	TI LI LO TS
CP0479149 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-5-methyl-2-methylsulfanylaniline Show/Hide	C12H17N3S	2
1	EC50 = 25.12 nM Bioactivity Info	TI LI LO TS
2	Ki = 63.1 nM Bioactivity Info	TI LI LO TS
CP0376829 Compound Info	2-[1-(4,5-dihydro-1H-imidazol-2-yl)ethoxy]benzaldehyde Show/Hide	C12H14N2O2	2
1	EC50 = 31.62 nM Bioactivity Info	TI LI LO TS
2	Ki = 1047.13 nM Bioactivity Info	TI LI LO TS
CP0412243 Compound Info	1-[(Imidazolidin-2-yl)imino]-7-methylindazole hydrochloride Show/Hide	C11H13N5	1
1	EC50 = 37 nM Bioactivity Info	TI LI LO TS
CP0874395 Compound Info	(4,5-Dihydro-1H-imidazol-2-ylmethyl)-(2-methylsulfanyl-phenyl)-amine hydrochloride Show/Hide	C11H16ClN3S	2
1	EC50 = 39.81 nM Bioactivity Info	TI LI LO TS
2	Ki = 47.86 nM Bioactivity Info	TI LI LO TS
CP0437316 Compound Info	2-[1-(2-thiophen-2-ylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C15H16N2OS	2
1	EC50 = 41.69 nM Bioactivity Info	TI LI LO TS
2	Ki = 16.98 nM Bioactivity Info	TI LI LO TS
CP0386170 Compound Info	2-[1-(2-cyclopentylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C16H22N2O	2
1	EC50 = 63.1 nM Bioactivity Info	TI LI LO TS
2	Ki = 50.12 nM Bioactivity Info	TI LI LO TS
CP0417504 Compound Info	2-[(1S)-1-(2-thiophen-3-ylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C15H16N2OS	2
1	EC50 = 63.1 nM Bioactivity Info	TI LI LO TS
2	Ki = 44.67 nM Bioactivity Info	TI LI LO TS
CP0456784 Compound Info	1-[2-[1-(4,5-dihydro-1H-imidazol-2-yl)ethoxy]phenyl]ethanone Show/Hide	C13H16N2O2	2
1	EC50 = 63.1 nM Bioactivity Info	TI LI LO TS
2	Ki = 1023.29 nM Bioactivity Info	TI LI LO TS
CP0385262 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-phenylaniline Show/Hide	C16H17N3	1
1	EC50 = 63.1 nM Bioactivity Info	TI LI LO TS
CP0900440 Compound Info	7-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydrochloride Show/Hide	C10H11Cl2N5	1
1	EC50 = 73 nM Bioactivity Info	TI LI LO TS
CP0413599 Compound Info	2-[(1S)-1-(2-phenylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C17H18N2O	2
1	EC50 = 74.13 nM Bioactivity Info	TI LI LO TS
2	Ki = 91.2 nM Bioactivity Info	TI LI LO TS
CP0427126 Compound Info	2-[1-(2-thiophen-3-ylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C15H16N2OS	2
1	EC50 = 75.86 nM Bioactivity Info	TI LI LO TS
2	Ki = 45.71 nM Bioactivity Info	TI LI LO TS
CP0423440 Compound Info	2-[1-(2-cyclohexylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C17H24N2O	2
1	EC50 = 79.43 nM Bioactivity Info	TI LI LO TS
2	Ki = 74.13 nM Bioactivity Info	TI LI LO TS
CP0912838 Compound Info	3-[(Imidazolidin-2-yl)imino]indazole hydrochloride Show/Hide	C10H12ClN5	1
1	EC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0451982 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-3-fluoro-2-methylsulfanylaniline Show/Hide	C11H14FN3S	2
1	EC50 = 100 nM Bioactivity Info	TI LI LO TS
2	Ki = 165.96 nM Bioactivity Info	TI LI LO TS
CP0373586 Compound Info	2-[1-[2-(3-fluorophenyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C17H17FN2O	2
1	EC50 = 104.71 nM Bioactivity Info	TI LI LO TS
2	Ki = 14.79 nM Bioactivity Info	TI LI LO TS
CP0039930 Compound Info	(-)-arterenol Show/Hide	C8H11NO3	2
1	EC50 = 110 nM Bioactivity Info	TI LI LO TS
2	EC50 = 371.54 nM Bioactivity Info	TI LI LO TS
CP0333694 Compound Info	2-[1-(2-phenylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C17H18N2O	2
1	EC50 = 114.82 nM Bioactivity Info	TI LI LO TS
2	Ki = 47.86 nM Bioactivity Info	TI LI LO TS
CP0379683 Compound Info	1-[(Imidazolidin-2-yl)imino]indazole hydrochloride Show/Hide	C10H11N5	1
1	EC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0468167 Compound Info	4-Chloro-1-[(imidazolidin-2-yl)imino]indazole hydrochloride Show/Hide	C10H10ClN5	1
1	EC50 = 180 nM Bioactivity Info	TI LI LO TS
CP0905429 Compound Info	4-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydrochloride Show/Hide	C10H11Cl2N5	1
1	EC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0899588 Compound Info	(4,5-Dihydro-1H-imidazol-2-ylmethyl)-(2-ethylsulfanyl-phenyl)-amine hydrochloride Show/Hide	C12H18ClN3S	2
1	EC50 = 251.19 nM Bioactivity Info	TI LI LO TS
2	Ki = 81.28 nM Bioactivity Info	TI LI LO TS
CP0427124 Compound Info	3-[2-[1-(4,5-dihydro-1H-imidazol-2-yl)ethoxy]phenyl]aniline Show/Hide	C17H19N3O	2
1	EC50 = 257.04 nM Bioactivity Info	TI LI LO TS
2	Ki = 37.15 nM Bioactivity Info	TI LI LO TS
CP0375447 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-fluoro-2-methylsulfanylaniline Show/Hide	C11H14FN3S	2
1	EC50 = 316.23 nM Bioactivity Info	TI LI LO TS
2	Ki = 58.88 nM Bioactivity Info	TI LI LO TS
CP0372449 Compound Info	3-[2-[1-(4,5-dihydro-1H-imidazol-2-yl)ethoxy]phenyl]pyridine Show/Hide	C16H17N3O	3
1	EC50 = 316.23 nM Bioactivity Info	TI LI LO TS
2	EC50 = 588.84 nM Bioactivity Info	TI LI LO TS
3	Ki = 138.04 nM Bioactivity Info	TI LI LO TS
CP0437314 Compound Info	N-[1-(4,5-dihydro-1H-imidazol-2-yl)ethyl]-2-phenylaniline Show/Hide	C17H19N3	2
1	EC50 = 389.05 nM Bioactivity Info	TI LI LO TS
2	Ki = 91.2 nM Bioactivity Info	TI LI LO TS
CP0845500 Compound Info	(4,5-Dihydro-1H-imidazol-2-ylmethyl)-(2-isopropylsulfanyl-phenyl)-amine hydrochloride Show/Hide	C13H20ClN3S	2
1	EC50 = 416.87 nM Bioactivity Info	TI LI LO TS
2	Ki = 81.28 nM Bioactivity Info	TI LI LO TS
CP0851097 Compound Info	2-[1-(4,5-Dihydro-1H-imidazol-2-yl)-ethoxy]-benzaldehyde Oxime Show/Hide	C12H15N3O2	2
1	EC50 = 501.19 nM Bioactivity Info	TI LI LO TS
2	Ki = 288.4 nM Bioactivity Info	TI LI LO TS
CP0391376 Compound Info	2-[1-(2-methylsulfonylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C12H16N2O3S	2
1	EC50 = 562.34 nM Bioactivity Info	TI LI LO TS
2	Ki = 3162.28 nM Bioactivity Info	TI LI LO TS
CP0396660 Compound Info	2-[phenyl-(2-phenylphenoxy)methyl]-4,5-dihydro-1H-imidazole Show/Hide	C22H20N2O	2
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
2	Ki = 239.88 nM Bioactivity Info	TI LI LO TS
CP0435289 Compound Info	2-[(1R)-1-(2-thiophen-3-ylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C15H16N2OS	2
1	EC50 = 3162.28 nM Bioactivity Info	TI LI LO TS
2	Ki = 165.96 nM Bioactivity Info	TI LI LO TS
CP0427121 Compound Info	2-[3-(2-phenylphenyl)oxiran-2-yl]-4,5-dihydro-1H-imidazole Show/Hide	C17H16N2O	2
1	EC50 = 3467.37 nM Bioactivity Info	TI LI LO TS
2	Ki = 1230.27 nM Bioactivity Info	TI LI LO TS
CP0378484 Compound Info	2-[(1R)-1-(2-phenylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C17H18N2O	2
1	EC50 = 28840.32 nM Bioactivity Info	TI LI LO TS
2	Ki = 186.21 nM Bioactivity Info	TI LI LO TS
CP0375544 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-5-methyl-2-methylsulfonylaniline Show/Hide	C12H17N3O2S	2
1	EC50 < 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 3890.45 nM Bioactivity Info	TI LI LO TS
CP0392166 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-methylsulfonyl-5-(trifluoromethyl)aniline Show/Hide	C12H14F3N3O2S	2
1	EC50 < 10000 nM Bioactivity Info	TI LI LO TS
2	Ki < 7943.28 nM Bioactivity Info	TI LI LO TS
CP0394131 Compound Info	NS-49 Show/Hide	C9H13FN2O3S	1
1	EC50 < 10000 nM Bioactivity Info	TI LI LO TS
CP0402493 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-fluoro-6-methylsulfonylaniline Show/Hide	C11H14FN3O2S	2
1	EC50 < 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 870.96 nM Bioactivity Info	TI LI LO TS
CP0404420 Compound Info	4-chloro-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-methylsulfonylaniline Show/Hide	C11H14ClN3O2S	2
1	EC50 < 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 5011.87 nM Bioactivity Info	TI LI LO TS
CP0409992 Compound Info	5-chloro-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-methylsulfonylaniline Show/Hide	C11H14ClN3O2S	2
1	EC50 < 10000 nM Bioactivity Info	TI LI LO TS
2	Ki < 7943.28 nM Bioactivity Info	TI LI LO TS
CP0420934 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-methylsulfanyl-5-(trifluoromethyl)aniline Show/Hide	C12H14F3N3S	2
1	EC50 < 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 199.53 nM Bioactivity Info	TI LI LO TS
CP0432293 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-1,1-dioxo-3,4-dihydro-2H-thiochromen-8-amine Show/Hide	C13H17N3O2S	2
1	EC50 < 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 794.33 nM Bioactivity Info	TI LI LO TS
CP0464188 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-5-fluoro-2-methylsulfonylaniline Show/Hide	C11H14FN3O2S	2
1	EC50 < 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 4466.84 nM Bioactivity Info	TI LI LO TS
CP0916328 Compound Info	(4,5-Dihydro-1H-imidazol-2-ylmethyl)-(2-methanesulfonyl-phenyl)-amine hydrochloride Show/Hide	C11H16ClN3O2S	2
1	EC50 < 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 5623.41 nM Bioactivity Info	TI LI LO TS
CP0397746 Compound Info	N-(4,5-dihydro-1H-imidazol-1-ium-2-ylmethyl)-2-methylsulfinylaniline;chloride Show/Hide	C11H16ClN3OS	2
1	EC50 < 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 977.24 nM Bioactivity Info	TI LI LO TS
CP0404419 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-propan-2-ylsulfonylaniline Show/Hide	C13H19N3O2S	2
1	EC50 < 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 2951.21 nM Bioactivity Info	TI LI LO TS
CP0406394 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-fluoro-2-methylsulfonylaniline Show/Hide	C11H14FN3O2S	2
1	EC50 < 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 398.11 nM Bioactivity Info	TI LI LO TS
CP0431046 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-ethylsulfonylaniline Show/Hide	C12H17N3O2S	2
1	EC50 < 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 1318.26 nM Bioactivity Info	TI LI LO TS
CP0461287 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-3-fluoro-2-methylsulfonylaniline Show/Hide	C11H14FN3O2S	2
1	EC50 < 10000 nM Bioactivity Info	TI LI LO TS
2	Ki < 7943.28 nM Bioactivity Info	TI LI LO TS
CP0380435 Compound Info	7-chloro-3-[2-(3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-2-methylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C22H20ClN3O2	1
1	IC50 = 0.2138 nM Bioactivity Info	TI LI LO TS
CP0509938 Compound Info	3-[2-(3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-7-iodo-2-methylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C22H20IN3O2	1
1	IC50 = 0.2399 nM Bioactivity Info	TI LI LO TS
CP0430308 Compound Info	3-[2-(3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-2,6-dimethylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C23H23N3O2	1
1	IC50 = 0.2884 nM Bioactivity Info	TI LI LO TS
CP0506685 Compound Info	3-[2-(3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-9-methoxy-2-methylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C23H23N3O3	1
1	IC50 = 0.2951 nM Bioactivity Info	TI LI LO TS
CP0375211 Compound Info	3-[2-(3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-2,6,8-trimethylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C24H25N3O2	1
1	IC50 = 0.3388 nM Bioactivity Info	TI LI LO TS
CP0398443 Compound Info	3-[2-(3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-2,7-dimethylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C23H23N3O2	1
1	IC50 = 0.3467 nM Bioactivity Info	TI LI LO TS
CP0480554 Compound Info	7-bromo-3-[2-(3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-2-methylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C22H20BrN3O2	1
1	IC50 = 0.3548 nM Bioactivity Info	TI LI LO TS
CP0462778 Compound Info	3-[2-(3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-2,8-dimethylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C23H23N3O2	1
1	IC50 = 0.4467 nM Bioactivity Info	TI LI LO TS
CP0437587 Compound Info	LUSAPERIDONE Show/Hide	C22H21N3O2	1
1	IC50 = 0.5495 nM Bioactivity Info	TI LI LO TS
CP0409638 Compound Info	7,9-dichloro-3-[2-(3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-2-methylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C22H19Cl2N3O2	1
1	IC50 = 0.5888 nM Bioactivity Info	TI LI LO TS
CP0375207 Compound Info	3-[2-(3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-2,9-dimethylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C23H23N3O2	1
1	IC50 = 0.6026 nM Bioactivity Info	TI LI LO TS
CP0479963 Compound Info	3-[2-(3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-9-hydroxy-2-methylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C22H21N3O3	1
1	IC50 = 0.6918 nM Bioactivity Info	TI LI LO TS
CP0503149 Compound Info	3-[2-(6-chloro-3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-2-methylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C22H20ClN3O2	1
1	IC50 = 0.8913 nM Bioactivity Info	TI LI LO TS
CP0373529 Compound Info	9-chloro-3-[2-(3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-2-methyl-7-(trifluoromethyl)pyrido[1,2-a]pyrimidin-4-one Show/Hide	C23H19ClF3N3O2	1
1	IC50 = 1.175 nM Bioactivity Info	TI LI LO TS
CP0467592 Compound Info	3-[2-(3,4-dihydro-1H-[1]benzothiolo[3,2-c]pyridin-2-yl)ethyl]-2-methylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C22H21N3OS	1
1	IC50 = 1.738 nM Bioactivity Info	TI LI LO TS
CP0375044 Compound Info	2-benzyl-3-[2-(3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]pyrido[1,2-a]pyrimidin-4-one Show/Hide	C28H25N3O2	1
1	IC50 = 2.188 nM Bioactivity Info	TI LI LO TS
CP0408409 Compound Info	3-[2-(3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-7,8-dimethoxy-2-methylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C24H25N3O4	1
1	IC50 = 3.548 nM Bioactivity Info	TI LI LO TS
CP0375053 Compound Info	3-[2-(8-chloro-3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-2-methylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C22H20ClN3O2	1
1	IC50 = 3.89 nM Bioactivity Info	TI LI LO TS
CP0037622 Compound Info	2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole Show/Hide	C11H12N2O2	2
1	IC50 = 8.318 nM Bioactivity Info	TI LI LO TS
2	Ki = 7.079 nM Bioactivity Info	TI LI LO TS
CP0380633 Compound Info	3-[3-(3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)propyl]-2-methylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C23H23N3O2	1
1	IC50 = 10.23 nM Bioactivity Info	TI LI LO TS
CP0030044 Compound Info	(+/-)-12-Methyl-1,2,3,4,9,13b-hexahydro-2,4a,5-triaza-tribenzo[a,c,e]cycloheptene Show/Hide	C17H19N3	1
1	IC50 = 85.11 nM Bioactivity Info	TI LI LO TS
CP0423436 Compound Info	(+)2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole Show/Hide	C12H14N2O3	1
1	Ki = 0.3631 nM Bioactivity Info	TI LI LO TS
CP0845670 Compound Info	1N-{10-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3,2-a]b-carbolin-1-ylcarboxamido]decyl}-2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3, dihydrochloride Show/Hide	C50H70Cl2N6O4	1
1	Ki = 0.39 nM Bioactivity Info	TI LI LO TS
CP0069692 Compound Info	(+)-yohimbine Show/Hide	C21H26N2O3	2
1	Ki = 0.42 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.13 nM Bioactivity Info	TI LI LO TS
CP0890682 Compound Info	1N-{8-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3,2-a]b-carbolin-1-ylcarboxamido]octyl}-2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3,2 dihydrochloride Show/Hide	C48H66Cl2N6O4	1
1	Ki = 0.76 nM Bioactivity Info	TI LI LO TS
CP0906422 Compound Info	1N-{7-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3,2-a]b-carbolin-1-ylcarboxamido]heptyl}-2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3, dihydrochloride Show/Hide	C47H64Cl2N6O4	1
1	Ki = 0.87 nM Bioactivity Info	TI LI LO TS
CP0887730 Compound Info	1N-{12-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3,2-a]b-carbolin-1-ylcarboxamido]dodecyl}-2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[ dihydrochloride Show/Hide	C52H74Cl2N6O4	1
1	Ki = 1.18 nM Bioactivity Info	TI LI LO TS
CP0397609 Compound Info	AGN-193080 Show/Hide	C12H16N4O	1
1	Ki = 1.2 nM Bioactivity Info	TI LI LO TS
CP0879132 Compound Info	1N-{9-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3,2-a]b-carbolin-1-ylcarboxamido]nonyl}-2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3,2 dihydrochloride Show/Hide	C49H68Cl2N6O4	1
1	Ki = 1.25 nM Bioactivity Info	TI LI LO TS
CP0479804 Compound Info	(4'aS,5R,9'aR)-spiro[1,4-dihydroimidazole-5,3'-2,4,4a,9,9a,10-hexahydro-1H-anthracene] Show/Hide	C16H20N2	1
1	Ki = 1.259 nM Bioactivity Info	TI LI LO TS
CP0914202 Compound Info	1N-{6-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3,2-a]b-carbolin-1-ylcarboxamido]hexyl}-2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3,2 dihydrochloride Show/Hide	C46H62Cl2N6O4	1
1	Ki = 1.35 nM Bioactivity Info	TI LI LO TS
CP0406514 Compound Info	(1H-Imidazol-2-yl)-(5-methyl-2,3-dihydro-benzo[1,4]dioxin-6-yl)-amine Show/Hide	C12H13N3O2	1
1	Ki = 1.7 nM Bioactivity Info	TI LI LO TS
CP0897024 Compound Info	1N-{5-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3,2-a]b-carbolin-1-ylcarboxamido]pentyl}-2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3, dihydrochloride Show/Hide	C45H60Cl2N6O4	1
1	Ki = 1.73 nM Bioactivity Info	TI LI LO TS
CP0083828 Compound Info	N-(4,5-dihydro-1H-imidazol-2-yl)-5-methylquinoxalin-6-amine Show/Hide	C12H13N5	1
1	Ki = 2 nM Bioactivity Info	TI LI LO TS
CP0041550 Compound Info	BRIMONIDINE Show/Hide	C11H10BrN5	1
1	Ki = 2.7 nM Bioactivity Info	TI LI LO TS
CP0443901 Compound Info	Aminoclonidine, p Show/Hide	C9H10Cl2N4	1
1	Ki = 2.9 nM Bioactivity Info	TI LI LO TS
CP0379392 Compound Info	ATIPAMEZOLE Show/Hide	C14H16N2	1
1	Ki = 3.162 nM Bioactivity Info	TI LI LO TS
CP0457109 Compound Info	(5R)-5-[(3R)-spiro[2,4-dihydro-1H-naphthalene-3,2'-cyclopropane]-1'-yl]-4,5-dihydro-1H-imidazole Show/Hide	C15H18N2	1
1	Ki = 3.162 nM Bioactivity Info	TI LI LO TS
CP0440279 Compound Info	5-(2,3-dihydro-1H-inden-2-ylmethyl)-4,5-dihydro-1H-imidazole Show/Hide	C13H16N2	1
1	Ki = 3.981 nM Bioactivity Info	TI LI LO TS
CP0496735 Compound Info	2-(4,5-dihydro-1,3-oxazol-2-yl)-1-(3-methoxyphenyl)-1-(4-methylphenyl)hydrazine Show/Hide	C17H19N3O2	1
1	Ki = 4.16 nM Bioactivity Info	TI LI LO TS
CP0436662 Compound Info	3-[N'-(4,5-Dihydro-oxazol-2-yl)-N-p-tolyl-hydrazino]-phenol Show/Hide	C16H17N3O2	1
1	Ki = 4.73 nM Bioactivity Info	TI LI LO TS
CP0373564 Compound Info	(4-tert-Butyl-3-methoxy-2,6-dimethyl-phenyl)-(1H-imidazol-2-yl)-amine Show/Hide	C16H23N3O	1
1	Ki = 4.9 nM Bioactivity Info	TI LI LO TS
CP0376585 Compound Info	(1H-Imidazol-2-yl)-(5-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-amine Show/Hide	C12H14N4O	1
1	Ki = 6 nM Bioactivity Info	TI LI LO TS
CP0464670 Compound Info	2-(4,5-dihydro-1H-imidazol-2-yl)-1-(3-methoxyphenyl)-1-(4-methylphenyl)hydrazine Show/Hide	C17H20N4O	1
1	Ki = 6.3 nM Bioactivity Info	TI LI LO TS
CP0035258 Compound Info	N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine Show/Hide	C17H18F3NO	1
1	Ki = 6.31 nM Bioactivity Info	TI LI LO TS
CP0410535 Compound Info	AGN-192172 Show/Hide	C12H17N5	1
1	Ki = 9.6 nM Bioactivity Info	TI LI LO TS
CP0506536 Compound Info	(1H-Imidazol-2-yl)-(4-methoxy-2-methyl-phenyl)-amine Show/Hide	C11H13N3O	1
1	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0879185 Compound Info	1N-{4-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3,2-a]b-carbolin-1-ylcarboxamido]butyl}-2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3,2 dihydrochloride Show/Hide	C44H58Cl2N6O4	1
1	Ki = 15.3 nM Bioactivity Info	TI LI LO TS
CP0434857 Compound Info	1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-4-((3-(2-phenoxypyridin-3-yl)-1,2,4-oxadiazol-5-yl)methyl)-1,4-diazepane Show/Hide	C28H29N5O4	2
1	Ki = 15.4 nM Bioactivity Info	TI LI LO TS
2	Ki = 44.8 nM Bioactivity Info	TI LI LO TS
CP0387342 Compound Info	2-[1-[2,6-bis(prop-2-enyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C17H22N2O	1
1	Ki = 16.6 nM Bioactivity Info	TI LI LO TS
CP0463553 Compound Info	5-(1-benzofuran-2-ylmethyl)-4,5-dihydro-1H-imidazole Show/Hide	C12H12N2O	1
1	Ki = 19.95 nM Bioactivity Info	TI LI LO TS
CP0157938 Compound Info	2-[(1S)-1-(2-cyclopropylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O	1
1	Ki = 20.89 nM Bioactivity Info	TI LI LO TS
CP0402735 Compound Info	2-[1-(2-cyclopropylphenyl)ethoxy]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O	1
1	Ki = 22.91 nM Bioactivity Info	TI LI LO TS
CP0110358 Compound Info	2-[1-(2-cyclopropylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O	1
1	Ki = 22.91 nM Bioactivity Info	TI LI LO TS
CP0202947 Compound Info	2-[1-(2-bromophenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C11H13BrN2O	1
1	Ki = 22.91 nM Bioactivity Info	TI LI LO TS
CP0485217 Compound Info	3-[N'-(4,5-Dihydro-1H-imidazol-2-yl)-N-p-tolyl-hydrazino]-phenol Show/Hide	C16H18N4O	1
1	Ki = 23.8 nM Bioactivity Info	TI LI LO TS
CP0387610 Compound Info	2-[1-(2-ethylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C13H18N2O	1
1	Ki = 23.99 nM Bioactivity Info	TI LI LO TS
CP0430994 Compound Info	2-[1-(2-methylphenyl)ethoxy]-4,5-dihydro-1H-imidazole Show/Hide	C12H16N2O	1
1	Ki = 24.55 nM Bioactivity Info	TI LI LO TS
CP0453377 Compound Info	5-[(8-chloronaphthalen-2-yl)methyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H13ClN2	1
1	Ki = 25.12 nM Bioactivity Info	TI LI LO TS
CP0846862 Compound Info	1N-{2-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3,2-a]b-carbolin-1-ylcarboxamido]ethyl}-2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3,2 dihydrochloride Show/Hide	C42H54Cl2N6O4	1
1	Ki = 26.4 nM Bioactivity Info	TI LI LO TS
CP0387572 Compound Info	2-(1-phenoxyethyl)-4,5-dihydro-1H-imidazole Show/Hide	C11H14N2O	1
1	Ki = 26.92 nM Bioactivity Info	TI LI LO TS
CP0439228 Compound Info	2-(1-phenylethoxy)-4,5-dihydro-1H-imidazole Show/Hide	C11H14N2O	1
1	Ki = 26.92 nM Bioactivity Info	TI LI LO TS
CP0399323 Compound Info	N-[2-[4-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)piperazin-1-yl]ethyl]-2-phenoxypyridine-3-carboxamide Show/Hide	C27H30N4O4	1
1	Ki = 27 nM Bioactivity Info	TI LI LO TS
CP0378483 Compound Info	3-[2-[1-(4,5-dihydro-1H-imidazol-2-yl)ethoxy]phenyl]phenol Show/Hide	C17H18N2O2	1
1	Ki = 27.54 nM Bioactivity Info	TI LI LO TS
CP0390643 Compound Info	2-[1-(2-chlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C11H13ClN2O	1
1	Ki = 28.84 nM Bioactivity Info	TI LI LO TS
CP0402335 Compound Info	(1H-Imidazol-2-yl)-(5-methyl-quinoxalin-6-yl)-amine Show/Hide	C12H11N5	1
1	Ki = 31 nM Bioactivity Info	TI LI LO TS
CP0448360 Compound Info	5-[(8-chloro-3,4-dihydronaphthalen-2-yl)methyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H15ClN2	1
1	Ki = 31.62 nM Bioactivity Info	TI LI LO TS
CP0428121 Compound Info	4-[2-[1-(4,5-dihydro-1H-imidazol-2-yl)ethoxy]phenyl]phenol Show/Hide	C17H18N2O2	1
1	Ki = 33.88 nM Bioactivity Info	TI LI LO TS
CP0402731 Compound Info	2-[(2-methylphenyl)methoxy]-4,5-dihydro-1H-imidazole Show/Hide	C11H14N2O	1
1	Ki = 34.67 nM Bioactivity Info	TI LI LO TS
CP0087650 Compound Info	2-[1-[2-(cyclopropylmethyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C15H20N2O	1
1	Ki = 36.31 nM Bioactivity Info	TI LI LO TS
CP0056760 Compound Info	CHEBI:8862 Show/Hide	C10H16N2O	1
1	Ki = 36.31 nM Bioactivity Info	TI LI LO TS
CP0402484 Compound Info	(5-tert-Butyl-4-methoxy-2-methyl-phenyl)-(1H-imidazol-2-yl)-amine Show/Hide	C15H21N3O	1
1	Ki = 39 nM Bioactivity Info	TI LI LO TS
CP0410628 Compound Info	5-[(8-fluoro-3,4-dihydronaphthalen-2-yl)methyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H15FN2	1
1	Ki = 39.81 nM Bioactivity Info	TI LI LO TS
CP0435288 Compound Info	3-[2-[(1R)-1-(4,5-dihydro-1H-imidazol-2-yl)ethoxy]phenyl]phenol Show/Hide	C17H18N2O2	1
1	Ki = 39.81 nM Bioactivity Info	TI LI LO TS
CP0441664 Compound Info	2-[1-[2-(4-methylphenyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C18H20N2O	1
1	Ki = 41.69 nM Bioactivity Info	TI LI LO TS
CP0157934 Compound Info	2-[(1S)-1-[2-(cyclopropylmethyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C15H20N2O	1
1	Ki = 41.69 nM Bioactivity Info	TI LI LO TS
CP0157942 Compound Info	2-[(1R)-1-(2-cyclopropylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O	1
1	Ki = 44.67 nM Bioactivity Info	TI LI LO TS
CP0087658 Compound Info	2-[(1R)-1-[2-(cyclopropylmethyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C15H20N2O	1
1	Ki = 44.67 nM Bioactivity Info	TI LI LO TS
CP0427125 Compound Info	2-[1-[2-(2-methylphenyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C18H20N2O	1
1	Ki = 46.77 nM Bioactivity Info	TI LI LO TS
CP0485691 Compound Info	6-butoxy-N-(2-(4-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1,4-diazepan-1-yl)ethyl)picolinamide Show/Hide	C26H36N4O4	2
1	Ki = 48.4 nM Bioactivity Info	TI LI LO TS
2	Ki = 118 nM Bioactivity Info	TI LI LO TS
CP0431035 Compound Info	2-[(2-propylphenyl)methoxy]-4,5-dihydro-1H-imidazole Show/Hide	C13H18N2O	1
1	Ki = 48.98 nM Bioactivity Info	TI LI LO TS
CP0029083 Compound Info	(S)-3,6-Diamino-hexanoic acid {(3S,9S,12S,15S)-3-((S)-6-hydroxy-2-imino-hexahydro-pyrimidin-4-yl)-9,12-bis-hydroxymethyl-2,5,8,11,14-pentaoxo-6-[1-ureido-meth-(Z)-ylidene]-1,4,7,10,13pentaaza-cyclohexadec-15-yl}-amide Show/Hide	C66H75Cl2N9O24	1
1	Ki = 50.12 nM Bioactivity Info	TI LI LO TS
CP0419106 Compound Info	2-[1-(2-propylphenyl)ethoxy]-4,5-dihydro-1H-imidazole Show/Hide	C14H20N2O	1
1	Ki = 50.12 nM Bioactivity Info	TI LI LO TS
CP0373596 Compound Info	2-[1-[2-(3-methylphenyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C18H20N2O	1
1	Ki = 51.29 nM Bioactivity Info	TI LI LO TS
CP0919132 Compound Info	1N-{3-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3,2-a]b-carbolin-1-ylcarboxamido]propyl}-2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquino[3, dihydrochloride Show/Hide	C43H56Cl2N6O4	1
1	Ki = 52 nM Bioactivity Info	TI LI LO TS
CP0157932 Compound Info	2-[(1S)-1-(2-prop-2-enylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O	1
1	Ki = 52.48 nM Bioactivity Info	TI LI LO TS
CP0072943 Compound Info	3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)amino]phenol;methanesulfonic acid Show/Hide	C17H19N3O	1
1	Ki = 55.9 nM Bioactivity Info	TI LI LO TS
CP0157930 Compound Info	2-[1-(2-prop-2-enylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O	1
1	Ki = 57.54 nM Bioactivity Info	TI LI LO TS
CP0419107 Compound Info	2-[1-(2-prop-2-enylphenyl)ethoxy]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O	1
1	Ki = 57.54 nM Bioactivity Info	TI LI LO TS
CP0376836 Compound Info	2-[1-(2-methoxyphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C12H16N2O2	1
1	Ki = 57.54 nM Bioactivity Info	TI LI LO TS
CP0044542 Compound Info	2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imidazole Show/Hide	C13H16N2O	1
1	Ki = 58.88 nM Bioactivity Info	TI LI LO TS
CP0378487 Compound Info	2-[1-[2-(3-nitrophenyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C17H17N3O3	1
1	Ki = 60.26 nM Bioactivity Info	TI LI LO TS
CP0510742 Compound Info	(4S)-4-[[(1aR)-1,2,3,7b-tetrahydrocyclopropa[a]naphthalen-1a-yl]methyl]-4,5-dihydro-1H-imidazole Show/Hide	C15H18N2	1
1	Ki = 63.1 nM Bioactivity Info	TI LI LO TS
CP0399322 Compound Info	1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-4-(2-((2-phenoxypyridin-3-yl)methoxy)ethyl)-1,4-diazepane Show/Hide	C28H33N3O4	2
1	Ki = 66.1 nM Bioactivity Info	TI LI LO TS
2	Ki = 275 nM Bioactivity Info	TI LI LO TS
CP0378486 Compound Info	2-[(1S)-1-[2-(3-nitrophenyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C17H17N3O3	1
1	Ki = 72.44 nM Bioactivity Info	TI LI LO TS
CP0372603 Compound Info	2-[1-(2-prop-1-en-2-ylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O	1
1	Ki = 72.44 nM Bioactivity Info	TI LI LO TS
CP0391378 Compound Info	2-[1-(2-propan-2-ylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H20N2O	1
1	Ki = 72.44 nM Bioactivity Info	TI LI LO TS
CP0439786 Compound Info	2-butoxy-N-(2-(4-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1,4-diazepan-1-yl)ethyl)nicotinamide Show/Hide	C26H36N4O4	2
1	Ki = 73.6 nM Bioactivity Info	TI LI LO TS
2	Ki = 81 nM Bioactivity Info	TI LI LO TS
CP0373437 Compound Info	(1H-Benzoimidazol-5-yl)-(1H-imidazol-2-yl)-amine Show/Hide	C10H9N5	1
1	Ki = 76 nM Bioactivity Info	TI LI LO TS
CP0378482 Compound Info	(R)-2-[1-(3'-nitrobiphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C17H17N3O3	1
1	Ki = 81.28 nM Bioactivity Info	TI LI LO TS
CP0110365 Compound Info	2-[1-(2-cyclopropyloxyphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O2	1
1	Ki = 83.18 nM Bioactivity Info	TI LI LO TS
CP0403607 Compound Info	2-[1-(2-propan-2-yloxyphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H20N2O2	1
1	Ki = 83.18 nM Bioactivity Info	TI LI LO TS
CP0386169 Compound Info	2-[phenoxy(phenyl)methyl]-4,5-dihydro-1H-imidazole Show/Hide	C16H16N2O	1
1	Ki = 93.33 nM Bioactivity Info	TI LI LO TS
CP0071147 Compound Info	(S)-N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide Show/Hide	C28H32N4O4	2
1	Ki = 94.4 nM Bioactivity Info	TI LI LO TS
2	Ki > 442 nM Bioactivity Info	TI LI LO TS
CP0453117 Compound Info	(2,6-Dichloro-phenyl)-(1H-imidazol-2-yl)-amine Show/Hide	C9H7Cl2N3	1
1	Ki = 95 nM Bioactivity Info	TI LI LO TS
CP0475547 Compound Info	3-[2-[(1S)-1-(4,5-dihydro-1H-imidazol-2-yl)ethoxy]phenyl]phenol Show/Hide	C17H18N2O2	1
1	Ki = 97.72 nM Bioactivity Info	TI LI LO TS
CP0376906 Compound Info	2-[1-(2-ethoxyphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C13H18N2O2	1
1	Ki = 97.72 nM Bioactivity Info	TI LI LO TS
CP0445268 Compound Info	5-(3,4-dihydronaphthalen-2-ylmethyl)-4,5-dihydro-1H-imidazole Show/Hide	C14H16N2	1
1	Ki = 100 nM Bioactivity Info	TI LI LO TS
CP0087659 Compound Info	2-[(1R)-1-(2-prop-2-enylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O	1
1	Ki = 100 nM Bioactivity Info	TI LI LO TS
CP0373590 Compound Info	2-[1-[2-(4-nitrophenyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C17H17N3O3	1
1	Ki = 123.03 nM Bioactivity Info	TI LI LO TS
CP0396661 Compound Info	2-(3-methoxy-5-phenyl-2H-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole Show/Hide	C18H18N2O3	1
1	Ki = 125.89 nM Bioactivity Info	TI LI LO TS
CP0375168 Compound Info	(3,4-Dimethoxy-2-methyl-phenyl)-(1H-imidazol-2-yl)-amine Show/Hide	C12H15N3O2	1
1	Ki = 130 nM Bioactivity Info	TI LI LO TS
CP0456177 Compound Info	2-(tert-butylamino)-N-(2-(4-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1,4-diazepan-1-yl)ethyl)nicotinamide Show/Hide	C26H37N5O3	2
1	Ki = 138 nM Bioactivity Info	TI LI LO TS
2	Ki = 366 nM Bioactivity Info	TI LI LO TS
CP0046852 Compound Info	1-Benzyl-4-chroman-2-ylmethyl-piperazine Show/Hide	C21H26N2O	2
1	Ki = 146.1 nM Bioactivity Info	TI LI LO TS
2	Ki = 167 nM Bioactivity Info	TI LI LO TS
CP0454917 Compound Info	5-[(7-fluoro-3,4-dihydronaphthalen-2-yl)methyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H15FN2	1
1	Ki = 158.49 nM Bioactivity Info	TI LI LO TS
CP0439785 Compound Info	1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-4-(2-methoxyphenyl)piperazine Show/Hide	C20H24N2O3	2
1	Ki = 167 nM Bioactivity Info	TI LI LO TS
2	Ki = 506 nM Bioactivity Info	TI LI LO TS
CP0373587 Compound Info	2-[1-[2-(2-nitrophenyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C17H17N3O3	1
1	Ki = 173.78 nM Bioactivity Info	TI LI LO TS
CP0376832 Compound Info	2-[1-[2-(trifluoromethyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C12H13F3N2O	1
1	Ki = 181.97 nM Bioactivity Info	TI LI LO TS
CP0445292 Compound Info	2-(3-cyanophenoxy)-N-(2-(4-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1,4-diazepan-1-yl)ethyl)nicotinamide Show/Hide	C29H31N5O4	2
1	Ki = 208 nM Bioactivity Info	TI LI LO TS
2	Ki = 501 nM Bioactivity Info	TI LI LO TS
CP0380658 Compound Info	(2-Bromo-phenyl)-(1H-imidazol-2-yl)-amine Show/Hide	C9H8BrN3	1
1	Ki = 210 nM Bioactivity Info	TI LI LO TS
CP0386168 Compound Info	(E)-1-[2-[1-(4,5-dihydro-1H-imidazol-2-yl)ethoxy]phenyl]-N-phenylmethoxymethanimine Show/Hide	C19H21N3O2	1
1	Ki = 213.8 nM Bioactivity Info	TI LI LO TS
CP0397965 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-5-methoxy-2-methylsulfanylaniline Show/Hide	C12H17N3OS	1
1	Ki = 218.78 nM Bioactivity Info	TI LI LO TS
CP0439781 Compound Info	N-[2-[4-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1,4-diazepan-1-yl]ethyl]-2-phenoxypyridine-3-carboxamide Show/Hide	C28H32N4O4	2
1	Ki = 220 nM Bioactivity Info	TI LI LO TS
2	Ki = 474 nM Bioactivity Info	TI LI LO TS
CP0423434 Compound Info	2-(5-phenyl-2,3-dihydro-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole Show/Hide	C17H16N2O2	1
1	Ki = 239.88 nM Bioactivity Info	TI LI LO TS
CP0423437 Compound Info	2-(2-methoxy-5-phenyl-3H-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole Show/Hide	C18H18N2O3	1
1	Ki = 257.04 nM Bioactivity Info	TI LI LO TS
CP0373597 Compound Info	4-[2-[1-(4,5-dihydro-1H-imidazol-2-yl)ethoxy]phenyl]pyridine Show/Hide	C16H17N3O	1
1	Ki = 281.84 nM Bioactivity Info	TI LI LO TS
CP0423443 Compound Info	2-(6-phenyl-2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole Show/Hide	C17H16N2O2	1
1	Ki = 281.84 nM Bioactivity Info	TI LI LO TS
CP0373595 Compound Info	2-[2-[1-(4,5-dihydro-1H-imidazol-2-yl)ethoxy]phenyl]phenol Show/Hide	C17H18N2O2	1
1	Ki = 309.03 nM Bioactivity Info	TI LI LO TS
CP0373585 Compound Info	2-[1-(2-phenylphenyl)sulfanylethyl]-4,5-dihydro-1H-imidazole Show/Hide	C17H18N2S	1
1	Ki = 338.84 nM Bioactivity Info	TI LI LO TS
CP0423442 Compound Info	2-(6-phenyl-2,3-dihydro-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole Show/Hide	C17H16N2O2	1
1	Ki = 398.11 nM Bioactivity Info	TI LI LO TS
CP0399099 Compound Info	2-[(2S,5R)-5-phenyl-1,4-dioxan-2-yl]-4,5-dihydro-1H-imidazole Show/Hide	C13H16N2O2	1
1	Ki = 398.11 nM Bioactivity Info	TI LI LO TS
CP0423441 Compound Info	(E)-1-[2-[1-(4,5-dihydro-1H-imidazol-2-yl)ethoxy]phenyl]-N-ethoxymethanimine Show/Hide	C14H19N3O2	1
1	Ki = 416.87 nM Bioactivity Info	TI LI LO TS
CP0388308 Compound Info	N-[2-[4-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1,4-diazepan-1-yl]ethyl]pyridine-3-carboxamide Show/Hide	C22H28N4O3	1
1	Ki = 443 nM Bioactivity Info	TI LI LO TS
CP0376827 Compound Info	2-[1-(2,6-diphenylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C23H22N2O	1
1	Ki = 489.78 nM Bioactivity Info	TI LI LO TS
CP0666295 Compound Info	rac-trans-2-(5-Phenyl-1,4-dioxan-2-yl)-4,5-dihydro-1H-imidazole Show/Hide	C13H16N2O2	1
1	Ki = 501.19 nM Bioactivity Info	TI LI LO TS
CP0392952 Compound Info	(5-Bromo-quinoxalin-6-yl)-(1H-imidazol-2-yl)-amine Show/Hide	C11H8BrN5	1
1	Ki = 510 nM Bioactivity Info	TI LI LO TS
CP0379033 Compound Info	(E)-1-[2-[1-(4,5-dihydro-1H-imidazol-2-yl)ethoxy]phenyl]-N-methoxymethanimine Show/Hide	C13H17N3O2	1
1	Ki = 660.69 nM Bioactivity Info	TI LI LO TS
CP0387574 Compound Info	2-(5-phenyl-2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole Show/Hide	C17H16N2O2	1
1	Ki = 724.44 nM Bioactivity Info	TI LI LO TS
CP0373584 Compound Info	2-[2-[1-(4,5-dihydro-1H-imidazol-2-yl)ethoxy]phenyl]pyridine Show/Hide	C16H17N3O	1
1	Ki = 1202.26 nM Bioactivity Info	TI LI LO TS
CP0427122 Compound Info	2-[3-(2-phenylphenyl)oxiran-2-yl]-4,5-dihydro-1H-imidazole;hydrochloride Show/Hide	C17H17ClN2O	1
1	Ki = 1513.56 nM Bioactivity Info	TI LI LO TS
CP0387054 Compound Info	N-(2,6-dichlorophenyl)-5-methyl-4,5-dihydro-1H-imidazol-2-amine Show/Hide	C10H11Cl2N3	1
1	Ki = 1949.84 nM Bioactivity Info	TI LI LO TS
CP0497542 Compound Info	N-(2-chloro-4-iodophenyl)-2-methyl-3,4-dihydro-2H-pyrrol-5-amine Show/Hide	C11H12ClIN2	1
1	Ki = 2570.4 nM Bioactivity Info	TI LI LO TS
CP0421105 Compound Info	N-(2-chlorophenyl)-3,4-dihydro-2H-pyrrol-5-amine Show/Hide	C10H11ClN2	1
1	Ki = 3019.95 nM Bioactivity Info	TI LI LO TS
CP0453851 Compound Info	(1H-Imidazol-2-yl)-quinoxalin-6-yl-amine Show/Hide	C11H9N5	1
1	Ki = 3100 nM Bioactivity Info	TI LI LO TS
CP0039634 Compound Info	3-Fluoromethyl-7-nitro-1,2,3,4-tetrahydro-isoquinoline Show/Hide	C10H11FN2O2	1
1	Ki = 3200 nM Bioactivity Info	TI LI LO TS
CP0209521 Compound Info	7-Nitro-1,2,3,4-tetrahydro-isoquinoline Show/Hide	C9H10N2O2	1
1	Ki = 3200 nM Bioactivity Info	TI LI LO TS
CP0063736 Compound Info	1,2,3,4-tetrahydroisoquinoline-7-sulfonamide Show/Hide	C9H12N2O2S	1
1	Ki = 3400 nM Bioactivity Info	TI LI LO TS
CP0101650 Compound Info	7-Nitro-3-trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline Show/Hide	C10H9F3N2O2	1
1	Ki = 3400 nM Bioactivity Info	TI LI LO TS
CP0278499 Compound Info	(+/-)-3-difluoromethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline Show/Hide	C10H10F2N2O2	1
1	Ki = 3600 nM Bioactivity Info	TI LI LO TS
CP0456864 Compound Info	N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-5-methoxy-2-methylsulfonylaniline Show/Hide	C12H17N3O3S	1
1	Ki = 3630.78 nM Bioactivity Info	TI LI LO TS
CP0405369 Compound Info	2-(6,6-diphenyl-1,4-dioxan-2-yl)-4,5-dihydro-1H-imidazole Show/Hide	C19H20N2O2	1
1	Ki = 3801.89 nM Bioactivity Info	TI LI LO TS
CP0177126 Compound Info	(+)-(7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl)methanol Show/Hide	C10H12N2O3	1
1	Ki = 3900 nM Bioactivity Info	TI LI LO TS
CP0035496 Compound Info	7-Bromo-3-trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline Show/Hide	C10H9BrF3N	1
1	Ki = 4350 nM Bioactivity Info	TI LI LO TS
CP0135923 Compound Info	CHEBI:6956 Show/Hide	C23H30N2O4	1
1	Ki = 4720 nM Bioactivity Info	TI LI LO TS
CP0180100 Compound Info	3-Methyl-7-nitro-1,2,3,4-tetrahydro-isoquinoline Show/Hide	C10H12N2O2	1
1	Ki = 4840 nM Bioactivity Info	TI LI LO TS
CP0410228 Compound Info	N-(dicyclopropylmethyl)-4-methyl-4,5-dihydro-1,3-oxazol-2-amine Show/Hide	C11H18N2O	1
1	Ki = 4897.79 nM Bioactivity Info	TI LI LO TS
CP0372845 Compound Info	2-[(2R,6S)-6-phenyl-1,4-dioxan-2-yl]-4,5-dihydro-1H-imidazole Show/Hide	C13H16N2O2	1
1	Ki = 5370.32 nM Bioactivity Info	TI LI LO TS
CP0387839 Compound Info	2-[(2R,6R)-6-phenyl-1,4-dioxan-2-yl]-4,5-dihydro-1H-imidazole Show/Hide	C13H16N2O2	1
1	Ki = 6309.57 nM Bioactivity Info	TI LI LO TS
CP0035979 Compound Info	7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydrochloride Show/Hide	C9H9Cl2N	1
1	Ki = 6520 nM Bioactivity Info	TI LI LO TS
CP0391979 Compound Info	2-[(2R,5S)-5-phenyl-1,4-dioxan-2-yl]-4,5-dihydro-1H-imidazole Show/Hide	C13H16N2O2	1
1	Ki = 7943.28 nM Bioactivity Info	TI LI LO TS
CP0373591 Compound Info	5-[1-(2-phenylphenoxy)ethyl]-3,4-dihydro-2H-pyrrole Show/Hide	C18H19NO	1
1	Ki = 8128.31 nM Bioactivity Info	TI LI LO TS
CP0442626 Compound Info	2-[1-(2-phenylphenoxy)ethyl]-4,5-dihydro-1,3-oxazole Show/Hide	C17H17NO2	1
1	Ki = 8128.31 nM Bioactivity Info	TI LI LO TS
CP0402201 Compound Info	2-(5,5-diphenyl-1,4-dioxan-2-yl)-4,5-dihydro-1H-imidazole Show/Hide	C19H20N2O2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0418816 Compound Info	2-[(2R,5R)-5-phenyl-1,4-dioxan-2-yl]-4,5-dihydro-1H-imidazole Show/Hide	C13H16N2O2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0421104 Compound Info	US9303019, 13 Show/Hide	C11H13ClN2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0151467 Compound Info	1-Benzyl-4-chroman-3-ylmethyl-piperazine Show/Hide	C21H26N2O	1
1	Ki > 500 nM Bioactivity Info	TI LI LO TS
CP0853864 Compound Info	(4,5-Dihydro-1H-imidazol-2-ylmethyl)-[2-(propane-1-sulfonyl)-phenyl]-amine hydrochloride Show/Hide	C13H20ClN3O2S	1
1	Ki < 7943.28 nM Bioactivity Info	TI LI LO TS
CP0373588 Compound Info	2-[1-(2-phenylphenoxy)ethyl]-4,5-dihydro-1,3-thiazole Show/Hide	C17H17NOS	1
1	Ki < 10000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000049 , C6

Cell Line Info

Cell Line ID: CL000406 , CHO-CPR C10

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000109 , COS-1

Cell Line Info

Cell Line ID: CL000053 , COS-7

Cell Line Info

Cell Line ID: CL000017 , HeLa

Cell Line Info

Cell Line ID: CL000007 , HT-29

Cell Line Info

Cell Line ID: CL000101 , L-M(TK-)

Cell Line Info

Cell Line ID: CL000041 , LTK-

Cell Line Info

Cell Line ID: CL000031 , MDCK

Cell Line Info

Cell Line ID: CL000028 , PC-12

Cell Line Info

Cell Line ID: CL000796 , SC-115

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0043469 Compound Info	ATC0175 Show/Hide	C23H25F2N5O	1
1	IC50 = 104 nM
CP0069692 Compound Info	(+)-yohimbine Show/Hide	C21H26N2O3	2
1	Ki = 1.4 nM
2	Ki = 3.1 nM
CP0072943 Compound Info	3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)amino]phenol;methanesulfonic acid Show/Hide	C17H19N3O	2
1	Ki = 1.7 nM
2	Ki = 2.6 nM
CP0041905 Compound Info	2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) Show/Hide	C9H9Cl2N3	3
1	Ki = 3.8 nM
2	Ki = 7.943 nM
3	Ki = 853 nM
CP0030044 Compound Info	(+/-)-12-Methyl-1,2,3,4,9,13b-hexahydro-2,4a,5-triaza-tribenzo[a,c,e]cycloheptene Show/Hide	C17H19N3	1
1	Ki = 20 nM
CP0157938 Compound Info	2-[(1S)-1-(2-cyclopropylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O	1
1	Ki = 20.89 nM
CP0110358 Compound Info	2-[1-(2-cyclopropylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O	1
1	Ki = 22.91 nM
CP0202947 Compound Info	2-[1-(2-bromophenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C11H13BrN2O	1
1	Ki = 22.91 nM
CP0087650 Compound Info	2-[1-[2-(cyclopropylmethyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C15H20N2O	1
1	Ki = 36.31 nM
CP0157934 Compound Info	2-[(1S)-1-[2-(cyclopropylmethyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C15H20N2O	1
1	Ki = 41.69 nM
CP0087658 Compound Info	2-[(1R)-1-[2-(cyclopropylmethyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C15H20N2O	1
1	Ki = 44.67 nM
CP0157942 Compound Info	2-[(1R)-1-(2-cyclopropylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O	1
1	Ki = 44.67 nM
CP0157932 Compound Info	2-[(1S)-1-(2-prop-2-enylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O	1
1	Ki = 52.48 nM
CP0157930 Compound Info	2-[1-(2-prop-2-enylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O	1
1	Ki = 57.54 nM
CP0044542 Compound Info	2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imidazole Show/Hide	C13H16N2O	1
1	Ki = 58.88 nM
CP0039930 Compound Info	(-)-arterenol Show/Hide	C8H11NO3	1
1	Ki = 66 nM
CP0110365 Compound Info	2-[1-(2-cyclopropyloxyphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O2	1
1	Ki = 83.18 nM
CP0087659 Compound Info	2-[(1R)-1-(2-prop-2-enylphenoxy)ethyl]-4,5-dihydro-1H-imidazole Show/Hide	C14H18N2O	1
1	Ki = 100 nM
CP0036700 Compound Info	6-Chloro-3-methyl-9-(3-methyl-but-2-enyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine Show/Hide	C16H22ClNO	1
1	Ki = 114 nM
CP0039841 Compound Info	ABT-866 Show/Hide	C12H15N3O2S	1
1	Ki = 169.82 nM
CP0056760 Compound Info	CHEBI:8862 Show/Hide	C10H16N2O	1
1	Ki = 181.97 nM
CP0040436 Compound Info	5-N-[3-(4,4-diphenylpiperidin-1-yl)propyl]-3-N,2,6-trimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide Show/Hide	C36H41N5O4	1
1	Ki = 398.11 nM
CP0087323 Compound Info	Niguldipine Show/Hide	C36H39N3O6	1
1	Ki = 530 nM
CP0645895 Compound Info	SID50112869 Show/Hide	C36H40N4O5	2
1	Ki = 1202.26 nM
2	Ki = 2417 nM

Clinical Information about the Protein

Target 1 ( Adrenergic receptor alpha-2A (ADRA2A) )

Target Type	Successful Target
Disease	6 Target-related Diseases				6
1	Attention deficit hyperactivity disorder [ICD-11: 6A05.Z]
2	Opioid dependence [ICD-11: 6C43.2Z]
3	Alcohol dependence [ICD-11: 6C40.2]
4	Alzheimer disease [ICD-11: 8A20]
5	Pain [ICD-11: MG30-MG3Z]
6	Obesity [ICD-11: 5B81]
Approved Drug(s)	3 Approved Drugs				3
1	Connexyn	Drug Info	Approved	Attention deficit hyperactivity disorder
2	Lofexidine	Drug Info	Approved	Opioid dependence
3	MOXONIDINE	Drug Info	Approved	Alcohol dependence
Clinical Trial Drug(s)	2 Clinical Trial Drugs				2
1	Guanfacine	Drug Info	Phase 3	Alzheimer disease
2	MEDETOMIDINE	Drug Info	Phase 2	Pain
Discontinued Drug(s)	1 Discontinued Drug				1
1	S-18616	Drug Info	Terminated	Pain
Investigative Drug(s)	1 Investigative Drug				1
1	Ciproxifan	Drug Info	Investigative	Obesity

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han