| Compound ID |
Compound Name |
Compound Formula |
|
CP0405395
|
2-phenyl-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
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|
C12H6F3N3OS
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0482624
|
2-(4-methoxyphenyl)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
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|
C13H8F3N3O2S
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0467693
|
2-(prop-2-enylamino)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
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|
C9H7F3N4OS
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0563374
|
2-(4-aminoanilino)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
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|
C12H8F3N5OS
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0405397
|
2-(3-methoxyanilino)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
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|
C13H9F3N4O2S
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0482618
|
2-[2-(dimethylamino)ethylamino]-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
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|
C10H12F3N5OS
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0471775
|
2-(3,5-dimethylphenyl)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
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|
C14H10F3N3OS
|
1
|
| 1 |
IC50 = 520 nM
|
|
|
|
CP0482625
|
7-(trifluoromethyl)-2-[3-(trifluoromethyl)phenyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Show/Hide
|
C13H5F6N3OS
|
1
|
| 1 |
IC50 = 520 nM
|
|
|
|
CP0482619
|
2-(3,4-dimethylphenyl)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
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|
C14H10F3N3OS
|
1
|
| 1 |
IC50 = 540 nM
|
|
|
|
CP0429927
|
3-[5-oxo-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl]benzonitrile
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|
C13H5F3N4OS
|
1
|
| 1 |
IC50 = 560 nM
|
|
|
|
CP0482617
|
2-(pentylamino)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
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|
C11H13F3N4OS
|
1
|
| 1 |
IC50 = 610 nM
|
|
|
|
CP0451005
|
2-(3-nitrophenyl)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Show/Hide
|
C12H5F3N4O3S
|
1
|
| 1 |
IC50 = 620 nM
|
|
|
|
CP0563494
|
2-(butylamino)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
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|
C10H11F3N4OS
|
1
|
| 1 |
IC50 = 880 nM
|
|
|
|
CP0213064
|
4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl-1H-pyrazole
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|
C12H10Cl2N2O
|
1
|
| 1 |
IC50 = 910 nM
|
|
|
|
CP0432302
|
2-(4-ethoxyphenyl)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Show/Hide
|
C14H10F3N3O2S
|
1
|
| 1 |
IC50 = 930 nM
|
|
|
|
CP0405396
|
2-(4-methylphenyl)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
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|
C13H8F3N3OS
|
1
|
| 1 |
IC50 = 1060 nM
|
|
|
|
CP0080093
|
(2R)-1-(4-chloro-3,5-dimethylpyrazol-1-yl)-2-[4-(2-methylpropyl)phenyl]propan-1-one
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|
C18H23ClN2O
|
1
|
| 1 |
IC50 = 1070 nM
|
|
|
|
CP0482622
|
2-(3-phenylphenyl)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Show/Hide
|
C18H10F3N3OS
|
1
|
| 1 |
IC50 = 1120 nM
|
|
|
|
CP0432301
|
2-(3,5-dimethoxyphenyl)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
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|
C14H10F3N3O3S
|
1
|
| 1 |
IC50 = 1150 nM
|
|
|
|
CP0482621
|
2-(3-fluorophenyl)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Show/Hide
|
C12H5F4N3OS
|
1
|
| 1 |
IC50 = 1390 nM
|
|
|
|
CP0451004
|
2-(propylamino)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
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|
C9H9F3N4OS
|
1
|
| 1 |
IC50 = 1440 nM
|
|
|
|
CP0346103
|
5-methyl-2-(4-methylbenzoyl)-1H-pyrazol-3-one
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|
C12H12N2O2
|
1
|
| 1 |
IC50 = 1510 nM
|
|
|
|
CP0455729
|
2-(dibutylamino)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Show/Hide
|
C14H19F3N4OS
|
1
|
| 1 |
IC50 = 1530 nM
|
|
|
|
CP0471820
|
2-(4-ethoxyanilino)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Show/Hide
|
C14H11F3N4O2S
|
1
|
| 1 |
IC50 = 1580 nM
|
|
|
|
CP0467691
|
2-(4-propan-2-ylanilino)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Show/Hide
|
C15H13F3N4OS
|
1
|
| 1 |
IC50 = 1980 nM
|
|
|
|
CP0451003
|
2-[amino(methyl)amino]-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Show/Hide
|
C7H6F3N5OS
|
1
|
| 1 |
IC50 = 2020 nM
|
|
|
|
CP0271237
|
(4-chloro-3,5-dimethylpyrazol-1-yl)-(3-methylphenyl)methanone
Show/Hide
|
C13H13ClN2O
|
1
|
| 1 |
IC50 = 2590 nM
|
|
|
|
CP0482620
|
2-(2-methoxyphenyl)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Show/Hide
|
C13H8F3N3O2S
|
1
|
| 1 |
IC50 = 3480 nM
|
|
|
|
CP0068517
|
(4-aminophenyl)-(3,5-dimethylpyrazol-1-yl)methanone
Show/Hide
|
C12H13N3O
|
1
|
| 1 |
IC50 = 3580 nM
|
|
|
|
CP0432303
|
2-(2-ethoxyphenyl)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Show/Hide
|
C14H10F3N3O2S
|
1
|
| 1 |
IC50 = 4520 nM
|
|
|
|
CP0080092
|
(3,5-dimethylpyrazol-1-yl)-(3-methylphenyl)methanone
Show/Hide
|
C13H14N2O
|
1
|
| 1 |
IC50 = 4580 nM
|
|
|
|
CP0360394
|
(4-aminophenyl)-[3,5-dimethyl-4-(4-methylphenoxy)pyrazol-1-yl]methanone
Show/Hide
|
C19H19N3O2
|
1
|
| 1 |
IC50 = 4910 nM
|
|
|
|
CP0080094
|
2-(4-aminobenzoyl)-5-methyl-1H-pyrazol-3-one
Show/Hide
|
C11H11N3O2
|
1
|
| 1 |
IC50 = 5430 nM
|
|
|
|
CP0249219
|
(4-chlorophenyl)-(3,5-dimethylpyrazol-1-yl)methanone
Show/Hide
|
C12H11ClN2O
|
1
|
| 1 |
IC50 = 5710 nM
|
|
|
|
CP0393057
|
(4-chlorophenyl)-[3,5-dimethyl-4-(4-methylphenoxy)pyrazol-1-yl]methanone
Show/Hide
|
C19H17ClN2O2
|
1
|
| 1 |
IC50 = 5780 nM
|
|
|
|
CP0197995
|
(3,5-dimethylpyrazol-1-yl)-naphthalen-2-ylmethanone
Show/Hide
|
C16H14N2O
|
1
|
| 1 |
IC50 = 6140 nM
|
|
|
|
CP0386818
|
(3,5-Dimethyl-pyrazol-1-yl)-pyridin-4-yl-methanone
Show/Hide
|
C11H11N3O
|
1
|
| 1 |
IC50 = 6510 nM
|
|
|
|
CP0248022
|
(4-aminophenyl)-(4-chloro-3,5-dimethylpyrazol-1-yl)methanone
Show/Hide
|
C12H12ClN3O
|
1
|
| 1 |
IC50 = 7860 nM
|
|
|
|
CP0393067
|
(3,5-dimethylpyrazol-1-yl)-(2-methylphenyl)methanone
Show/Hide
|
C13H14N2O
|
1
|
| 1 |
IC50 = 8240 nM
|
|
|
|
CP0392815
|
3,5-dimethyl-4-naphthalen-2-yloxy-1H-pyrazole
Show/Hide
|
C15H14N2O
|
1
|
| 1 |
IC50 = 11120 nM
|
|
|
|
CP0360393
|
(E)-1-(4-chloro-3,5-dimethylpyrazol-1-yl)-3-phenylprop-2-en-1-one
Show/Hide
|
C14H13ClN2O
|
1
|
| 1 |
IC50 = 13300 nM
|
|
|
|
CP0386814
|
(4-chloro-3,5-dimethylpyrazol-1-yl)-(4-methylphenyl)methanone
Show/Hide
|
C13H13ClN2O
|
1
|
| 1 |
IC50 = 17700 nM
|
|
|
|
CP0068518
|
(4-chloro-3,5-dimethylpyrazol-1-yl)-naphthalen-2-ylmethanone
Show/Hide
|
C16H13ClN2O
|
1
|
| 1 |
IC50 = 19100 nM
|
|
|
|
CP0035835
|
(S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole
Show/Hide
|
C11H12N2S
|
2
|
| 1 |
IC50 = 19200 nM
|
|
|
| 2 |
IC50 = 20210 nM
|
|
|
|
CP0393064
|
(4-chloro-3,5-dimethylpyrazol-1-yl)-(2-methylphenyl)methanone
Show/Hide
|
C13H13ClN2O
|
1
|
| 1 |
IC50 = 26400 nM
|
|
|
|
CP0360392
|
(4-chloro-3,5-dimethylpyrazol-1-yl)-pyridin-4-ylmethanone
Show/Hide
|
C11H10ClN3O
|
1
|
| 1 |
IC50 = 42000 nM
|
|
|
|
CP0042654
|
1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Show/Hide
|
C7H8N4O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0467692
|
2-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Show/Hide
|
C13H5F6N3O2S
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0467694
|
2-(2-fluorophenyl)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Show/Hide
|
C12H5F4N3OS
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0471819
|
2-(4-ethylphenyl)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Show/Hide
|
C14H10F3N3OS
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
