Brief Information of the Cell Line and Protein
Cell Line ID: CL000053 , COS-7
Synonyms
Cos-7
COS 7
Cos 7
COS7
Cos7
CV-1 in Origin Simian-7
Category Transformed cell line
Organism
Chlorocebus aethiops (Green monkey)
Cellosaurus ID
CVCL_0224
Protein ID: PT00903 , C-C chemokine receptor type 5
Gene Name CCR5
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P51681
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000053  Protein ID: PT00903
 
Compound ID Compound Name Compound Formula
CP0391269
3,4,7,8-tetramethyl-1,10-phenanthroline
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C16H16N2
 1
1
EC50 = 1000 nM
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CP0395739
1,10-phenanthroline-4,7-dicarbaldehyde
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C14H8N2O2
 1
1
EC50 = 10000 nM
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CP0871032
CENICRIVIROC MESYLATE
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C42H56N4O7S2
 1
1
IC50 = 0.1 nM
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CP0849521
(S)-(-)-8-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-(4-{[(4-propyl-4H-1,2,4-triazol-3-yl)methyl]sulfinyl}phenyl)-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide
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C40H51N5O4S
 1
1
IC50 = 0.19 nM
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CP0871030
(S)-(-)-8-{4-[2-(butoxy)ethoxy]phenyl}-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-N-(4-{[(1-propyl-1H-imidazol-5-yl)methyl]-sulfinyl}phenyl)-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide
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C42H50N6O4S
 1
1
IC50 = 0.21 nM
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CP0869198
(S)-(-)-8-{4-[2-(butoxy)ethoxy]phenyl}-1-propyl-N-(4-{[(1-propyl-1H-imidazol-5-yl)methyl]sulfinyl}phenyl)-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide
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C40H50N4O4S
 1
1
IC50 = 0.24 nM
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CP0390640
1-acetyl-N-{3-[4-(4-carbamoylbenzyl)piperidin-1-yl]propyl}-N-(3-chloro-4-methylphenyl)piperidine-4-carboxamide
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C31H41ClN4O3
 1
1
IC50 = 0.42 nM
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CP0849520
(S)-(-)-9-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-(4-{[(1-propyl-1H-imidazol-5-yl)methyl]sulfinyl}phenyl)-2,3,4,5-tetrahydro-1H-1-benzazonine-6-carboxamide
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C42H54N4O4S
 1
1
IC50 = 0.48 nM
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CP0439500
N-(3,4-dichlorophenyl)-1-methylsulfonyl-N-[3-[4-[(4-methylsulfonylphenyl)methyl]piperidin-1-yl]propyl]piperidine-4-carboxamide
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C29H39Cl2N3O5S2
 1
1
IC50 = 0.8 nM
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CP0883433
(S)-(-)-8-{4-[2-(butoxy)ethoxy]phenyl}-1-propyl-N-(4-{[(4-propyl-4H-1,2,4-tri azol-3-yl)methyl]sulfinyl}phenyl)-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide
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C39H49N5O4S
 1
1
IC50 = 0.95 nM
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CP0424888
7-(4-(2-butoxyethoxy)phenyl)-1-isobutyl-N-(4-((1-propyl-1H-imidazol-5-yl)methylsulfinyl)phenyl)-2,3-dihydro-1H-benzo[b]azepine-4-carboxamide
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C40H50N4O4S
 1
1
IC50 = 1 nM
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CP0666580
Dimethyl-(tetrahydro-pyran-4-yl)-{4-[(3-p-tolyl-8,9-dihydro-7H-benzocycloheptene-6-carbonyl)-amino]-benzyl}-ammonium chloride(TAK-779)
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C33H39ClN2O2
 1
1
IC50 = 1.4 nM
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CP0435461
N-[3-[4-[(4-cyanophenyl)methyl]piperidin-1-yl]propyl]-N-(3,4-dichlorophenyl)-1-methylsulfonylpiperidine-4-carboxamide
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C29H36Cl2N4O3S
 1
1
IC50 = 1.4 nM
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CP0523077
1-acetyl-N-(3,4-dichlorophenyl)-N-(3-{4-[(4-fluorophenyl)sulfanyl]piperidin-1-yl}propyl)piperidine-4-carboxamide
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C28H34Cl2FN3O2S
 1
1
IC50 = 1.8 nM
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CP0449506
N-[3-[4-[(3-carbamoylphenyl)methyl]piperidin-1-yl]propyl]-N-(3,4-dichlorophenyl)-1-methylsulfonylpiperidine-4-carboxamide
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C29H38Cl2N4O4S
 1
1
IC50 = 2 nM
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CP0449508
N-(3,4-dichlorophenyl)-N-[3-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]propyl]-1-methylsulfonylpiperidine-4-carboxamide
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C28H36Cl2FN3O3S
 1
1
IC50 = 2.1 nM
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CP0532106
1-acetyl-N-{3-[4-(4-carbamoylbenzyl)piperidin-1-yl]propyl}-N-(3,4-dichlorophenyl)piperidine-4-carboxamide
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C30H38Cl2N4O3
 1
1
IC50 = 2.2 nM
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CP0449507
1-acetyl-N-(3,4-dichlorophenyl)-N-(3-{4-[(4-fluorophenyl)-sulfinyl]piperidin-1-yl}propyl)piperidine-4-carboxamide
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C28H34Cl2FN3O3S
 1
1
IC50 = 2.7 nM
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CP0441886
1-acetyl-N-(3,4-dichlorophenyl)-N-[3-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]propyl]piperidine-4-carboxamide
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C29H36Cl2FN3O2
 1
1
IC50 = 3 nM
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CP0436922
1-acetyl-N-(3,4-dichlorophenyl)-N-(3-{4-[(4-fluorophenyl)sulfonyl]piperidin-1-yl}propyl)piperidine-4-carboxamide
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C28H34Cl2FN3O4S
 1
1
IC50 = 3.9 nM
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CP0424819
N-(3,4-dichlorophenyl)-N-[3-[4-[(4-fluorophenyl)sulfonylamino]piperidin-1-yl]propyl]-1-methylsulfonylpiperidine-4-carboxamide
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C27H35Cl2FN4O5S2
 1
1
IC50 = 4.1 nM
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CP0435458
N-[3-[4-[(4-carbamoylphenyl)methyl]piperidin-1-yl]propyl]-N-(3,4-dichlorophenyl)-1-methylsulfonylpiperidine-4-carboxamide
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C29H38Cl2N4O4S
 1
1
IC50 = 5.8 nM
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CP0435457
N-[3-[4-[(2-carbamoylphenyl)methyl]piperidin-1-yl]propyl]-N-(3,4-dichlorophenyl)-1-methylsulfonylpiperidine-4-carboxamide
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C29H38Cl2N4O4S
 1
1
IC50 = 6.4 nM
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CP0435459
methyl 4-[[1-[3-(3,4-dichloro-N-(1-methylsulfonylpiperidine-4-carbonyl)anilino)propyl]piperidin-4-yl]methyl]benzoate
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C30H39Cl2N3O5S
 1
1
IC50 = 7 nM
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CP0525141
N-(3,4-dichlorophenyl)-N-[3-[4-[[4-(dimethylcarbamoyl)phenyl]methyl]piperidin-1-yl]propyl]-1-methylsulfonylpiperidine-4-carboxamide
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C31H42Cl2N4O4S
 1
1
IC50 = 8.2 nM
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CP0503096
N-(3,4-dichlorophenyl)-N-[3-[4-[[4-(methylcarbamoyl)phenyl]methyl]piperidin-1-yl]propyl]-1-methylsulfonylpiperidine-4-carboxamide
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C30H40Cl2N4O4S
 1
1
IC50 = 9.8 nM
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CP0435456
N-[3-[4-[[4-(tert-butylcarbamoyl)phenyl]methyl]piperidin-1-yl]propyl]-N-(3,4-dichlorophenyl)-1-methylsulfonylpiperidine-4-carboxamide
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C33H46Cl2N4O4S
 1
1
IC50 = 12 nM
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CP0424818
1-acetyl-N-(3,4-dichlorophenyl)-N-{3-[4-(4-fluoroanilino)piperidin-1-yl]propyl}piperidine-4-carboxamide
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C28H35Cl2FN4O2
 1
1
IC50 = 26 nM
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CP0432712
4-({1-[3-((3,4-dichlorophenyl){[1-(methylsulfonyl)piperidin-4-yl]carbonyl}amino)propyl]piperidin-4-yl}methyl)benzoic acid
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C29H37Cl2N3O5S
 1
1
IC50 = 44 nM
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CP0442044
1-acetyl-N-(3-(4-benzylpiperidin-1-yl)propyl)-N-phenylpiperidine-4-carboxamide
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C29H39N3O2
 1
1
IC50 = 72 nM
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