Brief Information of the Cell Line and Protein
Cell Line ID: CL000101 , L-M(TK-)
 Cell Line Info 
Synonyms
L-M[TK-]
LM TK negative
L-M (TK-)
L M (TK-)
LM(TK-)
LM(tk-)
LM-TK-
LMTK-
L cells (TK-)
L(TK-)
L(tk-)
Category Spontaneously immortalized cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_4536
Protein ID: PT00827 , 5-hydroxytryptamine receptor 1D
 Protein Info 
Gene Name HTR1D
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P28221
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000101
 Cell Line Info 
 Protein ID: PT00827
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0434306
 Compound Info 
(S)-1-(2-((S)-4-(6-cyanonaphthalen-1-yl)-2-methylpiperazin-1-yl)ethyl)-3,4-dihydro-1H-isochromene-6-carboxamide
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C28H30N4O2
  1
1
Ki = 0.9 nM
 Bioactivity Info 
   TI
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CP0484359
 Compound Info 
(S)-1-(2-(4-(6-cyanonaphthalen-1-yl)piperazin-1-yl)ethyl)-3,4-dihydro-1H-isochromene-6-carboxamide
   Show/Hide
C27H28N4O2
  1
1
Ki = 1 nM
 Bioactivity Info 
   TI
   LI
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CP0910646
 Compound Info 
(1R)-1-(2-((S)-4-(6-cyanonaphthalen-1-yl)-2-methylpiperazin-1-yl)ethyl)-1,3,7,7a-tetrahydroisobenzofuran-5-carboxamide
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C27H28N4O2
  1
1
Ki = 1.8 nM
 Bioactivity Info 
   TI
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CP0382352
 Compound Info 
1-[2-(4-Naphthalen-1-yl-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-isochroman-6-carboxylic acid amide
   Show/Hide
C27H28N2O2
  1
1
Ki = 5.4 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0484374
 Compound Info 
(S)-1-(2-((R)-4-(6-fluoronaphthalen-1-yl)-2-methylpiperazin-1-yl)ethyl)-3,4-dihydro-1H-isochromene-6-carboxamide
   Show/Hide
C27H30FN3O2
  1
1
Ki = 7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0077951
 Compound Info 
1-(2-(4-(6-fluoro-1H-indol-3-yl)-5,6-dihydropyridin-1(2H)-yl)ethyl)-3,4-dihydro-1H-isochromene-6-carboxamide
   Show/Hide
C25H26FN3O2
  2
1
Ki = 8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 56 nM
 Bioactivity Info 
   TI
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CP0429491
 Compound Info 
1-{2-[4-(6-Fluoro-1H-indol-3-yl)-piperidin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C25H28FN3O2
  1
1
Ki = 8.4 nM
 Bioactivity Info 
   TI
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CP0485357
 Compound Info 
(S)-1-(2-(4-(6-fluoronaphthalen-2-yl)piperazin-1-yl)ethyl)isochroman-6-carboxamide
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C26H28FN3O2
  1
1
Ki = 10 nM
 Bioactivity Info 
   TI
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CP0414812
 Compound Info 
1-[2-(4-Naphthalen-1-yl-piperidin-1-yl)-ethyl]-isochroman-6-carboxylic acid amide
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C27H30N2O2
  1
1
Ki = 14 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0485429
 Compound Info 
(S)-1-(2-((S)-4-(6-fluoronaphthalen-2-yl)-2-methylpiperazin-1-yl)ethyl)isochroman-6-carboxamide
   Show/Hide
C27H30FN3O2
  1
1
Ki = 14 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0897706
 Compound Info 
(1S)-1-(2-((S)-4-(6-fluoronaphthalen-1-yl)-2-methylpiperazin-1-yl)ethyl)-1,3,7,7a-tetrahydroisobenzofuran-5-carboxamide
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C26H28FN3O2
  1
1
Ki = 14 nM
 Bioactivity Info 
   TI
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CP0405805
 Compound Info 
(1S)-1-[2-[4-(7-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-3,4-dihydro-1H-isochromene-6-carboxamide
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C25H26FN3O2
  1
1
Ki = 15 nM
 Bioactivity Info 
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CP0377764
 Compound Info 
1-{2-[4-(6-Fluoro-benzo[b]thiophen-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
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C25H25FN2O2S
  1
1
Ki = 20 nM
 Bioactivity Info 
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CP0493033
 Compound Info 
1-{2-[4-(6-Fluoro-1H-indazol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
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C24H25FN4O2
  1
1
Ki = 24 nM
 Bioactivity Info 
   TI
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CP0449623
 Compound Info 
(1R)-1-[2-[4-(7-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-3,4-dihydro-1H-isochromene-6-carboxamide
   Show/Hide
C25H26FN3O2
  1
1
Ki = 25 nM
 Bioactivity Info 
   TI
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   LO
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CP0431122
 Compound Info 
1-{2-[4-(7-Fluoro-naphthalen-1-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C27H27FN2O2
  1
1
Ki = 26 nM
 Bioactivity Info 
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CP0453762
 Compound Info 
1-{2-[4-(7-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C25H26FN3O2
  1
1
Ki = 26 nM
 Bioactivity Info 
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CP0402049
 Compound Info 
1-[2-[4-(4-fluoro-1-benzofuran-7-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-3,4-dihydro-1H-isochromene-6-carboxamide
   Show/Hide
C25H25FN2O3
  1
1
Ki = 27 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0382349
 Compound Info 
1-{2-[4-(6-Fluoro-benzofuran-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C25H25FN2O3
  1
1
Ki = 28 nM
 Bioactivity Info 
   TI
   LI
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CP0496521
 Compound Info 
1-{2-[(S)-4-(6-Fluoro-1H-indol-3-yl)-2-methyl-piperidin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C26H30FN3O2
  1
1
Ki = 28 nM
 Bioactivity Info 
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CP0460141
 Compound Info 
1-{2-[4-(5-Methoxy-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
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C26H29N3O3
  1
1
Ki = 31 nM
 Bioactivity Info 
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CP0406435
 Compound Info 
1-{2-[4-(6-Fluoro-benzo[d]isothiazol-3-yl)-piperidin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C24H26FN3O2S
  1
1
Ki = 40 nM
 Bioactivity Info 
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CP0496522
 Compound Info 
1-{2-[3-(6-Fluoro-1H-indol-3-yl)-pyrrolidin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C24H26FN3O2
  1
1
Ki = 40 nM
 Bioactivity Info 
   TI
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CP0374878
 Compound Info 
1-{2-[4-(6-Fluoro-1-methyl-1H-indazol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C25H27FN4O2
  1
1
Ki = 51 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0460217
 Compound Info 
1-(2-((R)-4-(6-fluoronaphthalen-1-yl)-2-methylpiperazin-1-yl)ethyl)-3,4-dihydro-1H-isochromene-6-carboxamide
   Show/Hide
C27H30FN3O2
  1
1
Ki = 56 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0471466
 Compound Info 
1-{2-[4-(6,7-Difluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C25H25F2N3O2
  1
1
Ki = 57 nM
 Bioactivity Info 
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CP0371723
 Compound Info 
1-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C24H24FN3O3
  1
1
Ki = 63 nM
 Bioactivity Info 
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CP0374882
 Compound Info 
1-{2-[4-(6-Fluoro-1-methyl-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C26H28FN3O2
  1
1
Ki = 65 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0876644
 Compound Info 
(1R)-1-(2-((S)-4-(6-fluoronaphthalen-1-yl)-2-methylpiperazin-1-yl)ethyl)-1,3,7,7a-tetrahydroisobenzofuran-5-carboxamide
   Show/Hide
C26H28FN3O2
  1
1
Ki = 67 nM
 Bioactivity Info 
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CP0391779
 Compound Info 
1-{2-[4-(6-Fluoro-naphthalen-2-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C27H27FN2O2
  1
1
Ki = 71 nM
 Bioactivity Info 
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CP0378425
 Compound Info 
1-{2-[4-(6-Fluoro-1H-indol-3-yl)-piperazin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C24H27FN4O2
  1
1
Ki = 74 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0444835
 Compound Info 
(R)-1-(2-((R)-4-(6-fluoronaphthalen-1-yl)-2-methylpiperazin-1-yl)ethyl)-3,4-dihydro-1H-isochromene-6-carboxamide
   Show/Hide
C27H30FN3O2
  1
1
Ki = 88 nM
 Bioactivity Info 
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CP0524051
 Compound Info 
1-{2-[4-(6-Trifluoromethyl-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C26H26F3N3O2
  1
1
Ki = 122 nM
 Bioactivity Info 
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CP0460685
 Compound Info 
1-{2-[4-(7-Cyano-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C26H26N4O2
  1
1
Ki = 130 nM
 Bioactivity Info 
   TI
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CP0496529
 Compound Info 
1-{2-[4-(5-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C25H26FN3O2
  1
1
Ki = 130 nM
 Bioactivity Info 
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CP0460873
 Compound Info 
1-{2-[4-(6-Chloro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C25H26ClN3O2
  1
1
Ki = 145 nM
 Bioactivity Info 
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CP0397314
 Compound Info 
1-{2-[4-(6,7-Dichloro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
   Show/Hide
C25H25Cl2N3O2
  1
1
Ki = 165 nM
 Bioactivity Info 
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