Brief Information of the Cell Line and Protein
Cell Line ID: CL000053 , COS-7
Synonyms
Cos-7
COS 7
Cos 7
COS7
Cos7
CV-1 in Origin Simian-7
Category Transformed cell line
Organism
Chlorocebus aethiops (Green monkey)
Cellosaurus ID
CVCL_0224
Protein ID: PT01303 , Endothelial lipase
Gene Name LIPG
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID Q9Y5X9
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000053  Protein ID: PT01303
 
Compound ID Compound Name Compound Formula
CP0230197
5-amino-2,4-dioxo-N-[(1R)-5-phenylmethoxy-2,3-dihydro-1H-inden-1-yl]-1H-pyrimidine-6-carboxamide
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C21H20N4O4
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0164059
5-amino-2,4-dioxo-N-[4-(4-phenylmethoxyphenyl)cyclohexyl]-1H-pyrimidine-6-carboxamide
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C24H26N4O4
 1
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
CP0210858
5-hydroxy-2,4-dioxo-N-(4-phenylcyclohexyl)-1H-pyrimidine-6-carboxamide
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C17H19N3O4
 1
1
IC50 = 26 nM
   TI
   LI
   LO
   TS
CP0140160
5-amino-2,4-dioxo-N-[(1R)-5-phenylmethoxy-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-pyrimidine-6-carboxamide
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C22H22N4O4
 1
1
IC50 = 49 nM
   TI
   LI
   LO
   TS
CP0143507
5-amino-2,4-dioxo-N-[(1R,4R)-4-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-pyrimidine-6-carboxamide
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C21H20N4O3
 1
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
CP0140179
5-hydroxy-3-(2-methylpropyl)-2,4-dioxo-N-(4-phenylcyclohexyl)-1H-pyrimidine-6-carboxamide
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C21H27N3O4
 1
1
IC50 = 59 nM
   TI
   LI
   LO
   TS
CP0230198
5-hydroxy-3-(2-hydroxyethyl)-2,4-dioxo-N-(4-phenylcyclohexyl)-1H-pyrimidine-6-carboxamide
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C19H23N3O5
 1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
CP0565190
1-ethyl-4-hydroxy-5-oxo-N-(4-phenylcyclohexyl)-2H-pyrrole-3-carboxamide
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C19H24N2O3
 1
1
IC50 = 82 nM
   TI
   LI
   LO
   TS
CP0439917
5-amino-2,4-dioxo-N-(4-phenylcyclohexyl)-1H-pyrimidine-6-carboxamide
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C17H20N4O3
 1
1
IC50 = 91 nM
   TI
   LI
   LO
   TS
CP0426419
3-benzyl-5-hydroxy-2,4-dioxo-N-(4-phenylcyclohexyl)-1H-pyrimidine-6-carboxamide
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C24H25N3O4
 1
1
IC50 = 117 nM
   TI
   LI
   LO
   TS
CP0565169
CHEMBL4440524
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C22H28N4O3
 1
1
IC50 = 156 nM
   TI
   LI
   LO
   TS
CP0326153
5-amino-2,4-dioxo-N-[(1R,3S)-3-phenylcyclopentyl]-1H-pyrimidine-6-carboxamide
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C16H18N4O3
 1
1
IC50 = 175 nM
   TI
   LI
   LO
   TS
CP0210857
5-amino-2,4-dioxo-N-[(1S,3R)-3-phenylcyclopentyl]-1H-pyrimidine-6-carboxamide
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C16H18N4O3
 1
1
IC50 = 218 nM
   TI
   LI
   LO
   TS
CP0405325
N-[4-(3,4-dichlorophenyl)butan-2-yl]-1-ethyl-4-hydroxy-5-oxo-2H-pyrrole-3-carboxamide
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C17H20Cl2N2O3
 1
1
IC50 = 218 nM
   TI
   LI
   LO
   TS
CP0355382
5-amino-N-[4-(4-fluorophenyl)-4-methoxycyclohexyl]-2,4-dioxo-1H-pyrimidine-6-carboxamide
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C18H21FN4O4
 1
1
IC50 = 1010 nM
   TI
   LI
   LO
   TS
CP0471737
5-amino-2,6-dioxo-3-phenyl-N-(4-phenylcyclohexyl)pyrimidine-4-carboxamide
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C23H24N4O3
 1
1
IC50 = 2350 nM
   TI
   LI
   LO
   TS