Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate

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PubChem ID

CID: 5311299

SID: 14776683

Canonical SMILES	COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCC1 Show/Hide
Compound Formula	C15H21ClN2O3

Compound Structure

Protein Name

Protein Info

5-hydroxytryptamine receptor 4

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Serotonin receptor

Uniprot ID

Q13639

Gene Name

HTR4

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000049	C6 Cell Line Info	Rattus norvegicus (Rat)	4
1	EC50 = 51 nM	TI LI LO TS
2	Ki = 1 nM	TI LI LO TS
3	Ki = 5 nM	TI LI LO TS
4	Ki = 5.6 nM	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	3
1	EC50 = 2.5 nM	TI LI LO TS
2	Ki = 3.5 nM	TI LI LO TS
3	Ki = 5.7 nM	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	4
1	Ki = 3.69 nM	TI LI LO TS
2	Ki = 7.98 nM	TI LI LO TS
3	Ki = 8.4 nM	TI LI LO TS
4	Ki = 10.7 nM	TI LI LO TS

Biochemical Assays

1	Ki = 5 nM