| Compound ID |
Compound Name |
Compound Formula |
|
CP0118147
|
4-[(2S)-2-methylpyrrolidin-1-yl]naphthalene-1-carbonitrile
Show/Hide
|
C16H16N2
|
1
|
| 1 |
EC50 = 0.19 nM
|
|
|
|
CP0370115
|
2-chloro-4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]-3-methylbenzonitrile
Show/Hide
|
C13H15ClN2O
|
1
|
| 1 |
EC50 = 0.19 nM
|
|
|
|
CP0089356
|
4-[(2S)-2-ethylpyrrolidin-1-yl]naphthalene-1-carbonitrile
Show/Hide
|
C17H18N2
|
1
|
| 1 |
EC50 = 0.24 nM
|
|
|
|
CP0335959
|
4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]naphthalene-1-carbonitrile
Show/Hide
|
C16H16N2O
|
1
|
| 1 |
EC50 = 0.25 nM
|
|
|
|
CP0196083
|
2-fluoro-4-[(2S,3S)-3-hydroxy-2,3-dimethylpyrrolidin-1-yl]-3-methylbenzonitrile
Show/Hide
|
C14H17FN2O
|
1
|
| 1 |
EC50 = 0.29 nM
|
|
|
|
CP0511471
|
4-[(2S,3R)-3-hydroxy-2-methylpyrrolidin-1-yl]naphthalene-1-carbonitrile
Show/Hide
|
C16H16N2O
|
1
|
| 1 |
EC50 = 0.32 nM
|
|
|
|
CP0396677
|
2-chloro-4-[(2S,3S,4S)-2-ethyl-3-hydroxy-4-methyl-5-oxopyrrolidin-1-yl]benzonitrile
Show/Hide
|
C14H15ClN2O2
|
1
|
| 1 |
EC50 = 0.39 nM
|
|
|
|
CP0196190
|
2-chloro-4-[(2S,3S,4S)-3-hydroxy-2,4-dimethyl-5-oxopyrrolidin-1-yl]benzonitrile
Show/Hide
|
C13H13ClN2O2
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0259546
|
4-[(2S,3S)-3-(hydroxymethyl)-2-methylpyrrolidin-1-yl]naphthalene-1-carbonitrile
Show/Hide
|
C17H18N2O
|
1
|
| 1 |
EC50 = 1.2 nM
|
|
|
|
CP0365753
|
4-[(2R)-2-propan-2-ylpyrrolidin-1-yl]naphthalene-1-carbonitrile
Show/Hide
|
C18H20N2
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
|
CP0358467
|
4-[(2S)-2-methyl-3-oxopyrrolidin-1-yl]naphthalene-1-carbonitrile
Show/Hide
|
C16H14N2O
|
1
|
| 1 |
EC50 = 2.2 nM
|
|
|
|
CP0148231
|
4-pyrrolidin-1-ylnaphthalene-1-carbonitrile
Show/Hide
|
C15H14N2
|
1
|
| 1 |
EC50 = 2.5 nM
|
|
|
|
CP0044960
|
(1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-one
Show/Hide
|
C19H30O2
|
7
|
| 1 |
EC50 = 3 nM
|
|
|
| 2 |
EC50 = 6.2 nM
|
|
|
| 3 |
EC50 = 12 nM
|
|
|
| 4 |
EC50 = 15 nM
|
|
|
| 5 |
EC50 = 20 nM
|
|
|
| 6 |
IC50 > 10000 nM
|
|
|
| 7 |
Ki = 0.2 nM
|
|
|
|
CP0197757
|
2-chloro-4-[(2S,3S,4S)-4-ethyl-3-hydroxy-2-methyl-5-oxopyrrolidin-1-yl]benzonitrile
Show/Hide
|
C14H15ClN2O2
|
1
|
| 1 |
EC50 = 3.6 nM
|
|
|
|
CP0072605
|
4-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile
Show/Hide
|
C14H13F3N2O2
|
1
|
| 1 |
EC50 = 4.7 nM
|
|
|
|
CP0558569
|
2-chloro-4-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]benzonitrile
Show/Hide
|
C13H13ClN2O2
|
1
|
| 1 |
EC50 = 6 nM
|
|
|
|
CP0356682
|
2-chloro-4-[(2S,3R)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]benzonitrile
Show/Hide
|
C13H13ClN2O2
|
1
|
| 1 |
EC50 = 8 nM
|
|
|
|
CP0565451
|
2-chloro-4-[(4R,5S)-3,3-difluoro-4-hydroxy-5-methyl-2-oxopyrrolidin-1-yl]benzonitrile
Show/Hide
|
C12H9ClF2N2O2
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0089354
|
4-(2,2-dimethylpyrrolidin-1-yl)naphthalene-1-carbonitrile
Show/Hide
|
C17H18N2
|
1
|
| 1 |
EC50 = 21 nM
|
|
|
|
CP0310585
|
(2R)-1-(4-cyanonaphthalen-1-yl)pyrrolidine-2-carboxamide
Show/Hide
|
C16H15N3O
|
1
|
| 1 |
EC50 = 21 nM
|
|
|
|
CP0541563
|
2-chloro-4-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-3-methylbenzonitrile
Show/Hide
|
C14H15ClN2O2
|
1
|
| 1 |
EC50 = 23 nM
|
|
|
|
CP0196188
|
4-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-2-methoxybenzonitrile
Show/Hide
|
C14H16N2O3
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0086426
|
2-chloro-4-[(4S,5S)-4-hydroxy-3,3,5-trimethyl-2-oxopyrrolidin-1-yl]benzonitrile
Show/Hide
|
C14H15ClN2O2
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0058400
|
1-(4-nitronaphthalen-1-yl)pyrrolidine
Show/Hide
|
C14H14N2O2
|
1
|
| 1 |
EC50 = 41 nM
|
|
|
|
CP0230599
|
4-[(2S,3S)-3-(2-hydroxypropan-2-yl)-2-methylpyrrolidin-1-yl]naphthalene-1-carbonitrile
Show/Hide
|
C19H22N2O
|
1
|
| 1 |
EC50 = 45 nM
|
|
|
|
CP0372488
|
4-[4-[(4-fluorophenyl)methyl]-3,5-dimethylpyrazol-1-yl]-2-(trifluoromethyl)benzonitrile
Show/Hide
|
C20H15F4N3
|
4
|
| 1 |
EC50 = 62 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
| 3 |
IC50 = 110 nM
|
|
|
| 4 |
IC50 > 10000 nM
|
|
|
|
CP0372562
|
2-chloro-4-[4-[(4-fluorophenyl)methyl]-3,5-dimethylpyrazol-1-yl]benzonitrile
Show/Hide
|
C19H15ClFN3
|
4
|
| 1 |
EC50 = 62 nM
|
|
|
| 2 |
EC50 = 1100 nM
|
|
|
| 3 |
IC50 = 75 nM
|
|
|
| 4 |
IC50 > 10000 nM
|
|
|
|
CP0544851
|
2-chloro-4-[(2S,3S)-3-hydroxy-2,3-dimethyl-5-oxopyrrolidin-1-yl]benzonitrile
Show/Hide
|
C13H13ClN2O2
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
|
CP0089357
|
(2R)-1-(4-cyanonaphthalen-1-yl)pyrrolidine-2-carbonitrile
Show/Hide
|
C16H13N3
|
1
|
| 1 |
EC50 = 160 nM
|
|
|
|
CP0072607
|
2-chloro-4-[(2S,3S)-3-hydroxy-2-(2-methylpropyl)-5-oxopyrrolidin-1-yl]benzonitrile
Show/Hide
|
C15H17ClN2O2
|
1
|
| 1 |
EC50 = 170 nM
|
|
|
|
CP0146696
|
Bicalutamide
Show/Hide
|
C18H14F4N2O4S
|
6
|
| 1 |
EC50 = 180 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
| 3 |
IC50 = 330 nM
|
|
|
| 4 |
IC50 = 470 nM
|
|
|
| 5 |
IC50 > 10000 nM
|
|
|
| 6 |
Ki = 151 nM
|
|
|
|
CP0356684
|
4-[(2S,3S,4S)-4-benzyl-3-hydroxy-2-methyl-5-oxopyrrolidin-1-yl]-2-chlorobenzonitrile
Show/Hide
|
C19H17ClN2O2
|
1
|
| 1 |
EC50 = 220 nM
|
|
|
|
CP0465805
|
2-chloro-4-[(2S,3S)-3-hydroxy-2-methyl-5-oxopyrrolidin-1-yl]benzonitrile
Show/Hide
|
C12H11ClN2O2
|
1
|
| 1 |
EC50 = 810 nM
|
|
|
|
CP0074026
|
2-chloro-4-[(2S,3S)-3-hydroxy-2-methyl-5-oxopyrrolidin-1-yl]-3-methylbenzonitrile
Show/Hide
|
C13H13ClN2O2
|
1
|
| 1 |
EC50 = 1000 nM
|
|
|
|
CP0456774
|
2-chloro-4-[4-[(4-fluorophenyl)-hydroxymethyl]-3,5-dimethylpyrazol-1-yl]benzonitrile
Show/Hide
|
C19H15ClFN3O
|
4
|
| 1 |
EC50 = 1600 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
| 3 |
IC50 = 48 nM
|
|
|
| 4 |
IC50 = 180 nM
|
|
|
|
CP0392737
|
4-(4-cyanophenyl)-2,5-dimethyl-1-(pyridin-3-ylmethyl)pyrrole-3-carbonitrile
Show/Hide
|
C20H16N4
|
6
|
| 1 |
EC50 = 2200 nM
|
|
|
| 2 |
EC50 = 3600 nM
|
|
|
| 3 |
EC50 > 10000 nM
|
|
|
| 4 |
IC50 = 65 nM
|
|
|
| 5 |
IC50 = 180 nM
|
|
|
| 6 |
IC50 = 190 nM
|
|
|
|
CP0392731
|
methyl 1-benzyl-4-[4-cyano-3-(trifluoromethyl)phenyl]-2,5-dimethylpyrrole-3-carboxylate
Show/Hide
|
C23H19F3N2O2
|
5
|
| 1 |
EC50 = 5400 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
| 3 |
IC50 = 320 nM
|
|
|
| 4 |
IC50 = 690 nM
|
|
|
| 5 |
IC50 = 3300 nM
|
|
|
|
CP0390357
|
1-[1-benzyl-2,5-dimethyl-4-(4-nitrophenyl)pyrrol-3-yl]ethanone
Show/Hide
|
C21H20N2O3
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 900 nM
|
|
|
| 3 |
IC50 = 4600 nM
|
|
|
| 4 |
IC50 = 6500 nM
|
|
|
|
CP0390359
|
1-benzyl-2,5-dimethyl-4-(4-nitrophenyl)pyrrole-3-carboxylic acid
Show/Hide
|
C20H18N2O4
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 6500 nM
|
|
|
| 3 |
IC50 = 8700 nM
|
|
|
| 4 |
IC50 > 10000 nM
|
|
|
|
CP0390361
|
ethyl 1,2,5-trimethyl-4-(4-nitrophenyl)pyrrole-3-carboxylate
Show/Hide
|
C16H18N2O4
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 210 nM
|
|
|
| 3 |
IC50 = 500 nM
|
|
|
| 4 |
IC50 = 6200 nM
|
|
|
|
CP0390363
|
[1-benzyl-2,5-dimethyl-4-(4-nitrophenyl)pyrrol-3-yl]methanol
Show/Hide
|
C20H20N2O3
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 660 nM
|
|
|
| 3 |
IC50 = 3800 nM
|
|
|
| 4 |
IC50 > 10000 nM
|
|
|
|
CP0391733
|
ethyl 2,5-dimethyl-4-(4-nitrophenyl)-1-(2-phenylethyl)pyrrole-3-carboxylate
Show/Hide
|
C23H24N2O4
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 970 nM
|
|
|
| 3 |
IC50 = 4100 nM
|
|
|
| 4 |
IC50 > 10000 nM
|
|
|
|
CP0391873
|
ethyl 2,5-dimethyl-4-(4-nitrophenyl)-1H-pyrrole-3-carboxylate
Show/Hide
|
C15H16N2O4
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 240 nM
|
|
|
| 3 |
IC50 = 340 nM
|
|
|
| 4 |
IC50 = 4200 nM
|
|
|
|
CP0392430
|
ethyl 1-benzyl-2,5-dimethyl-4-(4-nitrophenyl)pyrrole-3-carboxylate
Show/Hide
|
C22H22N2O4
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 160 nM
|
|
|
| 3 |
IC50 = 340 nM
|
|
|
| 4 |
IC50 = 3200 nM
|
|
|
|
CP0392431
|
methyl 1-benzyl-2,5-dimethyl-4-phenylpyrrole-3-carboxylate
Show/Hide
|
C21H21NO2
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 1300 nM
|
|
|
| 3 |
IC50 = 2600 nM
|
|
|
| 4 |
IC50 = 3700 nM
|
|
|
|
CP0392434
|
1-[(6-chloropyridin-3-yl)methyl]-4-(4-cyanophenyl)-2,5-dimethylpyrrole-3-carbonitrile
Show/Hide
|
C20H15ClN4
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 45 nM
|
|
|
| 3 |
IC50 = 100 nM
|
|
|
| 4 |
IC50 = 910 nM
|
|
|
|
CP0392435
|
ethyl 1-benzoyl-2,5-dimethyl-4-(4-nitrophenyl)pyrrole-3-carboxylate
Show/Hide
|
C22H20N2O5
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 1500 nM
|
|
|
| 3 |
IC50 = 2400 nM
|
|
|
| 4 |
IC50 = 7700 nM
|
|
|
|
CP0392437
|
1-benzyl-2,5-dimethyl-3-(4-nitrophenyl)pyrrole
Show/Hide
|
C19H18N2O2
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 210 nM
|
|
|
| 3 |
IC50 = 490 nM
|
|
|
| 4 |
IC50 = 3100 nM
|
|
|
|
CP0392728
|
1-benzyl-4-(4-cyanophenyl)-2,5-dimethylpyrrole-3-carbonitrile
Show/Hide
|
C21H17N3
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 40 nM
|
|
|
| 3 |
IC50 = 41 nM
|
|
|
| 4 |
IC50 = 380 nM
|
|
|
|
CP0392734
|
1-[[6-chloro-5-(hydroxymethyl)pyridin-3-yl]methyl]-4-(4-cyanophenyl)-2,5-dimethylpyrrole-3-carbonitrile
Show/Hide
|
C21H17ClN4O
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 25 nM
|
|
|
| 3 |
IC50 = 110 nM
|
|
|
| 4 |
IC50 = 280 nM
|
|
|
|
CP0392736
|
4-(4-cyanophenyl)-1-[[5-(hydroxymethyl)pyridin-3-yl]methyl]-2,5-dimethylpyrrole-3-carbonitrile
Show/Hide
|
C21H18N4O
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 100 nM
|
|
|
| 3 |
IC50 = 440 nM
|
|
|
| 4 |
IC50 = 600 nM
|
|
|
|
CP0392738
|
ethyl 1-(benzenesulfonyl)-2,5-dimethyl-4-(4-nitrophenyl)pyrrole-3-carboxylate
Show/Hide
|
C21H20N2O6S
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 4700 nM
|
|
|
| 3 |
IC50 > 10000 nM
|
|
|
|
CP0396090
|
ethyl 2,5-dimethyl-4-(4-nitrophenyl)-1-phenylpyrrole-3-carboxylate
Show/Hide
|
C21H20N2O4
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 4300 nM
|
|
|
| 3 |
IC50 > 10000 nM
|
|
|
| 4 |
IC50 > 2100 nM
|
|
|
|
CP0396091
|
1-[[6-chloro-5-(hydroxymethyl)pyridin-3-yl]methyl]-4-(4-cyanophenyl)-5-methylpyrrole-3-carbonitrile
Show/Hide
|
C20H15ClN4O
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 320 nM
|
|
|
| 3 |
IC50 = 810 nM
|
|
|
| 4 |
IC50 = 1400 nM
|
|
|
|
CP0398338
|
ethyl 1-(cyclohexylmethyl)-2,5-dimethyl-4-(4-nitrophenyl)pyrrole-3-carboxylate
Show/Hide
|
C22H28N2O4
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 3700 nM
|
|
|
| 3 |
IC50 = 3800 nM
|
|
|
| 4 |
IC50 = 7200 nM
|
|
|
|
CP0398339
|
methyl 1-benzyl-2,5-dimethyl-4-(4-nitrophenyl)pyrrole-3-carboxylate
Show/Hide
|
C21H20N2O4
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 150 nM
|
|
|
| 3 |
IC50 = 300 nM
|
|
|
| 4 |
IC50 = 740 nM
|
|
|
|
CP0398340
|
1-[[6-chloro-5-(hydroxymethyl)pyridin-3-yl]methyl]-4-(4-cyanophenyl)-2-methylpyrrole-3-carbonitrile
Show/Hide
|
C20H15ClN4O
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 170 nM
|
|
|
| 3 |
IC50 = 760 nM
|
|
|
| 4 |
IC50 = 910 nM
|
|
|
|
CP0457167
|
methyl 1-benzyl-4-(4-cyanophenyl)-2,5-dimethylpyrrole-3-carboxylate
Show/Hide
|
C22H20N2O2
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 120 nM
|
|
|
| 3 |
IC50 = 270 nM
|
|
|
| 4 |
IC50 = 710 nM
|
|
|
|
CP0372563
|
4-[[1-(3-chloro-4-cyanophenyl)-3,5-dimethylpyrazol-4-yl]methyl]-N,N-dimethylbenzamide
Show/Hide
|
C22H21ClN4O
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 4000 nM
|
|
|
| 3 |
IC50 = 6300 nM
|
|
|
|
CP0372566
|
N-[5-[1-(3-chloro-4-cyanophenyl)-3,5-dimethylpyrazol-4-yl]oxypyridin-2-yl]acetamide
Show/Hide
|
C19H16ClN5O2
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 350 nM
|
|
|
| 3 |
IC50 = 7100 nM
|
|
|
|
CP0372567
|
3-[[1-(3-chloro-4-cyanophenyl)-3,5-dimethylpyrazol-4-yl]methyl]benzamide
Show/Hide
|
C20H17ClN4O
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 700 nM
|
|
|
| 3 |
IC50 = 1900 nM
|
|
|
|
CP0382455
|
2-chloro-4-[4-(4-fluorophenyl)-3,5-dimethylpyrazol-1-yl]benzonitrile
Show/Hide
|
C18H13ClFN3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 270 nM
|
|
|
| 3 |
IC50 = 6200 nM
|
|
|
|
CP0382456
|
4-[[1-(3-chloro-4-cyanophenyl)-3,5-dimethylpyrazol-4-yl]methyl]benzamide
Show/Hide
|
C20H17ClN4O
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 140 nM
|
|
|
| 3 |
IC50 = 420 nM
|
|
|
|
CP0382457
|
2-chloro-4-[3,5-dimethyl-4-[4-(morpholine-4-carbonyl)phenoxy]pyrazol-1-yl]benzonitrile
Show/Hide
|
C23H21ClN4O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 720 nM
|
|
|
| 3 |
IC50 = 3000 nM
|
|
|
|
CP0382458
|
3-chloro-4-[4-[(4-fluorophenyl)methyl]-3,5-dimethylpyrazol-1-yl]benzonitrile
Show/Hide
|
C19H15ClFN3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 820 nM
|
|
|
| 3 |
IC50 > 10000 nM
|
|
|
|
CP0382659
|
2-chloro-4-[4-[2-(4-fluorophenyl)ethyl]-3,5-dimethylpyrazol-1-yl]benzonitrile
Show/Hide
|
C20H17ClFN3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 140 nM
|
|
|
| 3 |
IC50 = 1100 nM
|
|
|
|
CP0382660
|
4-[[1-(3-chloro-4-cyanophenyl)-3,5-dimethylpyrazol-4-yl]methyl]-N-methylbenzamide
Show/Hide
|
C21H19ClN4O
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
| 3 |
IC50 = 1300 nM
|
|
|
|
CP0397140
|
N-[6-[1-(3-chloro-4-cyanophenyl)-3,5-dimethylpyrazol-4-yl]oxypyridin-3-yl]-2,2-dimethylpropanamide
Show/Hide
|
C22H22ClN5O2
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 190 nM
|
|
|
| 3 |
IC50 = 4000 nM
|
|
|
|
CP0397142
|
2-chloro-4-[4-(4-fluorophenoxy)-3,5-dimethylpyrazol-1-yl]benzonitrile
Show/Hide
|
C18H13ClFN3O
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
| 3 |
IC50 = 670 nM
|
|
|
|
CP0397143
|
N-tert-butyl-4-[[1-(3-chloro-4-cyanophenyl)-3,5-dimethylpyrazol-4-yl]methyl]benzamide
Show/Hide
|
C24H25ClN4O
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 770 nM
|
|
|
| 3 |
IC50 = 970 nM
|
|
|
|
CP0400267
|
2-[[1-(3-chloro-4-cyanophenyl)-3,5-dimethylpyrazol-4-yl]methyl]benzamide
Show/Hide
|
C20H17ClN4O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0400676
|
2-chloro-4-[3,5-dimethyl-4-[[4-(morpholine-4-carbonyl)phenyl]methyl]pyrazol-1-yl]benzonitrile
Show/Hide
|
C24H23ClN4O2
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 2400 nM
|
|
|
| 3 |
IC50 > 10000 nM
|
|
|
|
CP0400677
|
4-[1-(3-chloro-4-cyanophenyl)-3,5-dimethylpyrazol-4-yl]oxy-N-(2-hydroxy-2-methylpropyl)benzamide
Show/Hide
|
C23H23ClN4O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 180 nM
|
|
|
| 3 |
IC50 = 1800 nM
|
|
|
|
CP0400678
|
4-[4-[(4-fluorophenyl)methyl]-3,5-dimethylpyrazol-1-yl]benzonitrile
Show/Hide
|
C19H16FN3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 170 nM
|
|
|
| 3 |
IC50 = 700 nM
|
|
|
|
CP0403482
|
4-[[1-(3-chloro-4-cyanophenyl)-3,5-dimethylpyrazol-4-yl]methyl]-N-(2-hydroxyethyl)benzamide
Show/Hide
|
C22H21ClN4O2
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 2100 nM
|
|
|
| 3 |
IC50 = 2700 nM
|
|
|
|
CP0403484
|
N-[6-[1-(3-chloro-4-cyanophenyl)-3,5-dimethylpyrazol-4-yl]oxypyridin-3-yl]acetamide
Show/Hide
|
C19H16ClN5O2
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 1600 nM
|
|
|
| 3 |
IC50 > 10000 nM
|
|
|
|
CP0403488
|
4-[[1-(3-chloro-4-cyanophenyl)-3,5-dimethylpyrazol-4-yl]methyl]-N-(2-hydroxy-2-methylpropyl)benzamide
Show/Hide
|
C24H25ClN4O2
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 590 nM
|
|
|
| 3 |
IC50 = 1100 nM
|
|
|
|
CP0356086
|
2-chloro-4-[(4R,5R)-4-hydroxy-3,3,5-trimethyl-2-oxopyrrolidin-1-yl]benzonitrile
Show/Hide
|
C14H15ClN2O2
|
1
|
| 1 |
EC50 = 10000 nM
|
|
|
|
CP0558579
|
2-chloro-4-[(2S,3S)-2-(cyanomethyl)-3-hydroxy-5-oxopyrrolidin-1-yl]benzonitrile
Show/Hide
|
C13H10ClN3O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0089355
|
4-[(2R)-2-methylpyrrolidin-1-yl]naphthalene-1-carbonitrile
Show/Hide
|
C16H16N2
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0148232
|
methyl (2S,3S)-1-(4-cyanonaphthalen-1-yl)-2-methylpyrrolidine-3-carboxylate
Show/Hide
|
C18H18N2O2
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0845015
|
Asoprinsil
Show/Hide
|
C28H35NO4
|
1
|
| 1 |
IC50 = 6.1 nM
|
|
|
|
CP0035186
|
(10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]-14-hydroxy-15-methyl-14-(prop-1-yn-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1,6-dien-5-one
Show/Hide
|
C29H35NO2
|
1
|
| 1 |
IC50 = 6.9 nM
|
|
|
|
CP0385184
|
4-[(2S,3R)-1-(3-chloro-4-cyanophenyl)-3-hydroxy-2-methylpyrrolidin-3-yl]-N-methylbenzamide
Show/Hide
|
C20H20ClN3O2
|
2
|
| 1 |
IC50 = 8.6 nM
|
|
|
| 2 |
IC50 = 10 nM
|
|
|
|
CP0391673
|
4-[(2S,3R)-1-(3-chloro-4-cyanophenyl)-3-hydroxy-2-methylpyrrolidin-3-yl]benzamide
Show/Hide
|
C19H18ClN3O2
|
2
|
| 1 |
IC50 = 9 nM
|
|
|
| 2 |
IC50 = 17 nM
|
|
|
|
CP0449089
|
2-chloro-4-[(2S,3R)-3-hydroxy-2-methyl-3-[6-(2-oxopyrrolidin-1-yl)pyridin-3-yl]pyrrolidin-1-yl]benzonitrile
Show/Hide
|
C21H21ClN4O2
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 160 nM
|
|
|
|
CP0385183
|
2-chloro-4-[(2S,3R)-3-(4-fluorophenyl)-3-hydroxy-2-methylpyrrolidin-1-yl]benzonitrile
Show/Hide
|
C18H16ClFN2O
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0040191
|
2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide
Show/Hide
|
C11H11F3N2O4
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0385186
|
5-[(2S,3R)-1-(3-chloro-4-cyanophenyl)-3-hydroxy-2-methylpyrrolidin-3-yl]-N-methylpyridine-2-carboxamide
Show/Hide
|
C19H19ClN4O2
|
2
|
| 1 |
IC50 = 25 nM
|
|
|
| 2 |
IC50 = 99 nM
|
|
|
|
CP0449091
|
5-[(2S,3R)-1-(4-cyano-3-methoxyphenyl)-3-hydroxy-2-methylpyrrolidin-3-yl]-N-methylpyridine-2-carboxamide
Show/Hide
|
C20H22N4O3
|
2
|
| 1 |
IC50 = 62 nM
|
|
|
| 2 |
IC50 = 730 nM
|
|
|
|
CP0385185
|
2-chloro-4-[3-(4-fluorophenyl)-3-hydroxypyrrolidin-1-yl]benzonitrile
Show/Hide
|
C17H14ClFN2O
|
2
|
| 1 |
IC50 = 65 nM
|
|
|
| 2 |
IC50 = 68 nM
|
|
|
|
CP0391690
|
2-chloro-4-(3-hydroxypyrrolidin-1-yl)benzonitrile
Show/Hide
|
C11H11ClN2O
|
2
|
| 1 |
IC50 = 82 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0385187
|
6-[(2S,3S)-1-(3-chloro-4-cyanophenyl)-3-hydroxy-2-methylpyrrolidin-3-yl]-N-methylpyridine-3-carboxamide
Show/Hide
|
C19H19ClN4O2
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
IC50 = 120 nM
|
|
|
|
CP0404871
|
5-(7-fluoro-3,3-dimethyl-2-oxo-1H-indol-5-yl)-1-methylpyrrole-2-carbonitrile
Show/Hide
|
C16H14FN3O
|
1
|
| 1 |
IC50 = 196 nM
|
|
|
|
CP0449090
|
2-chloro-4-(3-hydroxy-3-phenylpyrrolidin-1-yl)benzonitrile
Show/Hide
|
C17H15ClN2O
|
2
|
| 1 |
IC50 = 250 nM
|
|
|
| 2 |
IC50 = 380 nM
|
|
|
|
CP0449005
|
5-[(2S,3R)-1-(4-cyano-3-fluorophenyl)-3-hydroxy-2-methylpyrrolidin-3-yl]-N-methylpyridine-2-carboxamide
Show/Hide
|
C19H19FN4O2
|
2
|
| 1 |
IC50 = 290 nM
|
|
|
| 2 |
IC50 = 1700 nM
|
|
|
|
CP0391675
|
5-[(2S,3R)-1-(4-cyanophenyl)-3-hydroxy-2-methylpyrrolidin-3-yl]-N-methylpyridine-2-carboxamide
Show/Hide
|
C19H20N4O2
|
2
|
| 1 |
IC50 = 400 nM
|
|
|
| 2 |
IC50 = 1400 nM
|
|
|
|
CP0391689
|
4-(3-benzyl-3-hydroxypyrrolidin-1-yl)-2-chlorobenzonitrile
Show/Hide
|
C18H17ClN2O
|
2
|
| 1 |
IC50 = 450 nM
|
|
|
| 2 |
IC50 = 1000 nM
|
|
|
|
CP0373077
|
3-[5-Ethyl-5-(2-furyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-7-yl]-5-fluorobenzonitrile
Show/Hide
|
C22H17FN2O3
|
1
|
| 1 |
IC50 = 690 nM
|
|
|
|
CP0391672
|
5-[(2R,3S)-1-(3-chloro-4-cyanophenyl)-3-hydroxy-2-methylpyrrolidin-3-yl]-N-methylpyridine-2-carboxamide
Show/Hide
|
C19H19ClN4O2
|
2
|
| 1 |
IC50 = 1600 nM
|
|
|
| 2 |
IC50 = 6400 nM
|
|
|
|
CP0391674
|
5-[(2S,3R)-1-(3-chloro-4-cyanophenyl)-3-hydroxy-2-methylpyrrolidin-3-yl]-N,N-dimethylpyridine-2-carboxamide
Show/Hide
|
C20H21ClN4O2
|
2
|
| 1 |
IC50 = 1700 nM
|
|
|
| 2 |
IC50 = 10000 nM
|
|
|
|
CP0376523
|
(1S,12S,15S,20R)-15-hydroxy-1,16,16,20-tetramethyl-3-azapentacyclo[10.8.0.02,10.04,9.015,20]icosa-2(10),4,6,8-tetraen-17-one
Show/Hide
|
C23H29NO2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0376524
|
(1S,12S,15S,17R,20R)-1,16,16,20-tetramethyl-3-azapentacyclo[10.8.0.02,10.04,9.015,20]icosa-2(10),4,6,8-tetraene-15,17-diol
Show/Hide
|
C23H31NO2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0401079
|
3-(5,5-Dimethyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-7-yl)-5-fluorobenzonitrile
Show/Hide
|
C18H15FN2O2
|
1
|
| 1 |
IC50 > 3000 nM
|
|
|
|
CP0445223
|
3-[5,5-Di(2-furyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-7-yl]-5-fluorobenzonitrile
Show/Hide
|
C24H15FN2O4
|
1
|
| 1 |
IC50 > 3000 nM
|
|
|
|
CP0373230
|
10-hydroxy-4-(trifluoromethyl)-1,5-dihydrochromeno[3,4-f]quinolin-2-one
Show/Hide
|
C17H10F3NO3
|
1
|
| 1 |
Ki = 1.3 nM
|
|
|
|
CP0373219
|
10-hydroxy-4-(trifluoromethyl)-1H-isochromeno[3,4-f]quinoline-2,6-dione
Show/Hide
|
C17H8F3NO4
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0399724
|
9-hydroxy-10-methoxy-4-methyl-1H-chromeno[3,4-f]quinoline-2,5-dione
Show/Hide
|
C18H13NO5
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0373223
|
9-hydroxy-10-methoxy-4-methyl-1,5-dihydrochromeno[3,4-f]quinolin-2-one
Show/Hide
|
C18H15NO4
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0432040
|
4-(trifluoromethyl)-1,6-dihydroisochromeno[3,4-f]quinolin-2-one
Show/Hide
|
C17H10F3NO2
|
1
|
| 1 |
Ki = 8 nM
|
|
|
|
CP0373227
|
tert-butyl 4-methyl-2,5-dioxo-1H-chromeno[3,4-f]quinoline-10-carboxylate
Show/Hide
|
C22H19NO5
|
1
|
| 1 |
Ki = 8.7 nM
|
|
|
|
CP0394285
|
trifluoromethyl 10-methoxy-4-methyl-2,5-dioxo-1H-chromeno[3,4-f]quinoline-9-carboxylate
Show/Hide
|
C20H12F3NO6
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0373224
|
10-methoxy-4-(trifluoromethyl)-1,5-dihydrochromeno[3,4-f]quinolin-2-one
Show/Hide
|
C18H12F3NO3
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0373217
|
10-methoxy-4-methyl-9-propan-2-yloxy-1H-chromeno[3,4-f]quinoline-2,5-dione
Show/Hide
|
C21H19NO5
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0373226
|
10-(hydroxymethyl)-4-methyl-1,5-dihydrochromeno[3,4-f]quinolin-2-one
Show/Hide
|
C18H15NO3
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0432039
|
10-methoxy-4-(trifluoromethyl)-1,6-dihydroisochromeno[3,4-f]quinolin-2-one
Show/Hide
|
C18H12F3NO3
|
1
|
| 1 |
Ki = 27 nM
|
|
|
|
CP0373218
|
10-methoxy-4-methyl-1H-chromeno[3,4-f]quinoline-2,5-dione
Show/Hide
|
C18H13NO4
|
1
|
| 1 |
Ki = 28 nM
|
|
|
|
CP0394282
|
10-methoxy-4-(trifluoromethyl)-1H-isochromeno[3,4-f]quinoline-2,6-dione
Show/Hide
|
C18H10F3NO4
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0373229
|
10-methoxy-4-methyl-1,5-dihydrochromeno[3,4-f]quinolin-2-one
Show/Hide
|
C18H15NO3
|
1
|
| 1 |
Ki = 59 nM
|
|
|
|
CP0433628
|
9-ethoxy-10-methoxy-4-methyl-1H-chromeno[3,4-f]quinoline-2,5-dione
Show/Hide
|
C20H17NO5
|
1
|
| 1 |
Ki = 62 nM
|
|
|
|
CP0373249
|
10-methoxy-4,5-dimethyl-1,5-dihydrochromeno[3,4-f]quinolin-2-one
Show/Hide
|
C19H17NO3
|
1
|
| 1 |
Ki = 250 nM
|
|
|
|
CP0432041
|
9-methoxy-4-methyl-1H-chromeno[3,4-f]quinoline-2,5-dione
Show/Hide
|
C18H13NO4
|
1
|
| 1 |
Ki = 610 nM
|
|
|
|
CP0394256
|
9-fluoro-4-methyl-1H-chromeno[3,4-f]quinoline-2,5-dione
Show/Hide
|
C17H10FNO3
|
1
|
| 1 |
Ki = 1000 nM
|
|
|
|
CP0373228
|
5-hydroxy-10-methoxy-4-methyl-1,5-dihydrochromeno[3,4-f]quinolin-2-one
Show/Hide
|
C18H15NO4
|
1
|
| 1 |
Ki = 1300 nM
|
|
|
|
CP0373221
|
10-methoxy-4-methyl-5-prop-2-enyl-1,5-dihydrochromeno[3,4-f]quinolin-2-one
Show/Hide
|
C21H19NO3
|
1
|
| 1 |
Ki = 1593 nM
|
|
|
|
CP0373222
|
5,10-dimethoxy-4-methyl-1,5-dihydrochromeno[3,4-f]quinolin-2-one
Show/Hide
|
C19H17NO4
|
1
|
| 1 |
Ki = 2346 nM
|
|
|
