Brief Information of the Compound and Protein
Compound Name
(+)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine
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PubChem ID
CID: 4528
SID: 14773981
Canonical SMILES
CN1CC(c2ccccc2)c2cccc(N)c2C1
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Compound Formula C16H18N2
Compound Structure
Protein Name
Sodium-dependent dopamine transporter
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC06 neurotransmitter transporter family
Uniprot ID
Q01959
Gene Name
SLC6A3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  3
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
2
IC50 = 30.2 nM
   TI
   LI
   LO
   TS
3
IC50 = 31.62 nM
   TI
   LI
   LO
   TS
CL000053 COS-7 Chlorocebus aethiops (Green monkey)  1
1
IC50 = 31.62 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  3
1
IC50 = 281.84 nM
   TI
   LI
   LO
   TS
2
Ki = 10 nM
   TI
   LI
   LO
   TS
3
Ki = 109 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 23.5 nM
2 Ki = 79 nM
3 Ki = 84 nM