Compound ID |
Compound Name |
Compound Formula |
CP0381427
|
(+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-3-methylbutan-1-amine
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|
C17H25Cl2N
|
1
|
1 |
IC50 < 1 nM
|
|
|
CP0381428
|
(+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,3-dimethylbutan-1-amine
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|
C18H27Cl2N
|
1
|
1 |
IC50 = 9 nM
|
|
|
CP0051444
|
1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmethanamine
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|
C14H19Cl2N
|
1
|
1 |
IC50 = 21 nM
|
|
|
CP0378737
|
(+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)propan-1-amine
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|
C15H21Cl2N
|
1
|
1 |
IC50 = 29 nM
|
|
|
CP0086307
|
(+)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine
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|
C16H18N2
|
1
|
1 |
IC50 = 31.62 nM
|
|
|
CP0067008
|
N-methyl-1-(1-naphthalen-2-ylcyclohexyl)methanamine
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|
C18H23N
|
1
|
1 |
IC50 = 90 nM
|
|
|
CP0454408
|
(+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N,3-trimethylbutan-1-amine
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|
C19H29Cl2N
|
1
|
1 |
IC50 = 350 nM
|
|
|
CP0395777
|
1-(1-(biphenyl-4-yl)cyclohexyl)ethanamine
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|
C20H25N
|
1
|
1 |
IC50 = 530 nM
|
|
|
CP0378736
|
1-(1-(thiophen-2-yl)cyclohexyl)ethanamine
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|
C12H19NS
|
1
|
1 |
IC50 = 1000 nM
|
|
|
CP0378738
|
1-(1-(4-tert-butoxyphenyl)cyclohexyl)ethanamine
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|
C18H29NO
|
1
|
1 |
IC50 = 1520 nM
|
|
|
CP0471341
|
1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethanamine
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|
C15H20F3NO
|
1
|
1 |
IC50 = 2300 nM
|
|
|
CP0377979
|
1-(1-(naphthalen-1-yl)cyclohexyl)ethanamine
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|
C18H23N
|
1
|
1 |
IC50 = 4000 nM
|
|
|
CP0135457
|
(2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-8-methyl-8-azonia-bicyclo[3.2.1]octane
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|
C16H19Cl2NO2
|
2
|
1 |
Ki = 0.2 nM
|
|
|
2 |
Ki = 2.3 nM
|
|
|
CP0232539
|
1-[(2S,6R)-4-[2-[bis(4-fluorophenyl)methylsulfinyl]ethyl]-2,6-dimethylpiperazin-1-yl]-3-phenylpropan-2-ol
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|
C30H36F2N2O2S
|
2
|
1 |
Ki = 3.83 nM
|
|
|
2 |
Ki = 11.1 nM
|
|
|
CP0385310
|
US10913711, Compound 10j
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|
C28H32F2N2O2S
|
2
|
1 |
Ki = 6.5 nM
|
|
|
2 |
Ki = 12 nM
|
|
|
CP0055019
|
2-[3-(4-Chloro-phenyl)-isoxazol-5-yl]-8-methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane
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|
C24H25ClN2O
|
2
|
1 |
Ki = 9.7 nM
|
|
|
2 |
Ki = 27 nM
|
|
|
CP0492042
|
2-[3-[bis(4-fluorophenyl)methoxy]-8-azabicyclo[3.2.1]octan-8-yl]-N,N-dimethylethanamine
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|
C24H30F2N2O
|
2
|
1 |
Ki = 10 nM
|
|
|
2 |
Ki = 47 nM
|
|
|
CP0155932
|
WIN 35,428
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|
C16H20FNO2
|
1
|
1 |
Ki = 13 nM
|
|
|
CP0390123
|
N-[bis(4-fluorophenyl)methyl]-8-[2-(dimethylamino)ethyl]-8-azabicyclo[3.2.1]octan-3-amine
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|
C24H31F2N3
|
2
|
1 |
Ki = 16 nM
|
|
|
2 |
Ki = 40 nM
|
|
|
CP0161622
|
3-(4-Chloro-phenyl)-8-methyl-2-(3-p-tolyl-isoxazol-5-yl)-8-aza-bicyclo[3.2.1]octane
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|
C24H25ClN2O
|
2
|
1 |
Ki = 16 nM
|
|
|
2 |
Ki = 35 nM
|
|
|
CP0400723
|
2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl)-5-(5-{2-[3-(3,4-dichloro-phenyl)-2-methoxycarbonyl-8-aza-bicyclo[3.2.1]oct-8-yl]-ethylcarbamoyl}-pentylsulfamoyl)-benzenesulfonic acid anion
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|
C50H61Cl2N5O9S2
|
3
|
1 |
Ki = 18 nM
|
|
|
2 |
Ki = 20 nM
|
|
|
3 |
Ki = 62 nM
|
|
|
CP0509523
|
N-[bis(4-fluorophenyl)methyl]-8-butyl-8-azabicyclo[3.2.1]octan-3-amine
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|
C24H30F2N2
|
2
|
1 |
Ki = 24 nM
|
|
|
2 |
Ki = 62 nM
|
|
|
CP0393973
|
2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl)-5-(5-{2-[3-(3,4-dichloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carbonyloxy]-ethylcarbamoyl}-pentylsulfamoyl)-benzenesulfonic acid anion
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|
C50H61Cl2N5O9S2
|
2
|
1 |
Ki = 27 nM
|
|
|
2 |
Ki = 72 nM
|
|
|
CP0139957
|
3-[Bis-(4-fluoro-phenyl)-methoxy]-8-butyl-8-aza-bicyclo[3.2.1]octane
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|
C24H29F2NO
|
2
|
1 |
Ki = 47 nM
|
|
|
2 |
Ki = 161 nM
|
|
|
CP0853656
|
[1-(3-{2-[3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-8-azabicyclo[3.2.1]oct-8-yl]-ethylcarbamoyl}-propyl)-11,11-dimethyl-2,3,4,11-tetrahydro-1H-naphtho[2,3-g]quinolin-9-ylidene]-dimethyl-ammonium perchlorate
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|
C42H51Cl3N4O7
|
2
|
1 |
Ki = 50 nM
|
|
|
2 |
Ki = 250 nM
|
|
|
CP0368515
|
1-[(2S,6R)-4-[2-[bis(4-fluorophenyl)methylsulfanyl]ethyl]-2,6-dimethylpiperazin-1-yl]propan-2-ol
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|
C24H32F2N2OS
|
2
|
1 |
Ki = 58.3 nM
|
|
|
2 |
Ki = 100 nM
|
|
|
CP0390456
|
(R)-1-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3.2.1]oct-8-ylmethyl}-2-methyl-propylamine
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|
C25H32F2N2O
|
2
|
1 |
Ki = 81 nM
|
|
|
2 |
Ki = 133 nM
|
|
|
CP0451512
|
1-[4-[2-[bis(4-fluorophenyl)methylsulfanyl]ethyl]piperazin-1-yl]propan-2-ol
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|
C22H28F2N2OS
|
2
|
1 |
Ki = 101 nM
|
|
|
2 |
Ki = 200 nM
|
|
|
CP0560236
|
2-[8-[2-[bis(4-fluorophenyl)methylsulfanyl]ethyl]-2,8-diazaspiro[4.5]decan-2-yl]-1-phenylethanol
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|
C31H36F2N2OS
|
2
|
1 |
Ki = 104 nM
|
|
|
2 |
Ki = 268 nM
|
|
|
CP0407294
|
ethyl (2R,3S)-3-[bis(4-fluorophenyl)methoxy]-8-[2-(1H-indol-3-yl)ethyl]-8-azabicyclo[3.2.1]octane-2-carboxylate
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|
C33H34F2N2O3
|
2
|
1 |
Ki = 147 nM
|
|
|
2 |
Ki = 944 nM
|
|
|
CP0035807
|
Cocaine
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|
C17H21NO4
|
3
|
1 |
Ki = 200 nM
|
|
|
2 |
Ki = 223 nM
|
|
|
3 |
Ki = 450 nM
|
|
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CP0547854
|
ethyl (2R,3S)-8-[(2R)-2-amino-3-methylbutyl]-3-[bis(4-fluorophenyl)methoxy]-8-azabicyclo[3.2.1]octane-2-carboxylate
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|
C28H36F2N2O3
|
2
|
1 |
Ki = 221 nM
|
|
|
2 |
Ki = 1050 nM
|
|
|
CP0390121
|
3-(2-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3.2.1]oct-8-yl}-ethyl)-1H-indole
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|
C30H30F2N2O
|
1
|
1 |
Ki = 253 nM
|
|
|
CP0046624
|
US10913711, Compound 4a
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|
C15H17NS
|
2
|
1 |
Ki = 390 nM
|
|
|
2 |
Ki = 720 nM
|
|
|
CP0388238
|
1-[(2S,6R)-4-[2-[bis(4-fluorophenyl)methylsulfinyl]ethyl]-2,6-dimethylpiperazin-1-yl]propan-2-ol
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|
C24H32F2N2O2S
|
2
|
1 |
Ki = 406 nM
|
|
|
2 |
Ki = 552 nM
|
|
|
CP0393974
|
2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl)-5-[(4-{2-[3-(3,4-dichloro-phenyl)-2-methoxycarbonyl-8-aza-bicyclo[3.2.1]oct-8-yl]-ethylcarbamoyl}-cyclohexylmethyl)-sulfamoyl]-benzenesulfonic acid anion
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|
C52H63Cl2N5O9S2
|
1
|
1 |
Ki = 436 nM
|
|
|
CP0390315
|
(R)-Modafinil
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|
C15H15NO2S
|
1
|
1 |
Ki = 647 nM
|
|
|
CP0451508
|
N-[2-[bis(4-fluorophenyl)methylsulfanyl]ethyl]-3-phenylpropan-1-amine
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|
C24H25F2NS
|
2
|
1 |
Ki = 720 nM
|
|
|
2 |
Ki = 890 nM
|
|
|
CP0061816
|
2-(Diphenyl-methanesulfinyl)-acetamide
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|
C15H15NO2S
|
3
|
1 |
Ki = 927 nM
|
|
|
2 |
Ki = 3090 nM
|
|
|
3 |
Ki = 13000 nM
|
|
|
CP0464096
|
US10913711, Compound 10d
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|
C22H28F2N2O2S
|
2
|
1 |
Ki = 1200 nM
|
|
|
2 |
Ki = 1730 nM
|
|
|
CP0389631
|
US10913711, Compound 4b
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|
C15H15Cl2NS
|
2
|
1 |
Ki = 1210 nM
|
|
|
2 |
Ki = 1370 nM
|
|
|
CP0510706
|
(S)-Modafinil
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|
C15H15NO2S
|
1
|
1 |
Ki = 1960 nM
|
|
|
CP0407053
|
US10913711, Compound 2h
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|
C16H15Cl2NOS
|
2
|
1 |
Ki = 2300 nM
|
|
|
2 |
Ki = 3700 nM
|
|
|
CP0432905
|
US10913711, Compound 2g
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|
C16H17NOS
|
2
|
1 |
Ki = 3600 nM
|
|
|
2 |
Ki = 5500 nM
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