General Information of the Compound
Compound ID
CP0794045
Compound Name
3-(1H-Indol-3-yl)-2-(3-mercapto-2-naphthalen-1-yl-propionylamino)-propionic acid
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Structure
Formula
C24H22N2O3S
Molecular Weight
418.518
Canonical SMILES
O=C(O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CS)c1cccc2ccccc12
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InChI
InChI=1S/C24H22N2O3S/c27-23(20(14-30)19-10-5-7-15-6-1-2-8-17(15)19)26-22(24(28)29)12-16-13-25-21-11-4-3-9-18(16)21/h1-11,13,20,22,25,30H,12,14H2,(H,26,27)(H,28,29)
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InChIKey
XDZFLVUHADAPKO-UHFFFAOYSA-N
Physicochemical Property
logP
4.1466
Rotatable Bonds
7
Heavy Atom Count
30
Polar Areas
82.19
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
3
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44283511
ChEMBL ID
CHEMBL287261
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01982, Endothelin-converting enzyme 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000053 COS-7 Chlorocebus aethiops (Green monkey)  1
1
Ki = 1560 nM
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