General Information of the Protein
Protein ID
PT05799
Protein Name
Galanin receptor type 2
Gene Name
GALR2
Secondarily
Gene Name
Galnr2
Sequence
MNGSGSQGAENTSQEGGSGGWQPEAVLVPLFFALIFLVGTVGNALVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDDWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLALLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDLCTFVFSYLLPVLVLSLTYARTLRYLWRTVDPVTAGSGSQRAKRKVTRMIIIVAVLFCLCWMPHHALILCVWFGRFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRKICAGLLRPAPRRASGRVSILAPGNHSGSMLEQESTDLTQVSEAAGPLVPPPALPNCTASSRTLDPAC
    Show/Hide
Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Galanin receptor
Function
Receptor for the hormone galanin, GALP and spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).
    Show/Hide
Uniprot ID
O08726
Ensembl ID
ENSG00000182687
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000053 , COS-7
Compound ID Compound Name Compound Formula
CP0399290
(2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophenyl)methoxy)propanoic acid
   Show/Hide
C23H22FNO4
 1
1
IC50 = 21.1 nM
   TI
   LI
   LO
   TS
CP0476239
(3S,6S,9S,15aR)-9-sec-butyl-6-((1-methoxy-1H-indol-3-yl)methyl)-3-(5-oxohexyl)octahydro-1H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(12H,13H,14H)-tetraone
   Show/Hide
C32H45N5O6
 1
1
IC50 = 87.7 nM
   TI
   LI
   LO
   TS
CP0497907
(3S,6S,9S,12S)-3-benzyl-6,9,12-tri-sec-butyl-1,4,7,10-tetraazacyclododecane-2,5,8,11-tetraone
   Show/Hide
C27H42N4O4
 1
1
IC50 = 226 nM
   TI
   LI
   LO
   TS
CP0441398
(3S,6S,9S,12S)-3-benzyl-9,12-di-sec-butyl-6-((2S,3R)-3-hydroxybutan-2-yl)-1,4,7,10-tetraazacyclododecane-2,5,8,11-tetraone
   Show/Hide
C27H42N4O5
 1
1
IC50 = 278 nM
   TI
   LI
   LO
   TS
CP0474576
(3S,6S,9S,12S)-3-benzyl-9-sec-butyl-6-((2S,3R)-3-hydroxybutan-2-yl)-12-isopropyl-1,4,7,10-tetraazacyclododecane-2,5,8,11-tetraone
   Show/Hide
C26H40N4O5
 1
1
IC50 = 450 nM
   TI
   LI
   LO
   TS
CP0476238
(3S,6S,9S,12S)-3-benzyl-6-((2S,3R)-3-hydroxybutan-2-yl)-9,12-diisopropyl-1,4,7,10-tetraazacyclododecane-2,5,8,11-tetraone
   Show/Hide
C25H38N4O5
 1
1
IC50 = 542 nM
   TI
   LI
   LO
   TS
CP0437601
(3S,6S,9S,12S)-3-benzyl-12-sec-butyl-6-((2S,3R)-3-hydroxybutan-2-yl)-9-isopropyl-1,4,7,10-tetraazacyclododecane-2,5,8,11-tetraone
   Show/Hide
C26H40N4O5
 1
1
IC50 = 574 nM
   TI
   LI
   LO
   TS
CP0456132
(S)-2-((2S,5S,8S,11S)-5-benzyl-8,11-di-sec-butyl-3,6,9,12-tetraoxo-1,4,7,10-tetraazacyclododecan-2-yl)-3-oxobutane-1-sulfonic acid
   Show/Hide
C27H40N4O8S
 1
1
IC50 = 2260 nM
   TI
   LI
   LO
   TS