General Information of the Protein
Protein ID
PT02832
Protein Name
Sodium/glucose cotransporter 2
Secondarily
Protein Name
Low affinity sodium-glucose cotransporter
Solute carrier family 5 member 2
Gene Name
SLC5A2
Secondarily
Gene Name
Sglt2
Sequence
MEGHVEEGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAVTSLTVSKDPAVGNISSTCYQPRPDSYHLLRDPVTGGLPWPALLLGLTIVSGWHWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLIGGLLMGLARLIPEFFFGTGSCVRPSACPAIFCRVHYLYFAIILFFCSGFLTLAISRCTAPIPQKHLHRLVFSLRHSKEEREDLDAEELEGPAPPPVQNGCQECAMGIEEVQSPAPGLLRQCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPSWARVVNLNALLMMTVAVFLWGFYA
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Organism
Rattus norvegicus, Rat
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC05 family of sodium-dependent glucose transporters
Function
Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:7493971). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).
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Uniprot ID
P53792
Ensembl ID
ENSG00000140675
Subcellular Location
Apical cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0198642
 Compound Info 
(2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)oxane-3,4,5-triol
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C21H25ClO6
  1
1
EC50 = 3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0466100
 Compound Info 
4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triazol-3-yl)methyl)-6-(trifluoromethyl)-2H-benzo[b][1,4]thiazin-3(4H)-one
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C20H16ClF3N4OS2
  1
1
IC50 = 400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0198642
 Compound Info 
(2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)oxane-3,4,5-triol
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C21H25ClO6
  1
1 EC50 = 3 nM
CP0207318
 Compound Info 
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[[4-[(4-hydroxy-2-methylphenyl)methyl]-5-propan-2-yl-1H-pyrazol-3-yl]oxy]oxane-3,4,5-triol
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C20H28N2O7
  1
1 IC50 = 4370 nM
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT00292 Sodium/glucose cotransporter 1 Mus musculus, Mouse
 Protein Info 
PT02415 Sodium/glucose cotransporter 2 Homo sapiens, Human
 Protein Info 
PT03804 Sodium/glucose cotransporter 1 Homo sapiens, Human
 Protein Info 
PT03888 Sodium/glucose cotransporter 1 Rattus norvegicus, Rat
 Protein Info