Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3H-GR113808
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 PubChem ID
CID: 119376
SID: 14756648
Canonical SMILES
Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
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Compound Formula C19H27N3O4S
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 4
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
Q13639
Gene Name
HTR4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6
 Cell Line Info 
Rattus norvegicus (Rat)  2
1
Ki = 0.1 nM
   TI
   LI
   LO
   TS
2
Ki = 0.5 nM
   TI
   LI
   LO
   TS
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  3
1
IC50 = 0.21 nM
   TI
   LI
   LO
   TS
2
Ki = 0.5 nM
   TI
   LI
   LO
   TS
3
Ki = 0.7 nM
   TI
   LI
   LO
   TS
CL000053 COS-7
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  4
1
Ki = 0.078 nM
   TI
   LI
   LO
   TS
2
Ki = 0.33 nM
   TI
   LI
   LO
   TS
3
Ki = 0.41 nM
   TI
   LI
   LO
   TS
4
Ki = 0.53 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  3
1
Ki = 0.03981 nM
   TI
   LI
   LO
   TS
2
Ki = 0.07413 nM
   TI
   LI
   LO
   TS
3
Ki = 0.2512 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.1585 nM