General Information of the Protein
Protein ID
PT02459
Protein Name
Hepatic triacylglycerol lipase
Secondarily
Protein Name
Lipase member C
Lysophospholipase
Phospholipase A1
Gene Name
LIPC
Secondarily
Gene Name
HTGL
Sequence
MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQGCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQFINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKWENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQEKIFVKCEIKSKTSKRKIR
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
Function
Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (PubMed:7592706, PubMed:8798474, PubMed:12032167, PubMed:26193433). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (PubMed:26193433).
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Uniprot ID
Primary ID:
P11150

Secondarily ID:
A2RUB4
A8K9B6
O43571
P78529
Q99465
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HGNC ID
HGNC:6619
Subcellular Location
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0323320
 Compound Info 
2-(6-phenyl-1,3-benzothiazole-2-carbonyl)-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole
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C17H13N5O4S2
  1
1
IC50 = 2 nM
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CP0468663
 Compound Info 
US9169240, 27
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C18H15N5O4S2
  1
1
IC50 = 3 nM
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CP0058220
 Compound Info 
(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate
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C29H53NO5
  1
1
IC50 = 3 nM
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CP0412063
 Compound Info 
5-fluoro-2-[5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole-2-carbonyl]-N-(2,2,2-trifluoroethyl)-1,3-benzothiazole-6-carboxamide
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C14H10F4N6O5S2
  1
1
IC50 = 4 nM
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CP0517674
 Compound Info 
4-[6-fluoro-2-[5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole-2-carbonyl]-1,3-benzothiazol-5-yl]-N-(2,2,2-trifluoroethyl)benzamide
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C20H14F4N6O5S2
  1
1
IC50 = 4 nM
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CP0419298
 Compound Info 
US9169240, 30
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C19H16N6O6S2
  1
1
IC50 = 5 nM
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CP0061225
 Compound Info 
2-benzylsulfonyl-N-[2-(cyclopropylamino)-2-oxoethyl]-2-[6-(6-fluoropyridin-3-yl)-1,3-benzothiazol-2-yl]acetamide
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C26H23FN4O4S2
  1
1
IC50 = 7 nM
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CP0401877
 Compound Info 
2-[5-fluoro-6-(6-fluoropyridin-3-yl)-1,3-benzothiazole-2-carbonyl]-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole
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C16H10F2N6O4S2
  1
1
IC50 = 9 nM
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CP0419297
 Compound Info 
US9169240, 29
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C17H12FN5O4S2
  1
1
IC50 = 10 nM
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CP0482818
 Compound Info 
[5-[(methylsulfamoylamino)methyl]-1,3,4-oxadiazol-2-yl]-(6-phenyl-1,3-benzothiazol-2-yl)methanone
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C18H15N5O4S2
  1
1
IC50 = 10 nM
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CP0384150
 Compound Info 
2-[2-methoxyethylsulfonyl-(6-phenyl-1,3-benzothiazol-2-yl)methyl]-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole
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C20H21N5O6S3
  1
1
IC50 < 10 nM
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CP0384151
 Compound Info 
2-[(6-phenyl-1,3-benzothiazol-2-yl)-propan-2-ylsulfonylmethyl]-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole
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C20H21N5O5S3
  1
1
IC50 < 10 nM
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CP0384153
 Compound Info 
2-[benzylsulfonyl-[6-(3-chlorophenyl)-1,3-benzothiazol-2-yl]methyl]-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole
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C24H20ClN5O5S3
  1
1
IC50 < 10 nM
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CP0384200
 Compound Info 
2-[benzylsulfonyl-[6-(3,4-dichlorophenyl)-1,3-benzothiazol-2-yl]methyl]-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole
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C24H19Cl2N5O5S3
  1
1
IC50 = 10 nM
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CP0421688
 Compound Info 
2-[(6-phenyl-1,3-benzothiazol-2-yl)-(3,3,3-trifluoropropylsulfonyl)methyl]-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole
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C20H18F3N5O5S3
  1
1
IC50 < 10 nM
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CP0482586
 Compound Info 
5-[[5-[methylsulfonyl-(6-phenyl-1,3-benzothiazol-2-yl)methyl]-1,3,4-oxadiazol-2-yl]methyl]-1,3-thiazolidine-2,4-dione
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C21H16N4O5S3
  1
1
IC50 < 10 nM
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CP0323368
 Compound Info 
2-methylsulfonyl-2-(6-phenyl-1,3-benzothiazol-2-yl)-N-(2-sulfamoylethyl)acetamide
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C18H19N3O5S3
  1
1
IC50 = 15 nM
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CP0410982
 Compound Info 
N-[3-(3,4-dichlorophenyl)propyl]-3-hydroxy-1-methyl-2-oxopyridine-4-carboxamide
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C16H16Cl2N2O3
  1
1
IC50 = 16 nM
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CP0412064
 Compound Info 
2-[5-fluoro-6-(1-oxo-2,3-dihydroisoindol-5-yl)-1,3-benzothiazole-2-carbonyl]-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole
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C19H13FN6O5S2
  1
1
IC50 = 20 nM
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CP0412065
 Compound Info 
2-[6-fluoro-5-(1-oxo-2,3-dihydroisoindol-5-yl)-1,3-benzothiazole-2-carbonyl]-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole
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C19H13FN6O5S2
  1
1
IC50 = 20 nM
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CP0450725
 Compound Info 
2-[6-(6-fluoropyridin-3-yl)-1,3-benzothiazole-2-carbonyl]-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole
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C16H11FN6O4S2
  1
1
IC50 = 20 nM
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CP0384152
 Compound Info 
2-[benzylsulfonyl-(6-phenyl-1,3-benzothiazol-2-yl)methyl]-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole
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C24H21N5O5S3
  1
1
IC50 = 21 nM
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CP0429274
 Compound Info 
US9169240, 26
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C18H15N5O4S2
  1
1
IC50 = 30 nM
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CP0468661
 Compound Info 
2-[6-(3-oxo-1,2-dihydroisoindol-5-yl)-1,3-benzothiazole-2-carbonyl]-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole
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C19H14N6O5S2
  1
1
IC50 = 30 nM
 Bioactivity Info 
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CP0519336
 Compound Info 
4-[2-fluoro-4-[5-fluoro-2-[5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole-2-carbonyl]-1,3-benzothiazol-6-yl]benzoyl]morpholine
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C22H18F2N6O6S2
  1
1
IC50 = 40 nM
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CP0573101
 Compound Info 
N-[(cyclopropyl- carbamoyl) methyl]-2- methanesulfonyl- 2-(6-phenyl-1,3- benzothiazol- 2-yl)acetamide
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C21H21N3O4S2
  1
1
IC50 = 47 nM
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CP0323367
 Compound Info 
2-methylsulfonyl-2-(6-phenyl-1,3-benzothiazol-2-yl)-N-(3-sulfamoylpropyl)acetamide
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C19H21N3O5S3
  1
1
IC50 = 52 nM
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CP0384154
 Compound Info 
2-[methylsulfonyl-(6-phenyl-1,3-benzothiazol-2-yl)methyl]-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole
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C18H17N5O5S3
  1
1
IC50 = 53 nM
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CP0421750
 Compound Info 
5-methyl-5-[[5-[methylsulfonyl-(6-phenyl-1,3-benzothiazol-2-yl)methyl]-1,3,4-oxadiazol-2-yl]methyl]imidazolidine-2,4-dione
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C22H19N5O5S2
  1
1
IC50 = 53 nM
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CP0429256
 Compound Info 
US9169240, 25
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C18H15N5O4S2
  1
1
IC50 = 60 nM
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CP0480000
 Compound Info 
N-[3-(3,4-dichlorophenyl)propyl]-4-hydroxy-1-methyl-5-oxo-2H-pyrrole-3-carboxamide
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C15H16Cl2N2O3
  1
1
IC50 = 76 nM
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CP0126235
 Compound Info 
N-[(cyclopropyl- carbamoyl) methyl]-2-[6-(6- fluoropyridin-3- yl)-1,3- benzothiazol- 2-yl]-2-(3,3,3- trifluoropropane- sulfonyl)acetamide
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C22H20F4N4O4S2
  1
1
IC50 = 79 nM
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CP0224798
 Compound Info 
2-methylsulfonyl-2-(6-phenyl-1,3-benzothiazol-2-yl)-N-[2-(sulfamoylamino)ethyl]acetamide
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C18H20N4O5S3
  1
1
IC50 = 81 nM
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CP0455147
 Compound Info 
methyl N-[4-[2-[benzylsulfonyl-[5-[(sulfamoylamino)methyl]-1,3,4-oxadiazol-2-yl]methyl]-1,3-benzothiazol-6-yl]phenyl]carbamate
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C26H24N6O7S3
  1
1
IC50 = 90 nM
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CP0455148
 Compound Info 
4-[4-[2-[benzylsulfonyl-[5-[(sulfamoylamino)methyl]-1,3,4-oxadiazol-2-yl]methyl]-1,3-benzothiazol-6-yl]-2-chlorobenzoyl]morpholine
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C29H27ClN6O7S3
  1
1
IC50 = 121 nM
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CP0259244
 Compound Info 
N-[(cyclopropyl- carbamoyl) methyl]-2-[6-(6- fluoropyridin-3- yl)-1,3- benzothiazol- 2-yl]-2- methanesulfonyl- acetamide
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C20H19FN4O4S2
  1
1
IC50 = 130 nM
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CP0126236
 Compound Info 
N-[2-(cyclopropylamino)-2-oxoethyl]-2-[6-(6-fluoropyridin-3-yl)-1,3-benzothiazol-2-yl]-2-(2-methoxyethylsulfonyl)acetamide
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C22H23FN4O5S2
  1
1
IC50 = 230 nM
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CP0120856
 Compound Info 
US8987314, B101
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C23H26N4O7S3
  1
1
IC50 = 280 nM
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CP0066473
 Compound Info 
US8987314, B34
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C21H28N6O6S3
  1
1
IC50 = 310 nM
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CP0421749
 Compound Info 
4-[2-[benzylsulfonyl-[5-[(sulfamoylamino)methyl]-1,3,4-oxadiazol-2-yl]methyl]-1,3-benzothiazol-6-yl]-2-chloro-N,N-dimethylbenzamide
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C27H25ClN6O6S3
  1
1
IC50 = 391 nM
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CP0384139
 Compound Info 
5-[[5-[methylsulfonyl-[6-[4-(morpholine-4-carbonyl)phenyl]-1,3-benzothiazol-2-yl]methyl]-1,3,4-oxadiazol-2-yl]methyl]-1,3-thiazolidine-2,4-dione
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C26H23N5O7S3
  1
1
IC50 = 450 nM
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CP0127616
 Compound Info 
US8987314, B3
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C17H17FN4O5S3
  1
1
IC50 = 4400 nM
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CP0519335
 Compound Info 
US9169240, 49
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C18H13N5O3S
  1
1
IC50 > 10 nM
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0120856
 Compound Info 
US8987314, B101
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C23H26N4O7S3
  1
1 IC50 = 63 nM
CP0066473
 Compound Info 
US8987314, B34
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C21H28N6O6S3
  1
1 IC50 = 313 nM