General Information of the Protein
Protein ID
PT05354
Protein Name
Cytochrome b-245 heavy chain
Secondarily
Protein Name
CGD91-phox
Cytochrome b(558) subunit beta
Heme-binding membrane glycoprotein gp91phox
NADPH oxidase 2
Neutrophil cytochrome b 91 kDa polypeptide
Superoxide-generating NADPH oxidase heavy chain subunit
gp91-1
gp91-phox
p22 phagocyte B-cytochrome
Gene Name
CYBB
Secondarily
Gene Name
NOX2
Sequence
MGNWAVNEGLSIFVILVWLGLNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRVRRQLDRNLTFHKMVAWMIALHSAIHTIAHLFNVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGVVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHNITVCEQKISEWGKIKECPIPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYLTGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF
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Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Transmembrane 1-electron transfer carriers
Function
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
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Uniprot ID
Primary ID:
P04839

Secondarily ID:
A8K138
Q2PP16
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Ensembl ID
ENSG00000165168
HGNC ID
HGNC:2578
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000880 , COS
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0054000
 Compound Info 
(1R,8S,10S)-3-bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-(thiophen-2-ylmethyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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C22H26BrNS
  3
1
IC50 = 30 nM
 Bioactivity Info 
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2
IC50 = 32000 nM
 Bioactivity Info 
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3
IC50 = 38000 nM
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CP0129037
 Compound Info 
(1R,8S,10S)-3-(3,4-dichlorophenyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene
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C23H25Cl2N
  2
1
IC50 = 9000 nM
 Bioactivity Info 
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2
IC50 = 64000 nM
 Bioactivity Info 
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CP0364998
 Compound Info 
3-[[(1R,8S,10S)-3-bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-9-yl]methyl]-5-methyl-1,2-oxazole
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C22H27BrN2O
  2
1
IC50 = 12000 nM
 Bioactivity Info 
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2
IC50 = 48000 nM
 Bioactivity Info 
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CP0098703
 Compound Info 
(1R,8S,10S)-3-bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-pentyl-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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C22H32BrN
  1
1
IC50 = 20000 nM
 Bioactivity Info 
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CP0066079
 Compound Info 
(1R,8S,10S)-3,6-dibromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene
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C17H21Br2N
  2
1
IC50 = 25000 nM
 Bioactivity Info 
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2
IC50 = 40000 nM
 Bioactivity Info 
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CP0305214
 Compound Info 
(1R,8S,10S)-3-bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-methylsulfonyl-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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C18H24BrNO2S
  2
1
IC50 = 27000 nM
 Bioactivity Info 
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2
IC50 > 100000 nM
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CP0066364
 Compound Info 
(1R,8S,10S)-9-[(3-fluorophenyl)methyl]-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene
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C24H28FN
  2
1
IC50 = 30000 nM
 Bioactivity Info 
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2
IC50 = 68000 nM
 Bioactivity Info 
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CP0066363
 Compound Info 
(1R,8S,10S)-3-bromo-11,11-dimethyl-10-(2-methylpropyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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C17H24BrN
  2
1
IC50 = 31000 nM
 Bioactivity Info 
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2
IC50 = 78000 nM
 Bioactivity Info 
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CP0053883
 Compound Info 
(1R,8S,10S)-9-(1,3-benzodioxol-5-ylmethyl)-3-bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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C25H28BrNO2
  2
1
IC50 = 40000 nM
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2
IC50 = 88000 nM
 Bioactivity Info 
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CP0066077
 Compound Info 
(1R,8S,10S)-3-bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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C17H22BrN
  2
1
IC50 = 40000 nM
 Bioactivity Info 
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2
IC50 = 46000 nM
 Bioactivity Info 
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CP0230785
 Compound Info 
(1R,8S,10S)-3-bromo-9-[(3-fluorophenyl)methyl]-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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C24H27BrFN
  2
1
IC50 = 51000 nM
 Bioactivity Info 
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2
IC50 = 68000 nM
 Bioactivity Info 
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CP0048791
 Compound Info 
(1R,8S,10S)-3-(3,4-dichlorophenyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-pentyl-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene
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C28H35Cl2N
  2
1
IC50 = 79000 nM
 Bioactivity Info 
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2
IC50 > 100000 nM
 Bioactivity Info 
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CP0048790
 Compound Info 
(1R,8S,10S)-3-bromo-9-(4-fluorophenyl)sulfonyl-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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C23H25BrFNO2S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0385229
 Compound Info 
(1R,8S,10S)-3-bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-(quinolin-4-ylmethyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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C27H29BrN2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0048792
 Compound Info 
(1R,8S,10S)-3-bromo-9-(1H-indol-3-ylmethyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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C26H29BrN2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0053885
 Compound Info 
(1R,8S,10S)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene
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C17H23N
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0142521
 Compound Info 
(1R,8S,10S)-9-(1,3-benzodioxol-5-ylmethyl)-3-(3,4-dichlorophenyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene
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C31H31Cl2NO2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0098703
 Compound Info 
(1R,8S,10S)-3-bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-pentyl-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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C22H32BrN
  1
1 IC50 = 30 nM
CP0745894
 Compound Info 
(+/-)-(1S,4R,9S)-5-Bromo-3,3-Dimethyl-9-(2-methylallyl)-10-(thiophen-2-ylmethyl)-1,2,3,4-tetrahydro-1,4-(epiminomethano)naphthalene
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C22H26BrNS
  1
1 IC50 = 30 nM
Clinical Information about the Protein
Target 1 ( NADPH oxidase 2 (CYBB) )
Target Type Literature-reported Target