Protein Information

General Information of the Protein

Protein ID	PT00827
Protein Name	5-hydroxytryptamine receptor 1D
Secondarily Protein Name	Serotonin 1D alpha receptor Serotonin receptor 1D
Gene Name	HTR1D
Secondarily Gene Name	HTR1DA HTRL
Sequence	MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Serotonin receptor
Function	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. Show/Hide
Uniprot ID	P28221
HGNC ID	HGNC:5289
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0056131 Compound Info	2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(3-methoxy-phenyl)-piperazin-1-yl]-ethanone Show/Hide	C23H28N4O3	1
1	EC50 = 0.24 nM Bioactivity Info	TI LI LO TS
CP0162751 Compound Info	2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-phenyl-piperazin-1-yl)-ethanone Show/Hide	C22H26N4O2	1
1	EC50 = 0.45 nM Bioactivity Info	TI LI LO TS
CP0102236 Compound Info	2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-tolyl-piperazin-1-yl)-ethanone Show/Hide	C23H28N4O2	1
1	EC50 = 0.6 nM Bioactivity Info	TI LI LO TS
CP0151604 Compound Info	2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphthalen-1-yl-piperazin-1-yl)-ethanone Show/Hide	C26H28N4O2	1
1	EC50 = 2.8 nM Bioactivity Info	TI LI LO TS
CP0005653 Compound Info	(3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide Show/Hide	C14H21N3O2S	5
1	EC50 = 30 nM Bioactivity Info	TI LI LO TS
2	IC50 = 2.951 nM Bioactivity Info	TI LI LO TS
3	Ki = 1.2 nM Bioactivity Info	TI LI LO TS
4	Ki = 5.7 nM Bioactivity Info	TI LI LO TS
5	Ki = 8.5 nM Bioactivity Info	TI LI LO TS
CP0010235 Compound Info	2-(5-Nonyloxy-1H-indol-3-yl)-ethylamine Show/Hide	C19H30N2O	1
1	EC50 = 68 nM Bioactivity Info	TI LI LO TS
CP0048312 Compound Info	3-(4-{7-[4-(5-carbamoyl-1H-3-indolyl)-3-cyclohexenylamino]heptylamino}-1-cyclohexenyl)-1H-5-indolecarboxamide Show/Hide	C37H46N6O2	1
1	IC50 = 0.05 nM Bioactivity Info	TI LI LO TS
CP0136962 Compound Info	3-(3-{4-[2-(3-Fluoro-phenyl)-ethyl]-piperazin-1-yl}-propyl)-5-[1,2,4]triazol-4-yl-1H-indole Show/Hide	C25H29FN6	1
1	IC50 = 0.6 nM Bioactivity Info	TI LI LO TS
CP0099897 Compound Info	(S)-4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one Show/Hide	C16H21N3O2	1
1	IC50 = 2.818 nM Bioactivity Info	TI LI LO TS
CP0454849 Compound Info	4-[[3-(3-aminocyclobutyl)-1H-indol-5-yl]methyl]-1,3-oxazolidin-2-one Show/Hide	C16H19N3O2	1
1	IC50 = 3.631 nM Bioactivity Info	TI LI LO TS
CP0463655 Compound Info	4-[[3-[3-(methylamino)cyclobutyl]-1H-indol-5-yl]methyl]-1,3-oxazolidin-2-one Show/Hide	C17H21N3O2	1
1	IC50 = 7.079 nM Bioactivity Info	TI LI LO TS
CP0449000 Compound Info	CP 122288 Show/Hide	C16H23N3O2S	1
1	IC50 = 7.244 nM Bioactivity Info	TI LI LO TS
CP0460129 Compound Info	3-(5-phenoxy-1H-indol-3-yl)cyclobutan-1-amine Show/Hide	C18H18N2O	1
1	IC50 = 14.45 nM Bioactivity Info	TI LI LO TS
CP0454850 Compound Info	3-[3-(dimethylamino)cyclobutyl]-1H-indole-5-carboxamide Show/Hide	C15H19N3O	1
1	IC50 = 14.79 nM Bioactivity Info	TI LI LO TS
CP0532404 Compound Info	(4S)-4-[[3-[[3-(dimethylamino)cyclobutyl]methyl]-1H-indol-5-yl]methyl]-1,3-oxazolidin-2-one Show/Hide	C19H25N3O2	1
1	IC50 = 28.84 nM Bioactivity Info	TI LI LO TS
CP0463786 Compound Info	N,N-dimethyl-3-(5-phenoxy-1H-indol-3-yl)cyclobutan-1-amine Show/Hide	C20H22N2O	1
1	IC50 = 64.57 nM Bioactivity Info	TI LI LO TS
CP0466096 Compound Info	N,N-dimethyl-2-(5-phenylmethoxy-1H-indol-3-yl)ethanamine Show/Hide	C19H22N2O	1
1	IC50 = 76 nM Bioactivity Info	TI LI LO TS
CP0421471 Compound Info	3-(2-Diethylamino-ethyl)-1H-indol-5-ol Show/Hide	C14H20N2O	1
1	IC50 = 77 nM Bioactivity Info	TI LI LO TS
CP0421474 Compound Info	N,N-diethyl-2-(5-phenylmethoxy-1H-indol-3-yl)ethanamine Show/Hide	C21H26N2O	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0374352 Compound Info	N-benzyl-3-[3-(dimethylamino)cyclobutyl]-1H-indole-5-carboxamide Show/Hide	C22H25N3O	1
1	IC50 = 141.25 nM Bioactivity Info	TI LI LO TS
CP0438598 Compound Info	1-[3-[3-(dimethylamino)cyclobutyl]-1H-indol-5-yl]-N-methylmethanesulfonamide Show/Hide	C16H23N3O2S	1
1	IC50 = 190.55 nM Bioactivity Info	TI LI LO TS
CP0508686 Compound Info	2-[2-[3-[3-(dimethylamino)cyclobutyl]-1H-indol-5-yl]ethyl]isoindole-1,3-dione Show/Hide	C24H25N3O2	1
1	IC50 = 194.98 nM Bioactivity Info	TI LI LO TS
CP0382996 Compound Info	N-benzyl-2-[3-[3-(dimethylamino)cyclobutyl]-1H-indol-5-yl]acetamide Show/Hide	C23H27N3O	1
1	IC50 = 338.84 nM Bioactivity Info	TI LI LO TS
CP0481162 Compound Info	N-[2-(5-phenylmethoxy-1H-indol-3-yl)ethyl]-N-propylpropan-1-amine Show/Hide	C23H30N2O	1
1	IC50 = 470 nM Bioactivity Info	TI LI LO TS
CP0502412 Compound Info	3-[2-[3-(3-aminocyclobutyl)-1H-indol-5-yl]ethyl]-5,5-dimethylimidazolidine-2,4-dione Show/Hide	C19H24N4O2	1
1	IC50 = 501.19 nM Bioactivity Info	TI LI LO TS
CP0382933 Compound Info	N,N-dimethyl-3-[5-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-indol-3-yl]cyclobutan-1-amine Show/Hide	C17H20N4O	1
1	IC50 = 562.34 nM Bioactivity Info	TI LI LO TS
CP0456955 Compound Info	2-[3-[3-(dimethylamino)cyclobutyl]-1H-indol-5-yl]acetamide Show/Hide	C16H21N3O	1
1	IC50 = 724.44 nM Bioactivity Info	TI LI LO TS
CP0133551 Compound Info	3-(2-Dipropylamino-ethyl)-1H-indol-5-ol Show/Hide	C16H24N2O	1
1	IC50 = 820 nM Bioactivity Info	TI LI LO TS
CP0528891 Compound Info	N,N-dimethyl-3-[5-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]-1H-indol-3-yl]cyclobutan-1-amine Show/Hide	C18H22N4O	1
1	IC50 = 933.25 nM Bioactivity Info	TI LI LO TS
CP0422303 Compound Info	3-[2-[3-[3-(dimethylamino)cyclobutyl]-1H-indol-5-yl]ethyl]-5,5-dimethylimidazolidine-2,4-dione Show/Hide	C21H28N4O2	1
1	IC50 = 1479.11 nM Bioactivity Info	TI LI LO TS
CP0460915 Compound Info	N,N-dimethyl-3-[5-[(5-methyl-1H-1,2,4-triazol-3-yl)methyl]-1H-indol-3-yl]cyclobutan-1-amine Show/Hide	C18H23N5	1
1	IC50 = 2041.74 nM Bioactivity Info	TI LI LO TS
CP0463326 Compound Info	3-[[3-[3-(dimethylamino)cyclobutyl]-1H-indol-5-yl]methyl]imidazolidine-2,4-dione Show/Hide	C18H22N4O2	1
1	IC50 = 2454.71 nM Bioactivity Info	TI LI LO TS
CP0502478 Compound Info	3-[[3-[3-(dimethylamino)cyclobutyl]-1H-indol-5-yl]methyl]-5,5-dimethylimidazolidine-2,4-dione Show/Hide	C20H26N4O2	1
1	IC50 = 3090.3 nM Bioactivity Info	TI LI LO TS
CP0479795 Compound Info	2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-[4-(4-{2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-acetyl}-piperazin-1-yl)-phenyl]-acetamide Show/Hide	C34H39N7O4	1
1	Ki = 0.09 nM Bioactivity Info	TI LI LO TS
CP0234879 Compound Info	2-(5-((4-((3-(2-aminoethyl)-1H-indol-5-yloxy)methyl)phenyl)methoxy)-1H-indol-3-yl)ethanamine Show/Hide	C28H30N4O2	1
1	Ki = 0.11 nM Bioactivity Info	TI LI LO TS
CP0436395 Compound Info	2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-(4-{2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-acetylamino}-phenyl)-acetamide Show/Hide	C30H32N6O4	1
1	Ki = 0.11 nM Bioactivity Info	TI LI LO TS
CP0394213 Compound Info	2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-{2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-ethyl}-piperazin-1-yl)-ethanone Show/Hide	C28H36N6O3	1
1	Ki = 0.16 nM Bioactivity Info	TI LI LO TS
CP0492326 Compound Info	2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-{2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-ethyl}-acetamide Show/Hide	C24H29N5O3	1
1	Ki = 0.18 nM Bioactivity Info	TI LI LO TS
CP0403765 Compound Info	2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(1'-{2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-acetyl}-[4,4']bipiperidinyl-1-yl)-ethanone Show/Hide	C34H44N6O4	1
1	Ki = 0.27 nM Bioactivity Info	TI LI LO TS
CP0190867 Compound Info	(E)-3-[3-(2-Dimethylamino-ethyl)-1H-indol-5-yl]-N-(4-methoxy-benzyl)-acrylamide Show/Hide	C23H27N3O2	1
1	Ki = 0.3 nM Bioactivity Info	TI LI LO TS
CP0441180 Compound Info	2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-(3-{2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-acetylamino}-propyl)-acetamide Show/Hide	C27H34N6O4	1
1	Ki = 0.3 nM Bioactivity Info	TI LI LO TS
CP0070886 Compound Info	4-fluoro-N-(3-{1-[7-(4-{5-[(4-fluorobenzene)amido]-1H-indol-3-yl}piperidin-1-yl)heptyl]piperidin-4-yl}-1H-indol-5-yl)benzamide Show/Hide	C47H52F2N6O2	1
1	Ki = 0.3 nM Bioactivity Info	TI LI LO TS
CP0446193 Compound Info	2-(5-{3-[3-(2-Amino-ethyl)-1H-indol-5-yloxymethyl]-benzyloxy}-1H-indol-3-yl)-ethylamine Show/Hide	C28H30N4O2	1
1	Ki = 0.35 nM Bioactivity Info	TI LI LO TS
CP0449404 Compound Info	2-{5-[2-(4-{2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-ethyl}-piperazin-1-yl)-ethoxy]-1H-indol-3-yl}-ethylamine Show/Hide	C28H38N6O2	1
1	Ki = 0.35 nM Bioactivity Info	TI LI LO TS
CP0418821 Compound Info	1,3-Bis-{2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-ethyl}-urea Show/Hide	C25H32N6O3	1
1	Ki = 0.4 nM Bioactivity Info	TI LI LO TS
CP0106415 Compound Info	2-(5-(2-(8-(4-methylpiperazin-1-yl)naphthalen-2-yloxy)ethoxy)-1H-indol-3-yl)ethanamine Show/Hide	C27H32N4O2	1
1	Ki = 0.4 nM Bioactivity Info	TI LI LO TS
CP0394215 Compound Info	2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-{2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-acetyl}-piperazin-1-yl)-ethanone Show/Hide	C28H34N6O4	1
1	Ki = 0.42 nM Bioactivity Info	TI LI LO TS
CP0372361 Compound Info	Biphenyl-4,4'-disulfonic acid bis-({6-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-hexyl}-amide) Show/Hide	C44H56N6O6S2	1
1	Ki = 0.45 nM Bioactivity Info	TI LI LO TS
CP0460901 Compound Info	2-(5-{6-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-hexyloxy}-1H-indol-3-yl)-ethylamine Show/Hide	C26H34N4O2	1
1	Ki = 0.46 nM Bioactivity Info	TI LI LO TS
CP0001238 Compound Info	14C-5-hydroxy tryptamine creatinine disulfate Show/Hide	C10H12N2O	2
1	Ki = 0.5 nM Bioactivity Info	TI LI LO TS
2	Ki = 5.06 nM Bioactivity Info	TI LI LO TS
CP0435734 Compound Info	4-fluoro-N-(3-{1-[6-(4-{5-[(4-fluorobenzene)amido]-1H-indol-3-yl}piperidin-1-yl)hexyl]piperidin-4-yl}-1H-indol-5-yl)benzamide Show/Hide	C46H50F2N6O2	1
1	Ki = 0.6 nM Bioactivity Info	TI LI LO TS
CP0169227 Compound Info	C-[3-(2-Dimethylamino-ethyl)-1H-indol-5-yl]-N-[4-({[3-(2-dimethylamino-ethyl)-1H-indol-5-ylmethanesulfonyl]-methyl-amino}-methyl)-benzyl]-N-methyl-methanesulfonamide Show/Hide	C36H48N6O4S2	1
1	Ki = 0.89 nM Bioactivity Info	TI LI LO TS
CP0388169 Compound Info	N,N'-bis[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]undecanediamide Show/Hide	C39H54N6O2	1
1	Ki = 0.9 nM Bioactivity Info	TI LI LO TS
CP0439237 Compound Info	N,N'-bis[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]octanediamide Show/Hide	C36H48N6O2	1
1	Ki = 0.9 nM Bioactivity Info	TI LI LO TS
CP0446013 Compound Info	(S)-1-(2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)-N-methyl-3,4-dihydro-1H-isochromene-6-carboxamide Show/Hide	C24H31N3O3	1
1	Ki = 0.9 nM Bioactivity Info	TI LI LO TS
CP0422477 Compound Info	N,N'-bis[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]pentanediamide Show/Hide	C33H42N6O2	1
1	Ki = 0.95 nM Bioactivity Info	TI LI LO TS
CP0474372 Compound Info	N,N'-bis[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]decanediamide Show/Hide	C38H52N6O2	1
1	Ki = 0.95 nM Bioactivity Info	TI LI LO TS
CP0446075 Compound Info	2-(5-{2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-ethoxy}-1H-indol-3-yl)-ethylamine Show/Hide	C22H26N4O2	1
1	Ki = 1 nM Bioactivity Info	TI LI LO TS
CP0493405 Compound Info	4-fluoro-N-(3-{1-[9-(4-{5-[(4-fluorobenzene)amido]-1H-indol-3-yl}piperidin-1-yl)nonyl]piperidin-4-yl}-1H-indol-5-yl)benzamide Show/Hide	C49H56F2N6O2	1
1	Ki = 1 nM Bioactivity Info	TI LI LO TS
CP0473794 Compound Info	N,N'-bis[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]tridecanediamide Show/Hide	C41H58N6O2	1
1	Ki = 1.4 nM Bioactivity Info	TI LI LO TS
CP0403731 Compound Info	2-(5-{2-[3-(2-Amino-ethyl)-1H-indol-5-yloxymethyl]-benzyloxy}-1H-indol-3-yl)-ethylamine Show/Hide	C28H30N4O2	1
1	Ki = 1.5 nM Bioactivity Info	TI LI LO TS
CP0435738 Compound Info	4-fluoro-N-{3-[1-(2-{2-[2-(4-{5-[(4-fluorobenzene)amido]-1H-indol-3-yl}piperidin-1-yl)ethoxy]ethoxy}ethyl)piperidin-4-yl]-1H-indol-5-yl}benzamide Show/Hide	C46H50F2N6O4	1
1	Ki = 1.5 nM Bioactivity Info	TI LI LO TS
CP0275909 Compound Info	N-[4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]piperazin-1-yl]phenyl]acetamide Show/Hide	C24H29N5O3	1
1	Ki = 1.7 nM Bioactivity Info	TI LI LO TS
CP0439236 Compound Info	N,N'-bis[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]tetradecanediamide Show/Hide	C42H60N6O2	1
1	Ki = 1.7 nM Bioactivity Info	TI LI LO TS
CP0493409 Compound Info	N,N'-bis[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]pentadecanediamide Show/Hide	C43H62N6O2	1
1	Ki = 2.3 nM Bioactivity Info	TI LI LO TS
CP0135602 Compound Info	[3-(2-aminoethyl)-1H-indol-5-yl] trifluoromethanesulfonate Show/Hide	C11H11F3N2O3S	1
1	Ki = 2.8 nM Bioactivity Info	TI LI LO TS
CP0196504 Compound Info	[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl] trifluoromethanesulfonate Show/Hide	C13H15F3N2O3S	1
1	Ki = 3.2 nM Bioactivity Info	TI LI LO TS
CP0455102 Compound Info	N,N'-bis[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]propanediamide Show/Hide	C31H38N6O2	1
1	Ki = 3.4 nM Bioactivity Info	TI LI LO TS
CP0497725 Compound Info	4-fluoro-N-(3-{1-[2-(2-{2-[2-(4-{5-[(4-fluorobenzene)amido]-1H-indol-3-yl}piperidin-1-yl)ethoxy]ethoxy}ethoxy)ethyl]piperidin-4-yl}-1H-indol-5-yl)benzamide Show/Hide	C48H54F2N6O5	1
1	Ki = 3.9 nM Bioactivity Info	TI LI LO TS
CP0393093 Compound Info	(R)-8-Dipropylamino-4-fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H25FN2O	1
1	Ki = 4.4 nM Bioactivity Info	TI LI LO TS
CP0497437 Compound Info	8-Dipropylamino-4-fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H25FN2O	1
1	Ki = 4.6 nM Bioactivity Info	TI LI LO TS
CP0065057 Compound Info	(R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbonitrile Show/Hide	C19H25N3	1
1	Ki = 6.7 nM Bioactivity Info	TI LI LO TS
CP0043151 Compound Info	8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbonitrile Show/Hide	C19H25N3	1
1	Ki = 7.5 nM Bioactivity Info	TI LI LO TS
CP0500731 Compound Info	(4-Fluoro-1-propyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine Show/Hide	C21H31FN2	1
1	Ki = 8.4 nM Bioactivity Info	TI LI LO TS
CP0393274 Compound Info	8-Dipropylamino-4-fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbonitrile Show/Hide	C19H24FN3	1
1	Ki = 8.6 nM Bioactivity Info	TI LI LO TS
CP0393208 Compound Info	(4-Fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine Show/Hide	C18H25FN2	1
1	Ki = 11 nM Bioactivity Info	TI LI LO TS
CP0457588 Compound Info	N,N'-bis[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]hexadecanediamide Show/Hide	C44H64N6O2	1
1	Ki = 11.3 nM Bioactivity Info	TI LI LO TS
CP0332330 Compound Info	[3-[2-(diethylamino)ethyl]-1H-indol-5-yl] trifluoromethanesulfonate Show/Hide	C15H19F3N2O3S	1
1	Ki = 12 nM Bioactivity Info	TI LI LO TS
CP0422474 Compound Info	4-fluoro-N-(3-{1-[12-(4-{5-[(4-fluorobenzene)amido]-1H-indol-3-yl}piperidin-1-yl)dodecyl]piperidin-4-yl}-1H-indol-5-yl)benzamide Show/Hide	C52H62F2N6O2	1
1	Ki = 13 nM Bioactivity Info	TI LI LO TS
CP0467895 Compound Info	4-fluoro-N-(3-{1-[11-(4-{5-[(4-fluorobenzene)amido]-1H-indol-3-yl}piperidin-1-yl)undecyl]piperidin-4-yl}-1H-indol-5-yl)benzamide Show/Hide	C51H60F2N6O2	1
1	Ki = 13 nM Bioactivity Info	TI LI LO TS
CP0497724 Compound Info	4-fluoro-N-(3-{1-[10-(4-{5-[(4-fluorobenzene)amido]-1H-indol-3-yl}piperidin-1-yl)decyl]piperidin-4-yl}-1H-indol-5-yl)benzamide Show/Hide	C50H58F2N6O2	1
1	Ki = 13 nM Bioactivity Info	TI LI LO TS
CP0492002 Compound Info	((R)-4-Fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine Show/Hide	C18H25FN2	1
1	Ki = 14 nM Bioactivity Info	TI LI LO TS
CP0056626 Compound Info	(8R)-N,N-dipropyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C18H26N2	1
1	Ki = 16 nM Bioactivity Info	TI LI LO TS
CP0384127 Compound Info	(1-Methylsulfanyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine Show/Hide	C19H28N2S	1
1	Ki = 18 nM Bioactivity Info	TI LI LO TS
CP0348071 Compound Info	(1-Chloro-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine Show/Hide	C18H25ClN2	1
1	Ki = 23 nM Bioactivity Info	TI LI LO TS
CP0457582 Compound Info	4-fluoro-N-(3-{1-[(2E)-4-(4-{5-[(4-fluorobenzene)amido]-1H-indol-3-yl}piperidin-1-yl)but-2-en-1-yl]piperidin-4-yl}-1H-indol-5-yl)benzamide Show/Hide	C44H44F2N6O2	1
1	Ki = 24 nM Bioactivity Info	TI LI LO TS
CP0378932 Compound Info	8-Dipropylamino-1,3,6,7,8,9-hexahydro-benzo[e]indol-2-one Show/Hide	C18H26N2O	1
1	Ki = 26 nM Bioactivity Info	TI LI LO TS
CP0276816 Compound Info	(R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H26N2O	1
1	Ki = 31 nM Bioactivity Info	TI LI LO TS
CP0425321 Compound Info	(S)-8-Dipropylamino-4-fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H25FN2O	1
1	Ki = 34 nM Bioactivity Info	TI LI LO TS
CP0503251 Compound Info	1-(8-Dipropylamino-4-fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indol-1-yl)-propan-1-one Show/Hide	C21H29FN2O	1
1	Ki = 36 nM Bioactivity Info	TI LI LO TS
CP0467899 Compound Info	5-amino-3-(N-methylpiperidin-4-yl)-1H-indole Show/Hide	C14H19N3	1
1	Ki = 39.6 nM Bioactivity Info	TI LI LO TS
CP0258010 Compound Info	(+/-)-Dipropyl-(6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-amine Show/Hide	C18H26N2	1
1	Ki = 40 nM Bioactivity Info	TI LI LO TS
CP0099933 Compound Info	(S)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbonitrile Show/Hide	C19H25N3	1
1	Ki = 42 nM Bioactivity Info	TI LI LO TS
CP0373268 Compound Info	(1-Methyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine Show/Hide	C19H28N2	1
1	Ki = 43 nM Bioactivity Info	TI LI LO TS
CP0431157 Compound Info	(1-Methanesulfonyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine Show/Hide	C19H28N2O2S	1
1	Ki = 52 nM Bioactivity Info	TI LI LO TS
CP0216553 Compound Info	N,N-dipropyl-1-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C20H27F3N2	1
1	Ki = 54 nM Bioactivity Info	TI LI LO TS
CP0408685 Compound Info	2-((R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indol-1-yl)-2-oxo-acetamide Show/Hide	C20H27N3O2	1
1	Ki = 54 nM Bioactivity Info	TI LI LO TS
CP0501934 Compound Info	4-fluoro-N-(3-{1-[3-(4-{5-[(4-fluorobenzene)amido]-1H-indol-3-yl}piperidin-1-yl)propyl]piperidin-4-yl}-1H-indol-5-yl)benzamide Show/Hide	C43H44F2N6O2	1
1	Ki = 79 nM Bioactivity Info	TI LI LO TS
CP0440286 Compound Info	2-(8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indol-1-yl)-2-oxo-acetamide Show/Hide	C20H27N3O2	1
1	Ki = 87 nM Bioactivity Info	TI LI LO TS
CP0430125 Compound Info	1-(8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indol-1-yl)-ethanone Show/Hide	C20H28N2O	1
1	Ki = 108 nM Bioactivity Info	TI LI LO TS
CP0497094 Compound Info	1-(8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indol-1-yl)-2,2,2-trifluoro-ethanone Show/Hide	C20H25F3N2O	1
1	Ki = 112 nM Bioactivity Info	TI LI LO TS
CP0078427 Compound Info	4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide Show/Hide	C21H22FN3O	1
1	Ki = 137 nM Bioactivity Info	TI LI LO TS
CP0425349 Compound Info	4-fluoro-N-{3-[1-({3-[(4-{5-[(4-fluorobenzene)amido]-1H-indol-3-yl}piperidin-1-yl)methyl]phenyl}methyl)piperidin-4-yl]-1H-indol-5-yl}benzamide Show/Hide	C48H46F2N6O2	1
1	Ki = 151 nM Bioactivity Info	TI LI LO TS
CP0221880 Compound Info	(S)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H26N2O	1
1	Ki = 155 nM Bioactivity Info	TI LI LO TS
CP0037227 Compound Info	7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol Show/Hide	C16H25NO	1
1	Ki = 164 nM Bioactivity Info	TI LI LO TS
CP0052478 Compound Info	(+/-)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H26N2O	1
1	Ki = 173 nM Bioactivity Info	TI LI LO TS
CP0036796 Compound Info	[3-[2-(dipropylamino)ethyl]-1H-indol-5-yl] trifluoromethanesulfonate Show/Hide	C17H23F3N2O3S	1
1	Ki = 190 nM Bioactivity Info	TI LI LO TS
CP0495965 Compound Info	(4-Fluoro-3-methyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine Show/Hide	C19H27FN2	1
1	Ki = 217 nM Bioactivity Info	TI LI LO TS
CP0467900 Compound Info	4-fluoro-N-(3-{1-[2-(4-{5-[(4-fluorobenzene)amido]-1H-indol-3-yl}piperidin-1-yl)ethyl]piperidin-4-yl}-1H-indol-5-yl)benzamide Show/Hide	C42H42F2N6O2	1
1	Ki = 219 nM Bioactivity Info	TI LI LO TS
CP0383969 Compound Info	((S)-4-Fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine Show/Hide	C18H25FN2	1
1	Ki = 294 nM Bioactivity Info	TI LI LO TS
CP0393209 Compound Info	8-Dipropylamino-3-methyl-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C20H28N2O	1
1	Ki = 334 nM Bioactivity Info	TI LI LO TS
CP0497101 Compound Info	8-Dipropylamino-4-fluoro-3-methyl-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C20H27FN2O	1
1	Ki = 419 nM Bioactivity Info	TI LI LO TS
CP0216619 Compound Info	(8S)-N,N-dipropyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C18H26N2	1
1	Ki = 440 nM Bioactivity Info	TI LI LO TS
CP0431098 Compound Info	2-((S)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indol-1-yl)-2-oxo-acetamide Show/Hide	C20H27N3O2	1
1	Ki = 440 nM Bioactivity Info	TI LI LO TS
CP0384025 Compound Info	(6-Fluoro-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amine Show/Hide	C13H18FN	1
1	Ki = 585 nM Bioactivity Info	TI LI LO TS
CP0404397 Compound Info	2-Fluoro-N6,N6-dipropyl-5,6,7,8-tetrahydro-naphthalene-1,6-diamine Show/Hide	C16H25FN2	1
1	Ki = 762 nM Bioactivity Info	TI LI LO TS
CP0449397 Compound Info	2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-piperazin-1-yl-ethanone Show/Hide	C16H22N4O2	1
1	Ki > 100 nM Bioactivity Info	TI LI LO TS
CP0422476 Compound Info	N-[3-[1-[3-amino-2-[4-[5-[(4-fluorobenzoyl)amino]-1H-indol-3-yl]piperidin-1-yl]-3-oxopropyl]piperidin-4-yl]-1H-indol-5-yl]-4-fluorobenzamide Show/Hide	C43H43F2N7O3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0439234 Compound Info	N-[3-(1-benzylpiperidin-4-yl)-1H-indol-5-yl]-4-fluorobenzamide Show/Hide	C27H26FN3O	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0439235 Compound Info	4-fluoro-N-(3-(1-octylpiperidin-4-yl)-1H-indol-5-yl)benzamide Show/Hide	C28H36FN3O	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0455100 Compound Info	4-fluoro-N-(3-{1-[3,3,3-trifluoro-2-(4-{5-[(4-fluorobenzene)amido]-1H-indol-3-yl}piperidin-1-yl)propyl]piperidin-4-yl}-1H-indol-5-yl)benzamide Show/Hide	C43H41F5N6O2	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0457584 Compound Info	10-(4-(5-(4-fluorobenzamido)-1H-indol-3-yl)piperidin-1-yl)decanoic acid Show/Hide	C30H38FN3O3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0467897 Compound Info	N-[3-[1-[3-(dimethylamino)propyl]piperidin-4-yl]-1H-indol-5-yl]-4-fluorobenzamide Show/Hide	C25H31FN4O	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0467898 Compound Info	4-fluoro-N-(3-(1-(2-hydroxyethyl)piperidin-4-yl)-1H-indol-5-yl)benzamide Show/Hide	C22H24FN3O2	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0497726 Compound Info	4-fluoro-N-(3-(1-(2-(piperidin-1-yl)ethyl)piperidin-4-yl)-1H-indol-5-yl)benzamide Show/Hide	C27H33FN4O	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL000053 , COS-7

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000065 , HEK293-EBNA

Cell Line Info

Cell Line ID: CL000017 , HeLa

Cell Line Info

Cell Line ID: CL000101 , L-M(TK-)

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0218850 Compound Info	6-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one Show/Hide	C24H26N4O2	1
1	EC50 = 0.5012 nM
CP0048312 Compound Info	3-(4-{7-[4-(5-carbamoyl-1H-3-indolyl)-3-cyclohexenylamino]heptylamino}-1-cyclohexenyl)-1H-5-indolecarboxamide Show/Hide	C37H46N6O2	1
1	IC50 = 0.05 nM
CP0115159 Compound Info	(S)-4-[3-(2-{(S)-3-[((S)-1-Phenyl-ethylamino)-methyl]-pyrrolidin-1-yl}-ethyl)-1H-indol-5-ylmethyl]-oxazolidin-2-one Show/Hide	C27H34N4O2	1
1	IC50 = 0.3 nM
CP0056703 Compound Info	(S)-4-(3-{2-[(S)-3-(Benzylamino-methyl)-pyrrolidin-1-yl]-ethyl}-1H-indol-5-ylmethyl)-oxazolidin-2-one Show/Hide	C26H32N4O2	1
1	IC50 = 0.35 nM
CP0079840 Compound Info	Benzyl-{(S)-1-[2-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)-ethyl]-pyrrolidin-3-ylmethyl}-amine Show/Hide	C24H28N6	1
1	IC50 = 0.5 nM
CP0136962 Compound Info	3-(3-{4-[2-(3-Fluoro-phenyl)-ethyl]-piperazin-1-yl}-propyl)-5-[1,2,4]triazol-4-yl-1H-indole Show/Hide	C25H29FN6	1
1	IC50 = 0.6 nM
CP0041353 Compound Info	C-(3-{2-[(S)-3-(Benzylamino-methyl)-pyrrolidin-1-yl]-ethyl}-1H-indol-5-yl)-N-methyl-methanesulfonamide Show/Hide	C24H32N4O2S	1
1	IC50 = 1.1 nM
CP0001238 Compound Info	14C-5-hydroxy tryptamine creatinine disulfate Show/Hide	C10H12N2O	5
1	IC50 = 3 nM
2	Ki = 1.7 nM
3	Ki = 2 nM
4	Ki = 4.8 nM
5	Ki = 5.06 nM
CP0005653 Compound Info	(3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide Show/Hide	C14H21N3O2S	10
1	IC50 = 39.81 nM
2	IC50 = 100 nM
3	IC50 = 2400 nM
4	Ki = 3.4 nM
5	Ki = 4.4 nM
6	Ki = 5.5 nM
7	Ki = 8.5 nM
8	Ki = 8.6 nM
9	Ki = 11 nM
10	Ki = 23.1 nM
CP0162751 Compound Info	2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-phenyl-piperazin-1-yl)-ethanone Show/Hide	C22H26N4O2	3
1	Ki = 0.4 nM
2	Ki = 0.6 nM
3	Ki = 1.2 nM
CP0056131 Compound Info	2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(3-methoxy-phenyl)-piperazin-1-yl]-ethanone Show/Hide	C23H28N4O3	2
1	Ki = 0.4 nM
2	Ki = 2 nM
CP0106415 Compound Info	2-(5-(2-(8-(4-methylpiperazin-1-yl)naphthalen-2-yloxy)ethoxy)-1H-indol-3-yl)ethanamine Show/Hide	C27H32N4O2	1
1	Ki = 0.4 nM
CP0173138 Compound Info	N-[3-[[1-[2-(2-methylquinolin-5-yl)oxyethyl]piperidin-4-yl]methyl]phenyl]methanesulfonamide Show/Hide	C25H31N3O3S	1
1	Ki = 0.5012 nM
CP0151604 Compound Info	2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphthalen-1-yl-piperazin-1-yl)-ethanone Show/Hide	C26H28N4O2	2
1	Ki = 0.52 nM
2	Ki = 0.95 nM
CP0099897 Compound Info	(S)-4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one Show/Hide	C16H21N3O2	3
1	Ki = 0.76 nM
2	Ki = 0.92 nM
3	Ki = 4 nM
CP0079263 Compound Info	2-methyl-5-[2-[4-(quinolin-8-ylmethyl)piperazin-1-yl]ethoxy]quinoline Show/Hide	C26H28N4O	1
1	Ki = 0.7943 nM
CP0102236 Compound Info	2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-tolyl-piperazin-1-yl)-ethanone Show/Hide	C23H28N4O2	4
1	Ki = 0.8 nM
2	Ki = 0.87 nM
3	Ki = 2.08 nM
4	Ki = 2.1 nM
CP0045584 Compound Info	(5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trione Show/Hide	C33H35N5O5	2
1	Ki = 0.8 nM
2	Ki = 6 nM
CP0169227 Compound Info	C-[3-(2-Dimethylamino-ethyl)-1H-indol-5-yl]-N-[4-({[3-(2-dimethylamino-ethyl)-1H-indol-5-ylmethanesulfonyl]-methyl-amino}-methyl)-benzyl]-N-methyl-methanesulfonamide Show/Hide	C36H48N6O4S2	1
1	Ki = 0.89 nM
CP0214664 Compound Info	2-(dimethylamino)-N-[3-[[1-[2-(2-methylquinolin-5-yl)oxyethyl]piperidin-4-yl]methyl]phenyl]acetamide Show/Hide	C28H36N4O2	1
1	Ki = 1 nM
CP0275909 Compound Info	N-[4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]piperazin-1-yl]phenyl]acetamide Show/Hide	C24H29N5O3	2
1	Ki = 1.4 nM
2	Ki = 2.8 nM
CP0152118 Compound Info	6-[[1-[2-(2-methylquinolin-5-yl)oxyethyl]piperidin-4-yl]methyl]-4H-1,4-benzoxazin-3-one Show/Hide	C26H29N3O3	1
1	Ki = 1.585 nM
CP0030068 Compound Info	N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine Show/Hide	C15H19N5	3
1	Ki = 4.3 nM
2	Ki = 13.5 nM
3	Ki = 40 nM
CP0061753 Compound Info	1-NP Show/Hide	C14H16N2	1
1	Ki = 6.18 nM
CP0077951 Compound Info	1-(2-(4-(6-fluoro-1H-indol-3-yl)-5,6-dihydropyridin-1(2H)-yl)ethyl)-3,4-dihydro-1H-isochromene-6-carboxamide Show/Hide	C25H26FN3O2	1
1	Ki = 56 nM
CP0037227 Compound Info	7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol Show/Hide	C16H25NO	1
1	Ki = 115 nM
CP0078427 Compound Info	4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide Show/Hide	C21H22FN3O	1
1	Ki = 430 nM
CP0096286 Compound Info	(R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidin-1-ylsulfonyl)phenol Show/Hide	C18H28N2O3S	1
1	Ki > 10000 nM

Clinical Information about the Protein

Target 1 ( 5-HT 1D receptor (HTR1D) )

Target Type	Successful Target
Disease	3 Target-related Diseases				3
1	Migraine [ICD-11: 8A80]
2	Hyperprolactinaemia [ICD-11: 5A60.1]
3	Major depressive disorder [ICD-11: 6A70.3]
Approved Drug(s)	7 Approved Drugs				7
1	Almogran	Drug Info	Approved	Migraine
2	Eletriptan	Drug Info	Approved	Migraine
3	Frovatriptan	Drug Info	Approved	Migraine
4	Metergolin	Drug Info	Approved	Hyperprolactinaemia
5	Rizatriptan	Drug Info	Approved	Migraine
6	Sumatriptan	Drug Info	Approved	Migraine
7	Zolmitriptan	Drug Info	Approved	Migraine
Discontinued Drug(s)	7 Discontinued Drugs				7
1	Alniditan	Drug Info	Discontinued in Phase 3	Migraine
2	CP-122288	Drug Info	Discontinued in Phase 2	Migraine
3	PNU-142633	Drug Info	Discontinued in Phase 2	Migraine
4	ALX-0646	Drug Info	Discontinued in Phase 1	Migraine
5	GR-127935	Drug Info	Terminated	Major depressive disorder
6	L-694247	Drug Info	Terminated	Migraine
7	PNU-109291	Drug Info	Terminated	Migraine

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han