Brief Information of the Compound and Protein
Compound Name
(S)-(-)-8-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-(4-{[(4-propyl-4H-1,2,4-triazol-3-yl)methyl]sulfinyl}phenyl)-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide
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PubChem ID
CID: 11650548
SID: 16753870
Canonical SMILES
CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4nncn4CCC)cc2)CCCN3CC(C)C)cc1
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Compound Formula C40H51N5O4S
Compound Structure
Protein Name
C-C chemokine receptor type 5
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Chemokine receptor
>
CC chemokine receptor
Uniprot ID
P51681
Gene Name
CCR5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 2.4 nM
   TI
   LI
   LO
   TS
CL000053 COS-7 Chlorocebus aethiops (Green monkey)  1
1
IC50 = 0.19 nM
   TI
   LI
   LO
   TS
CL001058 MOLT-4/CCR5 Homo sapiens (Human)  1
1
IC50 < 1.6 nM
   TI
   LI
   LO
   TS