Brief Information of the Cell Line and Protein
Cell Line ID: CL000053 , COS-7
Synonyms
Cos-7
COS 7
Cos 7
COS7
Cos7
CV-1 in Origin Simian-7
Category Transformed cell line
Organism
Chlorocebus aethiops (Green monkey)
Cellosaurus ID
CVCL_0224
Protein ID: PT01823 , Prostaglandin F2-alpha receptor
Gene Name PTGFR
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P43088
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000053  Protein ID: PT01823
 
Compound ID Compound Name Compound Formula
CP0295469
(Z)-7-{(1R,2R,3R,5S)-2-[(E)-(R)-4-(3-Chloro-phenoxy)-3-hydroxy-but-1-enyl]-3,5-dihydroxy-cyclopentyl}-hept-5-enoic acid
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C22H29ClO6
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0402541
7-{(1R,2R,3R,5S)-2-[(R)-4-(3-Chloro-phenoxy)-3-hydroxy-butyl]-3,5-dihydroxy-cyclopentyl}-heptanoic acid
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C22H33ClO6
 1
1
IC50 = 2.6 nM
   TI
   LI
   LO
   TS
CP0433187
7-[3,5-Dihydroxy-2-(3-hydroxy-4-phenylsulfanyl-butyl)-cyclopentyl]-heptanoic acid
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C22H34O5S
 1
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
CP0095751
(5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid
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C20H34O5
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0445340
7-{3,5-Dihydroxy-2-[3-hydroxy-4-(thiophen-2-ylsulfanyl)-butyl]-cyclopentyl}-heptanoic acid
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C20H32O5S2
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0438269
7-[3,5-Dihydroxy-2-(3-hydroxy-4-phenoxy-butyl)-cyclopentyl]-heptanoic acid
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C22H34O6
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0374214
7-{2-[4-(3-Chloro-phenylsulfanyl)-3-hydroxy-butyl]-3,5-dihydroxy-cyclopentyl}-heptanoic acid
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C22H33ClO5S
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0395236
7-{2-[4-(3-Fluoro-phenylsulfanyl)-3-hydroxy-butyl]-3,5-dihydroxy-cyclopentyl}-heptanoic acid
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C22H33FO5S
 1
1
IC50 = 29 nM
   TI
   LI
   LO
   TS
CP0372737
7-[3,5-Dihydroxy-2-(3-hydroxy-4-m-tolylsulfanyl-butyl)-cyclopentyl]-heptanoic acid
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C23H36O5S
 1
1
IC50 = 63 nM
   TI
   LI
   LO
   TS
CP0377752
7-[3,5-Dihydroxy-2-(3-hydroxy-4-phenylamino-butyl)-cyclopentyl]-heptanoic acid
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C22H35NO5
 1
1
IC50 = 90 nM
   TI
   LI
   LO
   TS
CP0448266
7-{3,5-Dihydroxy-2-[3-hydroxy-4-(3-trifluoromethyl-phenylsulfanyl)-butyl]-cyclopentyl}-heptanoic acid
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C23H33F3O5S
 1
1
IC50 = 320 nM
   TI
   LI
   LO
   TS
CP0432809
7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((S)-3-hydroxy-octyl)-cyclopentyl]-heptanoic acid
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C20H38O5
 1
1
IC50 = 350 nM
   TI
   LI
   LO
   TS
CP0402565
7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((R)-3-hydroxy-5-phenyl-pentyl)-cyclopentyl]-heptanoic acid
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C23H36O5
 1
1
IC50 = 570 nM
   TI
   LI
   LO
   TS
CP0432810
7-{3,5-Dihydroxy-2-[3-hydroxy-4-(thiazol-2-ylsulfanyl)-butyl]-cyclopentyl}-heptanoic acid
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C19H31NO5S2
 1
1
IC50 = 1424 nM
   TI
   LI
   LO
   TS