Brief Information of the Cell Line and Protein
Cell Line ID: CL000053 , COS-7
Synonyms
Cos-7
COS 7
Cos 7
COS7
Cos7
CV-1 in Origin Simian-7
Category Transformed cell line
Organism
Chlorocebus aethiops (Green monkey)
Cellosaurus ID
CVCL_0224
Protein ID: PT01982 , Endothelin-converting enzyme 1
Gene Name ECE1
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P42892
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000053  Protein ID: PT01982
 
Compound ID Compound Name Compound Formula
CP0092092
(2S)-2-[(2R)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-sulfanylpropanamido]-3-(1H-indol-3-yl)propanoic acid
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C23H24N2O3S
 1
1
Ki = 26 nM
   TI
   LI
   LO
   TS
CP0094878
(2S)-3-(1H-indol-3-yl)-2-[(2S,3S)-3-phenyl-2-(sulfanylmethyl)butanamido]propanoic acid
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C22H24N2O3S
 1
1
Ki = 100 nM
   TI
   LI
   LO
   TS
CP0197969
2-(2-Indan-1-yl-3-mercapto-propionylamino)-3-(1H-indol-3-yl)-propionic acid
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C23H24N2O3S
 1
1
Ki = 100 nM
   TI
   LI
   LO
   TS
CP0337715
(2S)-3-(1H-indol-3-yl)-2-[(2S,3S)-3-(4-phenylphenyl)-2-(sulfanylmethyl)butanamido]propanoic acid
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C28H28N2O3S
 1
1
Ki = 110 nM
   TI
   LI
   LO
   TS
CP0271471
(2S)-3-(1H-indol-3-yl)-2-[(2R,3R)-3-(4-phenylphenyl)-2-(sulfanylmethyl)butanamido]propanoic acid
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C28H28N2O3S
 1
1
Ki = 135 nM
   TI
   LI
   LO
   TS
CP0345607
(2S)-3-(1H-indol-3-yl)-2-[(2R,3S)-3-(4-phenylphenyl)-2-(sulfanylmethyl)butanamido]propanoic acid
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C28H28N2O3S
 1
1
Ki = 190 nM
   TI
   LI
   LO
   TS
CP0409194
(2S)-3-(1H-indol-3-yl)-2-[(2S)-3-sulfanyl-2-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]propanamido]propanoic acid
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C24H26N2O3S
 1
1
Ki = 190 nM
   TI
   LI
   LO
   TS
CP0405636
(2S)-3-(1H-indol-3-yl)-2-[(2R,3R)-3-phenyl-2-(sulfanylmethyl)butanamido]propanoic acid
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C22H24N2O3S
 1
1
Ki = 200 nM
   TI
   LI
   LO
   TS
CP0318717
(2S)-3-(1H-indol-3-yl)-2-[3-(4-phenylphenyl)-2-(sulfanylmethyl)butanamido]propanoic acid
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C28H28N2O3S
 1
1
Ki = 220 nM
   TI
   LI
   LO
   TS
CP0101112
(2S)-3-(1H-indol-3-yl)-2-[(2R)-3-sulfanyl-2-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]propanamido]propanoic acid
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C24H26N2O3S
 1
1
Ki = 250 nM
   TI
   LI
   LO
   TS
CP0356011
(2S)-2-[(2S)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-sulfanylpropanamido]-3-(1H-indol-3-yl)propanoic acid
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C23H24N2O3S
 1
1
Ki = 290 nM
   TI
   LI
   LO
   TS
CP0805141
3-(1H-Indol-3-yl)-2-[3-mercapto-2-(1,2,3,4-tetrahydro-naphthalen-1-yl)-propionylamino]-propionic acid
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C24H26N2O3S
 1
1
Ki = 300 nM
   TI
   LI
   LO
   TS
CP0897679
3-(1H-Indol-3-yl)-2-(2-mercaptomethyl-3-phenyl-butyrylamino)-propionic acid
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C22H24N2O3S
 1
1
Ki = 300 nM
   TI
   LI
   LO
   TS
CP0309407
(2S)-3-(1H-indol-3-yl)-2-[(2R,3S)-3-phenyl-2-(sulfanylmethyl)butanamido]propanoic acid
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C22H24N2O3S
 1
1
Ki = 580 nM
   TI
   LI
   LO
   TS
CP0823016
3-(1H-Indol-3-yl)-2-(2-mercaptomethyl-3-naphthalen-1-yl-butyrylamino)-propionic acid
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C26H26N2O3S
 1
1
Ki = 600 nM
   TI
   LI
   LO
   TS
CP0740813
3-(1H-Indol-3-yl)-2-[3-mercapto-2-(1,2,3,4-tetrahydro-naphthalen-1-yl)-propionylamino]-propionic acid
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C24H26N2O3S
 1
1
Ki = 670 nM
   TI
   LI
   LO
   TS
CP0215115
(2S)-2-[(2R)-2-[(1S)-2,3-dihydro-1H-inden-1-yl]-3-sulfanylpropanamido]-3-(1H-indol-3-yl)propanoic acid
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C23H24N2O3S
 1
1
Ki = 680 nM
   TI
   LI
   LO
   TS
CP0292023
(2S)-3-(1H-indol-3-yl)-2-[(2S,3R)-3-phenyl-2-(sulfanylmethyl)butanamido]propanoic acid
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C22H24N2O3S
 1
1
Ki = 780 nM
   TI
   LI
   LO
   TS
CP0702295
2-(2-Biphenyl-3-yl-3-mercapto-propionylamino)-3-(1H-indol-3-yl)-propionic acid
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C26H24N2O3S
 1
1
Ki = 900 nM
   TI
   LI
   LO
   TS
CP0171722
(2S)-3-(1H-indol-3-yl)-2-[(2S,3R)-3-(4-phenylphenyl)-2-(sulfanylmethyl)butanamido]propanoic acid
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C28H28N2O3S
 1
1
Ki = 920 nM
   TI
   LI
   LO
   TS
CP0717047
3-(1H-Indol-3-yl)-2-(2-mercaptomethyl-3-naphthalen-2-yl-butyrylamino)-propionic acid
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C26H26N2O3S
 1
1
Ki = 980 nM
   TI
   LI
   LO
   TS
CP0295980
(2S)-2-[(2S)-2-[(1S)-2,3-dihydro-1H-inden-1-yl]-3-sulfanylpropanamido]-3-(1H-indol-3-yl)propanoic acid
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C23H24N2O3S
 1
1
Ki = 1140 nM
   TI
   LI
   LO
   TS
CP0107766
(2S)-3-(1H-indol-3-yl)-2-[(2R)-3-sulfanyl-2-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]propanamido]propanoic acid
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C24H26N2O3S
 1
1
Ki = 1240 nM
   TI
   LI
   LO
   TS
CP0794045
3-(1H-Indol-3-yl)-2-(3-mercapto-2-naphthalen-1-yl-propionylamino)-propionic acid
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C24H22N2O3S
 1
1
Ki = 1560 nM
   TI
   LI
   LO
   TS
CP0731876
2-(2-Biphenyl-4-yl-3-mercapto-propionylamino)-3-(1H-indol-3-yl)-propionic acid
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C26H24N2O3S
 1
1
Ki = 4150 nM
   TI
   LI
   LO
   TS